| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiyuan Zhu, Pingde Zhang, Ning Li, Karrie Mei Yee Kiang, Stephen Yin Cheng, Vincent Kam-Wai Wong, Gilberto Ka-Kit Leun. Lovastatin Enhances Cytotoxicity of Temozolomide via Impairing Autophagic Flux in Glioblastoma Cells. BioMed research international. vol 2019. 2020-03-25. PMID:31662972. |
cytotoxicity was measured by mtt and colony formation assays; apoptosis was measured by flow cytometry; the cellular autophagic function was detected by the egfp-mrfp-lc3 reporter and western blot assay. |
2020-03-25 |
2023-08-13 |
Not clear |
| Jinghua Jiao, Yuheng Wang, Xiaofeng Sun, Xiaojing Jian. Midazolam induces A549 cell apoptosis International journal of clinical and experimental pathology. vol 11. issue 3. 2020-03-25. PMID:31938232. |
apoptosis of the nsclc cells in response to midazolam was determined by mtt assay, flow cytometry, and western blot. |
2020-03-25 |
2023-08-13 |
Not clear |
| Jie Cheng, Li Cheng, Yubin Tang, Huihua Li, Wenfang Peng, Shan Huan. Inhibition of lncRNA Dlx6os1 decreases cell proliferation and fibrosis and increases cell apoptosis in diabetic nephropathy. International journal of clinical and experimental pathology. vol 11. issue 7. 2020-03-25. PMID:31949705. |
nc-inhibitor plasmids and lncrna dlx6os1 inhibitor plasmids were transfected into sv40 mes13 cells cultured under hg conditions, and cell proliferation (at 0 h, 24 h, 48 h and 72 h), and the apoptosis rate (at 72 h), proteins and mrnas expressions for proliferation and fibrosis markers (at 72 h) were detected by cck-8, av-pi, western blot and qpcr assays, respectively. |
2020-03-25 |
2023-08-13 |
mouse |
| Hui Bi, Gui Wang, Zhiying Li, Lin Zhou, Ming Zhang, Jiru Ye, Zhigang Wan. Long Noncoding RNA (lncRNA) Maternally Expressed Gene 3 (MEG3) Participates in Chronic Obstructive Pulmonary Disease through Regulating Human Pulmonary Microvascular Endothelial Cell Apoptosis. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-03-24. PMID:32201430. |
cell apoptosis related proteins were tested using western blot assay. |
2020-03-24 |
2023-08-13 |
human |
| Elizabeth Hernandez Marin, Hana Paek, Mei Li, Yesung Ban, Marie Katie Karaga, Rangaiah Shashidharamurthy, Xinyu Wan. Caffeic acid phenethyl ester exerts apoptotic and oxidative stress on human multiple myeloma cells. Investigational new drugs. vol 37. issue 5. 2020-03-23. PMID:30465316. |
western blot analysis revealed the cape-induced activation of apoptosis executioner enzyme caspase-3, and corresponding cleavage of its downstream target poly(adp-ribose)polymerase (parp). |
2020-03-23 |
2023-08-13 |
human |
| Changwei Qiu, Tao Zhang, Xinying Zhu, Jinxia Qiu, Kangfeng Jiang, Gan Zhao, Haichong Wu, Ganzhen Den. Methylseleninic Acid Suppresses Breast Cancer Growth via the JAK2/STAT3 Pathway. Reproductive sciences (Thousand Oaks, Calif.). vol 26. issue 6. 2020-03-23. PMID:30526368. |
flow cytometry, western blot, and reverse transcription-polymerase chain reaction (rt-pcr) analyses indicated that msa inhibits cancer cell invasion and induces apoptosis by the activation of caspase-3, poly adp ribose polymerase 1 (parp1), and bcl2-associated x. |
2020-03-23 |
2023-08-13 |
mouse |
| Ruchi Singh Thakur, Bharti Ahirwa. A steroidal derivative from Trigonella foenum graecum L. that induces apoptosis in vitro and in vivo. Journal of food and drug analysis. vol 27. issue 1. 2020-03-23. PMID:30648576. |
the caspase glo assay and western blot analysis showed the significant caspase 3 cleavage, indicating caspase dependent apoptosis. |
2020-03-23 |
2023-08-13 |
zebrafish |
| Young Min Kwon, Jae-Young Je, Seung Heon Cha, Yunok Oh, Won Ho Ch. Synergistic combination of chemo‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment. Oncology reports. vol 42. issue 5. 2020-03-23. PMID:31436296. |
