| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiwei Li, Jieke Cui, Zhaoming Li, Xiaorui Fu, Jing Li, Hongwen Li, Shilei Wang, Mingzhi Zhan. ORP8 induces apoptosis by releasing cytochrome c from mitochondria in non‑small cell lung cancer. Oncology reports. vol 43. issue 5. 2021-02-05. PMID:32323800. |
further experiments demonstrated that orp8 overexpression induced the apoptosis of nsclc cells via the release of cytochrome c from mitochondria into the cytoplasm with western blot analysis and confocal microscopy results. |
2021-02-05 |
2023-08-13 |
Not clear |
| Weipeng Zhou, Xianjun Zeng, Xiaoping W. Effect of Oleanolic Acid on Apoptosis and Autophagy of SMMC-7721 Hepatoma Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-05. PMID:32424110. |
to evaluate the ability of oa on apoptosis and autophagy mechanisms on smmc 7721 cells, the related protein expression for apoptosis, autophagy, and the autophagic pathway were detected and analyzed by western blot. |
2021-02-05 |
2023-08-13 |
Not clear |
| May Al-Maghrebi, Abdullah S Alnajem, Ali Esmaei. Epigallocatechin-3-gallate modulates germ cell apoptosis through the SAFE/Nrf2 signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 4. 2021-02-03. PMID:31807839. |
biochemical assays were used to investigate the oxidative, apoptosis proteins and enzymes, while western blot was used to detect the expression of nox and nrf2. |
2021-02-03 |
2023-08-13 |
rat |
| Yaqi Xu, Qian Zhou, Xiaoli Feng, Yibo Dai, Yang Jiang, Wen Jiang, Xiaoli Liu, Xiangling Xing, Yongjing Wang, Yihong Ni, Chengyun Zhen. Disulfiram/copper markedly induced myeloma cell apoptosis through activation of JNK and intrinsic and extrinsic apoptosis pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 126. 2021-02-03. PMID:32145587. |
moreover, jc-1 and western blot results showed that dsf/cu disrupted mitochondrial membrane integrity and cleaved caspase-8 in mm cells, respectively, suggesting that it induced activation of extrinsic and intrinsic apoptosis pathways. |
2021-02-03 |
2023-08-13 |
mouse |
| Lili Ji, Xing Fan, Feng Zhou, Jun Gu, Xuedong Den. lncRNA RPL34-AS1 inhibits cell proliferation and invasion while promoting apoptosis by competitively binding miR-3663-3p/RGS4 in papillary thyroid cancer. Journal of cellular physiology. vol 235. issue 4. 2021-02-02. PMID:31587286. |
western blot analysis was used to assess the apoptosis proteins bax and bcl-2. |
2021-02-02 |
2023-08-13 |
Not clear |
| Yajun Deng, Liang Yang, Qiqi Xie, Fengbiao Yang, Guoqiang Li, Guangzhi Zhang, Shaoping Li, Zuolong Wu, Jing Wang, Xuewen Kan. Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis. Mediators of inflammation. vol 2020. 2021-02-01. PMID:32273830. |
western blot, elisa, and tunel assays were used to detect cell signal transduction, inflammation, and apoptosis, respectively. |
2021-02-01 |
2023-08-13 |
rat |
| Mitu Sharma, Mani Ganeshpandian, Munmi Majumder, Ajaykamal Tamilarasan, Mukesh Sharma, Rupak Mukhopadhyay, Nashreen S Islam, Mallayan Palaniandava. Octahedral copper(ii)-diimine complexes of triethylenetetramine: effect of stereochemical fluxionality and ligand hydrophobicity on Cu Dalton transactions (Cambridge, England : 2003). vol 49. issue 24. 2021-02-01. PMID:32510543. |
the finding of the up-regulation of the pro-apoptotic bax protein and down-regulation of parp protein in western blot analysis confirms the induction of apoptosis by these complexes. |
2021-02-01 |
2023-08-13 |
human |
| Shaoting Zhang, Guangrong Zhu, Jun Shi, Jihui Yang, Zongying Jiang, Liangying Zhang, Kaikai Dou, Jianmin Su. [PI3K isoforms PI3Kβ and PI3Kδ play different roles in KIT mutation-mediated cell transformation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 1. 2021-02-01. PMID:33441227. |
gist-t1 cells were treated with the same drug, and the activation of kit and its downstream signals was also detected by immunoprecipitation and western blot analysis, and cell proliferation and apoptosis were detected by mtt assay and flow cytometry, respectively. |
2021-02-01 |
2023-08-13 |
Not clear |
| Jie Wang, Yingze Ma, Min Guo, Haixia Yang, Xiaohui Gua. Salvianolic acid B suppresses EMT and apoptosis to lessen drug resistance through AKT/mTOR in gastric cancer cells. Cytotechnology. vol 73. issue 1. 2021-01-30. PMID:33505113. |
the colony formation, ros generation, apoptosis, migration, invasion and emt marker proteins were respectively analyzed through formation assay, ros kits, tunnel staining, wound healing, transwell assays and western blot. |
2021-01-30 |
2023-08-13 |
Not clear |
| Zhenqing Sun, Zhigang Qiu, Bin Ma, Zhengkun Wan. Encorafenib enhances TRAIL-induced apoptosis of colorectal cancer cells dependent on p53/PUMA signaling. Cytotechnology. vol 73. issue 1. 2021-01-30. PMID:33505114. |
flow cytometry was used to detect the cell apoptosis of crc cells and western blot was used to measure the expressions of apoptosis-related proteins. |
2021-01-30 |
2023-08-13 |
