| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingcheng Liu, Qiwang Liu, Yandong Pei, Miaomiao Gong, Xiaolin Cui, Jinjin Pan, Yunlong Zhang, Yang Liu, Ying Liu, Xiaocheng Yuan, Haoran Zhou, Yiying Chen, Jian Sun, Lin Wang, Xiya Zhang, Rui Wang, Shao Li, Jizhong Cheng, Yanchun Ding, Tonghui Ma, Yuhui Yua. Aqp-1 Gene Knockout Attenuates Hypoxic Pulmonary Hypertension of Mice. Arteriosclerosis, thrombosis, and vascular biology. vol 39. issue 1. 2019-12-03. PMID:30580569. |
immunohistochemistry, immunofluorescence and western blot, cell cycle, apoptosis, and migration analysis were performed in this study. |
2019-12-03 |
2023-08-13 |
mouse |
| Mehtab Khan, Bart P F Rutten, Myeong Ok Ki. MST1 Regulates Neuronal Cell Death via JNK/Casp3 Signaling Pathway in HFD Mouse Brain and HT22 Cells. International journal of molecular sciences. vol 20. issue 10. 2019-12-03. PMID:31117242. |
our western blot and immunofluorescence results indicate that hfd and stress-induced hippocampal ht22 cells activate mst1/jnk/caspase-3 (casp-3) signaling, which regulates neuronal cell apoptosis and beta-amyloid-cleaving enzyme (bace1) expression and leads to impaired cognition. |
2019-12-03 |
2023-08-13 |
mouse |
| Alexandra Teixeira, Déborah C DaCunha, Lillian Barros, Hugo R Caires, Cristina P R Xavier, Isabel C F R Ferreira, M Helena Vasconcelo. Eucalyptus globulus Labill. decoction extract inhibits the growth of NCI-H460 cells by increasing the p53 levels and altering the cell cycle profile. Food & function. vol 10. issue 6. 2019-12-03. PMID:31165800. |
for this, cell viability (by trypan blue exclusion assay), the cell cycle profile and apoptosis (by flow cytometry), cell proliferation (by bromodeoxyuridine assay) and protein expression (by western blot) were analyzed. |
2019-12-03 |
2023-08-13 |
human |
| Dong Chen, Dong Cao, Ping Su. Tetramethylpyrazine relieves LPS-induced pancreatic β-cell Min6 injury via regulation of miR-101/MKP-1. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-12-02. PMID:31213095. |
viability of min6 cells was detected through cck-8 assay, apoptosis process through flow cytometry, and the proteins involved in apoptosis through western blot. |
2019-12-02 |
2023-08-13 |
Not clear |
| Ruijie Qin, Lina Zhang, Dong Lin, Fei Xiao, Lixin Gu. Sirt1 inhibits HG-induced endothelial injury: Role of Mff-based mitochondrial fission and F‑actin homeostasis-mediated cellular migration. International journal of molecular medicine. vol 44. issue 1. 2019-11-27. PMID:31115479. |
furthermore, a lower expression of sirt1 was correlated with glucose metabolic abnormalities, aortic endothelial dysfunction and endothelial apoptosis as evidenced by western blot analysis and elisa in mice. |
2019-11-27 |
2023-08-13 |
mouse |
| Zhi Li, Tong-Qing Xue, Chao Yang, Yun-Liang Wang, Xiao-Li Zhu, Cai-Fang N. EGFL7 promotes hepatocellular carcinoma cell proliferation and inhibits cell apoptosis through increasing CKS2 expression by activating Wnt/β-catenin signaling. Journal of cellular biochemistry. vol 119. issue 12. 2019-11-25. PMID:30129142. |
after hcc cells respectively transfected with plko.1-egfl7-shrna, plvx-puro-egfl7 recombined vector or cks2 small interfering rna, cell counting kit-8 and flow cytometry was performed to examine the cell proliferation and apoptosis, respectively, and the expression of β-catenin, cks2, cdk2, and cleaved caspase-3 was measured by western blot analysis. |
2019-11-25 |
2023-08-13 |
mouse |
| Lin Pan, Deheng Liu, Lei Zhao, Liqin Wang, Miaomiao Xin, Xingfu L. Long noncoding RNA MALAT1 alleviates lipopolysaccharide-induced inflammatory injury by upregulating microRNA-19b in murine chondrogenic ATDC5 cells. Journal of cellular biochemistry. vol 119. issue 12. 2019-11-25. PMID:30145831. |
