| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Pan, Qingshang Li, Zhijun Cao, Shuliang Zha. The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses. Genes & diseases. vol 8. issue 6. 2021-09-16. PMID:34522711. |
rt-pcr, immunohistochemistry (ihc), western blot, cck-8 assay, cell apoptosis assay, cell cycle assay were used to further verify in gc tissue samples or cell line. |
2021-09-16 |
2023-08-13 |
Not clear |
| Jian-Lin Zhou, Shuang Deng, Hong-Song Fang, Xian-Jin Du, Hao Peng, Qiong-Jie H. Circular RNA circANKRD36 regulates Casz1 by targeting miR-599 to prevent osteoarthritis chondrocyte apoptosis and inflammation. Journal of cellular and molecular medicine. vol 25. issue 1. 2021-09-15. PMID:33205602. |
facs analysis and western blot showed that the knockdown of circankrd36 promotes the apoptosis and inflammation of chondrocytes in il-1β stress. |
2021-09-15 |
2023-08-13 |
human |
| Shu-Hsiang Huang, Sheng-Ting Fang, Yi-Cheng Che. Molecular Mechanism of Vitamin K2 Protection against Amyloid-β-Induced Cytotoxicity. Biomolecules. vol 11. issue 3. 2021-09-15. PMID:33805625. |
inhibitor assay and western blot analyses revealed that the possible mechanism of vitamin k2 protection against aβ-mediated apoptosis might be via regulating phosphatidylinositol 3-kinase (pi3k) associated-signaling pathway and inhibiting caspase-3-mediated apoptosis. |
2021-09-15 |
2023-08-13 |
Not clear |
| Canan Eroğlu Güneş, Ebru Güçlü, Hasibe Vural, Ercan Kura. Knockdown of lncRNA ZEB2NAT suppresses epithelial mesenchymal transition, metastasis and proliferation in breast cancer cells. Gene. vol 805. 2021-09-15. PMID:34418470. |
the effect of zeb2nat on the expression of important genes in emt, metastasis and apoptosis, and some protein levels was determined by qrt-pcr and western blot analysis, respectively. |
2021-09-15 |
2023-08-13 |
Not clear |
| Yogendra Prasad Kavalappa, Sowmya Shree Gopal, Ganesan Ponesakk. Lutein inhibits breast cancer cell growth by suppressing antioxidant and cell survival signals and induces apoptosis. Journal of cellular physiology. vol 236. issue 3. 2021-09-14. PMID:32710479. |
the protein expression of the markers of antioxidant defense, cell survival, and apoptosis was analyzed by western blot analysis. |
2021-09-14 |
2023-08-13 |
human |
| Wenxiang Fan, Ying Zhang, Xiaomin Li, Chi X. S-oxiracetam Facilitates Cognitive Restoration after Ischemic Stroke by Activating α7nAChR and the PI3K-Mediated Pathway. Neurochemical research. vol 46. issue 4. 2021-09-14. PMID:33481205. |
by using y-maze test, morris water maze, triphenyl tetrazolium chloride (ttc) staining, terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate (dutp) nick end labeling (tunel) assay, hematoxylin and eosin, immunohistochemical staining and western blot to evaluate the protective effect of s-orc on cognitive recovery, we were able to confirm that s-orc ameliorated spatial learning impairment, tissue loss, and hippocampal neuronal apoptosis and injury induced by mcao/r in rats. |
2021-09-14 |
2023-08-13 |
rat |
| Renjie Dou, Jinjun Qian, Wei Wu, Yanxin Zhang, Yuxia Yuan, Mengjie Guo, Rongfang Wei, Shu Yang, Artur Jurczyszyn, Siegfried Janz, Meral Beksac, Chunyan Gu, Ye Yan. Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma. Cell death & disease. vol 12. issue 2. 2021-09-14. PMID:33627630. |
transcriptomic sequencing, immunofluorescence, and western blot were used to investigate the effects of srd5a1 suppression on cell apoptosis and autophagy. |
2021-09-14 |
2023-08-13 |
