| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing He, Jing Li, Feng Dong, Chuanshu Cai, Xi Zo. LKB1 promotes radioresistance in esophageal cancer cells exposed to radiation, by suppression of apoptosis and activation of autophagy via the AMPK pathway. Molecular medicine reports. vol 16. issue 2. 2018-02-05. PMID:28656285. |
furthermore, it was demonstrated that lkb1 overexpression inhibited apoptosis and activated autophagy of eca‑109 cells following radiation treatment, as determined by flow cytometry and western blot analyses. |
2018-02-05 |
2023-08-13 |
mouse |
| Yanghe Wu, Jiguang Ding, Qingfeng Sun, Ke Zhou, Weiwei Zhang, Qingwei Du, Tingyan Xu, Wangwang X. Long noncoding RNA hypoxia-inducible factor 1 alpha-antisense RNA 1 promotes tumor necrosis factor-α-induced apoptosis through caspase 3 in Kupffer cells. Medicine. vol 97. issue 4. 2018-02-02. PMID:29369172. |
western blot was implied to the determination of lymphoid enhancer factor-1 (lef-1).in this study, we found that hif1a-as1 could be upregulated by tnf-α by lncrna array analysis and knockdown of hif1a-as1 significantly rescued cell apoptosis induced by tnf-α. |
2018-02-02 |
2023-08-13 |
Not clear |
| Hari Shanker Tiwari, Usha Kant Misra, Jayantee Kalita, Akanksha Mishra, Shubha Shukl. Oxidative stress and glutamate excitotoxicity contribute to apoptosis in cerebral venous sinus thrombosis. Neurochemistry international. vol 100. 2018-01-31. PMID:27620812. |
the markers of apoptosis were evaluated by expression of cleaved caspase-3 and specrtin break down product (sbdp) by western blot. |
2018-01-31 |
2023-08-13 |
Not clear |
| Zhengyun Liu, Guangmin Li, Ying Gou, Dongyan Xiao, Guo Luo, Joseph E Saavedra, Jie Liu, Huan Wan. JS-K, a nitric oxide prodrug, induces DNA damage and apoptosis in HBV-positive hepatocellular carcinoma HepG2.2.15 cell. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-01-31. PMID:28605880. |
the immunofluorescence, flow cytometry analysis, and western blot were used to study dna damage and cell apoptosis. |
2018-01-31 |
2023-08-13 |
Not clear |
| Ye Li, Shu-Xiang Cui, Shi-Yue Sun, Wen-Na Shi, Zhi-Yu Song, Shu-Qing Wang, Xin-Feng Yu, Zu-Hua Gao, Xian-Jun Q. Chemoprevention of intestinal tumorigenesis by the natural dietary flavonoid myricetin in APCMin/+ mice. Oncotarget. vol 7. issue 37. 2018-01-30. PMID:27507058. |
immunohistochemical and western blot analysis revealed that myricetin selectively inhibits cell proliferation and induces apoptosis in adenomatous polyps. |
2018-01-30 |
2023-08-13 |
mouse |
| Tong Chen, Zhanqiang Ma, Lingpeng Zhu, Wenjiao Jiang, Tingting Wei, Rui Zhou, Fen Luo, Kai Zhang, Qiang Fu, Chunhua Ma, Tianhua Ya. Suppressing Receptor-Interacting Protein 140: a New Sight for Salidroside to Treat Cerebral Ischemia. Molecular neurobiology. vol 53. issue 9. 2018-01-29. PMID:26563497. |
immunohistochemical and western blot results demonstrated that sal inhibited rip140-mediated inflammation and apoptosis in the mcao rats and sh-sy5y cells. |
2018-01-29 |
2023-08-13 |
rat |
| Xi-Yang Zhang, Chan Chen, Ya-Bing Zhang, Si-Yang Wang, Tao Zhu, Jin Liu, Gang Ma, Bin Li. Role of Toll-Like Receptor 3 in Lung Ischemia-Reperfusion Injury. Shock (Augusta, Ga.). vol 46. issue 4. 2018-01-29. PMID:26939037. |
pulmonary apoptosis was also inhibited after tlr3 knockout, as indicated by cleaved caspase-3 western blot and terminal deoxynucleotidyl transferase dutp nick end labeling staining. |
