| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yunyi Chen, Jiaojiao Liang, Xiao Liang, Jiebiao Chen, Yue Wang, Jinping Cao, Chongde Sun, Jiaming Ye, Qingjun Che. Limonin induces apoptosis of HL-60 cells by inhibiting NQO1 activity. Food science & nutrition. vol 9. issue 4. 2021-04-13. PMID:33841805. |
western blot results showed that limonin could activate the endogenous apoptosis pathway mediated by mitochondria via up-regulating pro-apoptotic proteins (bax, cytochrome c, caspase3, and caspase9) and down-regulating anti-apoptotic proteins (bcl-2), thus inhibiting the proliferation of hl-60 cells and promoting apoptosis, which further proved the anticancer activity of limonin from the molecular mechanism. |
2021-04-13 |
2023-08-13 |
human |
| Ziliang Wang, Hao Zhang, Zuheng Liu, Zhuang Ma, Dongqi An, Dingli X. Apigenin attenuates myocardial infarction-induced cardiomyocyte injury by modulating Parkin-mediated mitochondrial autophagy. Journal of biosciences. vol 45. 2021-04-08. PMID:32515357. |
autophagy was detected by mitochondrial autophagy marker proteins [atypical protein kinase c (apkc)-interacting protein (p62) and bcl-2/adenovirus e1b 19-kd interacting protein 3 (bnip3)] viawestern blot, mitochondrial function was detected by jc-1 probe, and apoptosis was detected by flow cytometry. |
2021-04-08 |
2023-08-13 |
mouse |
| Chunfang Han, Haiying Yu, Qingxia Zho. Calcitriol Attenuates HRV-Induced Respiratory Injury through the AMPK-mTOR-ER Stress Signaling Pathway. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 40. issue 2. 2021-04-08. PMID:33822515. |
after hrv infection and treatment with calcitriol, the changes of cell viability were detected by mtt assay, the expression of er stress-induced apoptosis and ampk-mtor related proteins by western blot, and the cell apoptosis by flow cytometry assay. |
2021-04-08 |
2023-08-13 |
human |
| Yingchun Zhang, Xiaojuan Chu, Qingjie We. MiR-451 Promotes Cell Apoptosis and Inhibits Autophagy in Pediatric Acute Myeloid Leukemia by Targeting HMGB1. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 40. issue 2. 2021-04-08. PMID:33822516. |
after cells were co-transfected with pcdna-hmgb1 and pc-dna-ctrl, we investigated apoptosis and autophagy in mir-451 overexpressed cells perturbed by exogenous hmgb1 through mtt, flow cytometry, and western blot. |
2021-04-08 |
2023-08-13 |
Not clear |
| Nannan Zhang, Dan Wang, Xianglong Yang, Dongnan Ho. Long noncoding RNA small nucleolar RNA host gene 1 contributes to sevoflurane-induced neurotoxicity through negatively modulating microRNA-181b. Neuroreport. vol 31. issue 5. 2021-04-07. PMID:32150149. |
cell viability, reactive oxygen species (ros) generation, inflammation and apoptosis were measured by cell counting kit-8 assay, ros kit, elisa, flow cytometry and western blot assay. |
2021-04-07 |
2023-08-13 |
Not clear |
| Yuan Zhou, Meigui Wang, Jing Zhang, Peng Xu, Haitao Wan. MicroRNA-29a-3p regulates abdominal aortic aneurysm development and progression via direct interaction with PTEN. Journal of cellular physiology. vol 235. issue 12. 2021-04-06. PMID:32383156. |
furthermore, luciferase assay analyzed the luciferase activity and western blot analysis determined mirna-19a-3p and pmepa1 protein expression in proliferation and apoptosis biomarkers. |
2021-04-06 |
2023-08-13 |
Not clear |
| Linlin Qu, Yan Chen, Fan Zhang, Liang H. The lncRNA DLGAP1-AS1/miR-149-5p/TGFB2 axis contributes to colorectal cancer progression and 5-FU resistance by regulating smad2 pathway. Molecular therapy oncolytics. vol 20. 2021-04-06. PMID:33816780. |
