| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Li, Ying Tan, Sainan Chen, Xiaochan Xiao, Mingming Zhang, Qi Wu, Maolong Don. Irisin alleviates LPS-induced liver injury and inflammation through inhibition of NLRP3 inflammasome and NF-κB signaling. Journal of receptor and signal transduction research. vol 41. issue 3. 2021-11-12. PMID:32814473. |
pyroptosis, apoptosis, and reactive oxygen species (ros) were evaluated using pi staining, tunel staining, dcfh-da fluorescence, and western blot, respectively. |
2021-11-12 |
2023-08-13 |
Not clear |
| Chen Chen, Lina Lu, Jie Zhu, Xiaoyu Gu, Bofei Liu, Di Li, Gang Che. Miro1 provides neuroprotection via the mitochondrial trafficking pathway in a rat model of traumatic brain injury. Brain research. vol 1773. 2021-11-12. PMID:34637761. |
real-time polymerase chain reaction, western blot, immunofluorescence, adenosine triphosphate (atp) level assay, neuronal apoptosis, brain water content measurement, and neurological score analyses were carried out. |
2021-11-12 |
2023-08-13 |
rat |
| Shuo Cong, Yongmei Liu, Yi Li, Yu Chen, Rui Chen, Baofang Zhang, Lei Yu, Yaxin Hu, Xueke Zhao, Mao Mu, Mingliang Cheng, Zhi Huan. MiR-571 affects the development and progression of liver fibrosis by regulating the Notch3 pathway. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:34750395. |
cck-8, cell scratch assays, transwell assays, flow cytometry were used to determine the effect of mir-571 on lx-2 proliferation, migration, apoptosis in human stem stellate cells, and rt-pcr, western blot assays were performed to determine the effect of mir-571 on the notch3 signaling pathway and the expression of profibrogenic factors. |
2021-11-12 |
2023-08-13 |
human |
| Houfeng Huang, Xinrong Fan, Yi Qiao, Ming Yang, Zhigang J. Knockdown of KNTC1 Inhibits the Proliferation, Migration and Tumorigenesis of Human Bladder Cancer Cells and Induces Apoptosis. Critical reviews in eukaryotic gene expression. vol 31. issue 1. 2021-11-11. PMID:33639055. |
human apoptosis antibody array and western blot were used to detect the expression level changes of related proteins after kntc1 knockdown to explore the possible mechanism. |
2021-11-11 |
2023-08-13 |
human |
| Yanhong Wu, Meiling Zhao, Zhaoheng Li. Pyrroloquinoline quinone (PQQ) alleviated sepsis-induced acute liver injury, inflammation, oxidative stress and cell apoptosis by downregulating CUL3 expression. Bioengineered. vol 12. issue 1. 2021-11-11. PMID:34227919. |
moreover, tunel staining, flow cytometric analysis and western blot were applied to determine cell apoptosis. |
2021-11-11 |
2023-08-13 |
rat |
| Xiangyu Cao, Chengying Liu, Mengmeng Zhang, Ruochen Bi, Mingyang Fu, Elena Korik, Jiahe Chen, Jianyun Gao, Igor Semak, Jianli Li. Bovine lactoferrin and Lentinus edodes mycelia polysaccharide complex: The formation and the activity to protect islet β cells. International journal of biological macromolecules. vol 191. 2021-11-11. PMID:34592222. |
cell viability, reactive oxygen species (ros) level, apoptosis and the related signaling pathways were detected with thiazolyl blue tetrazolium bromide (mtt) assay, 2,7-dichlorofluorescin diacetate (dcfh-da) staining, hoechst 33258 staining and western blot methods respectively. |
2021-11-11 |
2023-08-13 |
cattle |
| Junping Guo, Wei Chen, Beibei Bao, Dayong Zhang, Jianping Pan, Mao Zhan. Protective effect of berberine against LPS-induced endothelial cell injury via the JNK signaling pathway and autophagic mechanisms. Bioengineered. vol 12. issue 1. 2021-11-10. PMID:33896366. |
cell viability, proliferation, and apoptosis were detected by the cck-8 assay, the edu kit, and flow cytometry, respectively, and autophagy-related protein expression, the number of autophagic vacuoles, and lc3 double-fluorescence were examined using western blot analysis, transmission electron microscopy, and confocal microscopy, respectively. |
