| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shih-Chung Wang, Jyh-Ming Chow, Ming-Hsien Chien, Chiao-Wen Lin, Hui-Yu Chen, Pei-Ching Hsiao, Shun-Fa Yan. Cantharidic acid induces apoptosis of human leukemic HL-60 cells via c-Jun N-terminal kinase-regulated caspase-8/-9/-3 activation pathway. Environmental toxicology. vol 33. issue 4. 2018-04-17. PMID:29345422. |
western blot and flow cytometric assays demonstrated that cac induced several features of apoptosis such as sub g1-phase cell increase, phosphatidylserine (ps) externalization, and significantly activated proapoptotic signaling including caspase-8, -9, and -3 activation and poly(adp-ribose) polymerase (parp) cleavage in hl-60 aml cells. |
2018-04-17 |
2023-08-13 |
human |
| Lei Yu, Xin Wang, Zhi-Feng Chen, Bo Jiang, Dong-Yu Shang, Yong-Xue Sun, Jing-Hui Yang, Lian-Fang Zhang, Yu-Bin J. Cytisine induces apoptosis of HepG2 cells. Molecular medicine reports. vol 16. issue 3. 2018-04-16. PMID:28713951. |
furthermore, western blot analysis was performed to investigate the release of cytochrome c (cyt‑c) and activation of the caspase cascade, and the results indicated that treatment of hepg2 cells with cytisine induced caspase‑dependent apoptosis via the release of cyt‑c from the mitochondria, upregulation of caspase‑3 and downregulation of pro‑caspase‑3. |
2018-04-16 |
2023-08-13 |
human |
| Yonghui Zhang, Chong Zhang, Fulu Dong, Miaomiao Chen, Jingchen Cao, Haiyan Wang, Ming Jian. Inhibition of autophagy aggravated 4-nitrophenol-induced oxidative stress and apoptosis in NHPrE1 human normal prostate epithelial progenitor cells. Regulatory toxicology and pharmacology : RTP. vol 87. 2018-04-12. PMID:28476554. |
pnp also increased apoptosis of nhpre1 cells as evidenced by western blot and hoechst 33258 staining and activated autophagy in nhpre1 cells detected by rt-pcr and western blot. |
2018-04-12 |
2023-08-13 |
human |
| Elçin Telli, Hatice Genç, Burcugül Altuğ Tasa, S Sinan Özalp, A Tansu Kopara. In vitro evaluation of combination of EGCG and Erlotinib with classical chemotherapeutics on JAR cells. In vitro cellular & developmental biology. Animal. vol 53. issue 7. 2018-04-09. PMID:28462491. |
in addition, significant increase was observed in the apoptotic bax gene, but no notable protein synthesis occurred in the western blot analysis, which suggests that combination of erlotinib and egcg with classical chemotherapeutics acd or mtx may lead the jar cells to apoptosis, but not by a mitochondrial pathway. |
2018-04-09 |
2023-08-13 |
human |
| Jingdong Guo, Quan Lin, Ying Shao, Li Rong, Duo Zhan. BMP‑7 suppresses excessive scar formation by activating the BMP‑7/Smad1/5/8 signaling pathway. Molecular medicine reports. vol 16. issue 2. 2018-04-09. PMID:28627680. |
western blot assay was used to determine the level changes of related proteins and tunel assay was performed to assess the apoptosis of scar tissues. |
2018-04-09 |
2023-08-13 |
mouse |
| Qing Yang, Suoyuan Li, Zeze Fu, Binhui Lin, Zifei Zhou, Zhuoying Wang, Yingqi Hua, Zhengdong Ca. Shikonin promotes adriamycin‑induced apoptosis by upregulating caspase‑3 and caspase‑8 in osteosarcoma. Molecular medicine reports. vol 16. issue 2. 2018-04-06. PMID:28627658. |
the survival rate of cells decreased significantly in a dose‑ and time‑dependent manner when treated with a combination of sk and adm. western blot analysis revealed increased expression levels of bax, caspase‑3, caspase‑8 and parp in u2os and mg63 cells 48 h following treatment with sk and adm. flow cytometric analysis showed that the combined treatment of sk and adm significantly induced apoptosis in the osteosarcoma cells. |
2018-04-06 |
2023-08-13 |
Not clear |
