| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Wei, Xiao-Bing Lan, Ning Liu, Jia-Mei Yang, Juan Du, Lin Ma, Wen-Jin Zhang, Jian-Guo Niu, Tao Sun, Jian-Qiang Y. Echinacoside Alleviates Hypoxic-Ischemic Brain Injury in Neonatal Rat by Enhancing Antioxidant Capacity and Inhibiting Apoptosis. Neurochemical research. vol 44. issue 7. 2019-08-12. PMID:30911982. |
tunel staining and western blot analysis was performed to respectively estimate the extent of brain cell apoptosis and the expression level of the apoptosis-related proteins caspase-3, bax, and bcl-2. |
2019-08-12 |
2023-08-13 |
rat |
| Lingrong Zeng, Yu Sun, Xiaolei Li, Jingcheng Wang, Lianqi Ya. 10‑Hydroxycamptothecin induces apoptosis in human fibroblasts by regulating miRNA‑23b‑3p expression. Molecular medicine reports. vol 19. issue 4. 2019-08-01. PMID:30720099. |
the effects of hcpt and mir‑23b‑3p on fibroblast apoptosis were assessed using terminal deoxynucleotidyl‑transferase‑mediated dutp nick‑end labeling, flow cytometry and western blot analysis. |
2019-08-01 |
2023-08-13 |
human |
| Dingyun Li, Tao Zhang, Jiajun Lai, Jian Zhang, Ting Wang, Yafei Ling, Shengquan He, Zhiwei H. MicroRNA‑25/ATXN3 interaction regulates human colon cancer cell growth and migration. Molecular medicine reports. vol 19. issue 5. 2019-08-01. PMID:30942397. |
cell viability and cell migration were analyzed using mtt and wound healing assays, respectively, apoptosis was analyzed using flow cytometry, and western blot analysis was conducted to determine the protein expression of ataxin‑3 (atxn3), apoptosis regulator bax (bax) and cyclin d1. |
2019-08-01 |
2023-08-13 |
human |
| Jie Zheng, Su Min, Bin Hu, Qin Liu, Yunqiang Wa. Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels. International journal of molecular medicine. vol 43. issue 4. 2019-07-30. PMID:30720051. |
apoptosis in the hippocampus regions were measured using a terminal deoxynucleotidyl‑transferase‑mediated dutp nick end labelling assay, the viability and apoptosis level of the cells were measured via an mtt assay and flow cytometry, respectively, and the expression levels of nrdp1, erb‑b2 receptor tyrosine kinase 3 (erbb3), phosphorylated‑protein kinase b (p‑akt) and cleaved (c‑) caspase‑3 were detected using western blot analysis. |
2019-07-30 |
2023-08-13 |
rat |
| Guiping Luo, Zhao Jian, Yun Zhu, Yu Zhu, Baicheng Chen, Ruiyan Ma, Fuqin Tang, Yingbin Xia. Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress. International journal of molecular medicine. vol 43. issue 5. 2019-07-30. PMID:30864731. |
the data from the western blot analysis revealed that sirt1 promoted autophagic flux and reduced apoptosis in hypoxic h9c2 cells. |
2019-07-30 |
2023-08-13 |
mouse |
| Chia-Cheng Su, Kun-Lin Hsieh, Po-Len Liu, Hsin-Chih Yeh, Shu-Pin Huang, Shih-Hua Fang, Wei-Chung Cheng, Kuan-Hua Huang, Fang-Yen Chiu, I-Ling Lin, Ming-Yii Huang, Chia-Yang L. AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway. International journal of molecular sciences. vol 20. issue 7. 2019-07-30. PMID:30987073. |
cell growth was performed by mtt assay and soft agar assay; cell apoptosis was examined by annexin v/propidium iodide (pi) staining and poly adp ribose polymerase (parp) cleavage western blot, while cell migration and invasion were evaluated by wound-healing assay and transwell assay respectively. |
2019-07-30 |
2023-08-13 |
Not clear |
| Michiharu Yoshida, Hiroyuki Kobayashi, Shunsuke Terasaka, Shogo Endo, Shigeru Yamaguchi, Hiroaki Motegi, Rachmilevitch Itay, Shuji Suzuki, Omer Brokman, Yeruham Shapira, Kenji Moriyama, Yumiko Kawase, Toshiaki Akahane, Yasutaka Kato, Hajime Kamada, Kiyohiro Houki. Sonodynamic Therapy for Malignant Glioma Using 220-kHz Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound and 5-Aminolevulinic acid. Ultrasound in medicine & biology. vol 45. issue 2. 2019-07-29. PMID:30522817. |
