| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pingdong Lin, Xiaping Weng, Fayuan Liu, Yuhuan Ma, Houhuang Chen, Xiang Shao, Wenwei Zheng, Xianxiang Liu, Hongzhi Ye, Xihai L. Bushen Zhuangjin decoction inhibits TM-induced chondrocyte apoptosis mediated by endoplasmic reticulum stress. International journal of molecular medicine. vol 36. issue 6. 2016-09-12. PMID:26497741. |
to further elucidate the mechanisms responsible for the inhibitory effects of bzd on tm‑induced chondrocyte apoptosis mediated by er stress, the mrna and protein expression levels of binding immunoglobulin protein (bip), x‑box binding protein 1 (xbp1), activating transcription factor 4 (atf4), c/ebp‑homologous protein (chop), caspase‑9, caspase-3, b-cell lymphoma 2 (bcl-2) and bcl-2-associated x protein (bax) were measured by reverse transcription-polymerase chain reaction (rt-pcr) and western blot analysis. |
2016-09-12 |
2023-08-13 |
rat |
| Feng-Qi Fang, Hui-Shu Guo, Jie Zhang, Li-Ying Ban, Ji-Wei Liu, Pei-Yao Y. Anti-cancer effects of 2-oxoquinoline derivatives on the HCT116 and LoVo human colon cancer cell lines. Molecular medicine reports. vol 12. issue 6. 2016-09-12. PMID:26498992. |
apoptosis was identified based on cell morphological characteristics, including cell shrinkage and chromatin condensation as well as annexin v/propidium iodide double staining followed by flow cytometric analysis and detection of apoptosis-associated proteins by western blot analysis. |
2016-09-12 |
2023-08-13 |
human |
| Shruti Goyal, Saroj Kumar Amar, Divya Dubey, Manish Kumar Pal, Jyoti Singh, Ankit Verma, Hari Narayan Kushwaha, Ratan Singh Ra. Involvement of cathepsin B in mitochondrial apoptosis by p-phenylenediamine under ambient UV radiation. Journal of hazardous materials. vol 300. 2016-09-06. PMID:26223015. |
both lysosome and mitochondria is main target for ppd induced apoptosis which was proved through lysosomal destabilization and release of cathepsin b by immunofluorescence, real time pcr and western blot analysis. |
2016-09-06 |
2023-08-13 |
human |
| Fayuan Liu, Xiaping Weng, Pingdong Lin, Chunsong Zheng, Huifeng Xu, Xianxiang Liu, Hongzhi Ye, Xihai L. Duhuo Jisheng decoction inhibits endoplasmic reticulum stress in chondrocytes induced by tunicamycin through the downregulation of miR-34a. International journal of molecular medicine. vol 36. issue 5. 2016-09-06. PMID:26329269. |
to gain insight into the mechanisms of dhjsd that are responsible for enhancing the viability and inhibiting tm‑induced chondrocyte apoptosis, the associated mrna expressions and protein levels were detected by reverse transcription‑polymerase chain reaction (rt‑pcr) and western blot analysis, respectively. |
2016-09-06 |
2023-08-13 |
Not clear |
| Yihua Yang, Yan Jiang, Man Jiang, Jiamiao Zhang, Bing Yang, Yuanping She, Wanxue Wang, Yan Deng, Yuan Y. Protocadherin 10 inhibits cell proliferation and induces apoptosis via regulation of DEP domain containing 1 in endometrial endometrioid carcinoma. Experimental and molecular pathology. vol 100. issue 2. 2016-09-06. PMID:26970279. |
the mrna and protein expression levels were measured by quantitative real time pcr (qrt-pcr) and western blot, respectively; cell growth was determined by mts, cck-8 and colony formation assays; cell cycle was determined by flow cytometry, and cell apoptosis was examined by flow cytometry and tunel assay. |
2016-09-06 |
2023-08-13 |
Not clear |
| Ruihua Zhong, Aying Ma, Jianping Zhu, Guoting Li, Shuwu Xie, Zhao Li, Youlun Gui, Yan Zh. Kuntai Capsule Inhibited Endometriosis via Inducing Apoptosis in a Rat Model. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-09-06. PMID:27597876. |
tunel and western blot assay showed that ktc could induce apoptosis of endometriotic tissues, accompanied with the increased protein expression of caspases 8 and 9, activated caspase-3, and cytochrome c in a dose-dependent manner. |