cell counting kit-8 (cck-8) assay, transwell assay, flow cytometry, and western blot were utilized to measure the crc cell activity, invasiveness, and apoptosis. |
2021-04-06 |
2023-08-13 |
mouse |
| Lina Xing, Jinhai Ren, Xiaonan Guo, Shukai Qiao, Tian Tia. Decitabine shows anti-acute myeloid leukemia potential via regulating the miR-212-5p/CCNT2 axis. Open life sciences. vol 15. issue 1. 2021-04-06. PMID:33817287. |
cell apoptosis was evaluated by flow cytometry and western blot. |
2021-04-06 |
2023-08-13 |
Not clear |
| Bing-Fan Wu, Liu-Ji Zhang, Kai-Yan Li, Jian-Xia Wang, Wan-Qian Tu, Yu Zhan. [Protective effect of serum containing ginseng and Moutan Cortex on HUVEC injured by H_2O_2]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 6. 2021-04-02. PMID:33787145. |
the expressions of mitochondrial apoptosis pathway-related proteins bax, bcl-2, cytochrome c, caspase-3 and caspase-9 were detected by western blot. |
2021-04-02 |
2023-08-13 |
human |
| Xiang-Yang Zhou, Hong Liu, Zheng-Bin Ding, Hai-Peng Xi, Guang-Wei Wan. lncRNA SNHG16 Exerts Oncogenic Functions in Promoting Proliferation of Glioma Through Suppressing p21. Pathology oncology research : POR. vol 26. issue 2. 2021-03-31. PMID:30972632. |
the cell cycles and cell apoptosis were evaluated using flow cytometry, and the expression of snhg16, p21 and apoptosis biomarkers were qualified with qrt-pcr and western blot assays. |
2021-03-31 |
2023-08-13 |
human |
| Zviadi Aburjania, Jason D Whitt, Samuel Jang, Dwayaja H Nadkarni, Herbert Chen, J Bart Rose, Sadanandan E Velu, Renata Jaskula-Sztu. Synthetic Makaluvamine Analogs Decrease c-Kit Expression and Are Cytotoxic to Neuroendocrine Tumor Cells. Molecules (Basel, Switzerland). vol 25. issue 21. 2021-03-30. PMID:33114525. |
induction of apoptosis with these compounds was also supported by the decrease in myeloid cell leukemia-1 (mcl-1) and x-chromosome linked inhibitor of apoptosis (xiap) detected by western blot. |
2021-03-30 |
2023-08-13 |
Not clear |
| Yayu Li, Xue Jiang, Litao Song, Mengdie Yang, Jing Pa. Anti-apoptosis mechanism of triptolide based on network pharmacology in focal segmental glomerulosclerosis rats. Bioscience reports. vol 40. issue 4. 2021-03-29. PMID:32285909. |
tpl inhibited fsgs-induced cell apoptosis in rats and regulated il4, nephrin, podocin, and p53 protein levels via using cck8, tunel, and western blot assays. |
2021-03-29 |
2023-08-13 |
rat |
| Peibin Liu, Tufeng Chen, Fang Tan, Jingling Tian, Lei Zheng, Yingqing Deng, Jiaxin Chen, Xinjin Ch. Dexmedetomidine alleviated neuropathic pain in dorsal root ganglion neurons by inhibition of anaerobic glycolysis activity and enhancement of ROS tolerance. Bioscience reports. vol 40. issue 5. 2021-03-29. PMID:32285913. |
following treatment with h2o2, dexmedetomidine or ros inhibitor (nac), the apoptosis and ros levels were examined by flow cytometery; apoptosis- and anaerobic glycolysis-related proteins were determined by western blot assay; glucose consumption, pyruvic acid, lactic acid and atp/adp ratios were also measured. |
2021-03-29 |
2023-08-13 |
rat |
| Meng Jin, Xiuna Ji, Rostyslav Stoika, Kechun Liu, Lizhen Wang, Yang Son. Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study. Bioorganic chemistry. vol 101. 2021-03-29. PMID:32629278. |