Not clear |
| Hongyan Lv, Su Zhang, Xiaohong Ha. Swainsonine protects H9c2 cells against lipopolysaccharide-induced apoptosis and inflammatory injury via down-regulating miR-429. Cell cycle (Georgetown, Tex.). vol 19. issue 2. 2021-01-29. PMID:31876239. |
western blot was utilized to distinguish apoptosis and immune-related factors expression. |
2021-01-29 |
2023-08-13 |
Not clear |
| Jinfeng Zhou, Zhengxiang Huang, Xiao Ni, Chen L. Piperlongumine induces apoptosis and G Toxicology in vitro : an international journal published in association with BIBRA. vol 65. 2021-01-29. PMID:31987842. |
cell apoptosis was assessed via ao/eb staining and flow cytometry apoptosis as well as western blot analysis. |
2021-01-29 |
2023-08-13 |
Not clear |
| Ying Wang, Chun-Ping Yin, Yan-Lei Tai, Zi-Jun Zhao, Zhi-Yong Hou, Qiu-Jun Wan. Apoptosis inhibition is involved in improvement of sevoflurane-induced cognitive impairment following normobaric hyperoxia preconditioning in aged rats. Experimental and therapeutic medicine. vol 21. issue 3. 2021-01-29. PMID:33500697. |
the neurobehavioral assessment was performed using a morris water maze test, the expressions of the apoptosis proteins were determined using western blot analysis, and the apoptosis rate and cytosolic calcium concentration were measured by flow cytometry. |
2021-01-29 |
2023-08-13 |
rat |
| Sharareh Sharifi, Pargol Ghavam Mostafavi, Roghayeh Tarasi, Ali Mashinchian Moradi, Mohammad Hadi Givianrad, Mahdi Moridi Farimani, Samad Nejad Ebrahimi, Matthias Hamburger, Hassan Nikneja. Purified compounds from marine organism sea pen induce apoptosis in human breast cancer cell MDA-MB-231 and cervical cancer cell Hela. European journal of pharmacology. vol 877. 2021-01-27. PMID:32222494. |
immunocytochemistry and western blot analyses were used to evaluate the expression of apoptosis related markers caspase 3, caspase 8, bax and bcl2 in cancer cells after treating with three compounds. |
2021-01-27 |
2023-08-13 |
human |
| Li Cui, Ya-Nan Qiu, Ye Xu, Yu-Ou Teng, Peng Yu, Zhen Li. [Effect and mechanism of aspirin combined with vinorelbine on non-small cell lung cancer]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 24. 2021-01-27. PMID:33496142. |
furthermore, apoptosis, mitochondrial membrane potential, reactive oxygen species and western blot experiments were used to explore the synergistic mechanism of aspirin combined with vinorelbine in inhibiting cell proliferation. |
2021-01-27 |
2023-08-13 |
Not clear |
| Alexander V Sirotkin, Alexander V Makarevich, Elena Kubovicova, Marina Medvedova, Adriana Kolesarova, Abdel Halim Harrat. Relationship between body conditions and environmental contaminants in bovine ovarian cells. Theriogenology. vol 147. 2021-01-26. PMID:32120185. |
the accumulation of nuclear and cytoplasmic markers of apoptosis (p53 and bax, respectively), a proliferation marker (pcna), progesterone (p4), and insulin-like growth factor i (igf-i) was evaluated by western blot and radioimmunoassay (ria) experiments. |
2021-01-26 |
2023-08-13 |
cattle |
| Chenyue Ding, Qinyan Zou, Yifei Wu, Jiafeng Lu, Chunfeng Qian, Hong Li, Boxian Huan. EGF released from human placental mesenchymal stem cells improves premature ovarian insufficiency via NRF2/HO-1 activation. Aging. vol 12. issue 3. 2021-01-22. PMID:32040445. |
facs and western blot analyses showed that egf elevated the proliferation and reduced the apoptosis in hgcs. |
2021-01-22 |
2023-08-13 |
mouse |
| Ok Hyeon Kim, Ju-Hee Lee, Shinmee Mah, Sung Yun Park, Sungwoo Hong, Soon-Sun Hon. HS‑146, a novel phosphoinositide 3‑kinase α inhibitor, induces the apoptosis and inhibits the metastatic ability of human breast cancer cells. International journal of oncology. vol 56. issue 6. 2021-01-22. PMID:32236634. |
the induction of apoptosis by hs‑146 was confirmed by dapi staining and western blot analysis. |
2021-01-22 |
2023-08-13 |
human |
| Xueyan Zhang, Wen Liu, Shuxiang We. Luteolin affects keloid fibroblast proliferation and apoptosis by regulating FRAT1 gene expression. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 3. 2021-01-22. PMID:32538769. |
mtt method, western blot, flow cytometry, and real-time quantitative pcr (qpcr) were used to detect cell proliferation, cyclin d1 (cyclind1), p21, b-cell lymphoma / leukemia-2 (bcl-2), bcl-2 related x protein (bax), frat1 protein expression, apoptosis and arhi mrna expression. |
2021-01-22 |
2023-08-13 |
Not clear |
| Yan Duan, Wei An, Yunxia Wu, Jin Wan. Tetramethylpyrazine reduces inflammation levels and the apoptosis of LPS‑stimulated human periodontal ligament cells via the downregulation of miR‑302b. International journal of molecular medicine. vol 45. issue 6. 2021-01-21. PMID:32236610. |
cck‑8 assay was performed to evaluate cell viability, western blot analysis was performed to measure protein expression and flow cytometry was performed to detect cell apoptosis levels. |
2021-01-21 |
2023-08-13 |
human |