| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Geum-A Lee, Kyung-Chul Choi, Kyung-A Hwan. Treatment with Phytoestrogens Reversed Triclosan and Bisphenol A-Induced Anti-Apoptosis in Breast Cancer Cells. Biomolecules & therapeutics. vol 26. issue 5. 2020-09-30. PMID:29310425. |
based on these results, the effects of tcs, bpa, kaem, and dim on protein expression of apoptosis and ros production-related markers such as bax and bcl-xl, as well as endoplasmic reticulum (er) stress-related markers such as eif2α and chop were investigated by western blot assay. |
2020-09-30 |
2023-08-13 |
Not clear |
| Si Luo, Zhen Pan, Shuang Liu, Shujing Yuan, Nianlong Ya. Sphingomyelin synthase 2 overexpression promotes cisplatin-induced apoptosis of HepG2 cells. Oncology letters. vol 15. issue 1. 2020-09-30. PMID:29375716. |
furthermore, cell viability was quantified, and apoptosis was assessed by western blot and flow cytometry analysis as well as cell counting kit-8. |
2020-09-30 |
2023-08-13 |
Not clear |
| Qian-Ming Qi, Yin-Cun Xue, Jian Lv, Di Sun, Jian-Xin Du, Sheng-Qiang Cai, Yun-He Li, Tian-Cun Gu, Mu-Bing Wan. Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway. Oncology letters. vol 15. issue 5. 2020-09-30. PMID:29725398. |
autophagy in hepg2 cells was down regulated using 3-methyladenine (3-ma) or beclin-1-specific small interfering rna (sirna) and the expression of apoptosis associated proteins caspase-3, bax/bcl-2, and the autophagy-associated protein 5 and microtubule-associated protein 1a/1b-light chain 3 in the ga-treated hepg2 cells were all measured by western blot analysis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Dong Chen, Junyi Chen, Yihong Guo, Yining L. Cinobufacini promotes apoptosis of bladder cancer cells by influencing the expression of autophagy-related genes. Oncology letters. vol 15. issue 5. 2020-09-30. PMID:29725433. |
flow cytometry and hoechst staining were used to detect the changes in the apoptosis of bladder cancer cells after being treated with cinobufacini; the changes in the expression levels of human bladder cancer cell apoptosis-related genes and proteins, cleaved caspase-3, bax, b-cell lymphoma-2 (bcl-2) and autophagy-related genes and proteins, p62, light chain 3 (lc3) and autophagy-related protein 7 (atg7) after treatment with cinobufacini were detected by western blot analysis and reverse transcription polymerase chain reaction (rt-pcr). |
2020-09-30 |
2023-08-13 |
human |
| Sha Feng, Jue Liu, Biao Cheng, Aiping Deng, Hong Zhan. (-)-Epigallocatechin-3-gallate protects PC12 cells against corticosterone-induced neurotoxicity via the hedgehog signaling pathway. Experimental and therapeutic medicine. vol 15. issue 5. 2020-09-30. PMID:29731823. |
cell viability was assessed using an mtt assay, changes in cell morphology were observed using phase-contrast microscopy, cellular apoptosis was assessed by hoechst 33342 staining, cell proliferation was measured using a cell counting kit-8 assay, mrna levels were measured by reverse transcription-quantitative polymerase chain reaction and protein expression was assessed using western blot analysis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yuyang Xue, Cong Chen, Wei Xu, Hao Xu, Junnian Zheng, Yuming G. Downregulation of Frizzled-7 induces the apoptosis of hepatocellular carcinoma cells through inhibition of NF-κB. Oncology letters. vol 15. issue 5. 2020-09-30. PMID:29731900. |
additionally, it was revealed that silencing of fzd7 expression caused the downregulation of apoptosis regulator bcl-2 and bcl-xl in hepg2, and huh-7 cells, as determined through western blot analysis and reverse transcription-quantitative polymerase chain reaction. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yuchen Wang, Huali Xu, Zeyuan Lu, Xiaofeng Yu, Chen Lv, Yuan Tian, Dayun Su. Pseudo-Ginsenoside Rh2 induces A549 cells apoptosis via the Ras/Raf/ERK/p53 pathway. Experimental and therapeutic medicine. vol 15. issue 6. 2020-09-30. PMID:29805515. |
