| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong-Sheng Huo, Jian-Fang Sun, Zhi-Ping Cai, Xu-Sheng Yan, He Wang, Jian-Xin Jia, Zhan-Jun Yan. The protective mechanisms underlying Ginsenoside Rg1 effects on rat sciatic nerve injury. Journal of toxicology and environmental health. Part A. vol 82. issue 19. 2020-05-21. PMID:31739751. |
the following parameters were measured: (1) number of spinal cord motoneurons by nissl staining, (2) oxidation parameters including spinal cord malondialdehyde (mda) levels and activities of superoxide dismutase (sod) and glutathione peroxidase (gsh-px) as well as (3) involvement of apoptosis by determining caspase-3 and x-linked inhibitor of apoptosis protein (xiap) by immunohistochemistry and western blot. |
2020-05-21 |
2023-08-13 |
rat |
| Shuxia Liang, Panjian Lai, Xiaobing Li, Jie Xu, Yunguang Bao, Yuanshu Fang, Mingxing Din. Ulinastatin Reduces the Severity of Intestinal Damage in the Neonatal Rat Model of Necrotizing Enterocolitis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-05-21. PMID:31786582. |
to assess intestinal cell apoptosis, we examined the expression of caspase-3 by tunel staining and western blot analysis. |
2020-05-21 |
2023-08-13 |
human |
| Mei Yang, De-Yan Kong, Jian-Chang Che. Inhibition of miR-148b ameliorates myocardial ischemia/reperfusion injury via regulation of Wnt/β-catenin signaling pathway. Journal of cellular physiology. vol 234. issue 10. 2020-05-19. PMID:30820984. |
myocardial cell viability was measured using positron emission tomography combined with computer tomography and (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, and the apoptosis was assessed by terminal deoxynucleotidyl transferase-mediated nick-end labeling method and flow cytometry; quantitative reverse-transcription polymerase chain reaction and western blot were used to detect the related molecules expressions. |
2020-05-19 |
2023-08-13 |
rat |
| Hong Li, Changhu Dong, Yanning Tian, Xiang Li, Bing Wang, Dongzhi Zhai, Yingying Bai, Xu Cha. Knockdown of diacylglycerol kinase zeta (DGKZ) induces apoptosis and G2/M phase arrest in human acute myeloid leukemia HL-60 cells through MAPK/survivin/caspase pathway. Die Pharmazie. vol 74. issue 7. 2020-05-18. PMID:31288898. |
western blot analysis was performed to investigate expressions of the proteins related to apoptosis and cell cycle. |
2020-05-18 |
2023-08-13 |
human |
| Lu Zhang, PengFei Qiang, JingTing Yu, YiMing Miao, ZhiQiang Chen, Ju Qu, QianBing Zhao, Zhuo Chen, Yachao Liu, Xin Yao, Bin Liu, LiuQing Cui, HongJuan Jing, Gangchun Su. Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. Autophagy. vol 15. issue 3. 2020-05-13. PMID:30145925. |
results from western blot, immunofluorescence, and tdt-mediated dutp nick end labeling (tunel) assays showed that ca-5f inhibited autophagic flux, induced apoptosis, and did not affect the level of ctsb (cathepsin b) and ctsd (cathepsin d) in vivo, which were consistent with the in vitro data. |
2020-05-13 |
2023-08-13 |
human |
| Zhi-Feng Liu, Jing-Jing Ji, Dong Zheng, Lei Su, Tianqing Pen. Calpain-2 protects against heat stress-induced cardiomyocyte apoptosis and heart dysfunction by blocking p38 mitogen-activated protein kinase activation. Journal of cellular physiology. vol 234. issue 7. 2020-05-11. PMID:30417356. |
in cardiac-specific calpain-2 overexpressing transgenic mice, p38 phosphorylation and cardiomyocyte apoptosis were decreased in the heart tissue of heatstroke mice, as revealed by western blot and terminal deoxynucleotidyl transferase dutp nick end labelling assays, respectively. |
2020-05-11 |
2023-08-13 |
mouse |
| Sara Cheleschi, Sara Tenti, Nicola Mondanelli, Claudio Corallo, Marcella Barbarino, Stefano Giannotti, Ines Gallo, Antonio Giordano, Antonella Fioravant. MicroRNA-34a and MicroRNA-181a Mediate Visfatin-Induced Apoptosis and Oxidative Stress via NF-κB Pathway in Human Osteoarthritic Chondrocytes. Cells. vol 8. issue 8. 2020-05-11. PMID:31405216. |
apoptosis and reactive oxygen species (ros) production were detected by cytometry, mirna, antioxidant enzymes, nuclear factor erythroid (nrf)2 and b-cell lymphoma (bcl)2 expressions by quantitative real time polymerase chain reaction (real time pcr) and western blot. |
2020-05-11 |
2023-08-13 |
human |
| Chuan Chen, Zhu Han, Minjie Yang, Zhongke Jiang, Xiuyuan O. Induction of apoptosis by Xiakemycin A in human hepatoma HepG2 cells. Medicine. vol 99. issue 17. 2020-05-08. PMID:32332640. |
apoptosis of hepg2 cells treated with xka was determined by annexin v-fitc/propidium iodide double staining and western blot analysis, respectively.xka had a significant dose-dependent elevation of chromatic agglutination, reactive oxygen species generation, annexin v and propidium iodide staining, decrease of membrane potential. |
2020-05-08 |
2023-08-13 |
human |
| Lu Chen, Lei Liu, Zhi-Yang Xie, Feng Wang, Lei Zhu, Cong Zhang, Pan Fan, Arjun Sinkemani, Xin Hong, Xiao-Tao W. Protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2α pathway attenuates tumor necrosis factor alpha-induced apoptosis in nucleus pulposus cells by activating autophagy. Journal of cellular physiology. vol 234. issue 7. 2020-05-05. PMID:30515797. |
