| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanping Bei, Xue Chen, Quan Xu, Jiaming Lv, Jing Hu, Shaohui Yan. Apatinib weakens resistance of gastric cancer cells to paclitaxel by suppressing JAK/STAT3 signaling pathway. Drug development research. 2021-08-18. PMID:34405891. |
western blot was performed to measure the expressions of proteins concerning apoptosis, epithelial-mesenchymal transition and janus-activated kinase (jak)/signal transducer and activator of transcription (stat) pathway. |
2021-08-18 |
2023-08-13 |
Not clear |
| Xin Mao, Rong-Mei Yao, Yan-Yan Bao, Jing Sun, Xiao-Lan Cui, Hai-Jiang Zhang, Yu-Jing Sh. [Effect of polysaccharides from seeds of Vaccaria segetalis in alleviating urinary tract infection induced bladder injury by inhibiting NLRP3 inflammasome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 13. 2021-08-17. PMID:34396759. |
western blot and immunofluorescence staining were used to detect the expressions of sonic hedgehog( shh) and nlrp3 inflammasome [nod-like receptor thermoprotein domain 3( nlrp3),apoptosis associated speck like protein( asc) and pro-caspase-1]. |
2021-08-17 |
2023-08-13 |
rat |
| Zhuo-Qing Li, Hong Shen, Kun-Xian Shu, Jian-Jun Li, Yin Tang, Jing-Jing Su, Jun Yan, Jie Yang, Ze-Qing Wang, Yan Qiu, Yong Yang, Yang Liu, Yong Zho. Transplantation of a Novel Recombinant Adeno-Associated Virus (pAAV-HE1B19K-TE1A) Demonstrates Higher Anti-Tumor Effects in Tumor Cells. Annals of transplantation. vol 25. 2021-08-16. PMID:32883945. |
apoptosis was analyzed using qpcr and western blot assay. |
2021-08-16 |
2023-08-13 |
Not clear |
| Xiaohuan Ding, Jing Lv, Jia Luan, Jun Zhan. Calycosin may Alleviate Ang II-Induced Pro-proliferative Effects on Glomerular Mesangial Cells via Partially Inhibiting Autophagy and ERK Signaling Pathway. Biological & pharmaceutical bulletin. vol 43. issue 12. 2021-08-16. PMID:32999213. |
human glomerular mesangial cells (gmcs) were cultured and treated by ang ii and 0, 0.1, 1, or 10 µm calycosin, and the viability and proliferation of the cells were determined by methyl thiazolyl tetrazolium (mtt) and 5-ethynil-2'-deoxyuridine (edu) staining; moreover, the apoptosis of the cells was examined by flow cytometry assay; furthermore, the expression levels of extracellular signal-regulated kinase (erk), p-erk, anti-apoptotic factor bcl-2, as well as pro-apoptotic factor bax have been examined by western blot (wb) methods; finally, the expression of autophagic markers in each group was examined by wb and immunocytochemistry methods. |
2021-08-16 |
2023-08-13 |
human |
| Guanpeng Xu, Xi Li, Zhiyong Zhu, Huisheng Wang, Xizhuang Ba. Iron Overload Induces Apoptosis and Cytoprotective Autophagy Regulated by ROS Generation in Mc3t3-E1 Cells. Biological trace element research. vol 199. issue 10. 2021-08-16. PMID:33405076. |
cell apoptosis was examined using annexin v-fitc/pi staining with a flow cytometry, and levels of bax, bcl-2, cleaved caspase-3, and cleaved parp were evaluated with western blot. |
2021-08-16 |
2023-08-13 |
Not clear |
| Yu Zhu, Jianbo Yu, Jiangbiao Gong, Jie Shen, Di Ye, Dexin Cheng, Zhikai Xie, Jianping Zeng, Kangli Xu, Jian Shen, Hengjun Zhou, Yuxiang Weng, Jianwei Pan, Renya Zha. PTP1B inhibitor alleviates deleterious microglial activation and neuronal injury after ischemic stroke by modulating the ER stress-autophagy axis via PERK signaling in microglia. Aging. vol 13. issue 3. 2021-08-16. PMID:33495405. |
microglial activation/polarization, endoplasmic reticulum (er) stress, autophagy, and apoptosis were detected using western blot, immunohistology, elisa, and real-time pcr. |
2021-08-16 |
2023-08-13 |
rat |