mouse |
| Hyo In Kim, Sol Ji Lee, Yu-Jeong Choi, Min Jeong Kim, Tai Young Kim, Seong-Gyu K. Quercetin Induces Apoptosis in Glioblastoma Cells by Suppressing Axl/IL-6/STAT3 Signaling Pathway. The American journal of Chinese medicine. vol 49. issue 3. 2021-09-14. PMID:33657989. |
further western blot assays suggested that quercetin induces apoptosis but does not affect akt or mitogen-activated protein kinases, factors related to cell proliferation. |
2021-09-14 |
2023-08-13 |
Not clear |
| Xue Bai, Hui Yang, Jiayuan Pu, Yan Zhao, Ying Jin, Qin Y. MKRN1 Ubiquitylates p21 to Protect against Intermittent Hypoxia-Induced Myocardial Apoptosis. Oxidative medicine and cellular longevity. vol 2021. 2021-09-11. PMID:34504644. |
tunel, western blot, and immunohistochemistry assays were used to detect cell apoptosis. |
2021-09-11 |
2023-08-13 |
human |
| Wei DU, Changhe Pang, Yake Xue, Qingjun Zhang, Xinting We. Dihydroartemisinin inhibits the Raf/ERK/MEK and PI3K/AKT pathways in glioma cells. Oncology letters. vol 10. issue 5. 2021-09-10. PMID:26722323. |
moreover, western blot analysis indicated that dha-induced apoptosis was accompanied by inactivation of the raf/mek/erk and pi3k/akt signaling pathways, in addition to the downregulation of anti-apoptotic proteins mcl-1 and bcl-2 expression levels. |
2021-09-10 |
2023-08-13 |
Not clear |
| Wei Wu, Doudou Jing, Xin Huang, Wenbo Yang, Zengwu Sha. Drp1-mediated mitochondrial fission is involved in oxidized low-density lipoprotein-induced AF cella poptosis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 39. issue 7. 2021-09-07. PMID:32808688. |
the expression of proteins related to the mitochondrial apoptosis pathway was determined using western blot. |
2021-09-07 |
2023-08-13 |
Not clear |
| Mengqi Zhang, Yaping Liu, Zhikun Huan, Yan Wang, Jin X. Metformin protects chondrocytes against IL-1β induced injury by regulation of the AMPK/NF-κ B signaling pathway. Die Pharmazie. vol 75. issue 12. 2021-09-07. PMID:33303055. |
in our study, cell viability was measured using cell counting kit-8 assay, expressions of crucial factors involved in the extracellular matrix (ecm) metabolic, proinflammatory response, cell apoptosis, and nuclear factor κ b(nf-κ b) pathway were analyzed using western blot analysis and immunofluorescence staining. |
2021-09-07 |
2023-08-13 |
Not clear |
| Liwei Yan, Dandan Wang, Xiaoming Liu, Chao Gu, Shanyu Ga. Actein antagonizes colorectal cancer through blocking PI3K/Akt pathways by downregulating IMPDH2. Anti-cancer drugs. vol 32. issue 8. 2021-09-07. PMID:33929996. |
the cell counting kit-8 cell proliferation assays, cell cycle detection, apoptosis detection, reactive oxygen species and mitochondrial membrane potential evaluation, western blot, as well as sw480 xenograft mice model were conducted to illustrate the mechanisms of action on anti-crc effects of actein. |
2021-09-07 |
2023-08-13 |
mouse |
| Li Xue, Yuhua Tao, Yanjuan Yuan, Wei Qu, Wei Wan. Curcumin suppresses renal carcinoma tumorigenesis by regulating circ-FNDC3B/miR-138-5p/IGF2 axis. Anti-cancer drugs. vol 32. issue 7. 2021-09-07. PMID:34001703. |
cell proliferation and apoptosis were investigated via 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-h-tetrazolium bromide, colony formation analysis, flow cytometry and western blot. |
2021-09-07 |
2023-08-13 |
Not clear |
| Shican Zhou, Hang Wu, Wenjuan Ning, Xiao Wu, Xiaoxiao Xu, Yuanqiao Ma, Xingwang Li, Junhong Hu, Chenyu Wang, Junpeng Wan. Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth. Frontiers in pharmacology. vol 12. 2021-09-07. PMID:34483925. |