2018-01-29 |
2023-08-13 |
mouse |
| Hiroshi Matsushima, Taisuke Mori, Fumitake Ito, Takuro Yamamoto, Makoto Akiyama, Tetsuya Kokabu, Kaori Yoriki, Shiori Umemura, Kyoko Akashi, Jo Kitawak. Anti-tumor effect of estrogen-related receptor alpha knockdown on uterine endometrial cancer. Oncotarget. vol 7. issue 23. 2018-01-23. PMID:27153547. |
cell cycle and apoptosis assays using flow cytometry and western blot revealed that errα knockdown induced cell cycle arrest during the mitotic phase followed by apoptosis initiated by caspase-3. |
2018-01-23 |
2023-08-13 |
Not clear |
| Swayamsiddha Kar, Samir Kumar Patr. Overexpression of OCT4 induced by modulation of histone marks plays crucial role in breast cancer progression. Gene. vol 643. 2018-01-23. PMID:29203199. |
expression of oct4 in breast cancer tissues and cell lines was determined by qrt-pcr, western blot, immunohistochemistry and immunocytochemistry followed by investigation of pro-tumorigenic properties such as cell proliferation, migration and apoptosis by gene knockdown and treatment with epigenetic modulators. |
2018-01-23 |
2023-08-13 |
Not clear |
| Man Liu, Guoren Huang, Thomas T Y Wang, Xiangjun Sun, Liangli Lucy Y. 3-MCPD 1-Palmitate Induced Tubular Cell Apoptosis In Vivo via JNK/p53 Pathways. Toxicological sciences : an official journal of the Society of Toxicology. vol 151. issue 1. 2018-01-22. PMID:27008853. |
the changes in the mrna expressions were confirmed by qrt-pcr and western blot analyses and were consistent with the induction of tubular cell apoptosis as determined by histopathological, tunel, and immunohistochemistry analyses in the kidneys of the sprague dawley rats. |
2018-01-22 |
2023-08-13 |
mouse |
| Simona Ultimo, Carolina Simioni, Alberto M Martelli, Giorgio Zauli, Camilla Evangelisti, Claudio Celeghini, James A McCubrey, Giorgia Marisi, Paola Ulivi, Silvano Capitani, Luca M Ner. PI3K isoform inhibition associated with anti Bcr-Abl drugs shows in vitro increased anti-leukemic activity in Philadelphia chromosome-positive B-acute lymphoblastic leukemia cell lines. Oncotarget. vol 8. issue 14. 2018-01-12. PMID:28390196. |
the effects of single drugs and of several drug combinations were analyzed to assess cytotoxicity by mts assays, apoptosis and autophagy by flow cytometry and western blot, as well as the phosphorylation status of the pathway.zstk474, byl719 and ipi145 administered in combination with imatinib, nilotinib and gzd824 for 48 h, decreased cell viability, induced apoptosis and autophagy in a marked synergistic manner.these findings suggest that selected pi3k isoform inhibitors used in combination with anti bcr-abl drugs may be an attractive novel therapeutic intervention in ph+ b-all. |
2018-01-12 |
2023-08-13 |
Not clear |
| Di Wang, Qin Qin, Qin-Juan Jiang, Da-Fei Wan. Bortezomib sensitizes esophageal squamous cancer cells to radiotherapy by suppressing the expression of HIF-1α and apoptosis proteins. Journal of X-ray science and technology. vol 24. issue 4. 2018-01-11. PMID:27080362. |
the expression of hif-1α, vegf, and apoptosis proteins was evaluated by western blot. |
2018-01-11 |
2023-08-13 |
human |
| Lisa Marx-Blümel, Christian Marx, Marie Kühne, Jürgen Sonneman. Assessment of HDACi-Induced Cytotoxicity. Methods in molecular biology (Clifton, N.J.). vol 1510. 2018-01-09. PMID:27761811. |
