| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enxu Bi, Dengqiang Liu, Youxi Li, Xuying Mao, Aihua Wang, Jingtao Wan. Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 51. issue 12. 2018-12-11. PMID:30462771. |
cell apoptosis was determined by flow cytometry assay and western blot. |
2018-12-11 |
2023-08-13 |
human |
| Enxu Bi, Dengqiang Liu, Youxi Li, Xuying Mao, Aihua Wang, Jingtao Wan. Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 51. issue 12. 2018-12-11. PMID:30462771. |
western blot was used to evaluate the protein expression of apoptosis, dna damage and p53 function related factors. |
2018-12-11 |
2023-08-13 |
human |
| Yi Zheng, Yong Zhang, Yichun Zheng, Nan Zhan. Carnosol protects against renal ischemia-reperfusion injury in rats. Experimental animals. vol 67. issue 4. 2018-11-27. PMID:30068825. |
a renal myeloperoxidase activity assay, in-situ apoptosis examination, enzyme-linked immunosorbent assay, immunohistochemical assay, and western blot were also performed. |
2018-11-27 |
2023-08-13 |
rat |
| Yawen Ji, Linglu Jia, Yunpeng Zhang, Yixiao Xing, Xuan Wu, Bin Zhao, Dondjiao Zhang, Xin Xu, Xu Qia. Antitumor activity of the plant extract morin in tongue squamous cell carcinoma cells. Oncology reports. vol 40. issue 5. 2018-11-27. PMID:30132559. |
analyses of cell viability, using cell counting kit‑8 (cck‑8), edu incorporation, colony formation, flow cytometric analysis of cell cycle distribution and apoptosis, wound healing assay, western blot analysis and qrt‑pcr assays, were then performed. |
2018-11-27 |
2023-08-13 |
human |
| Wei Han, Fang Cao, Xiao-Jiao Gao, Hua-Bing Wang, Fang Chen, Si-Jian Cai, Cong Zhang, Yong-Wei Hu, Jun Ma, Xing Gu, Hou-Zhong Din. ZIC1 acts a tumor suppressor in breast cancer by targeting survivin. International journal of oncology. vol 53. issue 3. 2018-11-26. PMID:29956756. |
subsequently, the mda-mb-231 and sk-br3 cells with a lower zic1 expression were transfected with rlv-zic1-pgk-puro lentivirus or rlv-zsgreen-pgk‑puro lentivirus in order to observe any alterations in cell proliferation and apoptosis through mtt assay, colony formation assay, mitochondrial membrane potential assay and flow cytometric analysis, and to analyze the modulation of molecular mechanisms by western blot analysis. |
2018-11-26 |
2023-08-13 |
mouse |
| Dandan Yu, Yong Zhang, Gege Chen, Yongsheng Xie, Zhijian Xu, Shuaikang Chang, Liangning Hu, Bo Li, Wenxuan Bu, Yingcong Wang, Wenqin Xiao, Xi Sun, Gaomei Chang, Lu Gao, Sujing Qiang, Xiaosong Wu, Weiliang Zhu, Jumei Sh. Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression. Acta biochimica et biophysica Sinica. vol 50. issue 8. 2018-11-26. PMID:29961897. |
the antitumor activity of pte was examined by using the cell counting kit-8, apoptosis assays, cell cycle analysis, jc-1 mitochondrial membrane potential assay, western blot analysis, and tumor xenograft models. |
2018-11-26 |
2023-08-13 |
mouse |
| Yanyan Ma, Lifang Yang, Jipeng Ma, Linhe Lu, Xiaowu Wang, Jun Ren, Jian Yan. Rutin attenuates doxorubicin-induced cardiotoxicity via regulating autophagy and apoptosis. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 8. 2018-11-20. PMID:28069395. |
western blot analysis indicated that the underlying mechanisms included inhibition excessive autophagy and apoptosis mediated by akt activation. |
2018-11-20 |
2023-08-13 |
mouse |
