| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiang Gao, Zhenping Liu, Meifeng Zhong, Kunhe Wu, Yuzhao Zhang, Hongmei Wang, Tao Zen. Knockdown of DNA/RNA-binding protein KIN17 promotes apoptosis of triple-negative breast cancer cells. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655766. |
in addition, western blot analysis was performed to investigate the mechanism of kin17 in the apoptosis of mda-mb-231 cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Deliang Cheng, Jiageng Li, Lijun Zhang, Leiming H. miR-142-5p suppresses proliferation and promotes apoptosis of human osteosarcoma cell line, HOS, by targeting PLA2G16 through the ERK1/2 signaling pathway. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655907. |
western blot analysis indicated that mir-142-5p transfection reduced bcl2, apoptosis regulator expression and upregulated the expression of casp3 and bcl2 associated x, apoptosis regulator in hos cells. |
2020-09-30 |
2023-08-13 |
human |
| Zan Liu, Licheng Ren, Xu Cui, Le Guo, Bimei Jiang, Jie Zhou, Pengfei Liang, Jizhang Zeng, Zhiyou He, Pihong Zhan. Muscular proteomic profiling of deep pressure ulcers reveals myoprotective role of JAK2 in ischemia and reperfusion injury. American journal of translational research. vol 10. issue 11. 2020-09-30. PMID:30662596. |
finally, western blot analysis determined that p-jak2, p-akt, p-mtor and p-erk1/2 levels were significantly elevated, accompanied by jak2 overexpression but without p-stat3, and inhibition of the akt and erk1/2 pathway resulted in elevated apoptosis and/or autophagy. |
2020-09-30 |
2023-08-13 |
Not clear |
| Qiang Li, Ying Zhang, Jing Sun, Qiyu B. Paeonol-mediated apoptosis of hepatocellular carcinoma cells by NF-κB pathway. Oncology letters. vol 17. issue 2. 2020-09-30. PMID:30675235. |
the expression levels of nf-κb and protein apoptosis inhibitor-5 (p-api-5) were detected by semi-quantitative polymerase chain reaction (pcr) and western blot analysis, respectively, and the activity of nf-κb in cells was measured by nf-κb p65/50. |
2020-09-30 |
2023-08-13 |
human |
| Li Zhao, Xue Rong Yang, Xu Ha. MicroRNA-146b induces the PI3K/Akt/NF-κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN. Experimental and therapeutic medicine. vol 17. issue 2. 2020-09-30. PMID:30679990. |
an mtt assay, annexin v/propidium iodide (pi) apoptosis assay, elisa kits, western blot analysis and a caspase-3/8 activity assay were used to measure cell growth, vascular apoptosis inflammatory factors, and the b-cell lymphoma 2-associated x protein (bax), phosphatase and tensin homolog (pten), phosphoinositide 3-kinase (pi3k)/akt/nuclear factor (nf)-κb signaling pathway. |
2020-09-30 |
2023-08-13 |
rat |
| Ying Chen, Jian-Chang Wang, Chun-Min Yang, Qin Fan, Jun Zheng, Hao Li. Positive acceleration adaptive training attenuates gastric ischemia-reperfusion injury through COX-2 and PGE2 expression. Experimental and therapeutic medicine. vol 17. issue 4. 2020-09-30. PMID:30930978. |
a western blot assay was used to analyze tumor necrosis factor-α (tnf)-α, tumor necrosis factor receptor 1 (tnfr1), tumor necrosis factor-related apoptosis inducing ligand (trail), death receptor (dr) 4, dr5, cyclooxygenase (cox)-2, cox-1 and prostaglandin e2 (pge2) protein expression levels. |
2020-09-30 |
2023-08-13 |
rat |
| Toshiki Etani, Taku Naiki, Aya Naiki-Ito, Takayoshi Suzuki, Keitaro Iida, Satoshi Nozaki, Hiroyuki Kato, Yuko Nagayasu, Shugo Suzuki, Noriyasu Kawai, Takahiro Yasui, Satoru Takahash. NCL1, A Highly Selective Lysine-Specific Demethylase 1 Inhibitor, Suppresses Castration-Resistant Prostate Cancer Growth via Regulation of Apoptosis and Autophagy. Journal of clinical medicine. vol 8. issue 4. 2020-09-30. PMID:30935141. |