it was shown that the synthesized fluorescent derivative could penetrate into human breast carcinoma mcf7 cells, and then induced apoptosis detected by the western blot analysis as changed expression of apoptosis-related proteins, including bax, bcl2, and cyto c released from mitochondria, cleaved caspase 9, cleaved parp, pro-caspase 3, and cleaved caspase 3. |
2021-03-29 |
2023-08-13 |
human |
| Meng Jin, Xiuna Ji, Rostyslav Stoika, Kechun Liu, Lizhen Wang, Yang Son. Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study. Bioorganic chemistry. vol 101. 2021-03-29. PMID:32629278. |
together with the results of western blot analysis, these data indicated that the mitochondria pathway might be involved in berberine-induced apoptosis. |
2021-03-29 |
2023-08-13 |
human |
| Shan Tang, Hongyan Zhong, Ting Xiong, Xinquan Yang, Yongqing Mao, Daxin Wan. MiR-489 aggravates H2O2-induced apoptosis of cardiomyocytes via inhibiting IGF1. Bioscience reports. vol 40. issue 9. 2021-03-29. PMID:32880387. |
we observed that down-regulation of mir-489 reduced h2o2-induced apoptosis, while overexpression of mir-489 had the opposite effects, as revealed by flow cytometry and western blot analyses. |
2021-03-29 |
2023-08-13 |
Not clear |
| Francesca Costantini, Caterina Di Sano, Giovanna Barbier. The Hydroxytyrosol Induces the Death for Apoptosis of Human Melanoma Cells. International journal of molecular sciences. vol 21. issue 21. 2021-03-29. PMID:33137997. |
in particular, through mts assay, deadend™ colorimetric tunel assay, annexin v binding and pi uptake, western blot experiment, intracellular reactive oxygen species (ros) analysis, and the cell colony assay, we showed that the hydroxytyrosol treatment remarkably reduces the cell viability inducing the death for apoptosis of melanoma cells. |
2021-03-29 |
2023-08-13 |
human |
| Hongbin Zhang, Jianfei Ma, Fei Liu, Jun Zhan. Long non-coding RNA XIST promotes the proliferation of cardiac fibroblasts and the accumulation of extracellular matrix by sponging microRNA-155-5p. Experimental and therapeutic medicine. vol 21. issue 5. 2021-03-27. PMID:33767772. |
the apoptosis and fibrosis-related protein expression levels were detected using western blot analysis. |
2021-03-27 |
2023-08-13 |
human |
| Olof Gidlöf, Kerstin Bader, Selvi Celik, Mario Grossi, Shinichi Nakagawa, Tetsuro Hirose, Bernhard Metzler, Björn Olde, David Erling. Inhibition of the long non-coding RNA NEAT1 protects cardiomyocytes from hypoxia in vitro via decreased pri-miRNA processing. Cell death & disease. vol 11. issue 8. 2021-03-25. PMID:32826883. |
sirna-mediated knock down of neat1 reduced apoptosis and necrosis in murine cardiomyocytes (cm) and human ips-derived cms in response to prolonged hypoxia and hypoxia-reoxygenation, assessed with annexin v/propidium iodide-staining, a caspase 3/7 activity assay, ldh release, and western blot for cleaved caspase 3. |
2021-03-25 |
2023-08-13 |
mouse |
| Qianqian Dong, Yanting Chen, Wantao Liu, Xiaoyu Liu, An Chen, Xiulin Yang, Yining Li, Siyi Wang, Mingwei Fu, Jing-Song Ou, Lihe Lu, Jianyun Ya. 25-Hydroxycholesterol promotes vascular calcification via activation of endoplasmic reticulum stress. European journal of pharmacology. vol 880. 2021-03-24. PMID:32423869. |
in addition, western blot analysis showed that 25-hc significantly up-regulated the expression of endoplasmic reticulum stress (ers) signaling molecules including atf4 and chop in vsmcs and flow cytometry analysis revealed that 25-hc increased apoptosis of vsmcs. |
2021-03-24 |
2023-08-13 |
human |