| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Baiqi Wang, Lili Xu, Ju Zhang, Xinru Cheng, Qianya Xu, Jian Wang, Fengxia Ma. LncRNA NORAD accelerates the progression and doxorubicin resistance of neuroblastoma through up-regulating HDAC8 via sponging miR-144-3p. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 129. 2021-02-26. PMID:32563146. |
the proliferation, chemoresistance, apoptosis, metastasis and autophagy of nb cells were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt), flow cytometry, transwell migration and invasion assays and western blot assay, respectively. |
2021-02-26 |
2023-08-13 |
Not clear |
| Ting-Ting Xu, Han Li, Zhao Dai, George K Lau, Ben-Yue Li, Wen-Li Zhu, Xiao-Qi Liu, Hao-Fei Liu, Wei-Wu Cai, Shui-Qing Huang, Qi Wang, Shi-Jie Zhan. Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. Aging. vol 12. issue 7. 2021-02-25. PMID:32268299. |
in addition, western blot results (bcl-2, bax and caspase-3, nlrp3, il-18, il-1β) showed that spermidine and spermine prevented apoptosis and inflammation, and elevate the expression of neurotrophic factors, including ngf, psd95and psd93 and bdnf in neurons of samp8 mice. |
2021-02-25 |
2023-08-13 |
mouse |
| Jinbong Park, Seung Ho Bae. Combination Therapy with Cinnamaldehyde and Hyperthermia Induces Apoptosis of A549 Non-Small Cell Lung Carcinoma Cells via Regulation of Reactive Oxygen Species and Mitogen-Activated Protein Kinase Family. International journal of molecular sciences. vol 21. issue 17. 2021-02-24. PMID:32872198. |
this was attributed to an increase in the apoptosis markers and suppression of the survival/protective factors, as confirmed by western blot assays. |
2021-02-24 |
2023-08-13 |
Not clear |
| Reyes Benot-Dominguez, Maria Grazia Tupone, Vanessa Castelli, Michele d'Angelo, Elisabetta Benedetti, Massimiliano Quintiliani, Benedetta Cinque, Iris Maria Forte, Maria Grazia Cifone, Rodolfo Ippoliti, Barbara Barboni, Antonio Giordano, Annamaria Cimin. Olive leaf extract impairs mitochondria by pro-oxidant activity in MDA-MB-231 and OVCAR-3 cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 134. 2021-02-24. PMID:33360155. |
mts, cytofluorimetric, western blot analysis were performed to analyze cell viability, cell proliferation, apoptosis, and oxidative stress. |
2021-02-24 |
2023-08-13 |
Not clear |
| Qiongmei Xu, Jie Xu, Kefeng Zhang, Mingli Zhong, Houkang Cao, Riming Wei, Ling Jin, Ya Ga. Study on the protective effect and mechanism of Dicliptera chinensis (L.) Juss (Acanthaceae) polysaccharide on immune liver injury induced by LPS. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 134. 2021-02-24. PMID:33370627. |
immunohistochemistry, elisa, rt-pcr and western blot were used to detect protein or mrna expressions associated with inflammation response and apoptosis. |
2021-02-24 |
2023-08-13 |
mouse |
| Yanhui Liu, Pingchong Lei, Hong Qiao, Kai Sun, Xiling Lu, Fengchang Bao, Runhong Yu, Cheng Lian, Yao Li, Wei Chen, Fei Xu. MicroRNA-33b regulates sensitivity to daunorubicin in acute myelocytic leukemia by regulating eukaryotic translation initiation factor 5A-2. Journal of cellular biochemistry. vol 121. issue 1. 2021-02-23. PMID:31222822. |
cell apoptosis and the expression of eif5a-2 and mcl-1 protein were detected by flow cytometry analysis and western blot analysis, respectively. |
2021-02-23 |
2023-08-13 |
Not clear |
| Hao Hu, Jiawei Wu, Xiaofan Yu, Junling Zhou, Hua Yu, Likun M. Long noncoding RNA MALAT1 enhances the apoptosis of cardiomyocytes through autophagy modulation. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 98. issue 2. 2021-02-23. PMID:31985274. |
the cell apoptosis was evaluated using tunel staining and western blot analysis of apoptosis-related proteins. |