western blot analysis and reverse transcription‑quantitative polymerase chain reaction revealed that fe3o4‑tmz‑icg mnps with nir laser irradiation lead to significantly enhanced anticancer effects on u‑87 mg glioblastoma cells through the modulation of intrinsic and extrinsic apoptosis genes, including bcl‑2‑associated x protein, bcl‑2, cytochrome c, caspase‑3, fas associated via death domain and caspase‑8. |
2020-03-23 |
2023-08-13 |
human |
| Yun Zhang, Wei Huo, Yan Wen, Hai L. Silencing Nogo-B receptor inhibits penile corpus cavernosum vascular smooth muscle cell apoptosis of rats with diabetic erectile dysfunction by down-regulating ICAM-1. PloS one. vol 14. issue 8. 2020-03-23. PMID:31442237. |
reverse transcription quantitative polymerase chain reaction assay and western blot analysis were carried out for the assessment of ngbr, factors correlated to icam-1, including steroid receptor coactivator (src) and proline-rich tyrosine kinase2 (pyk2), and factors associated with apoptosis, including b-cell lymphoma-2 (bcl-2), bcl-2 associated protein x (bax), caspase 3 and cleaved-caspase 3. |
2020-03-23 |
2023-08-13 |
rat |
| Zhenyuan Qian, Lijie Gong, Yiping Mou, Yong Han, Shusen Zhen. MicroRNA‑203a‑3p is a candidate tumor suppressor that targets thrombospondin 2 in colorectal carcinoma. Oncology reports. vol 42. issue 5. 2020-03-23. PMID:31545460. |
total rna extraction and reverse transcription‑quantitative polymerase chain reaction analysis, transfection assay, and transwell and apoptosis assays, western blot analysis, a luciferase reporter assay and immunohistochemistry were performed. |
2020-03-23 |
2023-08-13 |
human |
| Xiaoqing Xi, Cong Zou, Zhenfeng Ye, Yawei Huang, Tongchang Chen, Honglin H. Pioglitazone protects tubular cells against hypoxia/reoxygenation injury through enhancing autophagy via AMPK-mTOR signaling pathway. European journal of pharmacology. vol 863. 2020-03-23. PMID:31560869. |
autophagy-related proteins were primarily assessed by western blot and tunel was performed to assess cell apoptosis. |
2020-03-23 |
2023-08-13 |
rat |
| Fengjie Wang, Xianbing Chen, Depei Yuan, Yongfen Yi, Yi Lu. Golgi reassembly and stacking protein 65 downregulation is required for the anti-cancer effect of dihydromyricetin on human ovarian cancer cells. PloS one. vol 14. issue 11. 2020-03-23. PMID:31770410. |
additionally, the knockdown of grasp65 by sirna resulted in increased apoptosis after dhm treatment, while western blot and flow cytometry analysis demonstrated that overexpression of grasp65 attenuated dhm-mediated apoptosis. |
2020-03-23 |
2023-08-13 |
human |
| Haifeng Yuan, Jinghua Zhang, Fuli Li, Wei Li, Haichao Wan. Sinomenine exerts antitumour effect in gastric cancer cells via enhancement of miR-204 expression. Basic & clinical pharmacology & toxicology. vol 125. issue 5. 2020-03-20. PMID:31243880. |
mkn45 and sgc-7901 cells were administered with sin for 24 hours, cell viability, proliferation, apoptosis, migration, invasion and the associated proteins in the above processes were examined via exploiting cck-8, brdu, flow cytometry, transwell and western blot. |
2020-03-20 |
2023-08-13 |
Not clear |
| Shengqiong Deng, Xianjin Zhou, Zhiru Ge, Yuting Song, Hairong Wang, Xinghui Liu, Denghai Zhan. Exosomes from adipose-derived mesenchymal stem cells ameliorate cardiac damage after myocardial infarction by activating S1P/SK1/S1PR1 signaling and promoting macrophage M2 polarization. The international journal of biochemistry & cell biology. vol 114. 2020-03-19. PMID:31276786. |