f98 cells were irradiated with focused ultrasound (fus) (4000 j, 20 w, 240 s, 100% duty cycle, target medium temperature <40°c) after treatment with 200 µg/ml 5-ala, and cell viability and apoptosis were evaluated with the water-soluble tetrazolium-1 assay, triple fluorescent staining and western blot analysis 20 h later. |
2019-07-29 |
2023-08-13 |
Not clear |
| Xinxin Liu, Fei Liu, Shuo Zhao, Bin Guo, Peixue Ling, Guanying Han, Zan Cu. Purification of an acidic polysaccharide from Suaeda salsa plant and its anti-tumor activity by activating mitochondrial pathway in MCF-7 cells. Carbohydrate polymers. vol 215. 2019-07-29. PMID:30981376. |
the data from the western blot showed an increase in the levels of bax, cytochrome c (cyto-c), caspase-3 and caspase-9 and a decrease in the level of bcl-2 further demonstrated that ssp2-2 could induce apoptosis via a mitochondrial pathway. |
2019-07-29 |
2023-08-13 |
Not clear |
| Ping Sun, Jun-Bo Yin, Li-Hua Liu, Jian Guo, Sheng-Hai Wang, Chun-Hui Qu, Chun-Xia Wan. Protective role of Dihydromyricetin in Alzheimer's disease rat model associated with activating AMPK/SIRT1 signaling pathway. Bioscience reports. vol 39. issue 1. 2019-07-26. PMID:30498091. |
then, the inflammatory cytokines expressions were determined by radioimmunoassay while expressions of ampk/sirt1 pathway-related proteins by western blot; and the apoptosis of hippocampal cells was detected by tdt-mediated dutp nick end labeling assay. |
2019-07-26 |
2023-08-13 |
rat |
| Leng-Xin Duan, Yang Gao, Xin-Fang Wu, Ke-Ke Qiu, Jian-Gang Wan. [Protective effect of earthworm active ingredients against endoplasmic reticulum stress induced L-02 hepatocyte apoptosis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 14. 2019-07-23. PMID:30111057. |
the cell viability was measured with cck-8, the apoptosis of l-02 cells was detected by flow cytometry, and the relevant protein and mrna expressions were detected by western blot and qpcr. |
2019-07-23 |
2023-08-13 |
Not clear |
| Min Zhang, Yuehou Zhang, Jun Ding, Xiaohong Li, Chengyu Zang, Siyuan Yin, Jiaxu Ma, Yibing Wang, Yongqian Ca. The role of TrkA in the promoting wounding-healing effect of CD271 on epidermal stem cells. Archives of dermatological research. vol 310. issue 9. 2019-07-22. PMID:30209580. |
the biological characteristics of escs and their proliferation and apoptosis were detected using immunohistochemistry and western blot. |
2019-07-22 |
2023-08-13 |
mouse |
| Hong-Yan Li, Shen Yang, Jing-Chun Li, Jian-Xun Fen. Galectin 3 inhibition attenuates renal injury progression in cisplatin-induced nephrotoxicity. Bioscience reports. vol 38. issue 6. 2019-07-22. PMID:30455396. |
mcp-treated mice also demonstrated decreased renal fibrosis and apoptosis, as revealed by masson trichrome staining and western blot analysis of cleaved caspase-3. |
2019-07-22 |
2023-08-13 |
mouse |
| Feng Xu, Qi Li, Zhiyu Wang, Xiangming Ca. Sinomenine inhibits proliferation, migration, invasion and promotes apoptosis of prostate cancer cells by regulation of miR-23a. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 112. 2019-07-22. PMID:30784907. |
the related factors of cell cycle, apoptosis, metastasis and pi3k/akt and jak/stat signal pathways were measured by western blot. |
2019-07-22 |
2023-08-13 |
Not clear |
| Yanhua Chang, Ruifang Kon. Ganoderic acid A alleviates hypoxia-induced apoptosis, autophagy, and inflammation in rat neural stem cells through the PI3K/AKT/mTOR pathways. Phytotherapy research : PTR. vol 33. issue 5. 2019-07-22. PMID:30838711. |