expressions of key factors involved in cell apoptosis, proinflammatory response, wnt/β-catenin, and nuclear factor κb (nf-κb) pathways were analyzed using western blot analysis. |
2019-11-25 |
2023-08-13 |
Not clear |
| Xiaoliang Li, Qianqian Zhang, Zhigang Yan. Silence of MEG3 intensifies lipopolysaccharide-stimulated damage of human lung cells through modulating miR-4262. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-11-22. PMID:31184231. |
cell viability, migration, apoptosis and meg3 level were assessed by cck-8, transwell, flow cytometry/western blot and qrt-pcr assays, respectively. |
2019-11-22 |
2023-08-13 |
human |
| Tianyi Zhao, Duo Lai, You Zhou, Hanhong Xu, Zhixiang Zhang, Shizi Kuang, Xuehua Sha. Azadirachtin A inhibits the growth and development of Bactrocera dorsalis larvae by releasing cathepsin in the midgut. Ecotoxicology and environmental safety. vol 183. 2019-11-22. PMID:31398584. |
further, pathological sections revealed that azadirachtin destroyed the midgut cell structure and intestinal walls, while tunel staining showed that azadirachtin could induce apoptosis of midgut cells, and western blot analysis indicated that bcl-xl expression was inhibited and cytochrome c (cytc) released into the cytoplasm. |
2019-11-22 |
2023-08-13 |
Not clear |
| Hongxia Shi, Li Li, Lan Yuan, Qihua He, Shenwu Wang, Debing Wan. [The Role of Calcium Ion in Apotopsis of HL-60 Cells Induced by VP-16] Zhongguo shi yan xue ye xue za zhi. vol 8. issue 4. 2019-11-20. PMID:12578667. |
[the role of calcium ion in apotopsis of hl-60 cells induced by vp-16] to study the significance of calcium in the apoptosis of hl-60 cells induced by vp-16, the technology of flow cytometry, confocal laser scanning microscopy and western blot were used. |
2019-11-20 |
2023-08-12 |
Not clear |
| Hengxiang Wang, Zikuan Guo, Shuquan J. [Homoharringtonine Induces Apoptosis of K562 Cells through Inhibition of P210(bcr/abl)] Zhongguo shi yan xue ye xue za zhi. vol 8. issue 4. 2019-11-20. PMID:12578668. |
k562 cell line was used to observe the effects of hht on the induction of apoptosis and on the expression of the specific chimeric protein p210(bcr/abl), as evaluated by flow cytometric annexin v-pi dual labeling technique and western blot. |
2019-11-20 |
2023-08-12 |
Not clear |
| Sharon Chui-Wah Luk, Stephanie Wing-Fai Siu, Chun-Kit Lai, Ying-Jye Wu, Shiu-Fun Pan. Cell Cycle Arrest by a Natural Product via G2/M Checkpoint. International journal of medical sciences. vol 2. issue 2. 2019-11-20. PMID:15968342. |
flow cytometric analysis indicated that ckbm induced g2/m cell cycle arrest and apoptosis, whereas differential protein expressions of p21, p53 and 14-3-3sigma (stratifin) using western blot analysis were enhanced. |
2019-11-20 |
2023-08-12 |
Not clear |
| X L Shu, H Xu, T T Yu, J X Zhong, T Le. Regulation of apoptosis in human gastric cancer cell line SGC-7901 by L-arginine. Panminerva medica. 2019-11-20. PMID:24642529. |
expression and activation of proteins pertinent to apoptosis (bcl2, surviving, p53, and xiap) were studied using pcr, western blot, and activity assays. |
2019-11-20 |
2023-08-12 |
human |
| Sung Phil Kim, Seok Hyun Nam, Mendel Friedma. The Tomato Glycoalkaloid α-Tomatine Induces Caspase-Independent Cell Death in Mouse Colon Cancer CT-26 Cells and Transplanted Tumors in Mice. Journal of agricultural and food chemistry. vol 63. issue 4. 2019-11-20. PMID:25614934. |
