| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanfei Jiang, Hao Nan, Na Shi, Wenfang Hao, Juane Dong, Hongying Che. Chlorogenic acid inhibits proliferation in human hepatoma cells by suppressing noncanonical NF-κB signaling pathway and triggering mitochondrial apoptosis. Molecular biology reports. vol 48. issue 3. 2021-05-19. PMID:33738723. |
further analyses by real-time quantitative pcr, western blot and flow cytometry revealed that cga effectually suppressed the noncanonical nf-κb signaling pathway, meanwhile it activated the mitochondrial apoptosis of hcc by upregulation of the bh3-only protein bcl-2 binding component 3 (bbc3). |
2021-05-19 |
2023-08-13 |
human |
| Golnaz Rashidi, Mahsa Rezaeepoor, Chiman Mohammadi, Ghasem Solgi, Rezvan Najaf. Inhibition of semaphorin 4D enhances chemosensitivity by increasing 5-fluorouracile-induced apoptosis in colorectal cancer cells. Molecular biology reports. vol 47. issue 9. 2021-05-18. PMID:32888127. |
flow cytometry and western blot were used to evaluate apoptosis rate and pro- and anti-apoptotic expression levels of proteins involved in apoptosis including bax, bcl-2, p53, and caspase-3. |
2021-05-18 |
2023-08-13 |
human |
| Mamdooh H Ghoneum, Nesrine S El Saye. Protective Effect of Biobran/MGN-3 against Sporadic Alzheimer's Disease Mouse Model: Possible Role of Oxidative Stress and Apoptotic Pathways. Oxidative medicine and cellular longevity. vol 2021. 2021-05-18. PMID:33574982. |
biomarkers for apoptosis, oxidative stress, and amyloidogenesis were measured using elisa and western blot analysis. |
2021-05-18 |
2023-08-13 |
mouse |
| Jinliang Ma, Jian Wang, Yunkui Feng, Liuming Zhang, Huiru Hu, Qiang Wang, Changjiang Chu, Jingwen Qu, Yanhu Wang, Yongjun L. Silencing MAP3K1 expression inhibits the proliferation of goat hair follicle stem cells. In vitro cellular & developmental biology. Animal. vol 57. issue 4. 2021-05-18. PMID:33748907. |
rt-qpcr and western blot were used to detect mrna gene and protein expression level, cck-8 and edu assays were used to detect cell proliferation, and cell cycle and apoptosis were detected by flow cytometry. |
2021-05-18 |
2023-08-13 |
Not clear |
| Ping Xu, Dingding Lv, Xihui Wang, Yongsheng Wang, Chengxiang Hou, Kun Gao, Xijie Gu. Inhibitory effects of Bombyx mori antimicrobial peptide cecropins on esophageal cancer cells. European journal of pharmacology. vol 887. 2021-05-17. PMID:32763299. |
rt-qpcr and western blot analysis showed that bmceca induced apoptosis of eca109 cells through the activation of a mitochondria-mediated caspase pathway, the upregulation of b-cell lymphoma 2 (bcl-2)-associated x protein and the downregulation of bcl-2. |
2021-05-17 |
2023-08-13 |
mouse |
| Elham Hatami, Prashanth K B Nagesh, Meena Jaggi, Subhash C Chauhan, Murali M Yallap. Gambogic acid potentiates gemcitabine induced anticancer activity in non-small cell lung cancer. European journal of pharmacology. vol 888. 2021-05-17. PMID:32805254. |
microarray and western blot studies confirm that ga + gem co-treatment strategy promotes cancer cell death by downregulating anti-apoptotic proteins, chemoresistance-associated proteins, and upregulation of apoptosis proteins. |
2021-05-17 |
2023-08-13 |
mouse |