| Theresa Noll, Susanne Schultze-Seemann, Irina Kuckuck, Marta Michalska, Philipp Wol. Synergistic cytotoxicity of a prostate cancer-specific immunotoxin in combination with the BH3 mimetic ABT-737. Cancer immunology, immunotherapy : CII. vol 67. issue 3. 2018-11-20. PMID:29188305. |
the combination of the immunotoxin with a subtoxic concentration of abt-737 caused additive or even synergistic effects, which were based on an enhanced apoptosis induction as detected by poly(adp-ribose) polymerase (parp) and caspase-3 cleavage in western blot. |
2018-11-20 |
2023-08-13 |
Not clear |
| Sze-Kwan Lam, Kin Pong U, Yuan-Yuan Li, Shi Xu, Paul Ning-Man Cheng, James Chung-Man H. Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models. Oncology reports. vol 40. issue 4. 2018-11-20. PMID:30066894. |
protein expression, arginine level, putrescine level, spermidine level and apoptosis were analyzed by western blotting, elisa, high performance liquid chromatography, dot blot and tunel assay, respectively. |
2018-11-20 |
2023-08-13 |
Not clear |
| Jianru Guo, Yan Li, Christopher Wai Kei Lam, Caiyun Wang, Meicun Yao, Wei Zhan. ZH-1 enhances the anticancer activity of gemcitabine via deoxyribonucleotide synthesis and apoptotic pathway against A549 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 119. 2018-11-19. PMID:29653181. |
furthermore, western blot analysis revealed that the combination treatment caused a549 cell apoptosis via the intrinsic pathway by up-regulating bax/bcl-2 ratio, activating caspase-9, caspase-3 and poly-adp-ribose polymerase, and promoting caspase-7, caspase-9 and poly-adp-ribose polymerase cleavage. |
2018-11-19 |
2023-08-13 |
Not clear |
| Zhaoyang Yan, Xiaoyong Huang, Yangzhouyun Xie, Meirong Song, Kui Zhu, Shuangyang Din. Macrolides induce severe cardiotoxicity and developmental toxicity in zebrafish embryos. The Science of the total environment. vol 649. 2018-11-14. PMID:30308910. |
lastly, apoptosis was observed in zebrafish embryos under tms treatment, with up-regulation of apoptosis associated genes such as p53, bcl 2, bax, caspase 3 and caspase 9, confirmed by increased protein expression based on western blot analysis. |
2018-11-14 |
2023-08-13 |
human |
| Caiying Wang, Zhili Chu, Wenkai Liu, Yu Pang, Xiaolong Gao, Qiuxia Tang, Jiangang Ma, Kejia Lu, Fathalrhman E A Adam, Ruyi Dang, Sa Xiao, Xinglong Wang, Zengqi Yan. Newcastle disease virus V protein inhibits apoptosis in DF-1 cells by downregulating TXNL1. Veterinary research. vol 49. issue 1. 2018-11-13. PMID:30290847. |
furthermore, the western blot and q-pcr results suggested that txnl1 induced cell apoptosis through a pathway involving bcl-2ax and caspase-3. |
2018-11-13 |
2023-08-13 |
chicken |
| Anuradha Vaidya, Vaijayanti Kale, Mariyah Poonawala, Suprita Ghod. Mesenchymal stromal cells enhance the hematopoietic stem cell-supportive activity of resveratrol. Regenerative medicine. vol 13. issue 4. 2018-11-08. PMID:29742966. |
materials & methods: proliferation assay, cell cycle analysis, apoptosis assay, flow cytometry, western blot. |
2018-11-08 |
2023-08-13 |
Not clear |
| Wenjing Zhao, Haifang Zhang, Jin-Ying S. MicroRNA‑29a contributes to intracranial aneurysm by regulating the mitochondrial apoptotic pathway. Molecular medicine reports. vol 18. issue 3. 2018-11-08. PMID:30015903. |
by using reverse transcription‑quantitative polymerase chain reaction and western blot analysis, the present study demonstrated that genes, including caspase‑3, ‑8 and ‑9, and proteins, including cytochrome c and myeloid cell leukemia 1 (mcl‑1), involved in mitochondrial apoptosis pathways were upregulated in ia groups compared with controls. |
