| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Degui Shu, Yufen Xu, Wenyu Che. Knockdown of lncRNA BLACAT1 reverses the resistance of afatinib to non-small cell lung cancer via modulating STAT3 signalling. Journal of drug targeting. vol 28. issue 3. 2021-07-16. PMID:31359792. |
mtt assay, colony formation assay, apoptosis analysis, qrt-pcr and western blot analysis, immunohistochemistry, and in vivo study were carried out. |
2021-07-16 |
2023-08-13 |
Not clear |
| Sina M Hopff, Liliane A Onambele, Marc Brandenburg, Albrecht Berkessel, Aram Proko. Sensitizing multidrug-resistant leukemia cells to common cytostatics by an aluminium-salen complex that has high-apoptotic effects in leukemia, lymphoma and mamma carcinoma cells. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 34. issue 2. 2021-07-16. PMID:33560473. |
western blot analysis and measurement of the mitochondrial membrane potential with a jc-1 dye were employed to identify the pathway of apoptosis. |
2021-07-16 |
2023-08-13 |
Not clear |
| Haitao Wen, Zhenwei Li, Sirong Song, Lixia Xu, Xiaoguang Tong, Hua Ya. Silencing of lncRNA LBX2-AS1 suppresses glioma cell proliferation and metastasis through the Akt/GSK3β pathway in vitro. Acta biochimica et biophysica Sinica. vol 53. issue 4. 2021-07-16. PMID:33637977. |
in vitro functional assays such as cck-8, annexin v, transwell assay, and western blot analysis showed that silencing of lbx2-as1 suppressed the proliferation, migration, and invasion of glioma cells and increased apoptosis. |
2021-07-16 |
2023-08-13 |
Not clear |
| Pengfei Liu, Quansheng Gao, Lei Guan, Yanting Hu, Jingwen Jiang, Teng Gao, Weixuan Sheng, Xinying Xue, Hui Qiao, Tianzuo L. Atorvastatin attenuates surgery-induced BBB disruption and cognitive impairment partly by suppressing NF-κB pathway and NLRP3 inflammasome activation in aged mice. Acta biochimica et biophysica Sinica. vol 53. issue 5. 2021-07-16. PMID:33674828. |
western blot analysis, immunohistochemistry, and enzyme-linked immunosorbent assay were used to examine the inflammatory response, bbb integrity, and cell apoptosis. |
2021-07-16 |
2023-08-13 |
mouse |
| Ke Hu, Bo Li, Ruye Ma, Hongfei Yi, Zhijian Xu, Yu Peng, Dandan Yu, Huiqun Wu, Taofang Cheng, Yumeng Lu, Yong Zhang, Rong Wei, Guang Yang, Xiaosong Wu, Weiliang Zhu, Jumei Sh. Anti-DLBCL efficacy of DCZ0825 in vitro and in vivo: involvement of the PI3K‒AKT‒mTOR/JNK pathway. Acta biochimica et biophysica Sinica. vol 53. issue 5. 2021-07-16. PMID:33821934. |
flow cytometry and western blot analysis results showed that dcz0825 also promoted cell apoptosis via both extrinsic and intrinsic apoptosis pathways mediated by caspase. |
2021-07-16 |
2023-08-13 |
Not clear |
| Pin Lv, Yi-Fan Luo, Wen-Yi Zhou, Ben Liu, Zheng Zhou, Yong-Zhong Shi, Ren Huang, Chuang Peng, Zi-Li He, Jun Wang, Hong-Hui Zhang, Sheng-Dan Ni. miR-373 inhibits autophagy and further promotes apoptosis of cholangiocarcinoma cells by targeting ULK1. The Kaohsiung journal of medical sciences. vol 36. issue 6. 2021-07-15. PMID:32125086. |
in addition, cck-8 assay, flow cytometry, western blot, and immunofluorescence were applied to evaluate the proliferation, apoptosis, and autophagy of cholangiocytic hepatocellular carcinoma cells. |
2021-07-15 |
2023-08-13 |
human |
| Chen Zhaohui, Wu Shuihu. Protective Effects of SIRT6 Against Inflammation, Oxidative Stress, and Cell Apoptosis in Spinal Cord Injury. Inflammation. vol 43. issue 5. 2021-07-15. PMID:32445068. |