trypan blue exclusion assay, cell flow cytometry, terminal deoxynucleotidyl transferase dutp nick end labeling staining, qrt-pcr, and western blot analyses were performed to examine the apoptosis of npcs. |
2020-05-05 |
2023-08-13 |
rat |
| Xiang Shao, Suhua Zhang, Ying Tang, Weixin Kon. Micro RNA-30b (inhibitor) nanoparticles suppressed the lipopolysaccharide (LPS)-induced acute kidney injury. IET nanobiotechnology. vol 13. issue 9. 2020-05-05. PMID:31811760. |
western blot analysis showed that lps induced severe apoptosis of hk-2 cells and the apoptosis was further promoted by the pag-mir (mimic). |
2020-05-05 |
2023-08-13 |
human |
| Yafeng Shang, Yanjie Kang, Jiantao Sun, Pengtao Wei, Jinhui Yang, Han Zhan. MiR-145-modulated SOX9-mediated hypospadias through acting on mitogen-activated protein kinase signaling pathway. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30565690. |
the expressions of proteins that symbolized cell apoptosis and oxidative stress were quantified via western blot analysis. |
2020-05-04 |
2023-08-13 |
rat |
| Elham Ramazani, Masoud Fereidoni, Zahra Tayarani-Najara. Protective effects of vitamin K2 on 6-OHDA-induced apoptosis in PC12 cells through modulation bax and caspase-3 activation. Molecular biology reports. vol 46. issue 6. 2020-05-01. PMID:31392537. |
the protective effects of vitamin k2 against 6-ohda-induced apoptosis in pc12 cells were assessed using resazurin for viability, dcf-da for ros level, dtnb for glutathione level, flow cytometry for sub g1, and western blot analysis for detecting bax and pro-caspase-3 expression level. |
2020-05-01 |
2023-08-13 |
Not clear |
| Pingping Sun, Lingqi Gu, Jiashan Luo, Yi Qin, Lingli Sun, Shengyang Jian. ROS-mediated JNK pathway critically contributes to PFOS-triggered apoptosis in SH-SY5Y cells. Neurotoxicology and teratology. vol 75. 2020-05-01. PMID:31401057. |
the doses of pfos that initiates jnk activation coincides with that inducing neuronal apoptosis, as confirmed by western blot and annexin v-pe/7-aad analyses. |
2020-05-01 |
2023-08-13 |
Not clear |
| Yan Hao, Weiwei Wang, Dong Wu, Kai Liu, Yihan Su. Bilobalide alleviates tumor necrosis factor-alpha-induced pancreatic beta-cell MIN6 apoptosis and dysfunction through upregulation of miR-153. Phytotherapy research : PTR. vol 34. issue 2. 2020-04-30. PMID:31667906. |
min6 cells were treated by tnf-α; then, viability, apoptosis, and insulin secretion were assessed by performing cell counting kit-8 assay, flow cytometry, glucose-stimulated insulin secretion assay, and western blot. |
2020-04-30 |
2023-08-13 |
Not clear |
| Haiyan Li, Zhe Wang, Yihai Wang, Jingwen Xu, Xiangjiu H. Triterpenoids with anti-proliferative effects from the seeds of Peganum harmala L. Phytochemistry. vol 174. 2020-04-30. PMID:32172018. |
additionally, these three triterpenoids induced the apoptosis in hela cells, which was detected by western blot analysis. |
2020-04-30 |
2023-08-13 |
Not clear |
| X Qin, X Y Wang, J W Fei, F H Li, J Han, H X Wan. MiR-20a promotes lung tumorigenesis by targeting RUNX3 via TGF-β signaling pathway. Journal of biological regulators and homeostatic agents. vol 34. issue 2. 2020-04-29. PMID:32347076. |
the analysis of cell growth and apoptosis were performed by mtt, xenograft models, western blot assays. |
2020-04-29 |
2023-08-13 |
human |
| Jun Zhou, Liang Xia, Yu Zhan. Naringin inhibits thyroid cancer cell proliferation and induces cell apoptosis through repressing PI3K/AKT pathway. Pathology, research and practice. vol 215. issue 12. 2020-04-27. PMID:31727500. |
moreover, cell proliferation and apoptosis related genes (cyclin d1, c-myc, survivin, caspase3, bcl-2, and bax) were measured by western blot assay and quantitative reverse transcription-polymerase chain reaction (qrt-pcr) respectively. |
2020-04-27 |
2023-08-13 |
Not clear |
| X Zhang, H Guo, A Xie, O Liao, F J. microRNA-331-3p attenuates neuropathic pain following spinal cord injury via targeting RAP1A. Journal of biological regulators and homeostatic agents. vol 34. issue 1. 2020-04-23. PMID:32264665. |
neuronal tissue damage and apoptosis were detected by histological analyses and western blot. |
2020-04-23 |
2023-08-13 |
rat |
| Peng Zhang, Long Zhou, Lei Wang, Qirong Don. A Novel Nanofiber Hydrogel Loaded with Platelet-Rich Plasma Promotes Wound Healing Through Enhancing the Survival of Fibroblasts. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-04-20. PMID:31739310. |
cell apoptosis was assessed by flow cytometry and western blot analysis. |
2020-04-20 |
2023-08-13 |
mouse |
| Liping Yan, Ani Sun, Xinwei X. Zafirlukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Reduces the Effect of Advanced Glycation End-Products in Rat Renal Mesangial Cells In Vitro. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-04-20. PMID:31745068. |
cell apoptosis was assessed by flow cytometry, and western blot was used to measure protein levels. |
2020-04-20 |
2023-08-13 |
rat |