| Haixia Zhao, Laixin Song, Na Ma, Chaoqi Liu, Yaoyan Dun, Zhiyong Zhou, Ding Yuan, Changcheng Zhan. The dynamic changes of Nrf2 mediated oxidative stress, DNA damage and base excision repair in testis of rats during aging. Experimental gerontology. vol 152. 2021-08-16. PMID:34175407. |
finally, tunel and western blot results further confirmed germ cell apoptosis progressively increased from 3 to 24 months of age as evidenced by decreased ratio of bcl-2/bax and levels of bcl-2 expression, and increased bax expression levels. |
2021-08-16 |
2023-08-13 |
rat |
| Qingchun Pan, Bei Li, Jin Zhang, Xiuluan Du, Donghua G. LncRNA THAP9-AS1 accelerates cell growth of esophageal squamous cell carcinoma through sponging miR-335-5p to regulate SGMS2. Pathology, research and practice. vol 224. 2021-08-16. PMID:34273804. |
cell proliferation, migration, invasion and apoptosis as well as emt process were analyzed by 5-ethynyl-2'-deoxyuridine ( edu), transwell, terminal deoxynucleotidyl transferase dutp nick-end labeling (tunel) and western blot experiments. |
2021-08-16 |
2023-08-13 |
human |
| Xuexia Liu, Qian Li, Zhixin Wang, Fujun Li. Identification of abnormal protein expressions associated with mouse spermatogenesis induced by cyclophosphamide. Journal of cellular and molecular medicine. vol 25. issue 3. 2021-08-15. PMID:33438283. |
the results of immunohistochemistry and western blot showed that cp reduced the proliferation of germ cells (pcna, plzf) and increased germ cell apoptosis (bax and tunel-positive cells) in cp-treated mice testes. |
2021-08-15 |
2023-08-13 |
mouse |
| Haiying Fu, Junjie Zhang, Mayu Huan. Topiroxostat ameliorates oxidative stress and inflammation in sepsis-induced lung injury. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 75. issue 11-12. 2021-08-13. PMID:32589612. |
the cell apoptosis in lung was detected by tunnel staining and western blot analysis of apoptosis-related proteins including pro-apoptosis proteins, bax, cleaved caspase9, cleaved caspase3 and anti-apoptosis protein bcl2. |
2021-08-13 |
2023-08-13 |
rat |
| Yifan Chen, Min Zhang, Xinghao Ji, Jinjin Zhao, Shuang Qin, Yinghua Ji, Ruijuan Fan, Yanting Liu, Ping L. The anti-cancer effect of metoclopramide on triple-negative breast cancer cells. Die Pharmazie. vol 76. issue 4. 2021-08-13. PMID:33849703. |
this study aimed at elucidating the effect of metoclopramide on triple-negative breast cancer, mda-mb-231 cells were treated with various concentrations of metoclopramide, the cell proliferation was detected by mtt method, the apoptosis rate was detected by annexin v/pi double staining method, the expression change of death-related protein was detected by western blot. |
2021-08-13 |
2023-08-13 |
Not clear |
| Wei Dong, Pengying Wu, Di Zhou, Jixiu Huang, Mengfan Qin, Xinxing Yang, Mingxi Wan, Yujin Zon. Ultrasound-Mediated Gene Therapy of Hepatocellular Carcinoma Using Pre-microRNA Plasmid-Loaded Nanodroplets. Ultrasound in medicine & biology. vol 46. issue 1. 2021-08-12. PMID:31668943. |
quantitative real-time polymerase chain reaction (qrt-pcr), western blot and cell apoptosis assay revealed that pre-mir-139, -203a, -378a and -422a plasmids among the six mirna overexpression vectors could suppress growth of the hepatoma cell line smmc-7721. |
2021-08-12 |
2023-08-13 |
mouse |
| Li-Bin Gao, Xin-Le Zhu, Jing-Xian Shi, Ling Yang, Zhen-Qiang Xu, Song-Lin Sh. HnRNPA2B1 promotes the proliferation of breast cancer MCF-7 cells via the STAT3 pathway. Journal of cellular biochemistry. vol 122. issue 3-4. 2021-08-12. PMID:33399232. |
besides this, the western blot results showed that knockout of hnrnpa2/b1 increased the rate of apoptosis and declined autophagy. |