cell apoptosis were evaluated by morphological examination using ao/eb fluorescent staining methods and key proteins related to apoptosis were explored via western blot. |
2021-07-15 |
2023-08-13 |
rat |
| Zhirong Wang, Kai Yan, Gaoran Ge, Di Zhang, Jiaxiang Bai, Xiaobin Guo, Jing Zhou, Tianpeng Xu, Menglei Xu, Xiao Long, Yuefeng Hao, Dechun Gen. Exosomes derived from miR-155-5p-overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration, attenuating apoptosis, and modulating extracellular matrix secretion in chondrocytes. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33099657. |
cck-8, transwell, and western blot analyses were used to detect proliferation, migration, extracellular matrix (ecm) secretion, and apoptosis of osteoarthritic chondrocytes. |
2021-07-15 |
2023-08-13 |
mouse |
| Yumei Ren, Yuling Liu, Shouchuan Wang, Zhen Lei, Yongbin Yan, Xutao Guan, Jianghong Hou, Shan Zhu, Haijun Shan, Xinlei Tian, Quan Wang, Caihong Cao, Yingying Zhang, Yunfeng M. Zhike pingchuan granules improve bronchial asthma by regulating the IL-6/JAK2/STAT3 pathway. Experimental and therapeutic medicine. vol 22. issue 2. 2021-07-15. PMID:34257712. |
the expression of proteins related to apoptosis and the il-6/janus kinase 2 (jak2)/stat3 pathway was detected by western blot analysis. |
2021-07-15 |
2023-08-13 |
mouse |
| Zhi-Wei Dai, Ke-Dan Cai, Ling-Cang Xu, Lai-Liang Wan. Perilipin2 inhibits diabetic nephropathy-induced podocyte apoptosis by activating the PPARγ signaling pathway. Molecular and cellular probes. vol 53. 2021-07-14. PMID:32387304. |
in vitro experiments demonstrated that perilipin2 inhibition could not only reduced pparγ expression in podocytes, it could also promote the apoptosis, and inhibit the viability in hg treated podocytes using western blot, cck8 and flow cytometry assays. |
2021-07-14 |
2023-08-13 |
mouse |
| Azam Najmafshar, Mahboubeh Rostami, Jaleh Varshosaz, Dariush Norouzian, Seyed Ziyae Aldin Samsam Sharia. Enhanced antitumor activity of bovine lactoferrin through immobilization onto functionalized nano graphene oxide: an Drug delivery. vol 27. issue 1. 2021-07-14. PMID:32812454. |
the anticancer mechanism of the cgo-peg-blf was studied by cell cycle analysis, apoptosis assay, and western blot technique. |
2021-07-14 |
2023-08-13 |
cattle |
| Qiming Shen, Zhe Xu, Shun X. Long non‑coding RNA LUCAT1 contributes to cisplatin resistance by regulating the miR‑514a‑3p/ULK1 axis in human non‑small cell lung cancer. International journal of oncology. vol 57. issue 4. 2021-07-14. PMID:32945379. |
functionally, lucat1 upregulation enhanced cisplatin resistance by promoting the viability, autophagy and metastasis, and inhibiting the apoptosis of nsclc cells, as demonstrated by cell counting kit‑8 (cck‑8) assay, western blot analysis, transwell assay and flow cytometric analysis. |
2021-07-14 |
2023-08-13 |
human |
| Jiawei Jiang, Jinlong Zhang, Chunshuai Wu, Chu Chen, Guofeng Bao, Guanhua Xu, Pengfei Xue, Yong Zhou, Yuyu Sun, Zhiming Cu. Knockdown of TRAF6 inhibits chondrocytes apoptosis and inflammation by suppressing the NF-κB pathway in lumbar facet joint osteoarthritis. Molecular and cellular biochemistry. vol 476. issue 4. 2021-07-14. PMID:33502650. |
meanwhile, western blot and immunofluorescent staining demonstrated that iκbα degradation and p65 nuclear transportation were also inhibited, revealing that knockdown of traf6 suppressed activation of the nf-κb pathway in lps-induced chondrocytes apoptosis model. |
2021-07-14 |
2023-08-13 |
human |