to examine the underlying mechanism, h9c2 cells, cardiac fibroblasts, and hapi cells were used to study the effect of adsc-exosomes on hypoxia-induced h9c2 apoptosis, tgf-β1-induced fibrosis of cardiac fibroblasts, and hypoxia-induced macrophage m1 polarization using qrt-pcr, western blot, elisa, immunohistochemistry, immunofluorescence and flow cytometry. |
2020-03-19 |
2023-08-13 |
Not clear |
| Qi Chen, Yu Liu, Xueyan Ding, Qinfeng Li, Fuyu Qiu, Meihui Wang, Zhida Shen, Hao Zheng, Guosheng F. Bone marrow mesenchymal stem cell-secreted exosomes carrying microRNA-125b protect against myocardial ischemia reperfusion injury via targeting SIRT7. Molecular and cellular biochemistry. vol 465. issue 1-2. 2020-03-19. PMID:31858380. |
the expression of cell apoptosis proteins and the levels of inflammatory factors were examined by western blot and elisa assay, respectively. |
2020-03-19 |
2023-08-13 |
rat |
| Esmail Nourmohammadi, Hoda Khoshdel-Sarkarizi, Reza Nedaeinia, Hamid Reza Sadeghnia, Leila Hasanzadeh, Majid Darroudi, Reza Kazemi Oskue. Evaluation of anticancer effects of cerium oxide nanoparticles on mouse fibrosarcoma cell line. Journal of cellular physiology. vol 234. issue 4. 2020-03-18. PMID:30187476. |
for apoptosis assay, the annexin v/pi test was done as well as measuring the mrna and protein expression levels of bax and bcl2 by real-time pcr and western blot method, respectively. |
2020-03-18 |
2023-08-13 |
mouse |
| Souvik Roy, Anweshan Sil, Tania Chakrabort. Potentiating apoptosis and modulation of p53, Bcl2, and Bax by a novel chrysin ruthenium complex for effective chemotherapeutic efficacy against breast cancer. Journal of cellular physiology. vol 234. issue 4. 2020-03-18. PMID:30246261. |
in vitro studies included cell viability, cell cycle analysis, dna fragmentation, and marker analysis by western blot analysis and found that complex treatment suppressed cell growth-induced cell cycle arrest and enhanced the induction of apoptosis in cancer cells. |
2020-03-18 |
2023-08-13 |
human |
| Lian Liu, Kwang Seok Ahn, Muthu K Shanmugam, Hong Wang, Hongyuan Shen, Frank Arfuso, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Yung Chang, Gautam Sethi, Feng Ru Tan. Oleuropein induces apoptosis via abrogating NF-κB activation cascade in estrogen receptor-negative breast cancer cells. Journal of cellular biochemistry. vol 120. issue 3. 2020-03-18. PMID:30260018. |
the effect of oleuropein on the viability of breast cancer cell lines was examined by mitochondrial dye-uptake assay, apoptosis by flow cytometric analysis, nuclear factor-κb (nf-κb) activation by dna binding/reporter assays and protein expression by western blot analysis. |
2020-03-18 |
2023-08-13 |
Not clear |
| M D Khurshidul Zahid, Michael Rogowski, Christopher Ponce, Mahua Choudhury, Naima Moustaid-Moussa, Shaikh M Rahma. CCAAT/enhancer-binding protein beta (C/EBPβ) knockdown reduces inflammation, ER stress, and apoptosis, and promotes autophagy in oxLDL-treated RAW264.7 macrophage cells. Molecular and cellular biochemistry. vol 463. issue 1-2. 2020-03-18. PMID:31686316. |
key proteins and genes involved in inflammation, er stress, apoptosis, and autophagy were analyzed by western blot and qpcr. |
2020-03-18 |
2023-08-13 |
Not clear |
| Yujie Liu, Guoying Che, Zhixin Di, Weinan Sun, Jiawei Tian, Min Re. Calycosin-7-O-β-D-glucoside attenuates myocardial ischemia-reperfusion injury by activating JAK2/STAT3 signaling pathway via the regulation of IL-10 secretion in mice. Molecular and cellular biochemistry. vol 463. issue 1-2. 2020-03-18. PMID:31712941. |
the hemodynamic measurement, ttc staining, tunel staining, and western blot results in vivo showed that the protective effects of cg on myocardial function and cell apoptosis were all reversed by the il-10r α neutralizing antibody. |
2020-03-18 |
2023-08-13 |
mouse |