2021-02-23 |
2023-08-13 |
mouse |
| Ayse Karatug Kaca. Indomethacin decreases insulin secretion by reducing KCa3.1 as a biomarker of pancreatic tumor and causes apoptotic cell death. Journal of biochemical and molecular toxicology. vol 34. issue 7. 2021-02-23. PMID:32128977. |
the relationship between cell death and insulin metabolism was determined with the administration of indomethacin. the cell viability by wst-1; the apoptosis and necrosis levels by elisa kits; malondialdehyde levels by spectrophotometer; and beclin, intracellular insulin, insulin secretion, kca3.1, insulin receptor (ir), glucose transporter type 2 (glut2), activating transcription factor 2 (atf2), elk1, c-jun, akt and phosphorylated atf2, elk1, c-jun, akt, intracellular betacellulin and betacellulin secretion levels by western blot analysis investigated. the ins1, ins2, ir, glut2, atf2, elk1, c-jun, akt, and betacellulin gene expression levels were determined by the real-time quantitative reverse transcription-polymerase chain reaction method. |
2021-02-23 |
2023-08-13 |
rat |
| Kai Wang, Wei H. Oxypaeoniflorin improves myocardial ischemia/reperfusion injury by activating the Sirt1/Foxo1 signaling pathway. Acta biochimica Polonica. vol 67. issue 2. 2021-02-19. PMID:32550708. |
furthermore, western blot assays indicated that opa inhibited apoptosis by activating the sirt1 (silent information regulator factor 2 related enzyme 1)/foxo1(forkhead transcription factor fkhr) signaling pathway in myocardial tissues and h9c2 cells. |
2021-02-19 |
2023-08-13 |
mouse |
| Yanping Wang, Bangjie Zuo, Nannan Wang, Shulin Li, Caixia Liu, Dong Su. Calcium dobesilate mediates renal interstitial fibrosis and delay renal peritubular capillary loss through Sirt1/p53 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 132. 2021-02-19. PMID:33011612. |
tissue hypoxia, cell apoptosis and fibrotic lesions were detected by immunostaining and western blot. |
2021-02-19 |
2023-08-13 |
mouse |
| Yao Dong, Shuairu Feng, Feijun Don. Maternally-Expressed Gene 3 (MEG3)/miR-143-3p Regulates Injury to Periodontal Ligament Cells by Mediating the AKT/Inhibitory κB Kinase (IKK) Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-18. PMID:32520926. |
lps-induced pdlcs injury was assessed via viability, apoptosis and inflammatory response using cell counting kit-8, flow cytometry, quantitative reverse transcription polymerase chain reaction, enzyme-linked immunosorbent assay, and western blot. |
2021-02-18 |
2023-08-13 |
Not clear |
| Weihua Liu, Yuqiang Ji, Haiping Chu, Mo Wang, Bin Yang, Chunyan Yi. SFRP5 mediates downregulation of the wnt5a/caveolin-1/JNK signaling pathway. The Journal of endocrinology. vol 247. issue 3. 2021-02-17. PMID:33108333. |
the expression of wnt 5a, caveolin-1, jnk and apoptosis-related proteins under different treatments were detected by the western blot method, and apoptosis was detected by flow cytometry. |
2021-02-17 |
2023-08-13 |
Not clear |
| Wenxi Zhang, Huan Zhang, Weijuan Yao, Li Li, Pei Niu, Yunlong Huo, Wenchang Ta. Morphometric, Hemodynamic, and Multi-Omics Analyses in Heart Failure Rats with Preserved Ejection Fraction. International journal of molecular sciences. vol 21. issue 9. 2021-02-16. PMID:32397533. |
western blot validated upregulated mff and itga9 and downregulated map1lc3a in the hs group, which likely contributed to accumulation of aberrant mitochondria to increase ros and elevation of myocyte stiffness, and subsequent contractile dysfunction and myocardial apoptosis. |
2021-02-16 |
2023-08-13 |
rat |
| Xingkai Xu, Lulei Liao, Baisheng Hu, Hao Jiang, Meichun Ta. Roflumilast, a Phosphodiesterases-4 (PDE4) Inhibitor, Alleviates Sepsis‑induced Acute Kidney Injury. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-16. PMID:32449901. |
