| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Jeong Kim, Jin Mo Ku, Se Hyang Hong, Hyo In Kim, Yun Young Kwon, Joon-Sang Park, Deok Hyun Jung, Yong Cheol Shin, Seong-Gyu K. Frontiers in pharmacology. vol 12. 2021-06-01. PMID:34054558. |
we used western blot and rt-pcr to measure the levels of the proteins of the unfolded protein response (upr) pathway and apoptosis markers. |
2021-06-01 |
2023-08-13 |
human |
| Yin-Gi Jang, Eul-Bee Ko, Kyung-Chul Cho. Gallic acid, a phenolic acid, hinders the progression of prostate cancer by inhibition of histone deacetylase 1 and 2 expression. The Journal of nutritional biochemistry. vol 84. 2021-05-31. PMID:32615369. |
western blot analysis revealed down-regulated expression of hdac1 and 2, leading to up-regulation of acetyl-p53 expression at the protein level, subsequent to down-regulating the expression of cell-cycle-related genes, i.e., proliferating cell nuclear antigen (pcna), cyclin d1 and e1, up-regulating the expression of cell cycle arrest gene p21 and regulating the expression of apoptosis intrinsic pathway-related genes, such as bax, bcl-2, cleaved caspase-3 and poly (adp-ribose) polymerase 1 in both pca cell lines. |
2021-05-31 |
2023-08-13 |
mouse |
| Tao Cheng, Weibing Shuang, Dawen Ye, Wenzhi Zhang, Zhao Yang, Wenge Fang, Haibin Xu, Mingli Gu, Weiqiang Xu, Chao Gua. SNHG16 promotes cell proliferation and inhibits cell apoptosis via regulation of the miR-1303-p/STARD9 axis in clear cell renal cell carcinoma. Cellular signalling. vol 84. 2021-05-31. PMID:33901578. |
western blot analysis was applied to examine protein levels associated with cell proliferation and apoptosis. |
2021-05-31 |
2023-08-13 |
Not clear |
| Kai Gao, Jianbing Niu, Xiaoqian Dan. Neuroprotection of netrin-1 on neurological recovery via Wnt/β-catenin signaling pathway after spinal cord injury. Neuroreport. vol 31. issue 7. 2021-05-28. PMID:32251100. |
in our study, western blot, transferase utp nick end labeling staining and immunofluorescence staining first showed that netrin-1 significantly decreased the expression levels of caspase-3, caspase-9, transferase utp nick end labeling-positive neurons, nuclear factor kappa-b, and tumor necrosis factor-α after spinal cord injury, which inhibited neuronal apoptosis and inflammatory response. |
2021-05-28 |
2023-08-13 |
Not clear |
| Ting Hao, Shu Huang, Fangzheng Ha. LINC-PINT suppresses tumour cell proliferation, migration and invasion through targeting miR-374a-5p in ovarian cancer. Cell biochemistry and function. vol 38. issue 8. 2021-05-26. PMID:32638404. |
cck-8, flow cytometry, wound-healing, transwell assays and western blot were performed to detect the effects of linc-pint on proliferation, apoptosis, migration, invasion and emt process in oc cells. |
2021-05-26 |
2023-08-13 |
Not clear |
| Qingqing Han, Lijuan Han, Fangfang Tie, Zhenhua Wang, Chengjun Ma, Ji Li, Honglun Wang, Gang L. (20S)-Protopanaxadiol Ginsenosides Induced Cytotoxicity via Blockade of Autophagic Flux in HGC-27 Cells. Chemistry & biodiversity. vol 17. issue 7. 2021-05-25. PMID:32384197. |
the sulforhodamine b (srb) assay, western blot analysis, fluorescence microscopy, confocal microscopy, high performance liquid chromatography (hplc) analysis, flow cytometry, and transmission electron microscopy (tem) were used to evaluate cell proliferation, apoptosis, and autophagy. |
2021-05-25 |
2023-08-13 |
human |
