| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing-Kui Wu, Qiao Yang, Yang-Yang Li, Dong-Jie Xi. [Effect of leech on VSMCs in early atherosclerosis rats via p38MAPK signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 16. 2019-04-19. PMID:29171240. |
immunological histological chemistry (ihc) was taken to measure the expression levels of proliferating cell nucleus antigen(pcna) and cell apoptosis proteinase-3(caspase-3), while the protein expression levels of mkk3, p38 and c-myc were detected by western blot. |
2019-04-19 |
2023-08-13 |
rat |
| Zhiyu He, Haoyu Tang, Xinru You, Keqing Huang, Arvind Dhinakar, Yang Kang, Qiaoli Yu, Jun W. BAPTA-AM Nanoparticle for the Curing of Acute Kidney Injury Induced by Ischemia/Reperfusion. Journal of biomedical nanotechnology. vol 14. issue 5. 2019-04-19. PMID:29883558. |
the assays of histological examination, elisa, immunohistochemistry, western blot, tunel and rt-pcr were utilized for the detection of apoptosis. |
2019-04-19 |
2023-08-13 |
rat |
| Hong Yao, Feijie Xu, Guangyu Wang, Shaowen Xie, Wenlong Li, Hequan Yao, Cong Ma, Zheying Zhu, Jinyi Xu, Shengtao X. Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors. European journal of medicinal chemistry. vol 167. 2019-04-18. PMID:30784881. |
flow cytometry and western blot analyses confirmed that compound 21c caused apoptosis of mcf-7 cells. |
2019-04-18 |
2023-08-13 |
human |
| Ya-Wei Li, Wei Zhang, Na Xu, Yan Li, Hong Zhang, Shi-Jie Lv, Wen-He Zh. [Dihydroartemisinin inhibits proliferation of pancreatic cancer JF-305 cells by regulating expression of apoptosis related proteins and production of reactive oxygen species]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 15. 2019-04-16. PMID:29139274. |
western blot was used to detect the protein expression changes of bax, bcl-2, cleaved caspase-3, cleaved caspase-9 and cyto c. as compared with the control group, the jf-305 cells proliferation was inhibited significantly(p<0.05) after treatment with different concentrations of dihydroartemisimin for 48 h; cell cycle was blocked in the g2/m phase; apoptotic morphology of nuclear condensation, aggregation, and fragmentation was found, and the apoptosis ratio was increased(p<0.05). |
2019-04-16 |
2023-08-13 |
human |
| Weijie Liang, Taibing Fan, Lin Liu, Lianzhong Zhan. Knockdown of growth-arrest specific transcript 5 restores oxidized low-density lipoprotein-induced impaired autophagy flux via upregulating miR-26a in human endothelial cells. European journal of pharmacology. vol 843. 2019-04-15. PMID:30468731. |
the effects of ox-ldl, gas5 or combined with mir-26a on apoptosis and autophagy were evaluated by flow cytometry analysis and western blot, respectively. |
2019-04-15 |
2023-08-13 |
human |
| Jinxin Wang, Ruilin Li, Zhiyuan Deng, Zuoyan Sun, Lijuan Chai, Hong Guo, Hong Wang, Lu Chen, Limin Hu, Shaoxia Wan. Xueshuantong for Injection Ameliorates Diabetic Nephropathy in a Rat Model of Streptozotocin-Induced Diabetes. The Chinese journal of physiology. vol 61. issue 6. 2019-04-15. PMID:30580505. |
apoptosis related factors such as cleaved caspase-3, bcl-2, bax and inflammationrelated factors, including tumor necrosis factor-α (tnf-α), interleukin 6 (il-6), il-1β, induciblenitric oxide synthase (inos) and intercellular adhesion molecule-1 (icam-1) were detected by pcror western blot. |
2019-04-15 |
2023-08-13 |
rat |
| Hoyoung Ryu, Hyunjin Jin, Jin-Nyoung Ho, Jungbum Bae, Eunsik Lee, Sang Eun Lee, Sangchul Le. Suberoylanilide Hydroxamic Acid Can Re-sensitize a Cisplatin-Resistant Human Bladder Cancer. Biological & pharmaceutical bulletin. vol 42. issue 1. 2019-04-15. PMID:30606990. |