as shown by western blot and flow cytometry analyses, ncl1 also dose-dependently induced caspase-dependent apoptosis. |
2020-09-30 |
2023-08-13 |
mouse |
| Zhao Luo, Zhen Zhang, Fuyu Zhang, Ying Liu, Yang Zhang, Xiaodong Sun, Ming Sang, Huiyu Lu. Ropivacaine mesylate exerts neurotoxicity via up-regulation of Fas/FasL expression in rat pheochromocytoma PC12 cells. American journal of translational research. vol 11. issue 3. 2020-09-30. PMID:30972188. |
then, cells in 0.5 mmol/l ropivacaine group, 2 mmol/l ropivacaine group and control group were subjected to morphological observation under a light microscope, assessment of cell necrosis by hoechst33342/pi staining and apoptosis by annexin v-fitc/pi staining, and the detection of fas and fasl expression by qpcr, immunofluorescence and western blot. |
2020-09-30 |
2023-08-13 |
rat |
| Jia Huang, Zhenping Ding, Qingquan Luo, Wenrong X. Cancer cell-derived exosomes promote cell proliferation and inhibit cell apoptosis of both normal lung fibroblasts and non-small cell lung cancer cell through delivering alpha-smooth muscle actin. American journal of translational research. vol 11. issue 3. 2020-09-30. PMID:30972195. |
western blot, immunofluorescence, qpcr, cck-8 and av/pi were used to detect protein level, gene expression, cell proliferation and cell apoptosis, respectively. |
2020-09-30 |
2023-08-13 |
Not clear |
| Miki Takata, Elena Pachera, Mojca Frank-Bertoncelj, Anastasiia Kozlova, Astrid Jüngel, Michael L Whitfield, Shervin Assassi, Maurizio Calcagni, Jeska de Vries-Bouwstra, Tom W Huizinga, Fina Kurreeman, Gabriela Kania, Oliver Distle. OTUD6B-AS1 Might Be a Novel Regulator of Apoptosis in Systemic Sclerosis. Frontiers in immunology. vol 10. 2020-09-30. PMID:31156645. |
apoptosis was measured by caspase 3/7 assay and western blot for cleaved caspase 3. |
2020-09-30 |
2023-08-13 |
human |
| Koita Sacko, Karthik Thangavel, Sunday A Shoyel. Codelivery of Genistein and miRNA-29b to A549 Cells Using Aptamer-Hybrid Nanoparticle Bioconjugates. Nanomaterials (Basel, Switzerland). vol 9. issue 7. 2020-09-30. PMID:31340494. |
the ability of gmlhn to downregulate targeted oncoproteins phosphorylated protein kinase, strain ak, thymoma (phosphorylated protein kinase b) (pakt), phosphorylated phosphoinositide 3-kinase (p-pi3k), dna (cytosine-5-)-methyltransferase 3 beta (dnmt3b) and myeloid cell leukemia sequence 1 (mcl 1) was evaluated using western blot, while antiproliferative effect and ability to initiate apoptosis was also assessed in a549 cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Wenwen Zhou, Xiaoyu Wang, Duanduan Yin, Lei Xue, Zhongfeng Ma, Zhenzhen Wang, Qianyi Zhang, Zishu Zhao, Haixia Wang, Yan Sun, Yanhong Yan. Effect of miR-140-5p on the regulation of proliferation and apoptosis in NSCLC and its underlying mechanism. Experimental and therapeutic medicine. vol 18. issue 2. 2020-09-30. PMID:31363375. |
western blot assays was performed to investigate the expression levels of yes1 and proteins associated with apoptosis in a549 cells following transfection. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yi Pei, Yueyan Zhang, Ke Zheng, Guanning Shang, Yuming Wang, Wei Wang, Enduo Qiu, Xiaojing Zhan. Ursolic acid suppresses the biological function of osteosarcoma cells. Oncology letters. vol 18. issue 3. 2020-09-30. PMID:31404298. |
