| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stéphan Hardivillé, Adelma Escobar-Ramirez, Soccoro Pina-Canceco, Elisabeth Elass, Annick Pierc. Delta-lactoferrin induces cell death via the mitochondrial death signaling pathway by upregulating bax expression. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 27. issue 5. 2015-07-24. PMID:24824995. |
western blot analyses showed that apoptosis was caspase-9, 7 and 8 dependent. |
2015-07-24 |
2023-08-13 |
Not clear |
| Yiping Zhang, Yuanqiao He, Hongbo Yu, Fuying Ma, Jianguo Wu, Xiaoyu Zhan. Liquiritigenin Protects Rats from Carbon Tetrachloride Induced Hepatic Injury through PGC-1α Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-07-22. PMID:26199636. |
sprague dawley rats were given ccl4 and lliquiritigenin alone or simultaneously for 8 weeks before liver was harvested to check histological changes by hematoxylin and eosin (h&e) staining, apoptosis by tunel assay, ros by dihydroethidium staining, antioxidant enzyme activities and malondialdehyde using specific kits, and gene expression by quantitative real-time pcr and western blot. |
2015-07-22 |
2023-08-13 |
rat |
| Kanjoormana A Manu, Muthu K Shanmugam, Lalitha Ramachandran, Feng Li, Kodappully Sivaraman Siveen, Arunachalam Chinnathambi, M E Zayed, Sulaiman Ali Alharbi, Frank Arfuso, Alan Prem Kumar, Kwang Seok Ahn, Gautam Seth. Isorhamnetin augments the anti-tumor effect of capecitabine through the negative regulation of NF-κB signaling cascade in gastric cancer. Cancer letters. vol 363. issue 1. 2015-07-20. PMID:25827070. |
the potential effect of ih on viability was analyzed by mtt assay, apoptosis by flow cytometric analysis, and nf-κb activation by dna binding as well as western blot assays. |
2015-07-20 |
2023-08-13 |
mouse |
| Jingbo Liu, Zhifei Chen, Jing He, Yan Zhang, Ting Zhang, Yiqun Jian. Anti-oxidative and anti-apoptosis effects of egg white peptide, Trp-Asn-Trp-Ala-Asp, against H2O2-induced oxidative stress in human embryonic kidney 293 cells. Food & function. vol 5. issue 12. 2015-07-17. PMID:25303143. |
furthermore, western blot results indicated that wnwad up-regulated the level of the anti-apoptotic protein bcl-2 and down-regulated the levels of apoptosis executor proteins, cleaved caspase-3 and cleaved prap, in h2o2-induced oxidative stress in hek-293 cells. |
2015-07-17 |
2023-08-13 |
human |
| Pei-Fang Wu, Hsien-Chun Tseng, Charng-Cherng Chyau, Jing-Hsien Chen, Fen-Pi Cho. Piper betle leaf extracts induced human hepatocellular carcinoma Hep3B cell death via MAPKs regulating the p73 pathway in vitro and in vivo. Food & function. vol 5. issue 12. 2015-07-17. PMID:25371988. |
the underlying mechanisms as evidenced by flow cytometry and western blot analysis showed that pbls triggered atm, cabl, and p73 expressions and activated jnk and p38 pathways that subsequently led to cell cycle arrest and mitochondria-dependent apoptosis. |
2015-07-17 |
2023-08-13 |
mouse |
| Jing Wang, Hong Wei, Baoxia Zhao, Mei Li, Weipeng Lv, Ling Lv, Bo Song, Shen L. The reverse effect of X-ray irradiation on acquired gefitinib resistance in non-small cell lung cancer cell line NCI-H1975 in vitro. Journal of molecular histology. vol 45. issue 6. 2015-07-15. PMID:25008024. |
in the three cell lines, subsequently cell growth curves and cell population doubling time were calculated by cell proliferation assay, the changes of cell viability were evaluated by trypan blue dye exclusion method and mtt assay, the cell cycle distribution and apoptosis were investigated by flow cytometry, the expressions of e-cadherin and vimentin used to indicate epithelial-mesenchymal transition (emt) were determined by western blot analysis, the protein expressions in egfr/kras/braf transduction pathway were detected by immunocytochemistry, and the mutations of egfr, kras and braf were detected by high resolution melting analysis and direct sequencing. |
2015-07-15 |
2023-08-13 |
human |