moreover, we summarize flow cytometric analysis of propidium iodide uptake, annexin v staining, cell cycle status, ros levels, and mitochondrial membrane potential as well as detection of apoptosis by western blot. |
2018-01-09 |
2023-08-13 |
Not clear |
| Qiurong Wang, Jun Re. mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1. Pharmacological research. vol 111. 2018-01-05. PMID:27363949. |
apoptosis and er stress were evaluated using tunel staining, caspase 3 assay and western blot. |
2018-01-05 |
2023-08-13 |
mouse |
| Hong-Wei Wang, Wen-Peng Zhao, Jing Liu, Pan-Pan Tan, Cai Zhang, Bian-Hua Zho. Fluoride-induced oxidative stress and apoptosis are involved in the reducing of oocytes development potential in mice. Chemosphere. vol 186. 2018-01-02. PMID:28826138. |
the protein expression levels of apoptosis factors, including bax, bcl-2, casepase-3, casepase-9 and cytochrome c, and the mrna expression levels of antioxidant enzymes, including sod1, gsh-px1, cat and inducible nitric oxide synthase were measured by western blot and real-time pcr, respectively. |
2018-01-02 |
2023-08-13 |
mouse |
| Jinning Hou, Kang Jin, Jin Li, Yuqi Jiang, Xiaoyang Li, Xuejian Wang, Yongxue Huang, Yingjie Zhang, Wenfang X. LJNK, an indoline-2,3-dione-based aminopeptidase N inhibitor with promising antitumor potency. Anti-cancer drugs. vol 27. issue 6. 2017-12-29. PMID:26872309. |
annexin v-fluorescein isothiocyanate/propidium iodide assay showed that ljnk could induce 28.1% plc/prf/5 cell apoptosis and the apoptotic pathway was probably identified by western blot. |
2017-12-29 |
2023-08-13 |
mouse |
| Chieh-Hsiang Lu, Shu-Hsin Chen, Yi-Sheng Chang, Yi-Wen Liu, Jin-Yi Wu, Yun-Ping Lim, Hui-I Yu, Ying-Ray Le. Honokiol, a potential therapeutic agent, induces cell cycle arrest and program cell death in vitro and in vivo in human thyroid cancer cells. Pharmacological research. vol 115. 2017-12-27. PMID:27940017. |
cell viability, cell cycle, apoptosis, and autophagy induction were determined through flow cytometry and western blot analysis. |
2017-12-27 |
2023-08-13 |
human |
| Ke-Wang Luo, Wei Chen, Wing-Yin Lung, Xia-Yun Wei, Bao-Hui Cheng, Zhi-Ming Cai, Wei-Ren Huan. EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down-regulation of NF-κB and MMP-9. The Journal of nutritional biochemistry. vol 41. 2017-12-22. PMID:28040581. |
western blot confirmed that egcg induced apoptosis in sw780 cells by activation of caspases-8, -9 and -3, bax, bcl-2 and parp. |
2017-12-22 |
2023-08-13 |
mouse |
| Liping Shao, Zongji Shen, Hua Qian, Sufang Zhou, Youguo Che. Knockdown of miR-629 Inhibits Ovarian Cancer Malignant Behaviors by Targeting Testis-Specific Y-Like Protein 5. DNA and cell biology. vol 36. issue 12. 2017-12-19. PMID:28972400. |
after transfection, cell apoptosis, the ability of migration, and invasion were explored, as well as the level of mir-629 and tspyl5 protein expression were detected by quantitative polymerase chain reaction and western blot. |
2017-12-19 |
2023-08-13 |
Not clear |
| Jin Li, Eric R Falcone, Sarah A Holstein, Amy C Anderson, Dennis L Wright, Andrew J Wieme. Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis. Pharmacological research. vol 113. issue Pt A. 2017-12-18. PMID:27663262. |
treatment of leukemia cell lines with the tropolone dose-dependently induces apoptosis as judged by staining with annexin v and propidium iodide and western blot analysis of cleaved caspase 3 and 7. |
2017-12-18 |
2023-08-13 |
human |