western blot analysis and reverse transcription-quantitative polymerase chain reaction were used to detect the effects of different concentrations of ursolic acid on egfr signaling pathway-related proteins, cell cycle, apoptosis and cell migration-related proteins. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xian-Liang Meng, Dong-Lin Zhang, Shi-Hua Su. Acute remote ischemic preconditioning alleviates free radical injury and inflammatory response in cerebral ischemia/reperfusion rats. Experimental and therapeutic medicine. vol 18. issue 3. 2020-09-30. PMID:31410157. |
in addition, cell apoptosis was markedly suppressed by iprec with an increased expression of b-cell lymphoma 2 (bcl-2)/bcl-2-associatd x protein using terminal deoxynucleotidyl-transferase-mediated dutp nick end labeling assay and western blot analysis. |
2020-09-30 |
2023-08-13 |
rat |
| Qi Wu, Xiaoqing Zhou, Peng Li, Wei Wang, Jun Wang, Mingyue Tan, Le Tao, Jianxin Qi. High NRBP1 expression promotes proliferation and correlates with poor prognosis in bladder cancer. Journal of Cancer. vol 10. issue 18. 2020-09-30. PMID:31413746. |
the expression of apoptosis markers was detected by western blot. |
2020-09-30 |
2023-08-13 |
Not clear |
| Doaa M Ali, Shariq S Ansari, Michael Zepp, Michaela Knapp-Mohammady, Martin R Berge. Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells. Cell death discovery. vol 5. 2020-09-30. PMID:31428460. |
the influence on cell cycle distribution and cell death signaling cascades was followed by facs, assays for apoptosis, rt-pcr, and western blot. |
2020-09-30 |
2023-08-13 |
human |
| Haiying Dong, Weiliang Cong, Xiwen Guo, Yuhua Wang, Shengju Tong, Qiang Li, Chengchong L. β-asarone relieves chronic unpredictable mild stress induced depression by regulating the extracellular signal-regulated kinase signaling pathway. Experimental and therapeutic medicine. vol 18. issue 5. 2020-09-30. PMID:31616508. |
in addition, the apoptosis of hippocampal neuronal cells was determined by flow cytometry, gene expression levels were detected by reverse transcription-quantitative polymerase chain reaction and protein levels were determined by western blot assay. |
2020-09-30 |
2023-08-13 |
rat |
| Juan Li, Lei Zheng, Mi Yan, Jing Wu, Yongqing Liu, Xiaona Tian, Wen Jiang, Lu Zhang, Rongmei Wan. Activity and mechanism of flavokawain A in inhibiting P-glycoprotein expression in paclitaxel resistance of lung cancer. Oncology letters. vol 19. issue 1. 2020-09-30. PMID:31897150. |
flow cytometry, western blot analysis and annexin v-fitc/pi apoptosis detection kit were used to assess cell apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yong-Bin Wang, Zhi-Ming Ge, Wei-Qiang Kang, Zhe-Xun Lian, Jian Yao, Chang-Yong Zho. Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes. Experimental and therapeutic medicine. vol 9. issue 2. 2020-09-29. PMID:25574214. |
the expression levels of cellular proteins associated with apoptosis were measured by western blot analysis, while the levels of inflammatory factors were assessed by immunohistochemical analyses. |
2020-09-29 |
2023-08-13 |
rat |
| Ming-Xin Ren, Xiao-Hui Deng, Fang Ai, Guo-Yan Yuan, Hai-Yan Son. Effect of quercetin on the proliferation of the human ovarian cancer cell line SKOV-3 Experimental and therapeutic medicine. vol 10. issue 2. 2020-09-29. PMID:26622357. |
cell apoptosis was determined using hoechst staining, and western blot analysis was used to analyze changes in the expression levels of survivin protein. |
2020-09-29 |
2023-08-13 |
human |