2016-09-06 |
2023-08-13 |
rat |
| Donghyun Lee, Wan-Kyu Ko, Deok-Sang Hwang, Dong Nyoung Heo, Sang Jin Lee, Min Heo, Kook-Sun Lee, Ji-Yoon Ahn, Junyoung Jo, Il Keun Kwo. Use of Baicalin-Conjugated Gold Nanoparticles for Apoptotic Induction of Breast Cancer Cells. Nanoscale research letters. vol 11. issue 1. 2016-08-31. PMID:27576521. |
apoptosis test results were evaluated by analyzing the expression of typical apoptic markers such as cleaved caspase-3, full length caspase-3, and apaf-1 in western blot assay. |
2016-08-31 |
2023-08-13 |
Not clear |
| Tao Peng, Min Hu, Tingting Wu, Zhe Chen, Cen Zhang, Shou Huang, Xuhong Zho. Effects of high‑mobility group box 1 knockdown on proliferation, migration and invasion of the HONE‑1 human nasopharyngeal carcinoma cell line. Molecular medicine reports. vol 12. issue 5. 2016-08-29. PMID:26459833. |
western blot analysis was used to determine the protein expression of apoptosis signaling proteins caspase‑3, b-cell lymphoma 2 (bcl-2), bcl-2-associated x protein, receptor for advanced glycation end products (rage) as well as phosphorylated and total extracellular signal-regulated kinase 1/2 in hone‑1 cells. |
2016-08-29 |
2023-08-13 |
human |
| Lanhai Lü, Xiqiang Liu, Cheng Wang, Fengchun Hu, Jianning Wang, Hongzhang Huan. Dissociation of E-cadherin/β-catenin complex by MG132 and bortezomib enhances CDDP induced cell death in oral cancer SCC-25 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 8. 2016-08-26. PMID:26165741. |
western blot results showed that mg132 or bortezomib induced high accumulation of ubiquitinated proteins and activation of apoptosis related protein caspase-3. |
2016-08-26 |
2023-08-13 |
human |
| Min Hee Sung, Ok-Kyoung Kwon, Sei-Ryang Oh, Joongku Lee, Sang-Hong Park, Sang Bae Han, Kyung-Seop Ah. Azorella compacta methanolic extract induces apoptosis via activation of mitogen-activated protein kinase. Molecular medicine reports. vol 12. issue 5. 2016-08-26. PMID:26397193. |
apoptosis induction was measured by mtt assay, fluorescence microscopy, dna fragmentation assay, flow cytometric analysis, reverse transcription quantitative polymerase chain reaction and western blot analyses. |
2016-08-26 |
2023-08-13 |
human |
| Hongfei Ren, Hongyu Ren, Xue Li, Dongdong Yu, Shuai Mu, Zhiguang Chen, Qin F. Effects of intermedin on proliferation, apoptosis and the expression of OPG/RANKL/M-CSF in the MC3T3-E1 osteoblast cell line. Molecular medicine reports. vol 12. issue 5. 2016-08-26. PMID:26398911. |
cell proliferation, apoptosis and the expression of receptor activator of nf‑κb ligand (rankl), osteoprotegerin (opg) and macrophage colony‑stimulating factor (m‑csf) were measured following treatment using multiple detection techniques, including an mtt assay, flow cytometry, reverse transcription‑quantitative polymerase chain reaction and western blot analysis. |
2016-08-26 |
2023-08-13 |
Not clear |
| S Manteniotis, S Wojcik, P Brauhoff, M Möllmann, L Petersen, J R Göthert, W Schmiegel, U Dührsen, G Gisselmann, H Hat. Functional characterization of the ectopically expressed olfactory receptor 2AT4 in human myelogenous leukemia. Cell death discovery. vol 2. 2016-08-23. PMID:27551494. |
western blot and flow cytometric experiments revealed that stimulation of or2at4 reduced the proliferation by decreasing p38-mapk phosphorylation and induced apoptosis via phosphorylation of p44/42-mapk. |
2016-08-23 |
2023-08-13 |
human |
| Cui-Ping Yin, Shang-Hui Guan, Bo Zhang, Xue-Xin Wang, Shou-Wei Yu. Upregulation of HIF-1α protects neuroblastoma cells from hypoxia-induced apoptosis in a RhoA-dependent manner. Molecular medicine reports. vol 12. issue 5. 2016-08-22. PMID:26323527. |
