| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanpeng Lv, Yanfang Zhang, Boris Rubinsk. Molecular and histological study on the effects of electrolytic electroporation on the liver. Bioelectrochemistry (Amsterdam, Netherlands). vol 125. 2018-12-19. PMID:30292929. |
western blot has shown the following molecular events after e2: cleaved caspase 3-downgraded at 1 h, upgraded at 24 h (apoptosis); cleaved caspase 1 and cleaved gsdmd-upgraded at 6 h (pyroptosis), rip3-upgraded at 1 h, mlkl-upgraded at 3 h (necroptosis). |
2018-12-19 |
2023-08-13 |
rat |
| Xue-Bin Zhao, Yi Qin, Yu-Ling Niu, Jun Yan. Matrine inhibits hypoxia/reoxygenation-induced apoptosis of cardiac microvascular endothelial cells in rats via the JAK2/STAT3 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-18. PMID:29957461. |
the mrna and protein expression of the jak2/stat3 signaling pathway and apoptosis related genes were determined through the use of rt-qpcr and western blot assay methods respectively. |
2018-12-18 |
2023-08-13 |
rat |
| Si Zhang, Yanan Liu, Daochun Xiang, Jinyu Yang, Dong Liu, Xiuhua Ren, Chengliang Zhan. Assessment of dose-response relationship of 5-fluorouracil to murine intestinal injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-18. PMID:30119262. |
tunel and western blot analysis showed cell apoptosis in the ileum and colon related to 5-fu dosage. |
2018-12-18 |
2023-08-13 |
mouse |
| Bosung Kim, Eun-Yeong Kim, Eun-Ji Lee, Jung Ho Han, Chung-Hwan Kwak, Yeon-Seop Jung, Syng-Ook Lee, Tae-Wook Chung, Ki-Tae H. Panax notoginseng Inhibits Tumor Growth through Activating Macrophage to M1 Polarization. The American journal of Chinese medicine. vol 46. issue 6. 2018-12-18. PMID:30168347. |
the transfer of culture media from pn-treated raw264.7 cells induced the apoptosis of llc cells as measured by flow cytometry using annexin-v staining and western blot analysis for caspase cascade-related proteins. |
2018-12-18 |
2023-08-13 |
Not clear |
| Guan Shi, Pu Jia, Hao Chen, Li Bao, Fei Feng, Hai Tan. Necroptosis occurs in osteoblasts during tumor necrosis factor-α stimulation and caspase-8 inhibition. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 1. 2018-12-17. PMID:30484493. |
specific marker proteins receptor interacting protein kinase (ripk3) and phosphorylated mixed lineage kinase domain-like protein (p-mlkl) for necroptosis, and cleaved caspase 3 for apoptosis were detected by western blot, and mrna was measured by quantitative real-time polymerase chain reaction (qrt-pcr). |
2018-12-17 |
2023-08-13 |
mouse |
| Bing-Gang Zhou, Chang-Sheng Wei, Song Zhang, Zhi Zhang, Huan-Min Ga. Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway. Journal of cellular biochemistry. vol 119. issue 5. 2018-12-11. PMID:29130495. |
methyl thiazolyl tetrazolium (mtt) assay was used to detect the inhibitory action; annexin v to detect apoptosis; fluorospectrophotometry to examine intracellular adriamycin (adr) accumulation; and western blot to label the proteins of p-glycoprotein (p-gp), mrp1, pten, p-akt, bcl-2, bax, and caspase-3. |
2018-12-11 |
2023-08-13 |
Not clear |
| Feng Tong, Youhua Ying, Haihua Pan, Wei Zhao, Hongchen Li, Xiaoli Zha. MicroRNA-466 (miR-466) functions as a tumor suppressor and prognostic factor in colorectal cancer (CRC). Bosnian journal of basic medical sciences. vol 18. issue 3. 2018-12-11. PMID:29338680. |
mrna and protein levels of cyclin d1, apoptosis regulator bax (bax), and matrix metalloproteinase-2 (mmp-2) were analyzed by qrt-pcr and western blot, respectively, in sw-620 crc cells transfected with mir-466 mimics or negative control mirna. |
