| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dan Jiang, Lingyao Wang, Tong Zhao, Zhaoyu Zhang, Renxia Zhang, Jingji Jin, Yong Cai, Fei Wan. Restoration of the tumor-suppressor function to mutant p53 by Ganoderma lucidum polysaccharides in colorectal cancer cells. Oncology reports. vol 37. issue 1. 2017-04-07. PMID:27878254. |
in addition, western blot assay and in vitro cell-free apoptosis assay suggested that the activation of mutant p53 was effective in both a transcriptional-dependent and -independent pathway. |
2017-04-07 |
2023-08-13 |
Not clear |
| Ansgar Brüning, Julia Jückstock, Bernd Kost, Panagiotis Tsikouras, Tobias Weissenbacher, Sven Mahner, Ioannis Mylona. Induction of DNA damage and apoptosis in human leukemia cells by efavirenz. Oncology reports. vol 37. issue 1. 2017-04-07. PMID:27878300. |
cell death induced by efavirenz was caused by apoptosis, as shown by facscan analysis (annexin binding) and western blot analysis (cleavage of caspases and parp). |
2017-04-07 |
2023-08-13 |
human |
| Marjan Shariatpanahi, Fariba Khodagholi, Ghorbangol Ashabi, Behnoosh Bonakdar Yazdi, Shokoufeh Hassani, Kian Azami, Mohammad Abdollahi, Farshid Noorbakhsh, Ghorban Taghizadeh, Mohammad Sharifzade. The involvement of protein kinase G inhibitor in regulation of apoptosis and autophagy markers in spatial memory deficit induced by Aβ. Fundamental & clinical pharmacology. vol 30. issue 4. 2017-04-06. PMID:26990910. |
we also measured the apoptosis and autophagy markers as two probable interfering pathways with pkg signaling by western blot method. |
2017-04-06 |
2023-08-13 |
rat |
| Chunyuan Liu, Aihong Zhang, Lei Cheng, Yang Ga. miR‑410 regulates apoptosis by targeting Bak1 in human colorectal cancer cells. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27177325. |
cell growth and apoptosis was tested using an mtt assay, western blot and cytochrome c assay. |
2017-04-06 |
2023-08-13 |
human |
| Sirajudheen Anwar, Deborah Fratantonio, Daniela Ferrari, Antonella Saija, Francesco Cimino, Antonio Special. Berry anthocyanins reduce proliferation of human colorectal carcinoma cells by inducing caspase-3 activation and p21 upregulation. Molecular medicine reports. vol 14. issue 2. 2017-04-06. PMID:27314273. |
in the present study, the effect of a standardized anthocyanin (acn)‑rich extract on proliferation, apoptosis and cell cycle in the caco-2 human colorectal cancer cell line was evaluated by trypan blue and clonogenic assays and western blot analysis of cleaved caspase‑3 and p21waf/cif1. |
2017-04-06 |
2023-08-13 |
human |
| Aiqing Zhang, Wei He, Huimin Shi, Xiaodan Huang, Guozhong J. Natural compound oblongifolin C inhibits autophagic flux, and induces apoptosis and mitochondrial dysfunction in human cholangiocarcinoma QBC939 cells. Molecular medicine reports. vol 14. issue 4. 2017-04-06. PMID:27499017. |
the effect of oc on cell apoptosis and its underlying mechanisms were investigated in cultured qbc939 cells by the methyl thiazol tetrazolium assay, mitochondrial membrane potential, atp content and western blot analysis. |
2017-04-06 |
2023-08-13 |
human |
| Eun Kyoung Choi, Seung-Mi Kim, Seung-Woo Hong, Jai-Hee Moon, Jae-Sik Shin, Jeong Hee Kim, Ih-Yeon Hwang, Soo-A Jung, Dae-Hee Lee, Eun Young Lee, Seul Lee, Hyunwoo Kim, Daejin Kim, Yeong Seok Kim, Youn Kyung Choi, Hyo In Kim, Hyeong Sim Choi, Sung-Gook Cho, Jeong Eun Kim, Kyu Pyo Kim, Yong Sang Hong, Won Keun Lee, Jung Shin Lee, Tae Won Kim, Seong-Gyu Ko, Dong-Hoon Ji. SH003 selectively induces p73‑dependent apoptosis in triple‑negative breast cancer cells. Molecular medicine reports. vol 14. issue 4. 2017-04-04. PMID:27599791. |