activation of caspase mediated apoptosis, down-regulated expression of the anti-apoptotic b-cell lymphoma-2 (bcl-2) and up-regulated expression of pro-apoptotic bcl-2-associated death promoter (bad) were observed in western blot. |
2019-04-15 |
2023-08-13 |
human |
| Dan Guo, Jiangtao Xie, Junjie Zhao, Tingqin Huang, Xiaoye Guo, Jinning Son. Resveratrol protects early brain injury after subarachnoid hemorrhage by activating autophagy and inhibiting apoptosis mediated by the Akt/mTOR pathway. Neuroreport. vol 29. issue 5. 2019-04-05. PMID:29360689. |
the results were assessed by western blot, reverse transcription-pcr , and immunohistochemistry and immunofluorescence at 24 h after injury to determine changes in the expression of the akt/mtor signaling pathway, autophagy, and apoptosis proteins. |
2019-04-05 |
2023-08-13 |
rat |
| Yu Shi, Weihong Yan, Qiaoyan Lin, Weimin Wan. Icariin influences cardiac remodeling following myocardial infarction by regulating the CD147/MMP-9 pathway. The Journal of international medical research. vol 46. issue 6. 2019-04-03. PMID:29734850. |
the ventricular systolic function, myocardial apoptosis rate, and expression of collagen type i (col i), col iii, cd147, matrix metalloproteinase 9 (mmp-9), and tissue inhibitor of metalloproteinase 1 (timp-1) were detected by hematoxylin-eosin staining, tunel assay, and western blot. |
2019-04-03 |
2023-08-13 |
rat |
| Xiuna Sun, Mengqi Jia, Wei Sun, Lu Feng, Chundong Gu, Taihua W. Functional role of RBM10 in lung adenocarcinoma proliferation. International journal of oncology. vol 54. issue 2. 2019-04-01. PMID:30483773. |
we found that rbm10 protein was overexpressed in lung adenocarcinoma cells and tissues, and it reduced p53 expression (as detected by immunofluorescence assay and western blot analysis) in a549 cells and inhibited apoptosis (as shown by flow cytometric assay). |
2019-04-01 |
2023-08-13 |
Not clear |
| Lei Fang, Wei Xu, Dedi Kon. Icariin inhibits cell proliferation, migration and invasion by down-regulation of microRNA-625-3p in thyroid cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-04-01. PMID:30551506. |
the different concentrations of ica were stimulated sw579 and tpc1 cells, and cell viability, apoptosis, migration, invasion and main factors of these processes were detected by cck-8, flow cytometry, transwell and western blot. |
2019-04-01 |
2023-08-13 |
Not clear |
| Jingyu Zhang, Jingmin Li, Haoran Song, Yanlian Xiong, Desheng Liu, Xianyong Ba. Hydroxysafflor yellow A suppresses angiogenesis of hepatocellular carcinoma through inhibition of p38 MAPK phosphorylation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-04-01. PMID:30551534. |
furthermore, western blot analysis on caspase-3 and cleaved-caspase-3 revealed that hsya could induce apoptosis of hepg2 cells. |
2019-04-01 |
2023-08-13 |
mouse |
| Yuping Yang, Zijun Jiang, Dong Zhug. Emodin Attenuates Lipopolysaccharide-Induced Injury via Down-Regulation of miR-223 in H9c2 Cells. International heart journal. vol 60. issue 2. 2019-03-28. PMID:30745529. |
thereafter, cell viability, apoptosis, the expression of cyclind1 and jnk-associated proteins, and the release of pro-inflammatory factors were assessed by cell counting kit-8, flow cytometry analysis, quantitative real-time polymerase chain reaction western blot, and enzyme-linked immunosorbent assay respectively. |
2019-03-28 |
2023-08-13 |
Not clear |
| Xiaozhu Tang, Jing Sun, Tao Ge, Kaiqi Zhang, Qiuyi Gui, Shantang Zhang, Weidong Che. PEGylated liposomes as delivery systems for Gambogenic acid: Characterization and in vitro/in vivo evaluation. Colloids and surfaces. B, Biointerfaces. vol 172. 2019-03-25. PMID:30125771. |