the protein expression was measured using western blot and cell apoptosis of kidney tissue was determined by tunel (terminal deoxynucleotidyl transferase dutp nick end labeling) assay. |
2021-02-16 |
2023-08-13 |
mouse |
| Tana Zhao, Shangjun Chen, Bingxin Wang, Dongliang Ca. L-Carnitine Reduces Myocardial Oxidative Stress and Alleviates Myocardial Ischemia-Reperfusion Injury by Activating Nuclear Transcription-Related Factor 2 (Nrf2)/Heme Oxygenase-1 (HO-1) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-16. PMID:32452468. |
the effect of lc on oxidative stress, apoptosis, and nuclear transcription-related factor 2/heme oxygenase-1 (nrf2/ho-1) signaling pathway of h9c2 cells were detected by western blot, rt-pcr, and flow cytometry. |
2021-02-16 |
2023-08-13 |
rat |
| Hanrong Xu, Liefeng Ji, Chunhua Yu, Qiming Chen, Qiangqiang Ge, Yinjiang L. MiR-423-5p Regulates Cells Apoptosis and Extracellular Matrix Degradation via Nucleotide-Binding, Leucine-Rich Repeat Containing X1 (NLRX1) in Interleukin 1 beta (IL-1β)-Induced Human Nucleus Pulposus Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-16. PMID:32467560. |
then, nlrx1 was overexpressed in il-1β-induced np cells to detect apoptosis-related proteins and the extracellular matrix (ecm) by western blot, along with the detection of apoptosis levels using flow cytometry. |
2021-02-16 |
2023-08-13 |
human |
| Liangjun Zhong, Jinxiang Yan, Haitao Li, Lei Men. HDAC9 Silencing Exerts Neuroprotection Against Ischemic Brain Injury Frontiers in cellular neuroscience. vol 14. 2021-02-16. PMID:33584204. |
next, primary neuronal apoptosis, expression of apoptosis-related factors (bax, cleaved caspase3 and bcl-2), ldh leakage rate, as well as the release of inflammatory factors (tnf-α, il-1β, and il-6) were evaluated by assays of tunel, western blot, and elisa. |
2021-02-16 |
2023-08-13 |
mouse |
| Yu Liao, Ziyan Wang, Lixin Wang, Yanzhao Lin, Ziyi Ye, Xufang Zeng, Fangning We. MicroRNA-27a-3p directly targets FosB to regulate cell proliferation, apoptosis, and inflammation responses in immunoglobulin a nephropathy. Biochemical and biophysical research communications. vol 529. issue 4. 2021-02-11. PMID:32819575. |
methylthiazolyldiphenyl-tetrazolium bromide (mtt), flow cytometry, real-time polymerase chain reaction, western blot, and enzyme-linked immunosorbent assays were used to verify the regulatory effects of mir-27a-3p and its inhibition on cell proliferation, apoptosis, and release of inflammatory factors in podocytes and hk2 cells. |
2021-02-11 |
2023-08-13 |
human |
| Ji-In Yang, Bohwan Jin, Su-Yeon Kim, Qiang Li, Aryung Nam, Min-Ok Ryu, Won Woo Lee, Min-Hee Son, Hye-Jin Park, Woo-Jin Song, Hwa-Young You. Antitumour effects of Liporaxel (oral paclitaxel) for canine melanoma in a mouse xenograft model. Veterinary and comparative oncology. vol 18. issue 2. 2021-02-10. PMID:31503379. |
tumour cell apoptosis was detected by terminal deoxynucleotidyl transferase dutp nick-end labeling assay, and cell cycle arrest was confirmed by western blot analysis. |
2021-02-10 |
2023-08-13 |
mouse |
| Serdar Goktas, Zehra B Azizoglu, Daniel Petersheim, Merve Erdogan, Hatice Eke Gungor, Atil Bisgin, Sevcan Tuğ Bozdoğan, Ahmet Eken, Ekrem Unal, Christoph Klein, Turkan Patirogl. A Novel Intronic Mutation Reduces HAX1 Level and is Associated With Severe Congenital Neutropenia. Journal of pediatric hematology/oncology. 2021-02-09. PMID:33560082. |
the western blot studies showed a complete absence of neutrophils from the patient showed increased apoptosis upon h2o2 exposure, whereas t-cell proliferative responses to various stimuli were intact. |
2021-02-09 |
2023-08-13 |
Not clear |