the expression of apoptosis associated proteins was identified by western blot analysis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Weixin Yan, Shouhui Chen, Yiyang Zhao, Xiaoyu Y. Fisetin inhibits the proliferation of gastric cancer cells and induces apoptosis through suppression of ERK 1/2 activation. Oncology letters. vol 15. issue 6. 2020-09-30. PMID:29805580. |
apoptosis was analyzed using an annexin v/propidium iodide apoptosis kit and phosphorylation of extracellular signal-regulated kinase (erk) 1/2 was analyzed by western blot assay. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jinhui Zhu, Yun Ji, Yuanquan Yu, Yun Jin, Xiaoxiao Zhang, Jiale Zhou, Yan Che. Knockdown of serine/threonine protein phosphatase 5 enhances gemcitabine sensitivity by promoting apoptosis in pancreatic cancer cells Oncology letters. vol 15. issue 6. 2020-09-30. PMID:29805615. |
western blot analysis was applied to detect the expression of certain key regulators of cell apoptosis in panc-1 cells treated with gem. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yan Ding, Wei Liu, Xiaoling Wang, Lingling Zhang, Meng Zhao, Huiyan Deng, Yueping Li. Bufalin induces apoptosis in human esophageal carcinoma ECA109 cells by inhibiting the activation of the mTOR/p70S6K pathway. Oncology letters. vol 15. issue 6. 2020-09-30. PMID:29805658. |
the levels of p70s6k, phosphorylated (p)-p70s6k, cellular inhibitor of apoptosis-1 (ciap-1) and bcl-2-associated death promoter (bad) in eca109 cells were examined by western blot analysis, and apoptosis was detected by flow cytometry analysis and giemsa staining. |
2020-09-30 |
2023-08-13 |
human |
| Hong-Ping Zhou, Lu-Xi Qian, Nan Zhang, Jia-Jia Gu, Kai Ding, Jing Wu, Zhi-Wei Lu, Ming-Yu Du, Hong-Ming Zhu, Jian-Zhong Wu, Xia He, Li Yi. MIIP gene expression is associated with radiosensitivity in human nasopharyngeal carcinoma cells. Oncology letters. vol 15. issue 6. 2020-09-30. PMID:29805670. |
the expression of bcl2 associated x, apoptosis regulator/b-cell lymphoma 2 was evaluated using western blot. |
2020-09-30 |
2023-08-13 |
human |
| Meifen Chu, Tongtong Wang, Aihua Sun, Yu Che. Nimesulide inhibits proliferation and induces apoptosis of pancreatic cancer cells by enhancing expression of PTEN. Experimental and therapeutic medicine. vol 16. issue 1. 2020-09-30. PMID:29896263. |
western blot analysis demonstrated that nimesulide increased expression of cleaved caspase-3 and apoptosis regulator bax (bcl-2 associated protein x), and decreased the expression of pro-caspase-3 and apoptosis regulator bcl-2 (b-cell lymphoma 2). |
2020-09-30 |
2023-08-13 |
Not clear |
| Aili Li, Qingqing Wang, Gaofeng He, Junfei Jin, Guojin Huan. DEP domain containing 1 suppresses apoptosis via inhibition of A20 expression, which activates the nuclear factor κB signaling pathway in HepG2 cells. Oncology letters. vol 16. issue 1. 2020-09-30. PMID:29963168. |
cell proliferation was examined using an mtt assay and apoptosis was analyzed via detection of the apoptotic marker caspase-3 using western blot analysis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yuan Wang, Shao-Wei Yin, Nan Zhang, Ping Zha. High-concentration sevoflurane exposure in mid-gestation induces apoptosis of neural stem cells in rat offspring. Neural regeneration research. vol 13. issue 9. 2020-09-30. PMID:30127118. |
the brains were harvested to examine neural stem cell apoptosis by immunofluorescence and to measure nestin and sox-2 levels by western blot assay at 6, 24 and 48 hours after anesthesia as well as on postnatal day (p) 0, 14 and 28. |