2018-11-08 |
2023-08-13 |
mouse |
| Nan Wang, Zhiping Feng, Wei Zhao, Zhiqiang Zhang, Lixin Zhan. Ultrashortwave radiation promotes the recovery of spinal cord injury by inhibiting inflammation via suppression of the MK2/TNF‑α pathway. International journal of molecular medicine. vol 42. issue 4. 2018-11-08. PMID:30066830. |
through gene level and protein level detection by using of rt‑qpcr, western blot, immunofluorescence assay and terminal deoxynucleotidyl transferase (tdt) dutp nick‑end labeling assay, it was demonstrated that usw radiation inhibited the expression of mk2/tnf‑α/il‑1β and suppressed the apoptosis of h2o2‑treated c8‑d1a cells. |
2018-11-08 |
2023-08-13 |
Not clear |
| Xiu-Rong Zhang, Shi-Yao Wang, Wen Sun, Chao We. Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway. Molecular medicine reports. vol 18. issue 3. 2018-11-08. PMID:30066879. |
apoptosis was assessed by flow cytometry, and the expression levels of apoptosis‑, autophagy‑ and signaling pathway‑related proteins were detected by western blot analysis. |
2018-11-08 |
2023-08-13 |
Not clear |
| Fei Teng, Zhiyuan Xu, Jiahui Chen, Guowei Zheng, Guodian Zheng, Hang Lv, Yiping Wang, Lijing Wang, Xiangdong Chen. DUSP1 induces apatinib resistance by activating the MAPK pathway in gastric cancer. Oncology reports. vol 40. issue 3. 2018-11-06. PMID:29956792. |
dusp1 gene was detected by rt‑qpcr assay, proteins in mapk pathway were quantified by western blot assay, and cck‑8 assay, flow cytometry and hoechest 33342 stain were performed to detect the resistance of cells, cell cycles and apoptosis, respectively. |
2018-11-06 |
2023-08-13 |
Not clear |
| Zhenhe Lin, Wenming Liu, Chuanxing Xiao, Yanyun Fan, Guohong Zhuang, Zhongquan Q. TIPE2 inhibits GC via regulation of cell proliferation, apoptosis and inflammation. Oncology reports. vol 40. issue 3. 2018-11-06. PMID:30015980. |
to clarify the role of tipe2 in the progression of human gc and to elucidate the underlying mechanism, the association between tipe2 and phosphatidylinositol 3‑kinase (pi3k)/akt, the cell cycle, the caspase‑related apoptosis pathway and the nf‑κb signaling pathway were investigated through western blot and flow cytometric analysis. |
2018-11-06 |
2023-08-13 |
human |
| Shohei Miyata, Li-Yan Wang, Susumu Kitanak. 3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt. Leukemia research. vol 64. 2018-11-05. PMID:29179029. |
we have previously used western blot analysis to show that the catalytic topoisomerase (topo) inhibitor, 3ez, 20ac-ingenol, induced dna damage response (ddr), which activated atr, downregulated p-akt through upregulation of pten level, and led to cell cycle arrest or apoptosis. |
2018-11-05 |
2023-08-13 |
Not clear |
| Wenqin Xiao, Bo Li, Xi Sun, Dandan Yu, Yongsheng Xie, Huiqun Wu, Shuaikang Chang, Yunfei Zhou, Houcai Wang, Xiucai Lan, Zhijian Xu, Jumei Shi, Weiliang Zh. DCZ3301, a novel aryl-guanidino inhibitor, induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma. Acta biochimica et biophysica Sinica. vol 50. issue 7. 2018-11-05. PMID:29688264. |
in the present study, we investigated the effects of dcz3301 on t-cell leukemia/lymphoma cells both in vitro and in vivo via cell proliferation, cell cycle analysis, apoptosis assay, mitochondrial membrane potential (mmp) assay, western blot analysis and tumor xenograft models. |
2018-11-05 |
2023-08-13 |
mouse |