| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valeria Sorrenti, Agata Grazia D'Amico, Ignazio Barbagallo, Valeria Consoli, Salvo Grosso, Luca Vanell. Tin Mesoporphyrin Selectively Reduces Non-Small-Cell Lung Cancer Cell Line A549 Proliferation by Interfering with Heme Oxygenase and Glutathione Systems. Biomolecules. vol 11. issue 6. 2021-09-22. PMID:34205698. |
to support these data, western blot analysis was performed to analyze glucose-6-phosphate dehydrogenase (g6pd), tp53-induced glycolysis and the apoptosis regulator (tigar), and the glutamate cysteine ligase catalytic (gclc) subunit, as they represent the main regulators of the pentose phosphate pathway (ppp) and glutathione synthesis, respectively. |
2021-09-22 |
2023-08-13 |
Not clear |
| Bin Sun, Xiaoxian Liu, Han Peng, Xin Xiang, Hua Yan. Circular RNA _NLRP1 targets mouse microRNA-199b-3p to regulate apoptosis and pyroptosis of hippocampal neuron under oxygen-glucose deprivation exposure. Bioengineered. vol 12. issue 1. 2021-09-22. PMID:34227902. |
after the cell model was pre-treated with short hairpin (sh)-circ_nlrp1 or mmu-mir-199b-3p inhibitor, ldh release and cell apoptosis were detected by ldh kit and tunel staining, respectively, while the expression of nlrp3 pyroptosis-related makers was analyzed through immunofluorescence (if) assay and western blot, respectively. |
2021-09-22 |
2023-08-13 |
mouse |
| Yue Li, Ming Yi, Dan Wang, Qiuxia Zhang, Li Yang, Chunsheng Yan. LncRNA KCNQ1OT1 Regulates Endoplasmic Reticulum Stress to Affect Cerebral Ischemia-Reperfusion Injury Through Targeting miR-30b/GRP78. Inflammation. vol 43. issue 6. 2021-09-21. PMID:32794050. |
tunel staining was used to detect apoptosis level, and western blot was used to detect the expressions of ers and apoptosis-related proteins. |
2021-09-21 |
2023-08-13 |
rat |
| Deping Sun, Dongsheng Zh. Circular RNA hsa_circ_0001649 suppresses the growth of osteosarcoma cells via sponging multiple miRNAs. Cell cycle (Georgetown, Tex.). vol 19. issue 20. 2021-09-21. PMID:32954926. |
os cells were stably transfected with pex-circ_0001649 or mirnas mimic, cck-8 kit, colony formation, apoptosis and western blot analysis were used to detect the roles of circ_0001649. |
2021-09-21 |
2023-08-13 |
Not clear |
| Kuang Peng, Peiyong Jiang, Yafang Du, Dianmei Zeng, Junbi Zhao, Meiling Li, Chunchen Xia, Zhong Xie, Jie W. Oxidized low-density lipoprotein accelerates the injury of endothelial cells via circ-USP36/miR-98-5p/VCAM1 axis. IUBMB life. vol 73. issue 1. 2021-09-21. PMID:33249762. |
western blot assay was performed to detect the expression of apoptosis and proliferation-related markers and vcam1 protein level. |
2021-09-21 |
2023-08-13 |
Not clear |
| Hong-Zhu Yan, Hua-Feng Wang, Yueling Yin, Jue Zou, Feng Xiao, Li-Na Yi, Ying He, Bo-Sheng H. GHR is involved in gastric cell growth and apoptosis via PI3K/AKT signalling. Journal of cellular and molecular medicine. vol 25. issue 5. 2021-09-21. PMID:33492754. |
flow cytometry showed that ghr knockout significantly stimulated gastric cancer cell apoptosis and caused g1 cell cycle arrest, which was also verified by western blot that ghr deficiency induced the protein level of cleaved-parp, a valuable marker of apoptosis. |
2021-09-21 |
2023-08-13 |
mouse |
| Xin Zhao, Li Jiang, Daixing Hu, Yu Tang, Guozhi Zhao, Xiaoyu Du, Shengjun Luo, Wei Tan. NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation. Experimental cell research. vol 403. issue 2. 2021-09-21. PMID:33905671. |
cck-8 assay, western blot analysis of apoptotic proteins, and flow cytometric analysis of apoptosis were applied to test niraparib sensitivity. |
2021-09-21 |
2023-08-13 |
Not clear |
| Bingwu Liu, Xinfeng Yan, Zuojia Hou, Lei Zhang, Duwen Zhan. Impact of Bupivacaine on malignant proliferation, apoptosis and autophagy of human colorectal cancer SW480 cells through regulating NF-κB signaling path. Bioengineered. vol 12. issue 1. 2021-09-21. PMID:34151717. |