2020-09-30 |
2023-08-13 |
rat |
| Xiangyu Cui, Dezhou Sun, Bin Shen, Xin Wan. MEG-3-mediated Wnt/β-catenin signaling pathway controls the inhibition of tunicamycin-mediated viability in glioblastoma. Oncology letters. vol 16. issue 3. 2020-09-30. PMID:30127865. |
western blot analysis, the reverse transcription-quantitative polymerase chain reaction, immunohistochemistry, apoptosis assays and immunofluorescence were employed to examine the effects of tunicamycin on apoptosis, viability, aggressiveness and cell cycle arrest of glioblastoma cells by downregulation of the expression levels of fibronectin and epithelial cadherin. |
2020-09-30 |
2023-08-13 |
Not clear |
| Shuna Yao, Yanyan Liu, Zhihua Yao, Yan Zhao, Haiying Wang, Yuanlin Xu, Jiuyang Zhang, Jing Li, Shujun Yan. MicroRNA-376a regulates cell proliferation and apoptosis by targeting forkhead box protein P2 in lymphoma. Oncology letters. vol 16. issue 3. 2020-09-30. PMID:30127911. |
the expression of mir-376a in lymphoma issue and cells was detected by reverse transcription quantitative polymerase chain reaction (rt-qpcr), the expression of forkhead box protein p2 (foxp2) was detected by rt-qpcr and western blot analysis, and the effect of mir-376a on cell proliferation and apoptosis were studied by an mtt assay and flow cytometry, respectively. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jingyan Liang, Weiguang Wang, Lifu Wei, Shan Gao, Yingge Wan. Oridonin inhibits growth and induces apoptosis of human neurocytoma cells via the Wnt/β-catenin pathway. Oncology letters. vol 16. issue 3. 2020-09-30. PMID:30127932. |
the annexin v-fluorescein isothiocyanate/propidium iodide assay and western blot analysis demonstrated that oridonin was able to induce apoptosis and alter the expression of apoptosis-associated proteins by downregulating anti-apoptotic protein, b-cell lymphoma-2 (bcl-2), and upregulating pro-apoptosis proteins, bcl-2-like protein 4, cleaved caspase-3 and cleaved poly(adp-ribose) polymerase 1. |
2020-09-30 |
2023-08-13 |
human |
| Zhiyao Zhang, Zhenyu Li, Wenming Che. Down-regulated G protein-coupled receptor kinase 6 leads to apoptosis in multiple myeloma MM1R cells. Experimental and therapeutic medicine. vol 16. issue 5. 2020-09-30. PMID:30402162. |
western blot analysis was performed to assess the apoptosis and signal transducer and activator of transcription 3 pathway-related factors. |
2020-09-30 |
2023-08-13 |
human |
| Fangping Bao, Xianhui Kang, Qing Xie, Jian W. HIF-α/PKM2 and PI3K-AKT pathways involved in the protection by dexmedetomidine against isoflurane or bupivacaine-induced apoptosis in hippocampal neuronal HT22 cells. Experimental and therapeutic medicine. vol 17. issue 1. 2020-09-30. PMID:30651766. |
the levels of apoptosis were examined by flow cytometry utilizing annexin v-fluorescein isothiocyanate/propidium iodide double staining, and the protein expression levels of cleaved caspase-3, phosphorylated phosphoinositide 3'-kinase (p-pi3k), p-protein kinase b (p-akt), hypoxia inducible factor (hif-α), pyruvate kinase m2 (pkm2), b-cell lymphoma (bcl-2)-associated x protein (bax), bcl-2 and cytochrome c were detected by western blot analysis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jian Hao, Xin Zhao, Weimin Yu, Xiaoguang Huang, Yirong Huan. Surfactant protein A induces the pathogenesis of renal fibrosis through binding to calreticulin. Experimental and therapeutic medicine. vol 17. issue 1. 2020-09-30. PMID:30651822. |
furthermore, cell apoptosis was assessed using an annexin v assay and the expression of various proteins was measured using western blot analysis. |
2020-09-30 |
2023-08-13 |
human |