| Xuefeng Qi, Jiamin Xu, Zugui Wang, Xueping Wang, Jingyu Wan. The role of hexon in egg drop syndrome virus (EDSV) inducing apoptosis in duck embryo fibroblast cells. Research in veterinary science. vol 114. 2018-04-06. PMID:28743080. |
in addition, caspase activity detection and western blot analysis indicates that either edsv infection or edsv hexon transfection both induced apoptosis of def cells via activating both the exogenous and the mitochondrial pathway. |
2018-04-06 |
2023-08-13 |
human |
| Zhenhuan Hou, Jun Mao, Ying Lu, Lianhong L. rApoptin induces apoptosis in human breast cancer cells via phosphorylation of Nur77 and Akt. Biochemical and biophysical research communications. vol 498. issue 1. 2018-04-06. PMID:29501489. |
furthermore, we found via western blot that rapoptin-induced apoptosis in mcf-7 and mda-mb-231 cells was associated with the phosphorylation of nur77 (p-nur77) and akt (p-akt). |
2018-04-06 |
2023-08-13 |
human |
| Xiaolei Li, Hui Chen, Yu Sun, Jihang Dai, Shuguang Wang, Jingcheng Wang, Lianqi Ya. Hydroxycamptothecin prevents intraarticular scar adhesion by activating the PERK signal pathway. European journal of pharmacology. vol 810. 2018-04-05. PMID:28603046. |
when human fibroblasts were treated with hcpt in vitro, cell viability was inhibited according to the results of cck-8 assay and hoechst staining, and cell apoptosis was induced according to the results of av/pi and western blot analysis. |
2018-04-05 |
2023-08-13 |
human |
| Xiaoling Song, Zheng Wang, Haibin Liang, Wenjie Zhang, Yuanyuan Ye, HuaiFeng Li, Yunping Hu, Yijian Zhang, Hao Weng, Jianhua Lu, Xuefeng Wang, Maolan Li, Yingbin Liu, Jun G. Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling. International journal of biological sciences. vol 13. issue 6. 2018-04-03. PMID:28656003. |
western blot analysis showed that akt activity was significantly downregulated after dsn treatment, and that inhibition/ectopic expression of akt enhanced/abolished dsn-induced apoptosis but not migration. |
2018-04-03 |
2023-08-13 |
human |
| Hai-Xu Wang, Chen Tan. Galangin suppresses human laryngeal carcinoma via modulation of caspase-3 and AKT signaling pathways. Oncology reports. vol 38. issue 2. 2018-04-03. PMID:28677816. |
also, flow cytometry, immunohistochemical and western blot analysis indicated that cell apoptosis was induced for galangin administration, promoting caspase-3 expression through regulating pi3k/akt/nf-κb. |
2018-04-03 |
2023-08-13 |
mouse |
| Huiying Zhao, Qingchun Liu, Saisai Wang, Fang Dai, Xiaofei Cheng, Xiaobin Cheng, Wenbin Chen, Min Zhang, Dong Che. In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells. Cancer medicine. vol 6. issue 7. 2018-03-29. PMID:28573788. |
the influence of dmc and 5-fu on cell cycle, apoptosis, reactive oxygen species (ros) production, and mitochondrial membrane potential in sw480 and sw620 cells was determined using flow cytometry, and the related signaling pathways were detected by western blot. |
2018-03-29 |
2023-08-13 |
Not clear |
| Yujiao Lu, Qin Luo, Hengmin Cui, Huidan Deng, Ping Kuang, Huan Liu, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zha. Sodium fluoride causes oxidative stress and apoptosis in the mouse liver. Aging. vol 9. issue 6. 2018-03-29. PMID:28657544. |
the current study was conducted to investigate the effect of sodium fluoride (naf) on the oxidative stress and apoptosis as well as their relationship in the mouse liver by using methods of flow cytometry, quantitative real-time polymerase chain reaction (qrt-pcr), western blot, biochemistry and experimental pathology. |
2018-03-29 |
2023-08-13 |
mouse |
| Elizabeth V Nguyen, Kaisa Huhtinen, Young Ah Goo, Katja Kaipio, Noora Andersson, Ville Rantanen, Johanna Hynninen, Riitta Lahesmaa, Olli Carpen, David R Goodlet. Hyper-phosphorylation of Sequestosome-1 Distinguishes Resistance to Cisplatin in Patient Derived High Grade Serous Ovarian Cancer Cells. Molecular & cellular proteomics : MCP. vol 16. issue 7. 2018-03-26. PMID:28455291. |