our work treated crc cells with bupivacaine, detected cell vitality through mtt assay, apoptosis through flow cytometry, cell migration through wound healing assay, nf-κb activity through immunofluorescence, inflammatory factor level, including tnf-α, il-1β as well as il-6 through eslia, apoptosis factor mrna expression, including bcl-2, bax and caspase-3q through qrt-pcr, and protein expression linking with nf-κb signaling pathway as well as autophagy-related proteins via western blot. |
2021-09-21 |
2023-08-13 |
human |
| Jinjun Shi, Chenchun Fu, Xiangyu Su, Shicheng Feng, Sheng Wan. Ultrasound-Stimulated Microbubbles Inhibit Aggressive Phenotypes and Promotes Radiosensitivity of esophageal squamous cell carcinoma. Bioengineered. vol 12. issue 1. 2021-09-21. PMID:34180353. |
the levels of proteins associated with cell apoptosis and angiogenesis were measured by western blot analysis. |
2021-09-21 |
2023-08-13 |
human |
| Aiping Wen, Le Luo, Chengchao Du, Xin Lu. Long non-coding RNA miR155HG silencing restrains ovarian cancer progression by targeting the microRNA-155-5p/tyrosinase-related protein 1 axis. Experimental and therapeutic medicine. vol 22. issue 5. 2021-09-21. PMID:34539833. |
it was demonstrated that knockdown of mir155hg markedly inhibited oc cell viability, migration and invasion while promoting apoptosis, as indicated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, wound healing, transwell and western blot assays. |
2021-09-21 |
2023-08-13 |
human |
| Zhenzhu Jiang, Jing Yin, Guangyao Peng, Xiaoping Lon. Circ_0074027 contributes to the progression of non-small cell lung cancer via microRNA-362-3p/clathrin heavy chain axis. Anti-cancer drugs. vol 32. issue 1. 2021-09-20. PMID:32932275. |
western blot assay was utilized to measure the levels of clathrin heavy chain (cltc), cyclin d1, bcl2-associated x, apoptosis regulator bax (bax), vimentin and matrix metallopeptidase 9. |
2021-09-20 |
2023-08-13 |
human |
| Lanwei Ouyang, Min Yang, Xiaolin Wang, Jidan Fan, Xing Liu, Yong Zhang, Yusheng Sh. Long non‑coding RNA FER1L4 inhibits cell proliferation and promotes cell apoptosis via the PTEN/AKT/p53 signaling pathway in lung cancer. Oncology reports. vol 45. issue 1. 2021-09-20. PMID:33416121. |
the expression levels of related proteins were detected by western blot assay, while cell apoptosis was determined by hoechst staining and flow cytometry. |
2021-09-20 |
2023-08-13 |
Not clear |
| Xiangde Li, Yun Liu, Shijie Liao, Chengsen Lin, Abu Moro, Jing Liu, Wenyu Feng, Kun Wang, Chunming Wan. Polyphyllin VII induces apoptosis and autophagy via mediating H2O2 levels and the JNK pathway in human osteosarcoma U2OS cells. Oncology reports. vol 45. issue 1. 2021-09-20. PMID:33416129. |
the western blot analysis results indicated that the c‑jun n‑terminal kinase (jnk) signaling pathway was closely associated with polyphyllin vii‑induced apoptosis and autophagy. |
2021-09-20 |
2023-08-13 |
human |
| Cihan Gur, Fatih Mehmet Kandemir, Ekrem Darendelioglu, Cuneyt Caglayan, Sefa Kucukler, Ozge Kandemir, Mustafa Ileritur. Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways. Environmental science and pollution research international. vol 28. issue 36. 2021-09-20. PMID:33939091. |
biochemical and western blot analyses showed that acr increased malondialdehyde (mda), p38α mitogen-activated protein kinase (p38α mapk), nuclear factor kappa-b (nf-κb), tumor necrosis factor alpha (tnf-α), interleukin-1 beta (il-1β), interleukin-6 (il-6), cyclooxygenase-2 (cox-2), p53, caspase-3, bcl-2 associated x protein (bax), beclin-1, light chain 3a (lc3a), and light chain 3b (lc3b) levels and decreased those of superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), glutathione (gsh), b-cell lymphoma-2 (bcl-2), mammalian target of rapamycin (mtor), phosphoinositide 3-kinase (pi3k), and protein kinase b (akt) in brain tissue and therefore induced neurotoxicity by causing oxidative stress, inflammation, apoptosis, and autophagy. |