proteins related to apoptosis, autophagy, and the pi3k/akt/mtor pathways were evaluated by western blot analysis. |
2019-07-22 |
2023-08-13 |
rat |
| Lijiang Wang, Liyue Wang, Xiaoxia Zhou, Guoran Ruan, Guangyong Yan. Qishen Yiqi Dropping Pills Ameliorates Doxorubicin-induced Cardiotoxicity in Mice via Enhancement of Cardiac Angiogenesis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-07-19. PMID:30943187. |
moreover, tunel staining and western blot analysis of bax protein, bcl-2 protein, and cleaved caspase-3 protein expression levels were conducted to explore whether qydp exerted effect on cardiac apoptosis. |
2019-07-19 |
2023-08-13 |
mouse |
| Biao Cai, Shu Ye, Yan Wang, Ting-Ting Wang, Liang Wang, Ai-Juan Jiang, Zheng-Qing Fang, Guo-Ming Shen, Dao-Jun Xi. [Effects of Huangpu Tongqiao capsule on apoptosis of Alzheimer's disease cell model]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 11. 2019-07-18. PMID:29945394. |
after primary cultured hippocampal neurons ad cell model was induced by aβ₂₅₋₃₅, cell survival rate was detected by mtt, cell apoptosis rate was assayed by flow cytometry, and protein expressions of bax, cyt c and caspase-3 were determined by western blot analysis. |
2019-07-18 |
2023-08-13 |
Not clear |
| Alyssa Cobbs, Xiaoming Chen, Yuanyuan Zhang, Jasmine George, Ming-Bo Huang, Vincent Bond, Winston Thompson, Xueying Zha. Saturated fatty acid stimulates production of extracellular vesicles by renal tubular epithelial cells. Molecular and cellular biochemistry. vol 458. issue 1-2. 2019-07-18. PMID:30993495. |
in nrk-52e cells, pa-enhanced ev release was associated with an induction of cell apoptosis reflected by an increase in cleaved caspase-3 protein by western blot and annexin v positive cells analyzed by flow cytometry. |
2019-07-18 |
2023-08-13 |
human |
| Qiang Chu, Yiying Zhao, Xuer Shi, Wen Han, Yanzhen Zhang, Xiaodong Zheng, Jing Zh. In vivo-like 3-D model for sodium nitrite- and acrylamide-induced hepatotoxicity tests utilizing HepG2 cells entrapped in micro-hollow fibers. Scientific reports. vol 7. issue 1. 2019-07-17. PMID:29093461. |
furthermore, western blot analysis of apoptosis pathways also supported the argument. |
2019-07-17 |
2023-08-13 |
Not clear |
| Chun-Miao Luo, Jun Feng, Jing Zhang, Chao Gao, Ji-Yu Cao, Gao-Liang Zhou, Yong-Jing Jiang, Xiao-Qing Jin, Meng-Si Yang, Jian-Yuan Pan, Ai-Ling Wan. 1,25-Vitamin D3 protects against cooking oil fumes-derived PM2.5-induced cell damage through its anti-inflammatory effects in cardiomyocytes. Ecotoxicology and environmental safety. vol 179. 2019-07-16. PMID:31054378. |
cell viability was measured using cck-8 assay, and cell apoptosis was analyzed by flow cytometry, qrt-pcr and western blot in cultured rat neonatal cardiomyocytes treated with 1,25-vitamin d3 and cofs-derived pm2.5. |
2019-07-16 |
2023-08-13 |
rat |
| Chang Min Lee, Jongsung Lee, Myeong Jin Nam, Youn Soo Choi, See-Hyoung Par. Tomentosin Displays Anti-Carcinogenic Effect in Human Osteosarcoma MG-63 Cells via the Induction of Intracellular Reactive Oxygen Species. International journal of molecular sciences. vol 20. issue 6. 2019-07-09. PMID:30917517. |
after treatment with tomentosin, mg-63 cells were analyzed using the mtt assay, colony formation assay, cell counting assay, wound healing assay, boyden chamber assay, zymography assay, cell cycle analysis, fitc annexin v apoptosis assay, terminal deoxynucleotidyl transferase dutp nick end labeling assay, western blot analysis, and ros detection analysis. |
2019-07-09 |
2023-08-13 |
human |