| Fengpei Chen, Shijia Chen, Jie Liu, Nashwa Amin, Weidong Jin, Marong Fan. Agomelatine Softens Depressive-Like Behavior through the Regulation of Autophagy and Apoptosis. BioMed research international. vol 2021. 2021-05-25. PMID:33791372. |
meanwhile, the expression of the bdnf/trkb/perk signaling pathway, apoptosis, autophagy, and inflammatory protein markers were assessed using western blot and immunofluorescence. |
2021-05-25 |
2023-08-13 |
mouse |
| Roujun Wang, Yumeng Sun, Xiaowen Jin, Weibo Wen, Yongjun Ca. Diosgenin Inhibits Excessive Proliferation and Inflammatory Response of Synovial Fibroblasts in Rheumatoid Arthritis by Targeting PDE3B. Inflammation. vol 44. issue 3. 2021-05-24. PMID:33237390. |
cck-8 detected the cell viability, tunel assay detected the apoptosis of cells and western blot detected the expression of apoptosis-related proteins. |
2021-05-24 |
2023-08-13 |
Not clear |
| Meihua Wang, Zhilin Chen, Lei Yang, Lei Din. Sappanone A Protects Against Inflammation, Oxidative Stress and Apoptosis in Cerebral Ischemia-Reperfusion Injury by Alleviating Endoplasmic Reticulum Stress. Inflammation. vol 44. issue 3. 2021-05-24. PMID:33411101. |
cell apoptosis was evaluated by terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) or flow cytometry, and the expression of apoptosis-associated proteins was determined using western blot analysis. |
2021-05-24 |
2023-08-13 |
rat |
| Chunmei Zhang, Xi Chen, Chao Wang, Yu Ran, Kai Shen. Inhibition of XBP1 Alleviates LPS-Induced Cardiomyocytes Injury by Upregulating XIAP through Suppressing the NF-κB Signaling Pathway. Inflammation. vol 44. issue 3. 2021-05-24. PMID:33453047. |
the protein expression related to apoptosis and nf-κb signaling pathway was detected by western blot analysis. |
2021-05-24 |
2023-08-13 |
Not clear |
| Mohammad Bani Ismail, Peramaiyan Rajendran, Hamad Mohammed AbuZahra, Vishnu Priya Veeraraghava. Mangiferin Inhibits Apoptosis in Doxorubicin-Induced Vascular Endothelial Cells via the Nrf2 Signaling Pathway. International journal of molecular sciences. vol 22. issue 8. 2021-05-24. PMID:33923922. |
cell apoptosis was assessed with a caspase-3 activity assay, transferase-mediated dutp-fluorescein nick end labeling (tunel) staining was performed to assess dna fragmentation, and protein expression was determined by western blot analysis. |
2021-05-24 |
2023-08-13 |
human |
| Duo Wen, Wan-Lin Liu, Zhong-Wu Lu, Yi-Ming Cao, Qing-Hai Ji, Wen-Jun We. SNHG9, a Papillary Thyroid Cancer Cell Exosome-Enriched lncRNA, Inhibits Cell Autophagy and Promotes Cell Apoptosis of Normal Thyroid Epithelial Cell Nthy-ori-3 Through YBOX3/P21 Pathway. Frontiers in oncology. vol 11. 2021-05-23. PMID:34017682. |
western blot showed that snhg9 could induce degradation of ybox3, thus interfering with the stability of p21 mrna and inducing cell apoptosis. |
2021-05-23 |
2023-08-13 |
human |
| Yasir I Mohammed Saleem, Mustafa I Seli. MDM2 as a target for ellagic acid‑mediated suppression of prostate cancer cells in vitro. Oncology reports. vol 44. issue 3. 2021-05-21. PMID:32705219. |
furthermore, we found that ea induced apoptosis in the absence of p53 by downregulating mdm2 and x‑linked inhibitor of apoptosis protein (xiap) protein expressions as determined by western blot analysis. |
2021-05-21 |
2023-08-13 |
human |
