| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Athanasios Bikas, Kirk Jensen, Aneeta Patel, John Costello, Gregory Kaltsas, Victoria Hoperia, Leonard Wartofsky, Kenneth Burman, Vasyl Vask. Mitotane induces mitochondrial membrane depolarization and apoptosis in thyroid cancer cells. International journal of oncology. vol 55. issue 1. 2019-12-20. PMID:31115496. |
mitochondrial membrane potential, cell viability and apoptosis were examined by jc‑1 staining and by western blot analysis using an antibody against caspase‑3. |
2019-12-20 |
2023-08-13 |
human |
| Liqiang Ji, Yifang Chen, Hongqiang Wang, Wei Zhang, Lanxiang He, Jingmin Wu, Yinghui Li. Overexpression of Sirt6 promotes M2 macrophage transformation, alleviating renal injury in diabetic nephropathy. International journal of oncology. vol 55. issue 1. 2019-12-20. PMID:31115579. |
a series of cell experiments in isolated culture or the co‑culture of macrophages and podocytes were conducted to examine the effects of the overexpression of sirt6 on macrophage transformation, podocyte apoptosis and associated genes, and analyses were performed using rt‑qpcr, flow cytometry and western blot analysis, where appropriate. |
2019-12-20 |
2023-08-13 |
rat |
| Hui Luo, Ling Wang, Ding Bao, Li Wang, Hongjun Zhao, Yun Lian, Mei Yan, Chandra Mohan, Quan-Zhen L. Novel Autoantibodies Related to Cell Death and DNA Repair Pathways in Systemic Lupus Erythematosus. Genomics, proteomics & bioinformatics. vol 17. issue 3. 2019-12-20. PMID:31494269. |
a group of autoabs associated with cell apoptosis and dna repair function, including those targeting apex1, aurka, polb, ago1, hmgb1, ifit5, mapkapk3, padi4, rgs3, srp19, ube2s, and vrk1, were further validated by elisa and western blot in a larger cohort. |
2019-12-20 |
2023-08-13 |
Not clear |
| Xian-Tao Wang, Xiao-Dan Wu, Yuan-Xi Lu, Yu-Han Sun, Han-Hua Zhu, Jia-Bao Liang, Wen-Kai He, Lang L. Egr-1 is involved in coronary microembolization-induced myocardial injury via Bim/Beclin-1 pathway-mediated autophagy inhibition and apoptosis activation. Aging. vol 10. issue 11. 2019-12-19. PMID:30391937. |
inhibition of egr-1 expression in vivo restored the autophagy flux and reduced myocardial apoptosis, at least partially, by inhibiting the egr-1/bim/beclin-1 pathway, as evidenced by the results of the western blot, rt-qpcr, and tunel staining. |
2019-12-19 |
2023-08-13 |
Not clear |
| Ganiou Assani, Akadiri Yessoufou, Yudi Xiong, Julien Segbo, Xiaoyuan Yu, Fuxiang Zhou, Yunfeng Zho. Role of TMPRSS4 Modulation in Breast Cancer Cell Proliferation. Asian Pacific journal of cancer prevention : APJCP. vol 20. issue 6. 2019-12-18. PMID:31244309. |
moreover, western blot was used to detect the expression of certain proteinsrelated to cell apoptosis (bax and bcl2) signaling pathway and telomere maintenance (pot1, tpp1, and ube2d3).cell cycle and cell apoptosis were also analyzed by using the flow cytometry analysis. |
2019-12-18 |
2023-08-13 |
Not clear |
| Chunming Yang, Yan Li, Liye Fu, Tao Jiang, Fandong Men. Betulinic acid induces apoptosis and inhibits metastasis of human renal carcinoma cells in vitro and in vivo. Journal of cellular biochemistry. vol 119. issue 10. 2019-12-17. PMID:29923216. |
western blot analysis showed that the occurrence of apoptosis was associated with upregulation of bcl2-associated x protein and cleaved caspase-3 and downregulation of b-cell lymphoma 2 in renal cancer cells. |
2019-12-17 |
2023-08-13 |
mouse |
| Jiantuan Xiong, Ning Ding, Tingting Gao, Yanhua Wang, Wei Guo, Hui Zhang, Xiaoli Ma, Fan Li, Jianmin Sun, Xiaoling Yang, Kai Wu, Huiping Zhang, Yideng Jian. Hypermethylation of endoplasmic reticulum disulfide oxidase 1α leads to trophoblast cell apoptosis through endoplasmic reticulum stress in preeclampsia. Journal of cellular biochemistry. vol 119. issue 10. 2019-12-17. PMID:30058081. |
