| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zibo Feng, Youpeng Zhu, Jing Zhang, Wenbo Yang, Zhimin Chen, Binghui L. Hsa-circ_0010283 Regulates Oxidized Low-Density Lipoprotein-Induced Proliferation and Migration of Vascular Smooth Muscle Cells by Targeting the miR-133a-3p/Pregnancy-Associated Plasma Protein A Axis. Circulation journal : official journal of the Japanese Circulation Society. vol 84. issue 12. 2021-05-11. PMID:33162460. |
the expression of proliferation, apoptosis and migration/invasion-related proteins was measured by using a western blot. |
2021-05-11 |
2023-08-13 |
human |
| Yue Yang, Lei Yang, Yu Wu, Jun Yua. [Dexmedetomidine-mediated Wnt Pathway Inhibits Sevoflurane-induced Cognitive Impairment in Neonatal Rats]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 43. issue 2. 2021-05-11. PMID:33966704. |
methods sixty 7-day-old sd rats were assigned into five groups:control group(without any intervention),dex group(intraperitoneal injection of 25 μg/kg dex),sevoflurane group(3% sevoflurane treatment for 4 hours),sevoflurane+dex group(inhalation of 3% sevoflurane after injection of 25 μg/kg dex for 4 hours),and sevoflurane+dex+wnt inhibitor group(wnt inhibitor xav393 and 25 μg/kg dex were injected and 3% sevoflurane was inhaled for 4 hours).three weeks later,morris water maze was used to detect the cognitive function;tdt-mediated dutp nick end labeling(tunel)staining was performed to detect the apoptosis of hippocampal neurons;neuronal nuclei (neun) staining was conducted to detect the survival of hippocampal neurons;western blot was carried out to detect the expression of apoptosis-related proteins.the expression of the factors involved in wnt/gsk-3β/β-catenin signaling pathway was detected by fluorescence quantitative polymerase chain reaction,and western blot. |
2021-05-11 |
2023-08-13 |
rat |
| Lei Zhao, BaoHua Wang, WeiJia Zhang, LiXia Su. Effect of miR-499a-5p on damage of cardiomyocyte induced by hypoxia-reoxygenation via downregulating CD38 protein. Journal of cellular biochemistry. vol 121. issue 2. 2021-05-10. PMID:31452254. |
the activity of lactate dehydrogenase (ldh), apoptosis rate and the expression of mir-499a-5p and cluster of differentiation 38 (cd38) in hypoxia-reoxygenation model cells were detected by ldh cytotoxicity assay kit, flow cytometry, real-time polymerase chain reaction, and western blot analysis, respectively. |
2021-05-10 |
2023-08-13 |
Not clear |
| Cai-Lian Fan, Zhi-Hong Yao, Meng-Nan Ye, Lei-Lei Fu, Guo-Nian Zhu, Yi Dai, Xin-Sheng Ya. Fuziline alleviates isoproterenol-induced myocardial injury by inhibiting ROS-triggered endoplasmic reticulum stress via PERK/eIF2α/ATF4/Chop pathway. Journal of cellular and molecular medicine. vol 24. issue 2. 2021-05-10. PMID:31811750. |
western blot analysis also showed that fuziline reduced er stress-induced apoptosis in vivo. |
2021-05-10 |
2023-08-13 |
rat |
| Bo Hu, Xiao-Bo Yang, Xu Yang, Xin-Ting San. LncRNA CYTOR affects the proliferation, cell cycle and apoptosis of hepatocellular carcinoma cells by regulating the miR-125b-5p/KIAA1522 axis. Aging. vol 13. issue 2. 2021-05-10. PMID:33318318. |
the proliferation, cell cycle and apoptosis of hcc cells after transfection were respectively detected by cell counting kit-8 (cck-8) assay and flow cytometry analysis, and related protein expression was determined by western blot analysis. |
2021-05-10 |
2023-08-13 |
Not clear |
| Hongwei Zhang, Fenqing Chi, Keru Qin, Xiuli Mu, Lieyang Wang, Bin Yang, Yanli Wang, Min Bai, Zhenhua Li, Liping Su, Baofeng Y. Chidamide induces apoptosis in DLBCL cells by suppressing the HDACs/STAT3/Bcl‑2 pathway. Molecular medicine reports. vol 23. issue 5. 2021-05-10. PMID:33649847. |
