| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ning Yang, Yuying Zhao, Zhipeng Wang, Yu Liu, Yanqiao Zhan. Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. Molecular medicine reports. vol 15. issue 2. 2017-05-16. PMID:28035355. |
human colon cancer cells were exposed to different concentrations of scutellarin, and cellular growth and apoptosis were evaluated by mtt assay, terminal deoxynucleotidyl transferase‑mediated dutp nick end labeling (tunel) staining, western blot analysis and other assays. |
2017-05-16 |
2023-08-13 |
human |
| HuaDong Zheng, DaJiang Cui, XiaoJuan Quan, WeiLin Yang, YingNa Li, Lin Zhang, EnQi Li. Lp-PLA2 silencing protects against ox-LDL-induced oxidative stress and cell apoptosis via Akt/mTOR signaling pathway in human THP1 macrophages. Biochemical and biophysical research communications. vol 477. issue 4. 2017-05-15. PMID:27392709. |
flow cytometry and western blot analyses showed that both cell apoptosis and lp-pla2 expression were dose-dependently elevated after ox-ldl treatment for 24 h and also time-dependently increased after 50 mg/l ox-ldl incubation in thp1 macrophages. |
2017-05-15 |
2023-08-13 |
human |
| Shuyi Zhang, Lei Shi, Hongwen Ma, Hongzhou Li, Yanru Li, Ying Lu, Qiaoping Wang, Wen L. Dihydroartemisinin induces apoptosis in human gastric cancer cell line BGC-823 through activation of JNK1/2 and p38 MAPK signaling pathways. Journal of receptor and signal transduction research. vol 37. issue 2. 2017-05-15. PMID:27401020. |
the expressions of extracellular signal-regulated kinase (erk), c-jun n-terminal kinase (jnk), p38 mitogen-activated protein kinase (p38 mapk) and their phosphorylated forms as well as apoptosis related proteins were examined by western blot analysis. |
2017-05-15 |
2023-08-13 |
human |
| Shang-Jyh Kao, Wei-Jiunn Lee, Jer-Hwa Chang, Jyh-Ming Chow, Chi-Li Chung, Wen-Yueh Hung, Ming-Hsien Chie. Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer. Environmental toxicology. vol 32. issue 4. 2017-05-15. PMID:27539140. |
results from mts, colony formation, western blot, flow cytometric, and jc-1 mitochondrial membrane potential assays revealed that dhm showed a selective cytotoxic effect against nsclc cells (a549 and h1975), but not against normal lung (wi-38) fibroblasts, by inducing apoptosis. |
2017-05-15 |
2023-08-13 |
human |
| Pallavee Srivastava, Meenal Kowshi. Anti-neoplastic selenium nanoparticles from Idiomarina sp. PR58-8. Enzyme and microbial technology. vol 95. 2017-05-15. PMID:27866615. |
the senps induced a caspase-dependent apoptosis in hela cell lines as exhibited by the ros assay, apoptotic index assay, and western blot analysis. |
2017-05-15 |
2023-08-13 |
human |
| Alessandro De Vita, Giacomo Miserocchi, Federica Recine, Laura Mercatali, Federica Pieri, Laura Medri, Alberto Bongiovanni, Davide Cavaliere, Chiara Liverani, Chiara Spadazzi, Dino Amadori, Toni Ibrahi. Activity of Eribulin in a Primary Culture of Well-Differentiated/Dedifferentiated Adipocytic Sarcoma. Molecules (Basel, Switzerland). vol 21. issue 12. 2017-05-15. PMID:27918490. |
finally, western blot analysis of apoptosis and migration proteins was performed. |
2017-05-15 |
2023-08-13 |
Not clear |
| Chunmiao Wang, Zhiyu Pan, Huaxin Hou, Danrong Li, Yuanyuan Mo, Chunyan Mo, Jing L. The Enhancement of Radiation Sensitivity in Nasopharyngeal Carcinoma Cells via Activation of the Rac1/NADPH Signaling Pathway. Radiation research. vol 185. issue 6. 2017-05-10. PMID:27243897. |