| Soraya Scuderi, Agata Grazia D'Amico, Alessandro Castorina, Concetta Federico, Giuseppina Marrazzo, Filippo Drago, Claudio Bucolo, Velia D'Agat. Davunetide (NAP) protects the retina against early diabetic injury by reducing apoptotic death. Journal of molecular neuroscience : MN. vol 54. issue 3. 2015-07-14. PMID:24488575. |
three weeks after diabetes induction, we assessed the retinal expression and distribution of apoptosis markers, cleaved caspase-3, and bcl2, by western blot and immunofluorescent analysis. |
2015-07-14 |
2023-08-12 |
rat |
| Eun-Sang Ji, You-Mi Kim, Mal-Soon Shin, Chang-Ju Kim, Kwang-Sik Lee, Kijeong Kim, Jonglin Ha, Yong-Rak Chun. Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington's disease rats. Journal of exercise rehabilitation. vol 11. issue 3. 2015-07-14. PMID:26171378. |
immunohistochemistry for caspase-3 and western blot for bax and bcl-2 were also conducted for the detection of apoptosis. |
2015-07-14 |
2023-08-13 |
rat |
| Ming Zhuang, Qin Shi, Xiuwei Zhang, Yongbin Ding, Liuqun Shan, Xia Shan, Jiaqi Qian, Xin Zhou, Zebo Huang, Wei Zhu, Yin Ding, Wenfang Cheng, Ping Liu, Yongqian Sh. Involvement of miR-143 in cisplatin resistance of gastric cancer cells via targeting IGF1R and BCL2. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 4. 2015-07-09. PMID:25492481. |
immunohistochemistry, immunofluorescence staining, western blot, cell proliferation, and clonogenic and apoptosis assay were used to elucidate the mechanism of mir-143 in cisplatin resistance formation. |
2015-07-09 |
2023-08-13 |
human |
| Ying Wang, Jingci Yang, Li Chen, Jiamin Wang, Yaqian Wang, Jianmin Luo, Ling Pan, Xuejun Zhan. Artesunate induces apoptosis through caspase-dependent and -independent mitochondrial pathways in human myelodysplastic syndrome SKM-1 cells. Chemico-biological interactions. vol 219. 2015-07-08. PMID:24704559. |
cck-8, western blot, jc-1 fluorescence, and annexin-v/propidium iodide (pi) labeling were used to assess cell proliferation, protein levels, mitochondrial membrane potentials (mmps) and apoptosis, respectively. |
2015-07-08 |
2023-08-13 |
human |
| Yogeeta O Agrawal, Pankaj Kumar Sharma, Birendra Shrivastava, Dharamvir Singh Arya, Sameer N Goya. Hesperidin blunts streptozotocin-isoproternol induced myocardial toxicity in rats by altering of PPAR-γ receptor. Chemico-biological interactions. vol 219. 2015-07-08. PMID:24954035. |
in western blot analysis, bcl-2 and ppar-γ expression were decreased where as bax expression was significantly increased, suggesting role of apoptosis in myocardial dysfunction. |
2015-07-08 |
2023-08-13 |
rat |
| Changhao Jiang, Ningning Ji, Gaojiang Luo, Shimao Ni, Jinbo Zong, Zhili Chen, Donglai Bao, Xinyan Gong, Ting F. The effects and mechanism of miR-92a and miR-126 on myocardial apoptosis in mouse ischemia-reperfusion model. Cell biochemistry and biophysics. vol 70. issue 3. 2015-07-08. PMID:25064220. |
annexin v/pi double staining was used to detect the apoptotic rate of myocardial cells, and terminal-deoxynucleotidyl transferase-mediated nick end labeling (tunel) was used to detect the number of apoptotic cells; western blot was used to detect expression of caspase 3 to evaluate the apoptosis of mouse myocardial cells; qrt-pcr was used to detect expression of mir-92a and mir-126 in mouse myocardium, and western blot was used to detect expression of hsp70 in two groups. |
2015-07-08 |
2023-08-13 |
mouse |
| Zhiyuan Wu, Bin Liu, Cailing E, Jie Liu, Qingyu Zhang, Juntao Liu, Nianping Chen, Rongyi Chen, Runzhi Zh. Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis. Molecular medicine reports. vol 11. issue 1. 2015-07-07. PMID:25333673. |
western blot analysis demonstrated that res induced the apoptosis of human melanoma a375 and sk-mel-31 cells by upregulating the expression of bcl-2-associated x protein and b-cell lymphoma 2, possibly via the p53 pathway and activation of caspase-9 and caspase-3. |
2015-07-07 |
2023-08-13 |
human |