the upregulation of hif‑α and rhoa by hypoxia was determined using reverse transcription‑quantitative polymerase chain reaction and western blot assays, cell apoptosis was analyzed using flow cytometry, and the activity of caspase 3 was examined using a western blot assay and caspase 3 activity assay kit. |
2016-08-22 |
2023-08-13 |
Not clear |
| Ae-Ran Choi, Ju-Hwa Kim, Yeon Hwa Woo, Hyung Sik Kim, Sungpil Yoo. Anti-malarial Drugs Primaquine and Chloroquine Have Different Sensitization Effects with Anti-mitotic Drugs in Resistant Cancer Cells. Anticancer research. vol 36. issue 4. 2016-08-22. PMID:27069141. |
facs analysis and western blot analysis revealed that g2arrest and apoptosis showed only a slight increase on co-treatment with vib or vio and chl. |
2016-08-22 |
2023-08-13 |
Not clear |
| Fei-Ting Hsu, Yu-Chang Liu, Tsu-Te Liu, Jeng-Jong Hwan. Curcumin Sensitizes Hepatocellular Carcinoma Cells to Radiation via Suppression of Radiation-Induced NF-κB Activity. BioMed research international. vol 2015. 2016-08-18. PMID:26539482. |
the effects of curcumin, radiation, and combination of both on cell viability, apoptosis, nf-κb activation, and expressions of nf-κb downstream effector proteins were investigated with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt), nf-κb reporter gene, mitochondrial membrane potential (mmp), electrophoretic mobility shift (emsa), and western blot assays in huh7-nf-κb-luc2, hep3b, and hepg2 cells. |
2016-08-18 |
2023-08-13 |
human |
| Jianfeng Wang, Yana Li, Yang Liu, Yanbo Li, Shouliang Gong, Fang Fang, Zhicheng Wan. Overexpression of truncated AIF regulated by Egr1 promoter radiation-induced apoptosis on MCF-7 cells. Radiation and environmental biophysics. vol 54. issue 4. 2016-08-17. PMID:26514806. |
after mcf-7-taif cells were exposed to x-rays, the aif and taif expressions, cell proliferation, apoptosis, cell cycle invasion, cytochrome c (cyt c) release and activation of caspase-9 were measured by using western blot, mtt assay, flow cytometry and matrigel transwell assay, respectively. |
2016-08-17 |
2023-08-13 |
Not clear |
| Ting Sun, Ganghua Tang, Hua Tian, Kongzhen Hu, Shaobo Yao, Yifan Su, Changqian Wan. Positron emission tomography imaging of cardiomyocyte apoptosis with a novel molecule probe [18F]FP-DPAZn2. Oncotarget. vol 6. issue 31. 2016-08-15. PMID:26416423. |
in vitro, the fluorescence imaging of dansyl-dpazn2 was suitable for detecting cardiomyocyte apoptosis, which was confirmed by confocal immunofluorescence imaging, terminal dutp nick-end labeling (tunel) assay, and western blot assay. |
2016-08-15 |
2023-08-13 |
rat |
| Mohamed M'baye, Guohua Hua, Hamid Ali Khan, Liguo Yan. RNAi-mediated knockdown of INHBB increases apoptosis and inhibits steroidogenesis in mouse granulosa cells. The Journal of reproduction and development. vol 61. issue 5. 2016-08-12. PMID:26063610. |
quantitative real-time polymerase chain reaction, western blot, flow cytometry and elisa were performed to evaluate the role of inhbb in the mouse gc cell cycle, apoptosis and steroid production in vitro. |
2016-08-12 |
2023-08-13 |
mouse |
| Yu Sun, Yingbin Ge, Yuxuan Fu, Lianqi Yan, Jun Cai, Kun Shi, Xiaojian Cao, Chun L. Mitomycin C induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-200b and its targeting of RhoE. European journal of pharmacology. vol 765. 2016-08-12. PMID:26254780. |
the effects of mmc and mir-200b on human fibroblasts apoptosis were evaluated using flow cytometry and western blot analysis. |
2016-08-12 |
2023-08-13 |
human |
| Yixiao Xu, Dexuan Wang, Zhizhi Zhuang, Keke Jin, Lvzhen Zheng, Qing Yang, Kunyuan Gu. Hypericin-mediated photodynamic therapy induces apoptosis in K562 human leukemia cells through JNK pathway modulation. Molecular medicine reports. vol 12. issue 5. 2016-08-11. PMID:26330116. |
the effects of hyp‑pdt on apoptosis were determined by detecting morphological changes under microscopy and by performing western blot analysis. |
2016-08-11 |
2023-08-13 |
human |