| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tao Yu, Ji Qu, Yang Wang, Hui Ji. Ligustrazine protects chondrocyte against IL-1β induced injury by regulation of SOX9/NF-κB signaling pathway. Journal of cellular biochemistry. vol 119. issue 9. 2019-10-17. PMID:29806884. |
cell viability, apoptosis, and apoptosis-related factors were examined by mtt, flow cytometry, and western blot. |
2019-10-17 |
2023-08-13 |
human |
| Hyo In Kim, Se Hyang Hong, Jin Mo Ku, Ye Seul Lim, Sol Ji Lee, Jungbin Song, Tai Young Kim, Chunhoo Cheon, Seong-Gyu K. Scutellaria Radix Promotes Apoptosis in Non-Small Cell Lung Cancer Cells via Induction of AMPK-Dependent Autophagy. The American journal of Chinese medicine. vol 47. issue 3. 2019-10-17. PMID:30974965. |
western blot assays showed increased expressions of bcl-2-associated x protein (bax), cleaved-caspase 3 and cleaved-poly adp ribose polymerase (parp), key factors of apoptosis. |
2019-10-17 |
2023-08-13 |
Not clear |
| Wen-Hu Liu, Jiang-Bei Yuan, Fan Zhang, Jin-Xia Chan. [Curcumin inhibits proliferation,migration and invasion of gastric cancer cells via Wnt3a/β-catenin/EMT signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 14. 2019-10-16. PMID:31602860. |
the migration and invasiveness of cells were determined by wound healing and transwell assays,the apoptosis rate was assessed by flow cytometry,the expression of n-cadherin,e-cadherin,snail1,wnt3 a,p-β-catenin,p-lrp6,bcl-2 and bax were detected by western blot,and the enzymatic activity of caspase-3,caspase-8 and caspase-9 was evaluated via caspase kit. |
2019-10-16 |
2023-08-13 |
human |
| Yiping Yang, Shuyan Ma, Fu Wei, Guiqiang Liang, Xiaobo Yang, Yuman Huang, Jian Wang, Yunfeng Zo. Pivotal role of cAMP-PKA-CREB signaling pathway in manganese-induced neurotoxicity in PC12 cells. Environmental toxicology. vol 34. issue 9. 2019-10-15. PMID:31161640. |
flow cytometry, immunofluorescence staining, enzyme-linked immunosorbent assay, and western blot analysis were used to detect the apoptosis rate, protein levels of pde4, camp signaling, and apoptosis-associated proteins, respectively. |
2019-10-15 |
2023-08-13 |
Not clear |
| Xiong-Bai Zhu, Wen-Jun Lin, Chen Lv, Lu Wang, Zheng-Xiang Huang, Sheng-Wu Yang, Xin Che. MicroRNA-539 promotes osteoblast proliferation and differentiation and osteoclast apoptosis through the AXNA-dependent Wnt signaling pathway in osteoporotic rats. Journal of cellular biochemistry. vol 119. issue 10. 2019-10-09. PMID:29893431. |
the expression of mir-53, axin1, the wnt pathway related-genes, apoptosis related-genes, and osteogenic markers were measured by rt-qpcr and western blot analysis, respectively. |
2019-10-09 |
2023-08-13 |
rat |
| Ru Yang, Suxuan Liu, Jian Wen, Leixi Xue, Yi Zhang, Dong Yan, Guokun Wang, Zhichun Li. Inhibition of maternally expressed gene 3 attenuated lipopolysaccharide-induced apoptosis through sponging miR-21 in renal tubular epithelial cells. Journal of cellular biochemistry. vol 119. issue 9. 2019-10-08. PMID:29923218. |
western blot assay showed that the expression of apoptosis regulator bcl-2 was increased in meg3-inhibited tkpts cells. |
2019-10-08 |
2023-08-13 |
Not clear |
| S Li, J J L. Zoledronic acid modulates human osteosarcoma cells proliferation via GSK-3β activation. Neoplasma. vol 66. issue 5. 2019-10-07. PMID:31288526. |
the effects of gsk-3β on zol-induced apoptosis among these groups were characterized by flow cytometry, mtt assay, transmission electron microscopy (tem) and western blot. |