western blot analysis revealed that the expression levels of poly‑adp‑ribose polymerase (parp) cleavage protein in cells treated with sh003 were increased dose‑dependent manner, indicating that sh003 induced apoptosis via a caspase‑dependent pathway. |
2017-04-04 |
2023-08-13 |
Not clear |
| Pengcheng Sun, Lu Wang, Yunhan Lu, Yuwei Liu, Lechen Li, Luyao Yin, Cheng Zhang, Weiming Zhao, Baozhong Shen, Wanhai X. MicroRNA-195 targets VEGFR2 and has a tumor suppressive role in ACHN cells via PI3K/Akt and Raf/MEK/ERK signaling pathways. International journal of oncology. vol 49. issue 3. 2017-04-03. PMID:27572273. |
additionally, apoptosis levels were evaluated using tunel assays, and signaling pathway changes were determined by western blot analysis. |
2017-04-03 |
2023-08-13 |
human |
| Yu Lei, Bo Zhang, Yaohua Zhang, Yuan Zhao, Jingying Sun, Xuejun Zhang, Sen Yan. Lentivirus-mediated downregulation of MAT2B inhibits cell proliferation and induces apoptosis in melanoma. International journal of oncology. vol 49. issue 3. 2017-04-03. PMID:27573889. |
the expression levels of bcl2 and xaf1 proteins, which were closely related to tumor cell apoptosis, were analyzed by western blot analysis. |
2017-04-03 |
2023-08-13 |
Not clear |
| Guo-Qiang Yu, Zhong-Ling Dou, Zhao-Hui Ji. 5‑bromo‑3‑(3‑hydroxyprop‑1‑ynyl)‑2H‑pyran‑2‑one induces apoptosis in T24 human bladder cancer cells through mitochondria-dependent signaling pathways. Molecular medicine reports. vol 15. issue 1. 2017-03-31. PMID:27922685. |
western blot analysis was performed for the determination of expression levels of apoptotic proteins, and 4,6‑diamidino‑2‑phenylindole dihydrochloride staining was used to observe apoptosis and dna damage. |
2017-03-31 |
2023-08-13 |
human |
| Meijuan Chen, Yuanyuan Guo, Ruolin Zhao, Xiaoxia Wang, Miao Jiang, Haian Fu, Xu Zhan. Ophiopogonin B induces apoptosis, mitotic catastrophe and autophagy in A549 cells. International journal of oncology. vol 49. issue 1. 2017-03-30. PMID:27175570. |
immunohistochemistry detection of lc3 and tunel assay both verified that high dose of op-b (75 mg/kg) induced autophagy and apoptosis in vivo, and western blot detection of p-histone h3 (ser10), survivin and xiap further indicated the molecular mechanism of op-b in vivo. |
2017-03-30 |
2023-08-13 |
Not clear |
| Yang Yu, Xiaofeng Yu, Jianxia Ma, Yili Tong, Jianfeng Ya. Effects of NVP-BEZ235 on the proliferation, migration, apoptosis and autophagy in HT-29 human colorectal adenocarcinoma cells. International journal of oncology. vol 49. issue 1. 2017-03-30. PMID:27176231. |
expression of proteins involved in cell cycle and proliferation (p-akt, p-mtor and cyclin d1), apoptosis (cleaved caspase-3), and autophagy (cleaved lc3b and beclin-1) were detected by western blot analysis. |
2017-03-30 |
2023-08-13 |
human |
| Shuang Chen, Jie Yan, Hai-Xiao Deng, Ling-Ling Long, Yong-Jun Hu, Mi Wang, Lei Shang, Dan Chen, Ju-Fang Huang, Kun Xion. Inhibition of calpain on oxygen glucose deprivation-induced RGC-5 necroptosis. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 5. 2017-03-30. PMID:27752886. |
western blot was used to detect the protein level of truncated apoptosis inducing factor (taif) in rgc-5 cells following ogd. |
2017-03-30 |
2023-08-13 |
Not clear |
| Cuilan Hou, Wenguang Li, Zengyou Li, Jing Gao, Zhenjie Chen, Xiqiong Zhao, Yaya Yang, Xiaoyu Zhang, Yong Son. Synthetic Isoliquiritigenin Inhibits Human Tongue Squamous Carcinoma Cells through Its Antioxidant Mechanism. Oxidative medicine and cellular longevity. vol 2017. 2017-03-27. PMID:28203317. |