2021-08-12 |
2023-08-13 |
mouse |
| Jinchun Wang, Zhujing Chen, Xiaojing Feng, Lu Yi. Shikonin ameliorates injury and inflammatory response of LPS-stimulated WI-38 cells via modulating the miR-489-3p/MAP2K1 axis. Environmental toxicology. vol 36. issue 9. 2021-08-12. PMID:34089293. |
cell apoptosis was detected by western blot and flow cytometry analysis. |
2021-08-12 |
2023-08-13 |
Not clear |
| Fang Tian, Huimin Ying, Shuaiju Liao, Yuanyuan Wang, Quansheng Wan. lncRNA SNHG14 promotes the proliferation, migration, and invasion of thyroid tumour cells by regulating miR-93-5p. Zygote (Cambridge, England). 2021-08-12. PMID:34380584. |
cck-8 and western blot were used to detect the effects of snhg14 on proliferation and apoptosis of thyroid tumour cells. |
2021-08-12 |
2023-08-13 |
Not clear |
| Luiz D Ramos, Leonardo H de Macedo, Nicholas R S Gobo, Kleber T de Oliveira, Giselle Cerchiaro, Karina P Morelli Fri. Understanding the photophysical properties of rhenium(I) compounds coordinated to 4,7-diamine-1,10-phenanthroline: synthetic, luminescence and biological studies. Dalton transactions (Cambridge, England : 2003). vol 49. issue 45. 2021-08-11. PMID:32270852. |
in addition, flow cytometry and western blot analyses showed an overexpression of pro-caspase-9, suggesting a caspase proteolytic cascade through an intrinsic-pathway apoptosis mechanism. |
2021-08-11 |
2023-08-13 |
Not clear |
| Shotaro Otsuka, Harutoshi Sakakima, Akira Tani, Kazuki Nakanishi, Seiya Takada, Kosuke Norimatsu, Hiroshi Maejima, Ikuro Maruyam. Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats. Brain structure & function. vol 226. issue 7. 2021-08-11. PMID:34114048. |
infarct volume, neurological deficits, sensorimotor function, expression levels of brain-derived neurotrophic factor (bdnf), hypoxia-induced factor-1α (hif-1α), glial fibrillary acidic protein (gfap), and p2x7 receptors, and apoptosis activity were examined using immunohistochemical and western blot analyses. |
2021-08-11 |
2023-08-13 |
rat |
| Jin Wang, Dan Li, Zhinan Zhang, Yan Zhang, Zhandong Lei, Wenwen Jin, Jimin Cao, Xiangying Jia. Autoantibody against angiotensin II type I receptor induces pancreatic β-cell apoptosis via enhancing autophagy. Acta biochimica et biophysica Sinica. vol 53. issue 6. 2021-08-10. PMID:33928341. |
ins-1 cells were treated with at1-aa, and cell viability, apoptosis, and autophagy-related proteins were detected by cell counting kit-8 assay, flow cytometry, and western blot analysis, respectively. |
2021-08-10 |
2023-08-13 |
rat |
| Zhonghua Fu, Zhengying Jiang, Guanghua Guo, Xincheng Liao, Mingzhuo Liu, Zhenfang Xion. rhKGF-2 Attenuates Smoke Inhalation Lung Injury of Rats Frontiers in pharmacology. vol 12. 2021-08-10. PMID:34366838. |
the pathological changes and cell apoptosis were determined by hematoxylin-eosin (he) staining and tdt-mediated dutp nick end labeling (tunel) assay, and the pi3k/akt/nrf2/ho-1/nqo1, and foxo1-nlrp3 inflammasome expression were verified by western blot (wb). |
2021-08-10 |
2023-08-13 |
human |
| Tai-Wei Zhang, Ze-Fang Li, Wang Ding, Hui-Ren Wang, Sheng-Long Ding, Guan-Jie Han, Xi-Lei Li, Jian Dong, Li-Bo Jian. Decorin inhibits nucleus pulposus apoptosis by matrix-induced autophagy via the mTOR pathway. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 39. issue 8. 2021-08-09. PMID:33034924. |
the western blot analysis and terminal deoxynucleotidyl transferase dutp nick end labeling assay results showed that dcn treatment induced autophagy and decreased apoptosis caused by interleukin (il)-1β application. |
2021-08-09 |
2023-08-13 |
rat |