| Jing Wei, Tao Yan, Yuanhong Lian. Targeting TRAF3IP2 alleviates high glucose-induced cardiomyocyte inflammation and apoptosis. Drug development research. 2021-07-14. PMID:34260107. |
next, cell apoptosis was detected employing tunel and western blot. |
2021-07-14 |
2023-08-13 |
Not clear |
| Zhiguo Chen, Jiangang Liu, Qingmei Chen, Min Su, Haifeng Lu, Yi Yang, Guoqing Zhou, Xianxian Zhang, Yuan Liu, Wanli Dong, Qi Fan. Down-regulation of UBA6 exacerbates brain injury by inhibiting the activation of Notch signaling pathway to promote cerebral cell apoptosis in rat acute cerebral infarction model. Molecular and cellular probes. vol 53. 2021-07-13. PMID:32497710. |
the results of flow cytometry and western blot assays further demonstrated that uba6 inhibition induced the apoptosis of hippocampal neurons and increased cleaved-caspase-3/9 protein levels. |
2021-07-13 |
2023-08-13 |
rat |
| Xiaowei Zhang, Yu Dong, Miao Gao, Minfeng Hao, Hui Ren, Ling Guo, Hua Gu. Knockdown of TRAP1 promotes cisplatin-induced apoptosis by promoting the ROS-dependent mitochondrial dysfunction in lung cancer cells. Molecular and cellular biochemistry. vol 476. issue 2. 2021-07-13. PMID:33196942. |
the expression of genes related to apoptosis and drug resistance as well as the cell cycle regulators, including mdm2, cyclinb1, and cdk1, were detected by western blot. |
2021-07-13 |
2023-08-13 |
Not clear |
| Jing Wang, Hongling Chen, Wanrong Li, Lingling Sha. Cordyceps acid alleviates lung cancer in nude mice. Journal of biochemical and molecular toxicology. vol 35. issue 3. 2021-07-13. PMID:33251677. |
the levels of nrf-2/ho-1/nlrp3/nf-κb pathway and apoptosis in tumor tissues of nude mice were detected by the western blot analysis and immunohistochemical methods. |
2021-07-13 |
2023-08-13 |
mouse |
| Kunchi Zhao, Ran Li, Qing Ruan, Chunyang Meng, Fei Yin, Qingsan Zh. microRNA-125b and its downstream Smurf1/KLF2/ATF2 axis as important promoters on neurological function recovery in rats with spinal cord injury. Journal of cellular and molecular medicine. 2021-07-13. PMID:33951295. |
after loss- and gain-function approaches were conducted in sci rat models and neural stem cells (nscs) isolated from foetal rats, the basso-beattie-bresnahan (bbb) score was calculated, and related protein expression was determined by western blot analysis and cell apoptosis by tunel staining. |
2021-07-13 |
2023-08-13 |
rat |
| Juan Tan, Weinan Pan, Huilin Chen, Yafang Du, Peiyong Jiang, Dianmei Zeng, Jie Wu, Kuang Pen. Circ_0124644 Serves as a ceRNA for miR-590-3p to Promote Hypoxia-Induced Cardiomyocytes Injury via Regulating SOX4. Frontiers in genetics. vol 12. 2021-07-13. PMID:34249089. |
the protein levels of apoptosis markers and sox4 were determined by western blot (wb) analysis, and the levels of oxidative stress markers were assessed using commercial assay kits. |
2021-07-13 |
2023-08-13 |
Not clear |
| Doğan Albayrak, Oğuzhan Doğanlar, Suat Erdoğan, Meryem Meraklı, Ayten Doğan, Pelin Turker, Ayten Bostancı, Zeynep Banu Doğanla. Naringin Combined with NF-κB Inhibition and Endoplasmic Reticulum Stress Induces Apoptotic Cell Death via Oxidative Stress and the PERK/eIF2α/ATF4/CHOP Axis in HT29 Colon Cancer Cells. Biochemical genetics. vol 59. issue 1. 2021-07-08. PMID:32979141. |
quantitative real-time pcr and western blot analysis demonstrated that drug combination-induced mitochondrial apoptosis was activated through the ros-mediated perk/eif2α/atf4/chop pathway. |
2021-07-08 |
2023-08-13 |
Not clear |