2021-09-20 |
2023-08-13 |
rat |
| Chunhua Bi, Jili Shan, Maoxiang Li, Qian Zhang, Caihua Li, Jianning Tong, Qikun Huan. Long noncoding RNA differentiation antagonizing nonprotein coding RNA promotes the proliferation, invasion and migration of neuroblastoma cells via targeting β-1, 4-galactosyltransferase III by sponging miR-338-3p. Neuroreport. vol 32. issue 12. 2021-09-20. PMID:34050113. |
moreover, western blot analysis was performed to assess the levels of b4galt3 and the proliferation, apoptosis and migration-related proteins. |
2021-09-20 |
2023-08-13 |
mouse |
| Jingyun Zhang, Liu Yang, Xiaoxiao Han, Chenchi Li, Ranyang Liu, Zihua Ma, Bing Han, Rujia Xie, Qin Yan. [Endoplasmic reticulum stress in hepatic stellate cells induced by tunicamycin promotes apoptosis and cell cycle arrest]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 9. 2021-09-20. PMID:34533126. |
hsc-t6 cells were randomized into control group, treatment group with 1 ml/l of dimethyl sulfoxide (dmso), and treatment group with 1 μg/ml of tunicamycin, and the cells were treated for 12 h. mtt assay was used to detect cell proliferation, flow cytometry to detect apoptosis and cell cycle, and western blot to detect the protein expressions of α-smooth muscle actin (α-sma), c/ebp camp homologous protein (chop), caspase-12, and cyclin d1. |
2021-09-20 |
2023-08-13 |
rat |
| Tianling Ding, Jie Ha. Sirtuin 2 knockdown inhibits cell proliferation and RAS/ERK signaling, and promotes cell apoptosis and cell cycle arrest in multiple myeloma. Molecular medicine reports. vol 24. issue 5. 2021-09-18. PMID:34476507. |
subsequently, the effect of sirt2 knockdown on mm cell proliferation, apoptosis, cell cycle progression and ras/erk signaling was investigated via cell counting kit‑8, flow cytometry, rt‑qpcr and western blot assays, respectively. |
2021-09-18 |
2023-08-13 |
Not clear |
| Cuixiang Xu, Xiaoyan Huang, Yubin Huang, Xiao Liu, Min Wu, Jianhua Wang, Xianglong Dua. Naringin induces apoptosis of gastric carcinoma cells via blocking the PI3K/AKT pathway and activating pro‑death autophagy. Molecular medicine reports. vol 24. issue 5. 2021-09-18. PMID:34490484. |
the protein levels pertaining to the pi3k/akt pathway and cell apoptosis and autophagy were monitored using western blot analysis. |
2021-09-18 |
2023-08-13 |
Not clear |
| Yuan Wang, Huazhang Wu, Nannan Dong, Xu Su, Mingxiu Duan, Yaqin Wei, Jun Wei, Gaofeng Liu, Qingjie Peng, Yunli Zha. Sulforaphane induces S-phase arrest and apoptosis via p53-dependent manner in gastric cancer cells. Scientific reports. vol 11. issue 1. 2021-09-17. PMID:33510228. |
in the present study, we investigate the effects of sfn on cell proliferation, cell cycle, cell apoptosis, and also the expression of several cell cycle and apoptosis-related genes by mtt assay, flow cytometry and western blot analysis in gastric cancer (gc) cells. |
2021-09-17 |
2023-08-13 |
Not clear |
| Tianqi Zhang, Yingying Tian, Qinghui Wang, Meng Fu, Changhu Xue, Jingfeng Wan. Comparative Study of DHA with Different Molecular Forms for Ameliorating Osteoporosis by Promoting Chondrocyte-to-Osteoblast Transdifferentiation in the Growth Plate of Ovariectomized Mice. Journal of agricultural and food chemistry. vol 69. issue 36. 2021-09-16. PMID:34464107. |
western blot results showed that both dha-tg and dha-pc downregulated the bax and cleaved-caspase3 expression and upregulated bcl-2 expression in the growth plate, suggesting that chondrocyte apoptosis is inhibited. |
2021-09-16 |
2023-08-13 |
mouse |