| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiqing Liu, Li Xu, Bingru Lu, Miaoqing Zhao, Li Li, Wenping Sun, Zhanjun Qiu, Bingchang Zhan. LncRNA H19/microRNA-675/PPARα axis regulates liver cell injury and energy metabolism remodelling induced by hepatitis B X protein via Akt/mTOR signalling. Molecular immunology. vol 116. 2020-01-22. PMID:31574452. |
mrna and mir-675 levels were determined by quantitative real-time pcr (qrt-pcr), protein levels were determined by western blot, cell viability was measured by the mtt assay, cell apoptosis was measured by flow cytometry, inflammatory cytokine production was determined by elisa, oxidative stress and energy metabolism were assessed by commercial kits, and the target relationship between pparα and mir-675 was confirmed by the dual-luciferase reporter assay. |
2020-01-22 |
2023-08-13 |
Not clear |
| Mateusz Psurski, Agnieszka Łupicka-Słowik, Agnieszka Adamczyk-Woźniak, Joanna Wietrzyk, Andrzej Sporzyńsk. Discovering simple phenylboronic acid and benzoxaborole derivatives for experimental oncology - phase cycle-specific inducers of apoptosis in A2780 ovarian cancer cells. Investigational new drugs. vol 37. issue 1. 2020-01-21. PMID:29779163. |
further studies of the mechanism of action consisted of the influence of the compounds on cell cycle progression and apoptosis induction, which was assessed by flow cytometry, caspase-3 enzymatic activity, fluorescence microscopy and western blot analysis. |
2020-01-21 |
2023-08-13 |
Not clear |
| Dan Zhou, Wei Zhai, Miaomiao Zhan. Mesenchymal stem cell-derived extracellular vesicles promote apoptosis in RSC96 Schwann cells through the activation of the ERK pathway. International journal of clinical and experimental pathology. vol 11. issue 11. 2020-01-21. PMID:31949596. |
the effects of msc-evs on rsc96 cell proliferation, migration, apoptosis, and the protein levels were analyzed using the mtt and colony-forming assays, the transwell and wound healing assays, flow cytometry, and western blot, respectively. |
2020-01-21 |
2023-08-13 |
rat |
| Peng Kang, Guihua Jiang, Qingyang Meng, Wenjuan Liu, Xia W. Long non-coding RNA taurine-upregulated gene 1 promotes cells proliferation, migration and invasion while represses apoptosis, and upregulates AURKA expression in hepatocellular carcinoma. International journal of clinical and experimental pathology. vol 11. issue 7. 2020-01-21. PMID:31949695. |
after the transfection of blank mimic, lncrna tug1 mimic, blank inhibitor and lncrna tug1 inhibitor plasmids into smmc7721 cells, ckk8, wound-healing, matrigel assay, av/pi, qpcr assay and western blot assays were performed to detect cells proliferation, migration, invasion, apoptosis, rna expression and protein expression respectively. |
2020-01-21 |
2023-08-13 |
Not clear |
| Céléna Dubuc, Martin Savard, Veronica Bovenzi, Andrée Lessard, Jérôme Côté, Witold Neugebauer, Sameh Geha, Sylvain Chemtob, Fernand Gobei. Antitumor activity of cell-penetrant kinin B1 receptor antagonists in human triple-negative breast cancer cells. Journal of cellular physiology. vol 234. issue 3. 2020-01-20. PMID:30132865. |
furthermore, the putative mechanisms underlying the anticancer activities of cell-penetrant b1r antagonists were assessed by analyzing cell cycle regulation and signaling molecules related to cell survival and apoptosis (facs and western blot). |
2020-01-20 |
2023-08-13 |
human |
| Xinhong Su, Yuqin Ye, Yongxiang Yang, Kailiang Zhang, Wei Bai, Huijun Chen, Enming Kang, Chuiguang Kong, Xiaosheng H. The Effect of SPTLC2 on Promoting Neuronal Apoptosis is Alleviated by MiR-124-3p Through TLR4 Signalling Pathway. Neurochemical research. vol 44. issue 9. 2020-01-20. PMID:31372925. |
after transfection, neuronal apoptosis was evaluated in an in vitro injury model of primary neurons using tunel staining and western blot. |
2020-01-20 |