changes in expression of apoptosis and autophagy related proteins caspase-3 and sqstm1, respectively, were validated by western blot analysis. |
2018-03-26 |
2023-08-13 |
Not clear |
| Hidenobu Sato, Yunyan Wu, Yukio Kato, Qiang Liu, Hideaki Hirai, Tadashi Yoshizawa, Satoko Morohashi, Jun Watanabe, Hiroshi Kijim. DEC2 expression antagonizes cisplatin‑induced apoptosis in human esophageal squamous cell carcinoma. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28498447. |
in the present study, alterations in expression of apoptosis‑related markers in human esophageal squamous cell carcinoma te‑11 cells treated with cisplatin were examined by western blot, while overall cell viability and apoptosis were analyzed by mts assay and hematoxylin and eosin staining, respectively. |
2018-03-26 |
2023-08-13 |
human |
| Xiaorong Mao, Senrong Du, Zhongxia Yang, Liting Zhang, Xuebin Peng, Ni Jiang, Haiyu Zho. Inhibitors of PARP-1 exert inhibitory effects on the biological characteristics of hepatocellular carcinoma cells in vitro. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28498459. |
flow cytometry was used to detect the apoptosis of hepg2 cells, western blot analysis was used to detect the protein expression of casepase‑3, casepase‑8, b‑cell lymphoma 2 (bcl‑2)‑associated x protein (bax), bcl‑2, phosphatase and tensin homolog (pten), tissue inhibitor of metalloproteinase (timp) 3 and matrix metalloprotease (mmp) 3. |
2018-03-26 |
2023-08-13 |
Not clear |
| Zuowen Liang, Hongliang Wang, Baofeng Guo, Fubiao Li, Jinsha Liu, Zhewen Liu, Libo Xu, Wenjing Yun, Xuejian Zhao, Ling Zhan. Inhibition of prostate cancer RM1 cell growth in vitro by hydroxyapatite nanoparticle‑delivered short hairpin RNAs against Stat3. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28534932. |
stat3 mrna expression levels were measured by reverse transcription‑quantitative polymerase chain reaction and stat3, cyclin d1, b cell lymphoma 2 apoptosis regulator (bcl‑2), vascular endothelial growth factor (vegf), bcl‑2 associated x apoptosis regulator (bax) and cleaved‑caspase‑3 protein expression levels were detected using western blot analysis. |
2018-03-26 |
2023-08-13 |
Not clear |
| Haiqiong Ye, Yujiao Zhang, Yongzhou Wang, Jiyi Xia, Xiguang Mao, Xiaolan Y. The restraining effect of baicalein and U0126 on human cervical cancer cell line HeLa. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28560420. |
reverse transcription‑quantitative polymerase chain reaction and western blot analysis was used to detect apoptosis gene and protein expression. |
2018-03-26 |
2023-08-13 |
human |
| Bo Meng, Hongyi Li, Xian Sun, Wei Qu, Binbin Yang, Fang Cheng, Liping Shi, Huiping Yua. σ-1 receptor stimulation protects against pressure-induced damage through InsR-MAPK signaling in human trabecular meshwork cells. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28560459. |
the changes of the cells were observed by optical and electron microscopy, the apoptosis and death of htmcs were detected by ethidium bromide/acridine orange dual staining assay and the expression of sig‑1r and insr by reverse transcription‑quantitative polymerase chain reaction and western blot analysis. |
2018-03-26 |
2023-08-13 |
human |
| Meilan Xue, Yinlin Ge, Chundong Yu, Zheng Zheng, Xinjia He, Jinglan Zha. Apoptosis is induced by docosahexaenoic acid in breast cancer cells via death receptor and mitochondria-mediated pathways. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28586001. |
flow cytometry and western blot analysis were performed to analyze apoptosis and the expression of protein factors in human breast cancer cells. |
2018-03-26 |
2023-08-13 |
human |