quantitative polymerase chain reaction and western blot analysis showed that the expression of endoplasmic reticulum disulfide oxidase 1α (ero1α) is suppressed in trophoblast cells under hypoxia due to the hypermethylation of the ero1α promoter region, and the inhibition of ero1α expression plays an important role in er stress and trophoblast cell apoptosis. |
2019-12-17 |
2023-08-13 |
rat |
| Dong Li, Jingyan Yang, Huanzhi Ma, Chengliang Sun, Rongjie Fen. Inositol polyphosphate-4-phosphatase type II and rucaparib treatment inhibit the growth of osteosarcoma cells dependent on phosphoinositide 3-kinase/protein kinase B pathway. Journal of cellular biochemistry. vol 119. issue 12. 2019-12-17. PMID:30132953. |
western blot assay uncovered the combined effects of inpp4b and rucaparib on cell cycle, apoptosis and phosphoinositide 3-kinase/protein kinase b (pi3k/akt) signal pathway. |
2019-12-17 |
2023-08-13 |
Not clear |
| Haifang Zhang, Hui Li, Zhenguo Liu, Ang Ge, Enyu Guo, Shuxia Liu, Zhiping Che. Triptolide inhibits the proliferation and migration of medulloblastoma Daoy cells by upregulation of microRNA-138. Journal of cellular biochemistry. vol 119. issue 12. 2019-12-17. PMID:30156009. |
western blot analysis was used to analyze the expression of key factors involved in cell apoptosis, cell migration, the phosphatidylinositol 3-kinase (pi3k)/protein kinase 3 (akt) pathway, and the notch pathway in daoy cells. |
2019-12-17 |
2023-08-13 |
Not clear |
| Yanji Zhu, Qian Li, Wenlong Xun, Yuan Chen, Caihui Zhang, Shuzhen Su. Blocking P2X7 receptor ameliorates oxidized LDL-mediated podocyte apoptosis. Molecular biology reports. vol 46. issue 4. 2019-12-16. PMID:31004300. |
p2x7r, bax, and caspase-3 protein expression were detected by western blot and immunofluorescence analysis.the expression of p2x7r, ros, bax, and caspase-3 in human podocytes incubated with oxldl was significantly up-regulated and was found to have higher intracellular lipid accumulation and podocyte apoptosis compared with the nc group. |
2019-12-16 |
2023-08-13 |
human |
| Yitong Shen, Rui Bian, Yaxiong Li, Yuan Gao, Yingbin Liu, Yuzhen Xu, Xiaoling Song, Yijian Zhan. Liensinine induces gallbladder cancer apoptosis and G2/M arrest by inhibiting ZFX-induced PI3K/AKT pathway. Acta biochimica et biophysica Sinica. vol 51. issue 6. 2019-12-16. PMID:31074773. |
western blot analysis was used to determine the expression of proteins corresponding to the related cell cycle and apoptosis. |
2019-12-16 |
2023-08-13 |
human |
| Jianqiang Zhang, Jing Wang, Xinan Wu, Yuhui We. Ginsenoside Rb1 inhibits proliferation and promotes apoptosis by regulating HMGB1 in uterine fibroid cells. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-12-16. PMID:31313594. |
to study the effects of ginsenoside rb1 and the molecular mechanisms on proliferation and apoptosis of uterine fibroid cells, rb1 + pc dna3.1, rb1 + pc dna3.1-hmgb1, si-nc or si-hmgb1 was transfected into uterine fibroid cells by liposome method; the inhibitory rate and proliferation of human uterine fibroid cells were detected by mtt assay; apoptosis of uterine fibroid cells was detected by flow cytometry assay; hmgb1 protein expression in uterine fibroid cells was detected by western blot assay. |
2019-12-16 |
2023-08-13 |
human |
| Lina Lv, Jing Zhang, Fengqun Tian, Xia Li, Dandan Li, Xiulian Y. Arbutin protects HK-2 cells against high glucose-induced apoptosis and autophagy by up-regulating microRNA-27a. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-12-16. PMID:31319730. |
flow cytometry and western blot tested cell apoptosis and the related protein levels in hk-2 cells after 45 mm glucose and 50 μm arb administration. |
2019-12-16 |
2023-08-13 |
Not clear |
| Wei Dai, Liyuan Mu, Yali Cui, Yingying Li, Ping Chen, Hongjian Xie, Xia Wan. Long non‑coding RNA CASC2 enhances berberine‑induced cytotoxicity in colorectal cancer cells by silencing BCL2. Molecular medicine reports. vol 20. issue 2. 2019-12-13. PMID:31173223. |