2019-10-07 |
2023-08-13 |
human |
| Tao Fan, Zhixin Huang, Wei Wang, Boyou Zhang, Yao Xu, Zhangfan Mao, Lei Chen, Hao Hu, Qing Gen. Proteasome inhibition promotes autophagy and protects from endoplasmic reticulum stress in rat alveolar macrophages exposed to hypoxia-reoxygenation injury. Journal of cellular physiology. vol 233. issue 10. 2019-10-03. PMID:29741768. |
proteasome inhibtion hindered cell apoptosis as demonstrated by decreased caspase-3/7 activity, immunolabelling, and western blot results. |
2019-10-03 |
2023-08-13 |
rat |
| Ying Xie, Xu Yan, Ling Su. The Mechanism of Bufalin-Induced Apoptosis of K562/A02. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-10-02. PMID:30955024. |
we used mtt and flow cytometry to detect apoptosis, and rt-pcr and western blot were used to detect endoplasmic reticulum stress and apoptosis gene action. |
2019-10-02 |
2023-08-13 |
Not clear |
| Xiaofeng Lai, Hu Zhao, Yong Zhang, Kai Guo, Yuqiao Xu, Suning Chen, Jian Zhan. Intranasal Delivery of Copper Oxide Nanoparticles Induces Pulmonary Toxicity and Fibrosis in C57BL/6 mice. Scientific reports. vol 8. issue 1. 2019-09-30. PMID:29540716. |
cuo nps induced apoptosis of epithelial cells as indicated by tunel staining, flow cytometry and western blot analysis, which was partially caused by increased reactive oxygen species (ros). |
2019-09-30 |
2023-08-13 |
mouse |
| Long-Bin Jeng, Bharath Kumar Velmurugan, Ming-Cheng Chen, Hsi-Hsien Hsu, Tsung-Jung Ho, Cecilia-Hsuan Day, Yueh-Min Lin, V Vijaya Padma, Chuan-Chou Tu, Chih-Yang Huan. Fisetin mediated apoptotic cell death in parental and Oxaliplatin/irinotecan resistant colorectal cancer cells in vitro and in vivo. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29574877. |
western blot assays suggested that apoptosis was induced by fisetin administration, promoting caspase-8, and cytochrome-c expressions possibly by inhibiting aberrant activation of igf1r and akt proteins. |
2019-09-30 |
2023-08-13 |
mouse |
| Ning Ren, Ming Wan. microRNA-212-induced protection of the heart against myocardial infarction occurs via the interplay between AQP9 and PI3K/Akt signaling pathway. Experimental cell research. vol 370. issue 2. 2019-09-30. PMID:30017933. |
the expression of mir-212, aqp9, pi3k, akt, vegf, bax, and b cell lymphoma 2 (bcl-2), along with cell apoptosis were determined using reverse transcription quantitative polymerase chain reaction (rt-qpcr), western blot analysis and flow cytometry. |
2019-09-30 |
2023-08-13 |
rat |
| Guoqiang Chen, Xiaqing Yu, Min Zhang, Aiwen Zheng, Zhennan Wang, Yufang Zuo, Qilian Liang, Danxian Jiang, Yaqing Chen, Lingqin Zhao, Liyuan Jiang, Dan Li, Sihai Lia. Inhibition of Euchromatic Histone Lysine Methyltransferase 2 (EHMT2) Suppresses the Proliferation and Invasion of Cervical Cancer Cells. Cytogenetic and genome research. vol 158. issue 4. 2019-09-30. PMID:31434093. |
cell viability, colony proliferation, apoptosis, adhesion, and invasion assays and western blot were performed to assess the function of ehmt2. |
2019-09-30 |
2023-08-13 |
human |
| Yingjie Wu, Jinhua Zhang, Yinghe Qi. S100A4 promotes the development of lipopolysaccharide-induced mouse endometritis. Biology of reproduction. vol 99. issue 5. 2019-09-27. PMID:29800090. |
western blot and immunohistochemical results showed that cell apoptosis in uterus during endometritis, marked by cleaved-caspase 3 protein, was significantly cut down in s100a4-/- mice; cell proliferation, which was indicated by ki-67, was also significantly decreased in the inflamed endometrial stroma of s100a4-/- mice. |