the apoptosis rate was analyzed by flow cytometry, and the expressions of p67(phox) and nfκb-p105/p50 were analyzed by western blot. |
2017-05-10 |
2023-08-13 |
Not clear |
| Sreetama Choudhury, Payal Gupta, Sayan Ghosh, Sudeshna Mukherjee, Priyanka Chakraborty, Urmi Chatterji, Sreya Chattopadhya. Arsenic-induced dose-dependent modulation of the NF-κB/IL-6 axis in thymocytes triggers differential immune responses. Toxicology. vol 357-358. 2017-05-10. PMID:27289040. |
analysis of molecular markers of apoptosis by western blot revealed a dose-dependent activation of the apoptotic cascade. |
2017-05-10 |
2023-08-13 |
mouse |
| Dipanwita Das Mukherjee, N Maruthi Kumar, Mukund P Tantak, Amlan Das, Arnab Ganguli, Satabdi Datta, Dalip Kumar, Gopal Chakrabart. Development of Novel Bis(indolyl)-hydrazide-Hydrazone Derivatives as Potent Microtubule-Targeting Cytotoxic Agents against A549 Lung Cancer Cells. Biochemistry. vol 55. issue 21. 2017-05-09. PMID:27110637. |
flow cytometry, western blot, and immunofluorescence studies in the a549 cell line revealed that nmk-bh3 induced g2/m arrest, mitochondrial depolarization, and apoptosis by depolymerizing the cellular interphase and spindle microtubules. |
2017-05-09 |
2023-08-13 |
human |
| J Jaworek, J Szklarczyk, J Bonior, M Kot, M Goralska, P Pierzchalski, R J Reiter, U Czech, R Tomaszewsk. Melatonin metabolite, N(1)-acetyl-N(1)-formyl-5-methoxykynuramine (AFMK), attenuates acute pancreatitis in the rat: in vivo and in vitro studies. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 67. issue 3. 2017-05-09. PMID:27512002. |
gpx, tnf-α, proapoptotic bax protein, antiapoptotic bcl-2 protein and the executor of apoptosis, caspase-3, were determined by western blot in ar42j cells subjected to afmk or to melatonin (both used at 10(-12), 10(-10), or 10(-8)m), without or with addition of caerulein (10(-8)m). |
2017-05-09 |
2023-08-13 |
rat |
| Norlaily Mohd Ali, M Nadeem Akhtar, Huynh Ky, Kian Lam Lim, Nadiah Abu, Seema Zareen, Wan Yong Ho, Han Kiat Alan-Ong, Sheau Wei Tan, Noorjahan Banu Alitheen, Jamil Bin Ismail, Swee Keong Yeap, Tunku Kamaru. Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line. Drug design, development and therapy. vol 10. 2017-05-08. PMID:27358555. |
the roles of plk-1, wee-1, and phosphorylation of cdc-2 in g2/m arrest and proapoptotic factors (bax, caspase 9, and p53) in promotion of apoptosis of fls against mcf-7 cells were discovered using fluorometric, quantitative real-time polymerase chain reaction, and western blot analysis. |
2017-05-08 |
2023-08-13 |
human |
| Hsin-Shun Tseng, Yu-Fen Wang, Yew-Min Tzeng, Dar-Ren Chen, Ya-Fan Liao, Hui-Yu Chiu, Wen-Tsong Hsie. Aloe-Emodin Enhances Tamoxifen Cytotoxicity by Suppressing Ras/ERK and PI3K/mTOR in Breast Cancer Cells. The American journal of Chinese medicine. vol 45. issue 2. 2017-05-08. PMID:28231748. |
the expression levels of signaling proteins were determined by western blot analysis, intracellular reactive oxygen species (ros), cell cycle distributions, and rates of apoptosis as estimated by flow cytometry. |
2017-05-08 |
2023-08-13 |
Not clear |
| Hao Jiang, Dong-Ping Liu, Dong Xie, Dong-Zhi We. [Up-regulation of ErbB3-binding protein 1 inhibits the growth of esophageal carcinoma cells]. Sheng li xue bao : [Acta physiologica Sinica]. vol 68. issue 6. 2017-05-05. PMID:28004068. |
apoptotic rates of esophageal carcinoma cells were detected by flow cytometry, and expression levels of the proteins involved in apoptosis were assessed by western blot. |
2017-05-05 |
2023-08-13 |
mouse |