this conclusion was supported by western blot analysis showing a localization of apoptosis-inducing mitochondrial protein (aif) to the nucleus and down-regulation of survivin (an inhibitor of apoptosis) expression as well as failure to detect the active form of caspase-3, -8, and -9 produced by proteolytic cleavage in ct-26 cancer cells. |
2019-11-20 |
2023-08-13 |
mouse |
| Ra Ham Lee, Jin Hyoung Cho, Young-Joo Jeon, Woong Bang, Jung-Jae Cho, Nag-Jin Choi, Kang Seok Seo, Jung-Hyun Shim, Jung-Il Cha. Quercetin Induces Antiproliferative Activity Against Human Hepatocellular Carcinoma (HepG2) Cells by Suppressing Specificity Protein 1 (Sp1). Drug development research. vol 76. issue 1. 2019-11-20. PMID:25619802. |
here, we demonstrated that quercetin decreased cell growth and induce apoptosis in hepg2 cells via suppression of sp1 using 3-(4,5-dimethyl-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2h-tetrazolium, inner salt (mts) assay, 4',6-diamidino-2-phenylindole (dapi) staining, annexin v, and western blot analysis, an effect that was dose- and time-dependent manner. |
2019-11-20 |
2023-08-13 |
human |
| Yingxiao Li, Kai-Chun Cheng, Akihiro Asakawa, Haruka Amitani, Yoshiyuki Takimoto, Joshua Runtuwene, Akio Inu. Activation of imidazoline-I3 receptors ameliorates pancreatic damage. Clinical and experimental pharmacology & physiology. vol 42. issue 9. 2019-11-20. PMID:26112210. |
the activity effect of agmatine against on streptozotocin (stz)-induced (5 mmol/l) rat β cell apoptosis was examined by using apotox-glo triplex assay, live/dead cell double staining assay, flow cytometric analysis, and western blot. |
2019-11-20 |
2023-08-13 |
rat |
| Jin-Hui Chen, Sen-Sen Lin, Wei-Xin Wang, Sheng-Tao Yuan, Ji-Sen Shi, Ai-Qun Ji. The extract, LXB-1, from the barks of Liriodendron × hybrid, induced apoptosis via Akt, JNK and ERK1/2 pathways in A549 lung cancer cells. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 70. issue 11-12. 2019-11-20. PMID:26618570. |
the potential mechanisms of lxb-1 inducing apoptosis - the expression and phosphorylation of erk, p38, jnk and akt - were investigated by western blot. |
2019-11-20 |
2023-08-13 |
human |
| Shixiu Feng, Min Zhang, Jing Xu, Yinming H. Prisconnatanones A, a cytotoxic naphthoquinone from Prismatomeris connata, suppresses the proliferation of human laryngocarcinoma HEp-2 cells in vitro. Natural product research. vol 30. issue 24. 2019-11-20. PMID:26983581. |
and, western blot analysis revealed that the levels of the apoptosis protein, cleaved caspase-3, parp, p21 and bax protein increased, while the level of anti-apoptosis protein bcl-2 decreased.. |
2019-11-20 |
2023-08-13 |
human |
| Wenwen Wang, Juan Liu, Jianni Qi, Junyong Zhang, Qiang Zhu, Jincai Ma, Chengyong Qi. Downregulation of RLIP76 is associated with vincristine resistance in human colorectal cancer HCT-8/VCR cells. International journal of oncology. vol 49. issue 4. 2019-11-20. PMID:27633085. |
the effects of rlip76 knockdown by the lentivirus were examined in cultured cells, including growth, apoptosis, invasion, and signaling pathways by qrt-pcr, western blot analysis and transwell assay. |
2019-11-20 |
2023-08-13 |
human |
| Yana Zhao, Shaojing Zhang, Pengfei Wang, Shengnan Fu, Di Wu, Anjun Li. Seleno-short-chain chitosan induces apoptosis in human non-small-cell lung cancer A549 cells through ROS-mediated mitochondrial pathway. Cytotechnology. vol 69. issue 6. 2019-11-20. PMID:28421411. |
furthermore, real-time pcr and western blot assay showed that sscc up-regulated bax and down-regulated bcl-2, subsequently incited the release of cytochrome c from mitochondria to cytoplasm, activated the increase of cleaved-caspase 3 and finally induced a549 cells apoptosis in vitro. |
2019-11-20 |
2023-08-13 |
human |