the associated regulatory mechanisms were examined using fcm and fluorescence microscopy for intracellular reactive oxygen species (ros) generation, gelatin zymography assay for matrix metalloproteinase (mmp) activities, and western blot for apoptosis regulatory proteins (bcl-2 and bax). |
2017-03-27 |
2023-08-13 |
human |
| Tanyarath Utaipan, Anan Athipornchai, Apichart Suksamrarn, Surasak Chunsrivirot, Warangkana Chunglo. Isomahanine induces endoplasmic reticulum stress and simultaneously triggers p38 MAPK-mediated apoptosis and autophagy in multidrug-resistant human oral squamous cell carcinoma cells. Oncology reports. vol 37. issue 2. 2017-03-23. PMID:28075474. |
apoptosis as determined by fitc‑annexin v/pi staining and western blot analysis of cleaved caspase-3 and cleaved poly(adp‑ribose) polymerase (parp) was significantly induced in a time-dependent manner upon isomahanine treatment. |
2017-03-23 |
2023-08-13 |
human |
| Hong-Yan Gong, Fang Zheng, Chao Zhang, Xi-Yan Chen, Jing-Jing Liu, Xiu-Qin Yu. Propofol protects hippocampal neurons from apoptosis in ischemic brain injury by increasing GLT-1 expression and inhibiting the activation of NMDAR via the JNK/Akt signaling pathway. International journal of molecular medicine. vol 38. issue 3. 2017-03-21. PMID:27430327. |
a significant decrease in cell viability and a significant increase in cell apoptosis were observed in the ibi group compared with the control group, accompanied by a decrease in glial glutamate transporter-1 (glt‑1) expression as determined by rt-qpcr and western blot analysis. |
2017-03-21 |
2023-08-13 |
Not clear |
| Fu-Qiang Zhu, Li Zeng, Na Tang, Ya-Ping Tang, Bo-Ping Zhou, Fang-Fang Li, Wei-Gang Wu, Xiao-Bing Zeng, Shu-Song Pen. MicroRNA-155 Downregulation Promotes Cell Cycle Arrest and Apoptosis in Diffuse Large B-Cell Lymphoma. Oncology research. vol 24. issue 6. 2017-03-21. PMID:28281962. |
real-time pcr was used to detect the expression levels of mir-155 in 118 lymphoma patients' tissues, and western blot was also used to analyze the expression level of proteins correlated with cell cycle and apoptosis in lymphoma cells. |
2017-03-21 |
2023-08-13 |
mouse |
| Hailong Zhang, Xiaogang Liu, Fengbo Wu, Feifei Qin, Ping Feng, Ting Xu, Xiang Li, Li Yan. A Novel Prostate-Specific Membrane-Antigen (PSMA) Targeted Micelle-Encapsulating Wogonin Inhibits Prostate Cancer Cell Proliferation via Inducing Intrinsic Apoptotic Pathway. International journal of molecular sciences. vol 17. issue 5. 2017-03-16. PMID:27196894. |
the western blot results suggested that acupa-m-wog could enhance the wog-induced apoptosis, which was mainly via the intrinsic signaling pathway rather than the extrinsic signaling pathway. |
2017-03-16 |
2023-08-13 |
human |
| K F Liu, Y X Sha. Effects of siRNA-mediated silencing of Sal-like 4 expression on proliferation and apoptosis of prostate cancer C4-2 cells. Genetics and molecular research : GMR. vol 15. issue 2. 2017-03-15. PMID:27323021. |
the influence of sall4 on apoptosis was assessed with flow cytometry, and the expression of apoptosis-related proteins b-cell lymphoma 2 (bcl-2) and bcl-like-protein 4 (bax) were detected by western blot. |
2017-03-15 |
2023-08-13 |
Not clear |
| Kang Zhu, Ying He, Cui Xia, Jing Yan, Jin Hou, Demin Kong, Yeye Yang, Guoxi Zhen. MicroRNA-15a Inhibits Proliferation and Induces Apoptosis in CNE1 Nasopharyngeal Carcinoma Cells. Oncology research. vol 24. issue 3. 2017-03-14. PMID:27458095. |
moreover, western blot was used to detect the expression changes of proliferation and apoptosis of related proteins. |
2017-03-14 |
2023-08-13 |
human |