2018-12-11 |
2023-08-13 |
Not clear |
| Chie Ishikawa, Masachika Senba, Naoki Mor. Anti-adult T‑cell leukemia/lymphoma activity of cerdulatinib, a dual SYK/JAK kinase inhibitor. International journal of oncology. vol 53. issue 4. 2018-12-11. PMID:30066853. |
cell proliferation, viability, cell cycle, apoptosis and intracellular signaling cascades were analyzed by the water-soluble tetrazolium-8 assay, flow cytometry and western blot analysis. |
2018-12-11 |
2023-08-13 |
human |
| Yi Qin, Jichao Ye, Fulan Zhao, Shaoyu Hu, Suwei Wan. TRIM2 regulates the development and metastasis of tumorous cells of osteosarcoma. International journal of oncology. vol 53. issue 4. 2018-12-11. PMID:30066883. |
the cell apoptosis was determined by flow cytometry and the protein level of the genes was detected by western blot analysis. |
2018-12-11 |
2023-08-13 |
mouse |
| Sanjay Kumar, Ibrahim O Farah, Paul B Tchounwo. Trisenox induces cytotoxicity through phosphorylation of mitogen-activated protein kinase molecules in acute leukemia cells. Journal of biochemical and molecular toxicology. vol 32. issue 10. 2018-12-11. PMID:30091188. |
apoptosis was evaluated by western blot analysis of apoptotic proteins expression, immunocytochemistry, and confocal imaging of annexin v and propidium iodide. |
2018-12-11 |
2023-08-13 |
Not clear |
| Jin Sun Lee, Myung Sun Lee, Eun Young Cha, Phuong Thien Thuong, Ji Young Sul, Jun Beom Park, Young Bok K. A natural ent‑kaurane diterpenoid induces antiproliferation in ovarian cancer cells via ERK1/2 regulation and inhibition of cellular migration and invasion. Molecular medicine reports. vol 18. issue 4. 2018-12-11. PMID:30106144. |
the objective of the present study was to determine the effect of crt1 on the cell viability, apoptosis and metastasis of skov3 human ovarian cancer cells using a cell counting kit‑8 assay, flow cytometric analysis of annexin v‑fluorescein isothiocyanate/propidium iodide staining, western blot analysis, soft agar colony forming assay, wound healing assay and matrigel invasion assay. |
2018-12-11 |
2023-08-13 |
human |
| Zhanshu Liu, Tonghua Me. Immune thrombocytopenia induces autophagy and suppresses apoptosis in megakaryocytes. Molecular medicine reports. vol 18. issue 4. 2018-12-11. PMID:30106156. |
meg‑01 cell line was cultured in vitro, and morphological changes were observed by light microscopy, apoptosis was evaluated by flow cytometric analysis of annexin v‑fitc/propidium iodide staining and western blot analysis of b‑cell lymphoma (bcl)‑2, bcl‑associated x protein (bax), beclin‑1 and cleaved caspase 3. |
2018-12-11 |
2023-08-13 |
Not clear |
| Yi Mu, Deyu Su. Lapatinib, a Dual Inhibitor of Epidermal Growth Factor Receptor (EGFR) and HER-2, Enhances Radiosensitivity in Mouse Bladder Tumor Line-2 (MBT-2) Cells In Vitro and In Vivo. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-11. PMID:30125265. |
western blot measured phosphorylated epidermal growth factor receptor (p-egfr), phosphorylated akt (p-akt), and phosphorylated her-2 (p-her2) and the apoptosis marker, parp. |
2018-12-11 |
2023-08-13 |
mouse |
| Ailing Sui, Yisheng Zhong, Anna M Demetriades, Jikui Shen, Ting Su, Yiyun Yao, Yushuo Gao, Yanji Zhu, Xi Shen, Bing Xi. ATN-161 as an Integrin α5β1 Antagonist Depresses Ocular Neovascularization by Promoting New Vascular Endothelial Cell Apoptosis. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-11. PMID:30133427. |