| Shumei Ma, Zhao Jin, Yi Liu, Lin Liu, Hao Feng, Ping Li, Zhujun Tian, Minghua Ren, Xiaodong Li. Furazolidone Increases Survival of Mice Exposed to Lethal Total Body Irradiation through the Antiapoptosis and Antiautophagy Mechanism. Oxidative medicine and cellular longevity. vol 2021. 2021-05-21. PMID:33613823. |
tunel and western blot showed that fzd protected intestinal tissue by downregulating radiation-induced apoptosis and autophagy. |
2021-05-21 |
2023-08-13 |
mouse |
| Aihua Liu, Zhongfu Zuo, Linlin Liu, Lihua Li. Down-regulation of NTSR3 inhibits cell growth and metastasis, as well as the PI3K-AKT and MAPK signaling pathways in colorectal cancer. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 98. issue 5. 2021-05-20. PMID:32125883. |
western blot analysis, real-time pcr, immunofluorescence staining, mtt, cell cycle assay, cell apoptosis assay, hoechst staining, caspase-3 and caspase-9 activity assays, cell adhesion assay, wound healing assay, and a transwell assay were used in this study. |
2021-05-20 |
2023-08-13 |
Not clear |
| Jinlong Zhang, Jiawei Jiang, Guofeng Bao, Guanhua Xu, Lingling Wang, Jiajia Chen, Chu Chen, Chunshuai Wu, Pengfei Xue, Dawei Xu, Yuyu Sun, Zhiming Cu. Interaction between C/EBPβ and RUNX2 promotes apoptosis of chondrocytes during human lumbar facet joint degeneration. Journal of molecular histology. vol 51. issue 4. 2021-05-20. PMID:32632701. |
the knockdown of c/ebpβ significantly decreased the expression levels of mmp13 and active caspase-3 (2.48 and 2.89 times as detected by western blot analysis) and inhibited chondrocyte apoptosis, which was further demonstrated using flow cytometry. |
2021-05-20 |
2023-08-13 |
human |
| Jiansheng Zhong, Jinli Zhang, Xiaoyang Yu, Xing Zhang, Linping Dia. Olmutinib Reverses Doxorubicin Resistance in ETS1-Overexpressing Leukemia Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32830792. |
cell apoptosis was observed by western blot and flow cytometry. |
2021-05-20 |
2023-08-13 |
mouse |
| Xiaobo Zhang, Ying Zhu, Ying Zhou, Bingru Fe. Interleukin 37 (IL-37) Reduces High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis of Podocytes by Inhibiting the STAT3-Cyclophilin A (CypA) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32931486. |
the expression of inflammatory factors and molecules related to oxidative stress was detected by elisa and western blot, and cell apoptosis was detected by flow cytometry and western blot. |
2021-05-20 |
2023-08-13 |
Not clear |
| Yan-Jun Wan, Yan-Hang Wang, Qiang Guo, Yong Jiang, Peng-Fei Tu, Ke-Wu Zen. Protocatechualdehyde protects oxygen-glucose deprivation/reoxygenation-induced myocardial injury via inhibiting PERK/ATF6α/IRE1α pathway. European journal of pharmacology. vol 891. 2021-05-19. PMID:33159933. |
further mechanism study suggested that pca suppressed er stress via inhibiting protein kinase r-like er kinase (perk), inositol-requiring enzyme1α (ire1α), and transcription factor 6α (atf6α) signaling pathway through western blot, dioc6 and er-tracker red staining, leading to a protective effect against er stress-mediated cardiomyocyte apoptosis. |
2021-05-19 |
2023-08-13 |
mouse |
| Yun Luo, Xi Dong, Shan Lu, Ye Gao, Guibo Sun, Xiaobo Su. Gypenoside XVII alleviates early diabetic retinopathy by regulating Müller cell apoptosis and autophagy in db/db mice. European journal of pharmacology. vol 895. 2021-05-19. PMID:33493483. |
retinal oxidative environment and cell apoptosis and autophagy were monitored using commercial kits, immunofluorescence, and western blot assays. |
2021-05-19 |
2023-08-13 |
mouse |