| Jing-Yi Liu, Yi-Chen Zhang, Rong-Rong Xie, Li-Ni Song, Wei-Li Yang, Zhong Xin, Xi Cao, Jin-Kui Yan. Nifuroxazide improves insulin secretion and attenuates high glucose-induced inflammation and apoptosis in INS-1 cells. European journal of pharmacology. vol 899. 2021-05-17. PMID:33745960. |
simultaneously, the effect of nifu on the inflammatory response, apoptosis, and stat3/socs3 signal pathway were validated by quantitative real-time pcr (qrt-pcr) and western blot. |
2021-05-17 |
2023-08-13 |
cat |
| Jing-Yi Liu, Yi-Chen Zhang, Rong-Rong Xie, Li-Ni Song, Wei-Li Yang, Zhong Xin, Xi Cao, Jin-Kui Yan. Nifuroxazide improves insulin secretion and attenuates high glucose-induced inflammation and apoptosis in INS-1 cells. European journal of pharmacology. vol 899. 2021-05-17. PMID:33745960. |
meanwhile, qrt-pcr and western blot results showed that inflammatory and apoptosis factors were remarkably inhibited by nifu. |
2021-05-17 |
2023-08-13 |
cat |
| Zeinab Mohseni, Hamid Sedighian, Raheleh Halabian, Jafar Amani, Elham Behzadi, Abbas Ali Imani Foolad. Potent in vitro antitumor activity of B-subunit of Shiga toxin conjugated to the diphtheria toxin against breast cancer. European journal of pharmacology. vol 899. 2021-05-17. PMID:33753109. |
t47d, skbr3, 4t1 and mcf7 cell lines were treated separately with purified dt389-stxb recombinant protein and functional activity of dt389-stxb was analyzed by the cell enzyme-linked immunosorbentassay (elisa), mtt, icc, western blot and apoptosis tests. |
2021-05-17 |
2023-08-13 |
human |
| Xuesong Zhang, Huawei Dong, Yong Liu, Junxia Han, Shouyi Tang, Jingna S. Tetramethylpyrazine partially relieves hypoxia-caused damage of cardiomyocytes H9c2 by downregulation of miR-449a. Journal of cellular physiology. 2021-05-16. PMID:30770559. |
the protein expression levels of sirt1 and key factors involved in cell apoptosis and phosphatidylinositol 3-kinase/protein kinase 3 (pi3k/akt) pathway were evaluated using western blot analysis. |
2021-05-16 |
2023-08-13 |
Not clear |
| Bingyu Chen, Yuanyuan Jia, Dongxue Lu, Zhiguang Su. Acute glucose fluctuation promotes Experimental and therapeutic medicine. vol 22. issue 1. 2021-05-16. PMID:33986853. |
the expression levels of proteins associated with apoptosis and involved in the signal transduction of janus kinase (jak)/stat3 pathway were assessed using western blot analysis. |
2021-05-16 |
2023-08-13 |
Not clear |
| Fengying Min, Guoyan Ch. Long noncoding RNA PCAT-1 knockdown prevents the development of ovarian cancer cells via microRNA-124-3p. Journal of cellular biochemistry. vol 121. issue 2. 2021-05-14. PMID:31674073. |
western blot was exploited for analysis of proteins involved in proliferation, apoptosis, migration and invasion, and signaling transduction. |
2021-05-14 |
2023-08-13 |
human |
| Honghe Xiao, Yuying Wang, Yutong Wu, Hongyan Li, Xicai Liang, Yin Lin, Liang Kong, Yingnan Ni, Yan Deng, Yan Li, Wanyi Li, Jingxian Yan. Osthole ameliorates cognitive impairments via augmenting neuronal population in APP / PS1 transgenic mice. Neuroscience research. vol 164. 2021-05-14. PMID:32302734. |
in this study, by using morris water maze (mwm) test, hematoxylin-eosin (he) staining, nissl staining, immunofluorescence analysis and western blot, we demonstrated that oral administration of ost could improve the learning and memory function, inhibit neuronal apoptosis, elevate the expression of glial cell line derived neurotrophic factor (gdnf), synaptophysin (syp) and postsynaptic density protein 95 (psd95). |