| Duo Zhang, Bin Chen, Jian Zhou, Lin Zhou, Qing Li, Fei Liu, Kuang-Yen Chou, Lei Tao, Li-Ming L. Low concentrations of trichosanthin induce apoptosis and cell cycle arrest via c-Jun N-terminal protein kinase/mitogen-activated protein kinase activation. Molecular medicine reports. vol 11. issue 1. 2015-07-07. PMID:25351837. |
flow cytometric assays were performed to detect apoptosis and cell cycle arrest in the hep-2 and amc-hn-8 cells, reverse transcription quantitative polymerase chain reaction was performed to detect the levels of p27, p21waf and western blot analysis was performed to detect changes in c-jun n-terminal protein kinase (jnk)/phosphorylated (phospho)-jnk, p38/phospho-p38, extracellular signal-regulated kinase (erk)/phospho-erk, caspase-3 and caspase-9 in the hep-2 and amc-hn-8 cancer cells. |
2015-07-07 |
2023-08-13 |
human |
| Jaemoo Chun, Lina Han, Mei Ying Xu, Bo Wang, Mao Sheng Cheng, Yeong Shik Ki. The induction of apoptosis by a newly synthesized diosgenyl saponin through the suppression of estrogen receptor-α in MCF-7 human breast cancer cells. Archives of pharmacal research. vol 37. issue 11. 2015-07-03. PMID:24263408. |
western blot analysis showed that compound 22 decreased the expression of procaspase-3, procaspase-8, and survivin; and increased the expression of fas ligand and cleaved parp1 in mcf-7 cells, indicating that compound 22-induced apoptosis was mediated by the extrinsic pathway. |
2015-07-03 |
2023-08-12 |
human |
| Zhen-Fang Liu, Xiao Zhang, Yan-Xiang Qiao, Wan-Qun Xu, Cheng-Tai Ma, Hua-Li Gu, Xiu-Mei Zhou, Lei Shi, Chang-Xing Cui, Di Xia, Yu-Guo Che. Neuroglobin protects cardiomyocytes against apoptosis and cardiac hypertrophy induced by isoproterenol in rats. International journal of clinical and experimental medicine. vol 8. issue 4. 2015-07-01. PMID:26131111. |
the annexin v-fitc/pi staining, western blot and qpcr analysis showed that the involvement in p53-mediated apoptosis of cardiomyocytes of ngb is might be the mechanism. |
2015-07-01 |
2023-08-13 |
rat |
| Chie-Pein Chen, Yi-Yung Chen, Jian-Pei Huang, Yi-Hsin W. The effect of conditioned medium derived from human placental multipotent mesenchymal stromal cells on neutrophils: possible implications for placental infection. Molecular human reproduction. vol 20. issue 11. 2015-06-29. PMID:25140001. |
the effect of conditioned medium of hpmscs with or without lipopolysaccharide (lps) pretreatment on neutrophil functions: migration, apoptosis and production of reactive oxygen species (ros) was assessed by flow cytometry and western blot. |
2015-06-29 |
2023-08-13 |
human |
| Bing-Jie Han, Guang-Bin Jiang, Jun-Hua Yao, Wei Li, Ji Wang, Hong-Liang Huang, Yun-Jun Li. DNA interaction, antioxidant activity, and bioactivity studies of two ruthenium(II) complexes. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 135. 2015-06-29. PMID:25150435. |
the apoptosis and cell cycle arrest were investigated, and the apoptotic mechanism of bel-7402 cells was studied by reactive oxygen species (ros), mitochondrial membrane potential and western blot analysis. |
2015-06-29 |
2023-08-13 |
Not clear |
| Renhua Xu, Enbing Tian, Haiping Tang, Chongdong Liu, Qingtao Wan. Proteomic analysis of gossypol induces necrosis in multiple myeloma cells. BioMed research international. vol 2014. 2015-06-29. PMID:25197664. |
importantly, proteomic and western blot analysis showed that apoptosis regulators bak and bax were upregulated in gossypol-treated cells, indicating that bcl-2 associated death pathway was activated. |
2015-06-29 |
2023-08-13 |
Not clear |
| Christine Möller Westerberg, Maria Ekoff, Gunnar Nilsso. Regulation of mast cell survival and apoptosis. Methods in molecular biology (Clifton, N.J.). vol 1220. 2015-06-29. PMID:25388256. |
to determine the regulation of mast cell survival and apoptosis, the expression of different bcl-2 protein family members can be measured by western blot. |
2015-06-29 |
2023-08-13 |
Not clear |