we used cck-8 assay to determine the cell viability, used an optical microscope to measure cell morphology, used annexin v-fitc/7-aad kit to determine cell apoptosis, used caspase 3/7 activity apoptosis assay kit to evaluate caspase 3/7 activity, used western blot to determine apoptosis-associated protein expression, and used flow cytometry and fluorescence microscope to determine the reactive oxygen species (ros) levels and cell cycle. |
2021-09-07 |
2023-08-13 |
human |
| Pan Pan, Xudong Liu, LingLing Wu, Xiaogang Li, Kaifei Wang, Xiaoting Wang, Xiang Zhou, Yun Long, Dawei Liu, Lixin Xie, Longxiang S. TREM-1 promoted apoptosis and inhibited autophagy in LPS-treated HK-2 cells through the NF-κB pathway. International journal of medical sciences. vol 18. issue 1. 2021-09-06. PMID:33390769. |
western blot analysis was performed to analyze apoptosis, autophagy and the relevant signaling pathways. |
2021-09-06 |
2023-08-13 |
human |
| Min-Hui Zhang, Rong Zhou, Fang Liu, Tzi B N. Purification of a novel protein with cytotoxicity against non-small-cell lung cancer cells from Boletus bicolor. Archiv der Pharmazie. vol 354. issue 9. 2021-09-03. PMID:34076300. |
the western blot analysis results showed that the expression of apoptosis and cell cycle-related proteins of cleaved caspase-3, cytochrome c, bax, p16, and p21 was significantly upregulated, whereas the expression of bcl-2, cdk4, cyclin d, p-rb, and e2f was significantly downregulated after treatment with protein d1. |
2021-09-03 |
2023-08-13 |
human |
| Man-Lin Guo, Xiang-Yu Ma, Yu-Qing Gong, Meng-Lin Feng, Yu-Wan Zhao, Leng-Xin Dua. [Protective effect of ethyl acetate extract from Bidens bipinnata on hepatocyte damage induced by endoplasmic reticulum stress]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 15. 2021-09-03. PMID:34472265. |
methyl thiazolyl tetrazolium(mtt) colorimetric assay was used to investigate the survival rate of ethyl acetate extract from b. bipinnata in l02 cells injury induced by endoplasmic reticulum stress; the protein expressions of endoplasmic reticulum stress-related molecule glucose regulated protein 78(grp78), pkr-like er kinase(perk), eukaryotic initiation factor-2(eif2α), activating transcription factor 4(atf4), c/ebp homologous protein(chop), b-cell cll/lymphoma 2(bcl-2), bal-2 associated x apoptosis regulator(bax) were examined by wes-tern blot. |
2021-09-03 |
2023-08-13 |
Not clear |
| Yichun He, Qin Li, Weijun Zhou, Yanhong Gu, Yu Jian. Coniferyl aldehyde alleviates LPS-induced WI-38 cell apoptosis and inflammation injury via JAK2-STAT1 pathway in acute pneumonia. Allergologia et immunopathologia. vol 49. issue 5. 2021-09-03. PMID:34476925. |
further, flow cytometry and western blot assay verified that lps treatment dramatically promoted apoptosis of wi-38 cells, while administration of ca notably inhibited apoptosis of wi-38 cells. |
2021-09-03 |
2023-08-13 |
Not clear |
| Hongkun Zhu, Xinjun Wang, Xiaoxiao Wang, Bei Liu, Yizhen Yuan, Xiangrong Zu. Curcumin attenuates inflammation and cell apoptosis through regulating NF-κB and JAK2/STAT3 signaling pathway against acute kidney injury. Cell cycle (Georgetown, Tex.). vol 19. issue 15. 2021-09-02. PMID:32615888. |
western blot analysis indicated that janus kinase (jak) 2/signal transducer and activator of transcription (stat) 3, p-65-nf-κb and cell apoptosis pathways were activated by lps but suppressed by curcumin. |
2021-09-02 |
2023-08-13 |
mouse |