2019-09-27 |
2023-08-13 |
mouse |
| Jing-Kang Wang, Li-Chao Wang, Yong Jiang, Peng-Fei Tu, Ke-Wu Zen. [Neuroprotective effects and mechanism of ethanol extract of Cistanche tubulosa against oxygen-glucose deprivation/reperfusion]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 13. 2019-09-24. PMID:31359678. |
5,25,50 mg·l-1) by detecting cell viability with mtt assay,apoptosis with ao/eb and hoechst 33258,mitochondrial membrane potential changes with jc-1 staining,mitochondrial oxidative stress with mitosox staining,as well as the apoptosis-related protein expression( parp,cleaved parp,caspase-3,cleaved caspase-3,bax,bcl-2) with western blot. |
2019-09-24 |
2023-08-13 |
Not clear |
| Kailiang Li, Wenjing Gu, Jie Xu, Aikun Wang, Hongchao Ha. Expression of TMEFF2 in Human Pancreatic Cancer Tissue and the Effects of TMEFF2 Knockdown on Cell, Proliferation, and Apoptosis in Human Pancreatic Cell Lines. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-18. PMID:31044775. |
rna expression, protein expression, cell proliferation, and apoptosis were studied using real-time polymerase chain reaction (rt-pcr), western blot, the cell counting kit-8 (cck-8) assay, and flow cytometry, respectively. |
2019-09-18 |
2023-08-13 |
human |
| Xu Chao, Guoquan Wang, Yuping Tang, Changhu Dong, Hong Li, Bin Wang, Jieqiong Wu, Jiarong Zha. The effects and mechanism of peiminine-induced apoptosis in human hepatocellular carcinoma HepG2 cells. PloS one. vol 14. issue 1. 2019-09-17. PMID:30615617. |
mitochondrial membrane potential evaluation and western blot analysis were performed to investigate the mechanism of peiminine-induced apoptosis. |
2019-09-17 |
2023-08-13 |
human |
| Junjun Liang, Nina Liu, Haibin Xi. Knockdown long non-coding RNA PEG10 inhibits proliferation, migration and invasion of glioma cell line U251 by regulating miR-506. General physiology and biophysics. vol 38. issue 4. 2019-09-11. PMID:31241046. |
the cell proliferation and apoptosis related p16, p53, bcl-2, bax, and pro-/cleaved-caspase-3/9, migration and invasion related-protein: matrix metalloproteinases mmp-2, mmp-9 and vimentin, and raf/mek/erk and jak1/stat3 pathways-related proteins were accessed by western blot. |
2019-09-11 |
2023-08-13 |
human |
| Yi Zheng, Pengfei Zhang, Conghui Zhang, Wenxian Zen. Surgery-induced cryptorchidism induces apoptosis and autophagy of spermatogenic cells in mice. Zygote (Cambridge, England). vol 27. issue 2. 2019-09-10. PMID:30888311. |
transmission electron microscopy, terminal deoxynucleotidyl transferase dutp nick end labelling (tunel) and western blot assays demonstrated cryptorchidism-induced apoptosis of spermatogenic cells. |
2019-09-10 |
2023-08-13 |
mouse |
| Yan Zhang, Yuliang Jiang, Dongjie L. Diosmetin Suppresses Neuronal Apoptosis and Inflammation by Modulating the Phosphoinositide 3-Kinase (PI3K)/AKT/Nuclear Factor-κB (NF-κB) Signaling Pathway in a Rat Model of Pneumococcal Meningitis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:30914630. |
in rat brain tissue, levels of inflammatory mediators were determined by enzyme-linked immunosorbent assay (elisa) and western blot for protein kinase b (akt), phosphoinositide 3-kinase (pi3k), myeloid differentiation primary response 88 (myd88), and nuclear factor-kappab (nf-kappab), and the tunel assay for apoptosis was performed. |
2019-09-10 |
2023-08-13 |
rat |