the activation of nuclear factor-κb (nf-κb), matrix metalloproteinase-2/9 (mmp-2/9), and cell apoptosis were detected by immunofluorescence staining, western blot, real-time rt-pcr, and terminal deoxynucleotidyl transferase dutp nick-end labeling (tunel). |
2018-12-11 |
2023-08-13 |
mouse |
| Xiu-Lian Yan, Yuan-Yuan Wang, Zhong-Fei Yu, Mi-Mi Tian, Hui L. Peroxisome proliferator-activated receptor-gamma activation attenuates diabetic cardiomyopathy via regulation of the TGF-β/ERK pathway and epithelial-to-mesenchymal transition. Life sciences. vol 213. 2018-12-11. PMID:30189217. |
we also performed western blot, pcr, elisa, immunohistochemistry, tunel assay, sirius red staining and gelatin zymography to investigate inflammation, apoptosis, mmp activity and epithelial-to-mesenchymal transition (emt). |
2018-12-11 |
2023-08-13 |
mouse |
| Biao Gu, Qi Wang, Weijie Dai, Gang Ma, Yaqi Song, Qingquan W. Effect of GDF11 on proliferation and apoptosis of esophageal cancer cells. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 11. 2018-12-11. PMID:30213293. |
in order to investigate the effect of recombinant gdf11 on the proliferation and apoptosis of esophageal cancer cells, the expression of apoptosis-promoting protein bax and proliferative-associated protein bcl-2 in esophageal cancer cells were determined using western blot. |
2018-12-11 |
2023-08-13 |
Not clear |
| Xianping Zhu, Lin Wang, Xiao Teng, Qi Chen, Chenshuai Pa. N-Methyl Pyrrolidone (NMP) Alleviates Lipopolysaccharide (LPS)-Induced Inflammatory Injury in Articular Chondrocytes. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-11. PMID:30218608. |
cell viability was measured using cck-8 assay; cell apoptosis was detected using fcm; related protein and mrna expressions were determined using western blot assay and qrt-pcr assay; and inflammatory factors (tumor necrosis factor (tnf)-α, interleukin (il)-1β, il-6, and il-8) productions were measured by performing elisa assay. |
2018-12-11 |
2023-08-13 |
Not clear |
| Fengxia Yang, Li Guo, Yujing Cao, Shizhen Li, Jianhua Li, Min Li. MicroRNA-7-5p Promotes Cisplatin Resistance of Cervical Cancer Cells and Modulation of Cellular Energy Homeostasis by Regulating the Expression of the PARP-1 and BCL2 Genes. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-11. PMID:30219819. |
western blot and flow cytometry were used to investigate cell apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Yuexia Liao, Yang Xu, Mengyao Cao, Yuanyuan Huan, Lei Zhu, Ye Jiang, Weigan Shen, Guoqiang Zh. Luteolin Induces Apoptosis and Autophagy in Mouse Macrophage ANA-1 Cells via the Bcl-2 Pathway. Journal of immunology research. vol 2018. 2018-12-11. PMID:30246034. |
the viability of the cells was determined by an mtt assay, apoptosis was determined by flow cytometric analysis, the level of cell autophagy was observed by confocal microscopy, and the expression levels of apoptotic or autophagic and antiapoptotic or antiautophagic proteins were detected by western blot analysis. |
2018-12-11 |
2023-08-13 |
mouse |
| Weiguo Liao, Jie Liu, Bin Liu, Xiaojie Huang, Yongxin Yin, De Cai, Mingyi Li, Runzhi Zh. JIB‑04 induces cell apoptosis via activation of the p53/Bcl‑2/caspase pathway in MHCC97H and HepG2 cells. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272369. |
annexin v/pi staining, a cck‑8 assay and western blot analysis demonstrated that jib‑04 induced apoptosis in mhcc97h and hepg2 cells, which was evidenced by the expression of proapoptotic and apoptotic proteins including p53, bak, bax, caspase‑3 and caspase‑9. |
2018-12-11 |
2023-08-13 |
human |