mechanistically, western blot analysis revealed that up-regulation of bax, down-regulation of bcl-2 and activation of caspase-3 contributed to apoptosis. |
2019-03-25 |
2023-08-13 |
Not clear |
| Ye Zhang, Peng Lu, Huaping Du, Lifei Zhan. LINK-A lncRNA Promotes Proliferation and Inhibits Apoptosis of Mantle Cell Lymphoma Cell by Upregulating Survivin. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-03-22. PMID:30636001. |
link-a lncrna shrna and expression vector were transfected into cells of human mantle cell lymphoma cell lines, followed by detection of cell proliferation, cell apoptosis, and survivin expression by cell proliferation assay, cell apoptosis assay, and western blot analysis, respectively. |
2019-03-22 |
2023-08-13 |
human |
| Ke-Feng Zhai, Hong Duan, Cai-Yue Cui, Yu-Yao Cao, Jia-Li Si, Hui-Jiao Yang, Yong-Chao Wang, Wen-Gen Cao, Gui-Zhen Gao, Zhao-Jun We. Liquiritin from Glycyrrhiza uralensis Attenuating Rheumatoid Arthritis via Reducing Inflammation, Suppressing Angiogenesis, and Inhibiting MAPK Signaling Pathway. Journal of agricultural and food chemistry. vol 67. issue 10. 2019-03-22. PMID:30785275. |
an mtt assay, hoechst 33342 staining, jc-1 staining, and western blot were used to check the viability, cell apoptosis, mitochondrial membrane potential changes, and the expression of related proteins, respectively. |
2019-03-22 |
2023-08-13 |
Not clear |
| H Ramamoorthy, P Abraham, B Isaac, D Selvakuma. Mitochondrial pathway of apoptosis and necrosis contribute to tenofovir disoproxil fumarate-induced renal damage in rats. Human & experimental toxicology. vol 38. issue 3. 2019-03-19. PMID:30326737. |
apoptosis was detected by terminal deoxynucleotidyl transferase biotin-deoxyuridine triphosphate nick end-labelling (tunel) assay and caspase 3 activity and protein expression; mitochondrial pathway of apoptosis by cyt c release; and parp activation by immunofluorescence, immunohistochemistry and western blot techniques. |
2019-03-19 |
2023-08-13 |
human |
| Wen Zhu, Xue-Rui Wang, Si-Qi Du, Chao-Qun Yan, Na-Na Yang, Lu-Lu Lin, Guang-Xia Shi, Cun-Zhi Li. Anti-oxidative and Anti-apoptotic Effects of Acupuncture: Role of Thioredoxin-1 in the Hippocampus of Vascular Dementia Rats. Neuroscience. vol 379. 2019-03-18. PMID:29592844. |
the protein and mrna levels of trx-1 and trxr-1, the activity of trxr-1 as well as the phosphorylation of the apoptosis signal-regulating kinase 1 (ask1)-c-jun n-terminal kinase (jnk)/p38 pathway were measured by western blot, real-time pcr analysis, trxr-1 activity analysis and immunofluorescence (if) staining respectively. |
2019-03-18 |
2023-08-13 |
rat |
| Hao Wu, Chao Zeng, Yiwang Ye, Jixian Liu, Zhimin Mu, Yuancai Xie, Baokun Chen, Qiaohong Nong, Da W. Exosomes from Irradiated Nonsmall Cell Lung Cancer Cells Reduced Sensitivity of Recipient Cells to Anaplastic Lymphoma Kinase Inhibitors. Molecular pharmaceutics. vol 15. issue 5. 2019-03-18. PMID:29595984. |
western blot, flow cytometry, mtt, and xenograft were employed to respectively assess activation of the alk pathway, apoptosis, cell viability, and tumor growth. |
2019-03-18 |
2023-08-13 |
mouse |
| Yue Guo, Fang Wang, Haopeng Li, Hui Liang, Yuhuan Li, Zhengchao Gao, Xijing H. Metformin Protects Against Spinal Cord Injury by Regulating Autophagy via the mTOR Signaling Pathway. Neurochemical research. vol 43. issue 5. 2019-03-18. PMID:29728793. |
western blot and immunofluorescent analysis revealed that mammalian target of rapamycin (mtor) and p70s6 kinase (p70s6k) decreased, while the expression of autophagy markers increased and apoptosis markers declined in animals treated with metformin following sci. |
2019-03-18 |
2023-08-13 |
rat |