in addition, rna immunoprecipitation, chromatin immunoprecipitation and western blot analysis were used to identify the functional regulation of casc2/ezh2/bcl2 axis in berberine‑induced crc cell apoptosis. |
2019-12-13 |
2023-08-13 |
human |
| Shaolong Ma, Chao Zhang, Ziyan Zhang, Yuxuan Dai, Rui Gu, Rui Jian. Geniposide protects PC12 cells from lipopolysaccharide-evoked inflammatory injury via up-regulation of miR-145-5p. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-12-10. PMID:31307231. |
the effects of geniposide were analyzed by utilizing cck-8 assay, apoptosis assay, elisa, rt-qpcr and western blot. |
2019-12-10 |
2023-08-13 |
Not clear |
| Lihua Wang, Zheng Zhu, Lei Han, Liqian Zhao, Jialei Weng, Hongbao Yang, Shijia Wu, Kaiyuan Chen, Liang Wu, Tongke Che. A curcumin derivative, WZ35, suppresses hepatocellular cancer cell growth via downregulating YAP-mediated autophagy. Food & function. vol 10. issue 6. 2019-12-06. PMID:31172987. |
cck-8 was used to detect cell viability with or without curcumin or wz35; cell apoptosis was determined by flow cytometry analysis; gfp-lc3 plasmids were used to investigate the level of autophagy-associated lc3; sirna transfection was applied to silence endogenous yap; and western blot was performed to detect the alteration of indicated molecules. |
2019-12-06 |
2023-08-13 |
Not clear |
| Huiliang Song, Yi Fu, Dan Wan, Wenjing Xia, Fengwei Lyu, Lijun Liu, Li She. Mytoxin B and Myrothecine A Induce Apoptosis in Human Hepatocarcinoma Cell Line SMMC-7721 via PI3K/Akt Signaling Pathway. Molecules (Basel, Switzerland). vol 24. issue 12. 2019-12-06. PMID:31226773. |
moreover, the expression levels of caspases-3, -8, and -9, and cleaved caspases-3, -8, and -9 were all upregulated in both mytoxin b and myrothecine a-treated cells in western blot analysis, which indicated that both compounds might induce smmc-7721 cells apoptosis through not only the death receptor pathway but also the mitochondrial pathway. |
2019-12-06 |
2023-08-13 |
human |
| Mingcheng Liu, Qiwang Liu, Yandong Pei, Miaomiao Gong, Xiaolin Cui, Jinjin Pan, Yunlong Zhang, Yang Liu, Ying Liu, Xiaocheng Yuan, Haoran Zhou, Yiying Chen, Jian Sun, Lin Wang, Xiya Zhang, Rui Wang, Shao Li, Jizhong Cheng, Yanchun Ding, Tonghui Ma, Yuhui Yua. Aqp-1 Gene Knockout Attenuates Hypoxic Pulmonary Hypertension of Mice. Arteriosclerosis, thrombosis, and vascular biology. vol 39. issue 1. 2019-12-03. PMID:30580569. |
immunohistochemistry, immunofluorescence and western blot, cell cycle, apoptosis, and migration analysis were performed in this study. |
2019-12-03 |
2023-08-13 |
mouse |
| Mehtab Khan, Bart P F Rutten, Myeong Ok Ki. MST1 Regulates Neuronal Cell Death via JNK/Casp3 Signaling Pathway in HFD Mouse Brain and HT22 Cells. International journal of molecular sciences. vol 20. issue 10. 2019-12-03. PMID:31117242. |
our western blot and immunofluorescence results indicate that hfd and stress-induced hippocampal ht22 cells activate mst1/jnk/caspase-3 (casp-3) signaling, which regulates neuronal cell apoptosis and beta-amyloid-cleaving enzyme (bace1) expression and leads to impaired cognition. |
2019-12-03 |
2023-08-13 |
mouse |
| Alexandra Teixeira, Déborah C DaCunha, Lillian Barros, Hugo R Caires, Cristina P R Xavier, Isabel C F R Ferreira, M Helena Vasconcelo. Eucalyptus globulus Labill. decoction extract inhibits the growth of NCI-H460 cells by increasing the p53 levels and altering the cell cycle profile. Food & function. vol 10. issue 6. 2019-12-03. PMID:31165800. |
for this, cell viability (by trypan blue exclusion assay), the cell cycle profile and apoptosis (by flow cytometry), cell proliferation (by bromodeoxyuridine assay) and protein expression (by western blot) were analyzed. |
2019-12-03 |
2023-08-13 |
human |