2023-08-13 |
Not clear |
| Yangyong Ou, Weisheng Lia. Silencing profilin-1 confers protection from oxLDL injury in human vascular endothelial cells. International journal of clinical and experimental pathology. vol 11. issue 6. 2020-01-19. PMID:31938431. |
expression of protein and mrna for profilin-1 and genes (caspase-3, bax, bcl-2, nf-κb and survivin) associated with apoptosis were determined using real-time pcr and western blot analysis, respectively. |
2020-01-19 |
2023-08-13 |
human |
| Ding Long, Junhui Yang, Xiaoling Wu, Yun Gui, Li Y. Urokinase-type plasminogen activator protects human umbilical vein endothelial cells from apoptosis in sepsis. International journal of clinical and experimental pathology. vol 12. issue 1. 2020-01-17. PMID:31933722. |
lipopolysaccharides (lps) were added to construct septic huvecs, then the septic huvecs were treated by upa, and cell viability, apoptosis, tnf-α, il-6, gmcsf and upar levels were evaluated by cck-8, av/pi, qpcr, western blot and elisa, respectively. |
2020-01-17 |
2023-08-13 |
human |
| Jian Ma, Na Zhao, Likun Du, Yang Wan. Downregulation of lncRNA NEAT1 inhibits mouse mesangial cell proliferation, fibrosis, and inflammation but promotes apoptosis in diabetic nephropathy. International journal of clinical and experimental pathology. vol 12. issue 4. 2020-01-17. PMID:31933932. |
cell proliferation, apoptosis, fibrosis, and inflammation were detected using counting kit-8, annexin v/propidium iodide, western blot and quantitative polymerase chain reaction assays. |
2020-01-17 |
2023-08-13 |
mouse |
| Junxia Liu, Wei Yue, Haiyan Che. The correlation between autophagy and tamoxifen resistance in breast cancer. International journal of clinical and experimental pathology. vol 12. issue 6. 2020-01-17. PMID:31934028. |
western blot, real-time pcr, and immunofluorescence analyses were conducted to detect autophagy and apoptosis related proteins and to evaluate pathways that stimulated autophagy in the two targeted cell lines. |
2020-01-17 |
2023-08-13 |
Not clear |
| Shengguang Ding, Yifan Zheng, Yiming Xu, Xiaojing Zhao, Chongjun Zhon. MiR-21/PTEN signaling modulates the chemo-sensitivity to 5-fluorouracil in human lung adenocarcinoma A549 cells. International journal of clinical and experimental pathology. vol 12. issue 6. 2020-01-17. PMID:31934061. |
using fl ow cytometry and western blot analysis, we measured the a549 cell apoptosis and necrosis and the potential mechanism. |
2020-01-17 |
2023-08-13 |
human |
| Dongyu Xie, Ping Zhou, Lin Liu, Wenjing Jiang, Haina Xie, Liang Zhang, Donghao Xi. Protective Effect of Astragaloside IV on Hepatic Injury Induced by Iron Overload. BioMed research international. vol 2019. 2020-01-15. PMID:31428632. |
the expression levels of apoptosis and autophagy-related proteins were determined by real-time pcr and western blot. |
2020-01-15 |
2023-08-13 |
human |
| Chun-Liang Tung, Da-Tong Ju, Bharath Kumar Velmurugan, Bo Ban, Tran D Dung, Dennis J-Y Hsieh, Vijaya P Viswanadha, Cecilia H Day, Yueh-Min Lin, Chih-Yang Huan. Carthamus tinctorius L. extract activates insulin-like growth factor-I receptor signaling to inhibit FAS-death receptor pathway and suppress lipopolysaccharides-induced H9c2 cardiomyoblast cell apoptosis. Environmental toxicology. vol 34. issue 12. 2020-01-14. PMID:31486215. |
lps treatment-induced apoptosis was determined by transferase-mediated dutp nick end labeling assay, and by western blot. |
2020-01-14 |
2023-08-13 |
Not clear |
| Yu Wang, Hongjing Zhao, Xin Yang, Mengyao Mu, Hui Zong, Liyang Luo, Mingwei Xin. Excessive Cu Chemosphere. vol 239. 2020-01-14. PMID:31514009. |
consequently, nuclear damage and organelle lesions, especially mitochondria were observed under cu or/and as stress, in which positive regulation of key proteins, dynamin-related protein 1 (drp1), cytochrome c (cyt c), bcl2-associated x (bax), caspases 3 and p53 was detected by qrcr and western blot analyses, indicating disturbed mitochondrial dynamic equilibrium and apoptosis execution. |