| Jian Xu, Di Xiao, Qing-Hua Lin, Jing-Feng He, Wen-Yuan Liu, Ning Xie, Feng Feng, Wei Q. Cytotoxic Tirucallane and Apotirucallane Triterpenoids from the Stems of Picrasma quassioides. Journal of natural products. vol 79. issue 8. 2017-05-02. PMID:27494664. |
flow cytometry and western blot analysis revealed that 2 induces the apoptosis of mkn-28 cells via activating caspase-3/-9, while increasing bax and bad and decreasing bcl-2 expression levels. |
2017-05-02 |
2023-08-13 |
human |
| Hui Chen, Lianqi Yan, Jingcheng Wang, Yu Sun, Xiaolei Li, Shuai Zhao, Daxin Wang, Gengyao Zhu, Yuan Lian. Methotrexate prevents epidural fibrosis through endoplasmic reticulum stress signalling pathway. European journal of pharmacology. vol 796. 2017-04-28. PMID:28012973. |
cck-8 assay, western blot (for apoptotic genes, such as cleaved parp) and annexin v-fitc/pi double-labelling showed that mtx could induce cell apoptosis. |
2017-04-28 |
2023-08-13 |
rat |
| Fidelia I Uche, Falko P Drijfhout, James McCullagh, Alan Richardson, Wen-Wu L. Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytotherapy research : PTR. vol 30. issue 9. 2017-04-24. PMID:27270992. |
both cycleanine and tetrandrine caused apoptosis as shown by activation of caspases 3/7 and cleavage of poly(adp-ribose) polymerase to form poly(adp-ribose) polymerase-1 by using western blot analysis. |
2017-04-24 |
2023-08-13 |
human |
| Jian-Guang Yang, Rui Lu, Xiao-Jing Ye, Jing Zhang, Ya-Qin Tan, Gang Zho. Icaritin Reduces Oral Squamous Cell Carcinoma Progression via the Inhibition of STAT3 Signaling. International journal of molecular sciences. vol 18. issue 1. 2017-04-24. PMID:28085115. |
the expressions of proteins related to proliferation, apoptosis, and autophagy, as well as signal transducer and activator of transcription 3 (stat3) signal network, were also evaluated by western blot. |
2017-04-24 |
2023-08-13 |
mouse |
| Annelies Paridaens, Sarah Raevens, Lindsey Devisscher, Eliene Bogaerts, Xavier Verhelst, Anne Hoorens, Hans Van Vlierberghe, Leo A van Grunsven, Anja Geerts, Isabelle Coll. Modulation of the Unfolded Protein Response by Tauroursodeoxycholic Acid Counteracts Apoptotic Cell Death and Fibrosis in a Mouse Model for Secondary Biliary Liver Fibrosis. International journal of molecular sciences. vol 18. issue 1. 2017-04-24. PMID:28117681. |
the kinetics of the hepatic upr and apoptosis during the development of biliary fibrosis was studied by measuring markers at six different timepoints post-surgery by qpcr and western blot. |
2017-04-24 |
2023-08-13 |
mouse |
| Ning Wang, Zhihan Wang, Shihong Nie, Linjiang Song, Tao He, Suleixin Yang, Xi Yang, Cheng Yi, Qinjie Wu, Changyang Gon. Biodegradable polymeric micelles coencapsulating paclitaxel and honokiol: a strategy for breast cancer therapy in vitro and in vivo. International journal of nanomedicine. vol 12. 2017-04-24. PMID:28260895. |
in addition, both the cytotoxicity and the cellular uptake of p-h/m were increased in 4t1 cells, and p-h/m induced more apoptosis than ptx-loaded micelles or hk-loaded micelles, as analyzed by flow cytometry assay and western blot. |
2017-04-24 |
2023-08-13 |
Not clear |
| Chengyi Huang, Yufeng Y. Synergistic Cytotoxicity of β-Elemene and Cisplatin in Gingival Squamous Cell Carcinoma by Inhibition of STAT3 Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2017-04-24. PMID:28355175. |
mtt assay, clonogenic assay, annexin v/pi apoptosis assay, western blot analysis, and xenograft model treatment were carried out in vitro and in vivo. |
2017-04-24 |
2023-08-13 |
Not clear |