moreover, chidamide promoted cellular apoptosis, which was identified via flow cytometry and western blot analysis, with an increase in cleaved caspase‑3 expression and a decrease in bcl‑2 expression. |
2021-05-10 |
2023-08-13 |
Not clear |
| Ke Li, Conghu Yua. MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer. International journal of molecular medicine. vol 46. issue 3. 2021-05-07. PMID:32582959. |
in addition, a series of methods, including mtt, colony formation, 5‑ethynyl‑2'‑deoxyuridine, transwell, wound healing, flow cytometric, reverse transcription‑quantitative pcr and western blot assays, were performed, which revealed that overexpression of mir‑103 enhanced cell growth, migration, invasion and epithelial‑mesenchymal transition (emt), and suppressed apoptosis of a549 and h1299 cells. |
2021-05-07 |
2023-08-13 |
Not clear |
| Peisen Zhang, Hefan He, Yuyan Bai, Weifeng Liu, Lirong Huan. Dexmedetomidine suppresses the progression of esophageal cancer via miR-143-3p/epidermal growth factor receptor pathway substrate 8 axis. Anti-cancer drugs. vol 31. issue 7. 2021-05-06. PMID:32701250. |
the proliferation, apoptosis and metastasis of esophageal cancer cells were detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry, transwell migration and invasion assays and western blot assay. |
2021-05-06 |
2023-08-13 |
Not clear |
| Bendan Long, Yun Wan, Siqin Zhang, Lisa L. LncRNA XIST protects podocyte from high glucose-induced cell injury in diabetic nephropathy by sponging miR-30 and regulating AVEN expression. Archives of physiology and biochemistry. 2021-05-06. PMID:33332155. |
further wb (western blot), mtt (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), and flow cytometry confirmed that xist could reverse the expression of aven and ameliorate hg-induced apoptosis. |
2021-05-06 |
2023-08-13 |
Not clear |
| Wan-Ting Xu, Gui-Nan Shen, Tian-Zhu Li, Yu Zhang, Tong Zhang, Hui Xue, Wen-Bo Zuo, Yan-Nan Li, Dong-Jie Zhang, Cheng-Hao Ji. Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways. International journal of oncology. vol 57. issue 2. 2021-05-05. PMID:32626938. |
moreover, flow cytometry and western blot analysis revealed that iso induced mitochondrial‑dependent apoptosis by reducing mitochondrial membrane potential. |
2021-05-05 |
2023-08-13 |
human |
| Jiong Li, Jing Xie, Yan-Zhen Wang, Yi-Rong Gan, Ling Wei, Guan-Waner Ding, Yan-Hong Ding, Ding-Xiong Xi. Overexpression of lncRNA Dancr inhibits apoptosis and enhances autophagy to protect cardiomyocytes from endoplasmic reticulum stress injury via sponging microRNA-6324. Molecular medicine reports. vol 23. issue 2. 2021-05-04. PMID:33300079. |
cell viability, apoptosis and levels of associated proteins, ers and autophagy in dancr-overexpression h9c2 cells and mir-6234 mimic-transfected h9c2 cells were assessed using cell counting kit-8, tunel staining and western blot assay, respectively. |
2021-05-04 |
2023-08-13 |
rat |
| Junmei Zhang, Xuyuan Sun, Lingling Zhong, Bei She. IL-32 exacerbates adenoid hypertrophy via activating NLRP3-mediated cell pyroptosis, which promotes inflammation. Molecular medicine reports. vol 23. issue 3. 2021-05-04. PMID:33495843. |
hnepcs with or without il-32 silencing were stimulated with lipopolysaccharide (lps), and cell proliferation, cell apoptosis, gasdermin d (gsdmd) activation, production of inflammatory cytokines and the expression levels of proteins related to the potential mechanisms were evaluated by cell counting kit-8, flow cytometry, immunofluorescence staining, elisa and western blot assays, respectively. |
2021-05-04 |
2023-08-13 |
human |
| Fengyu Wang, Fengli Wang, Shengyu Zhang, Xiaogang X. MicroRNA-325 inhibits the proliferation and induces the apoptosis of T cell acute lymphoblastic leukemia cells in a BAG2-dependent manner. Experimental and therapeutic medicine. vol 21. issue 6. 2021-05-04. PMID:33936287. |