2020-01-14 |
2023-08-13 |
Not clear |
| Chueh-Chuan Yen, Li-Tzong Chen, Chien-Feng Li, San-Chi Chen, Wei-Yang Chua, Yung-Chan Lin, Chiao-Han Yen, Yen-Chun Chen, Muh-Hwa Yang, Yee Chao, Jonathan A Fletche. Identification of phenothiazine as an ETV1‑targeting agent in gastrointestinal stromal tumors using the Connectivity Map. International journal of oncology. vol 55. issue 2. 2020-01-13. PMID:31268158. |
western blot analysis indicated that elk1 and early growth response 1 (egr1) were activated/upregulated following phenothiazine treatment, and the mek inhibitor/phenothiazine combination downregulated the erk/elk1/egr1 pathway, resulting in diminished autophagy, as well as enhanced apoptosis. |
2020-01-13 |
2023-08-13 |
Not clear |
| Dan-Ning Shi, Li-Xia Cui, Pi-Wen Zhao, Li-Ping Sun, Meng Chen, Jian-Zhao Ni. [Molecular mechanism of apoptosis of breast cancer SKBR-3 cells induced by cryptanshinone via G protein coupled estrogen receptor( GPER) mediated pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 22. 2020-01-10. PMID:31872599. |
the study aimed to illuminate the role of g protein coupled estrogen receptor( gper) and its mediated pi3 k/akt signaling pathway in cryptotanshinone( cpt) induced apoptosis of breast cancer skbr-3 cells,which is gper positive and er negative.the apoptosis rate of skbr-3 cells was tested by annexin v-fitc/pi staining and apoptosis effector caspase-3 was determined by western blot. |
2020-01-10 |
2023-08-13 |
Not clear |
| Yih-Gang Goan, Wen-Tung Wu, Chih-I Liu, Choo-Aun Neoh, Yu-Jen W. Involvement of Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and the PI3K/AKT/mTOR Pathway in Nobiletin-Induced Apoptosis of Human Bladder Cancer Cells. Molecules (Basel, Switzerland). vol 24. issue 16. 2020-01-09. PMID:31398899. |
using an mtt assay, agarose gel electrophoresis, a wound-healing assay, flow cytometry, and western blot analysis, this study investigated the signaling pathways involved in nob-induced apoptosis in bftc human bladder cancer cells. |
2020-01-09 |
2023-08-13 |
human |
| Jun Cheng, Xiaofeng Wang, Lei Qiu, Yunkai Li, Najat Marraiki, Abdallah M Elgorban, Li Xu. Green synthesized zinc oxide nanoparticles regulates the apoptotic expression in bone cancer cells MG-63 cells. Journal of photochemistry and photobiology. B, Biology. vol 202. 2020-01-09. PMID:31770706. |
decreased mmp has resulted in increased levels of apoptotic proteins bax, caspase-3 and caspase-9 and induction of apoptosis was substantiated by western blot analysis. |
2020-01-09 |
2023-08-13 |
Not clear |
| Xing Tu, Mengxia Wang, Yilin Liu, Wenyan Zhao, Xuxin Ren, Yuanjun Li, Hongqing Liu, Ziting Gu, Hui Jia, Jing Liu, Guoying Li, Li Lu. Pretreatment of Grape Seed Proanthocyanidin Extract Exerts Neuroprotective Effect in Murine Model of Neonatal Hypoxic-ischemic Brain Injury by Its Antiapoptotic Property. Cellular and molecular neurobiology. vol 39. issue 7. 2020-01-08. PMID:31147852. |
tunel staining was used to detect cells apoptosis, and the expressions of apoptosis-related proteins: bax, bcl2, and cleaved caspase-3 were assayed by western blot. |
2020-01-08 |
2023-08-13 |
mouse |
| Shilun Yang, Haigang Wang, Yinglin Yang, Rui Wang, Yuehua Wang, Chunfu Wu, Guanhua D. Baicalein administered in the subacute phase ameliorates ischemia-reperfusion-induced brain injury by reducing neuroinflammation and neuronal damage. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 117. 2020-01-08. PMID:31228802. |
western blot analysis of apoptosis- and autophagy-related proteins showed that baicalein increased the bcl-2/bax ratio and reduced caspase-3 expression to decrease neuronal apoptosis and ameliorate neuronal loss. |
2020-01-08 |
2023-08-13 |
human |