2021-05-14 |
2023-08-13 |
mouse |
| Hua Li, Li-Ying Lin, Yan Zhang, Yoon Lim, Mehreen Rahman, Andrew Beck, Mohammed Al-Hawwas, Shiqing Feng, Larisa Bobrovskaya, Xin-Fu Zho. Pro-BDNF Knockout Causes Abnormal Motor Behaviours and Early Death in Mice. Neuroscience. vol 438. 2021-05-14. PMID:32413397. |
abnormal morphologic changes were found in the dentate gyrus (dg) of the hippocampus in pro-bdnf ko mice, and western blot confirmed significant cell apoptosis in pro-bdnf ko mice brains. |
2021-05-14 |
2023-08-13 |
mouse |
| Syed Riaz Ud Din, Mintao Zhong, Muhammad Azhar Nisar, Muhammad Zubair Saleem, Akbar Hussain, Kavish H Khinsar, Shahid Alam, Gohar Ayub, Sadia Kanwal, Xingyun Li, Wei Zhang, Xiaoli Wang, Anhong Ning, Jing Cao, Min Huan. Latcripin-7A, derivative of Lentinula edodes C Applied microbiology and biotechnology. vol 104. issue 23. 2021-05-14. PMID:33044599. |
expressions of protein markers for apoptosis, autophagy, and cell cycle were confirmed via western blot analysis. |
2021-05-14 |
2023-08-13 |
Not clear |
| b' Paul J\\xc3\\xa4nicke, Claudia Lennicke, Annette Meister, Barbara Seliger, Ludger A Wessjohann, Goran N Kalu\\xc4\\x91erovi\\xc4\\x8. Fluorescent spherical mesoporous silica nanoparticles loaded with emodin: Synthesis, cellular uptake and anticancer activity. Materials science & engineering. C, Materials for biological applications. vol 119. 2021-05-14. PMID:33321661.' |
flow cytometry and western blot analysis showed that snm containing eo induced apoptosis in ht-29 cells. |
2021-05-14 |
2023-08-13 |
human |
| YuJian Xia, ZheWei Wei, WeiBin Huang, XiaoJing Wei, YuLong H. Trim47 overexpression correlates with poor prognosis in gastric cancer. Neoplasma. vol 68. issue 2. 2021-05-14. PMID:33350849. |
bioinformatics analysis and western blot indicated trim47 might regulate gc through nf-κb, emt, hypoxia, and apoptosis signaling pathway in gc. |
2021-05-14 |
2023-08-13 |
Not clear |
| Hanyu Chen, Hongqing Sheng, Yushuo Zhao, Guanghui Zh. Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-14. PMID:33382670. |
flow cytometry and western blot were used to determine cell apoptosis and the expression level of protein (cyto c, cleaved parp, cleaved caspase-3, bax, bcl-2, bad, bcl-xl, pi3k, ppi3k, akt, and pakt), respectively. |
2021-05-14 |
2023-08-13 |
mouse |
| Weize Yang, Xiaomin Luo, Yu Liu, Jun Xiong, Hongxia Xia, Yafeng Li. Potential role of lncRNA HULC/miR‑128‑3p/RAC1 axis in the inflammatory response during LPS‑induced sepsis in HMEC‑1 cells. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174038. |
flow cytometry and western blot assays were performed to detect cell apoptosis. |
2021-05-13 |
2023-08-13 |
human |
| Xiang Zhang, Jiong-Ming You, Xiao-Jun Dong, Yang W. Administration of mircoRNA-135b-reinforced exosomes derived from MSCs ameliorates glucocorticoid-induced osteonecrosis of femoral head (ONFH) in rats. Journal of cellular and molecular medicine. vol 24. issue 23. 2021-05-12. PMID:33089961. |
real-time pcr, western blot analysis, ihc assay, tunel assay, mtt assay and flow cytometry were performed to detect the effect of hips-msc-exos and mir-135b on cell apoptosis and the expression of pdcd4/caspase-3/ocn. |
2021-05-12 |
2023-08-13 |
rat |