the effects of mir-325 mimic and bag2 downregulation on the proliferation and apoptosis were assessed by an mtt assay, flow cytometry and western blot analysis. |
2021-05-04 |
2023-08-13 |
Not clear |
| Ting Chen, Chunyan Zhu, Chongyang Y. LncRNA CYTOR attenuates sepsis-induced myocardial injury via regulating miR-24/XIAP. Cell biochemistry and function. vol 38. issue 7. 2021-05-03. PMID:32181504. |
western blot was applied to determine the expression level of caspase 3, bax and x-chromosome-linked inhibitor of apoptosis (xiap). |
2021-05-03 |
2023-08-13 |
mouse |
| Xiaohu Yang, Suming Zhao, Hongxin Yuan, Rongfeng Shi, Weiwei Gu, Zhuxin Gu, Xiaohua Lu, Hui Zha. Knockdown of Ror2 suppresses TNF‑α‑induced inflammation and apoptosis in vascular endothelial cells. Molecular medicine reports. vol 22. issue 4. 2021-05-03. PMID:32945438. |
western blot and flow cytometry analyses were used to detect the activation of nuclear factor‑κb (nf‑κb) signaling and cell apoptosis. |
2021-05-03 |
2023-08-13 |
human |
| Faroogh Marofi, Navid Shomali, Laith A Younus, Ali Hassanzadeh, Ghasem Vahedi, Mariya Yurievna Kuznetsova, Saeed Solali, Tohid Gharibi, Arezoo Hosseini, Rebar N Mohammed, Hamed Mohammadi, Rozita Tamjidifar, Akram Firouzi-Amandi, Majid Farshdousti Hag. Under hypoxic conditions, MSCs affect the expression and methylation level of survival-related genes in ALL independent of apoptosis pathways in vitro. Biotechnology and applied biochemistry. 2021-05-03. PMID:33786874. |
then, mrna and protein expression of the mat2a, pdk1, and hk2 genes were evaluated by real-time pcr and western blot which was also followed by apoptosis measurement by a flow-cytometric method. |
2021-05-03 |
2023-08-13 |
Not clear |
| Ramesh Chaudhari, Pal Patel, Nikita Meghani, Simran Nasra, Ashutosh Kuma. Fabrication of methotrexate-loaded gold nanoconjugates and its enhanced anticancer activity in breast cancer. 3 Biotech. vol 11. issue 4. 2021-05-02. PMID:33927966. |
different assays like cell viability assay, cell cycle analysis, apoptosis, real-time pcr and western blot were carried out to evaluate the anti-cancer effect of mtx-gold nps on mcf-7 and mda-mb-231 cells. |
2021-05-02 |
2023-08-13 |
Not clear |
| Sze Wei Leong, Suet Lin Chia, Faridah Abas, Khatijah Yusof. Synthesis and in-vitro anti-cancer evaluations of multi-methoxylated asymmetrical diarylpentanoids as intrinsic apoptosis inducer against colorectal cancer. Bioorganic & medicinal chemistry letters. vol 30. issue 8. 2021-04-30. PMID:32127259. |
further western blot studies confirmed that 8 has induced intrinsic apoptosis in rko cells through the up-regulations of bad and bax pro-apoptotic proteins and down-regulations of bcl-2 and bcl-xl pro-survival proteins. |
2021-04-30 |
2023-08-13 |
Not clear |
| Ezgi Kıyga, Aslıhan Şengelen, Zelal Adıgüzel, Evren Önay Uça. Investigation of the role of quercetin as a heat shock protein inhibitor on apoptosis in human breast cancer cells. Molecular biology reports. vol 47. issue 7. 2021-04-30. PMID:32638319. |
the effects of quercetin on hsp levels, apoptosis and dna damage were examined by western blot analysis, caspase activity assay, comet assay and microscopy in human breast cancer cells. |
2021-04-30 |
2023-08-13 |
human |
| Min Lu, Xinglei Qin, Jungong Yao, Yuanyuan Yang, Minghu Zhao, Lin Su. MiR-134-5p targeting XIAP modulates oxidative stress and apoptosis in cardiomyocytes under hypoxia/reperfusion-induced injury. IUBMB life. vol 72. issue 10. 2021-04-30. PMID:32797709. |
expression of mir-134-5p and x-linked inhibitor of apoptosis protein (xiap) was detected using rt-qpcr and western blot. |
2021-04-30 |
2023-08-13 |
Not clear |