2021-11-10 |
2023-08-13 |
human |
| Jianhua Han, Shigeng Li, Yawei Feng, Yufeng He, Weilong Hong, Zhiqiang Y. A novel circular RNA (hsa_circ_0059930)-mediated miRNA-mRNA axis in the lipopolysaccharide-induced acute lung injury model of MRC-5 cells. Bioengineered. vol 12. issue 1. 2021-11-10. PMID:34002668. |
after hsa_circ_0059930 knockdown, the proliferation and apoptosis of mrc-5 cells were identified by cck-8, flow cytometer, and western blot assays. |
2021-11-10 |
2023-08-13 |
Not clear |
| Deyuan Zhi, Meng Zhang, Jin Lin, Pei Liu, Meili Dua. GPR120 Ameliorates Apoptosis and Inhibits the Production of Inflammatory Cytokines in Renal Tubular Epithelial Cells. Inflammation. vol 44. issue 2. 2021-11-09. PMID:33009637. |
cell apoptosis experiments included the annexin v and pi double-staining method combined with flow cytometry, tunel method, and western blot. |
2021-11-09 |
2023-08-13 |
mouse |
| Junting Kou, Xuewei Wang, Yuan Wei, Rong Zhao, Xiuli Wang, Jiefeng He, Xiaozhong Li, Xiaoxia Wan. Aurora kinase inhibitor VX-680 enhances sensitivity of esophageal squamous cell carcinoma cells to cisplatin chemotherapy. Anti-cancer drugs. vol 32. issue 9. 2021-11-09. PMID:34016831. |
2-(4-amidinophenyl)-6-indolecarbamidine dihydrochloride staining and western blot analysis suggested that vx-680 increased cisplatin-mediated cell apoptosis. |
2021-11-09 |
2023-08-13 |
Not clear |
| Eloisa D Castro, Pedro Paulo M Mathias, Wagner L Batista, Alex Yuri S Sato, Maytê S Toledo, Victor T de Almeida, Marli F Curcio, Paulo E da Costa, Arnold Stern, Hugo P Monteir. Knockdown of the inducible nitric oxide synthase (NOS2) splicing variant S3 promotes autophagic cell death from nitrosative stress in SW480 human colon cancer cells. Cell biology international. 2021-11-09. PMID:34719858. |
western blot analysis and quantitative real-time polymerase chain reaction (qrt-pcr) were used to determine apoptosis and autophagy markers. |
2021-11-09 |
2023-08-13 |
human |
| Xiao-Li Wang, Jing Shao, Guan-Xin Wu, Wei Zhang, Hong-Yan Zhou, Kai-Yan Li, Wei Su. [Guanxin Zhitong Capsules attenuate human endothelial cell damage induced by palmitic acid via MAPK signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 19. 2021-11-08. PMID:34738406. |
huvecs were detected for cell viability by cell counting kit-8(cck-8) assay, apoptosis by flow cytometry, mitochondrial membrane potential(mmp) by jc-1 labeled laser scanning confocal microscopy, and total and phosphorylated proteins of p38, erk1/2, and jnk1/2 in the mitogen-activated protein kinases(mapk) signaling pathway by western blot. |
2021-11-08 |
2023-08-13 |
human |
| Cihan Gur, Ozge Kandemir, Fatih Mehmet Kandemi. Investigation of the effects of hesperidin administration on abamectin-induced testicular toxicity in rats through oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, autophagy, and JAK2/STAT3 pathways. Environmental toxicology. 2021-11-08. PMID:34748272. |
markers of oxidative stress, inflammation, ers, apoptosis, and autophagy in the testicular tissues removed after the animals are sacrificed were analyzed using biochemical, real-time polymerase chain reaction (rt-pcr), or western blot techniques. |
2021-11-08 |
2023-08-13 |
rat |
| Jingli Zhang, Lixia Li. Anagliptin alleviates lipopolysaccharide-induced inflammation, apoptosis and endothelial dysfunction of lung microvascular endothelial cells. Experimental and therapeutic medicine. vol 22. issue 6. 2021-11-06. PMID:34737812. |
western blot analysis was performed to assess expression levels of proteins involved in nf-κb signaling, cell apoptosis and migration, as well as high mobility group box 1 (hmgb1)/receptor for advanced glycation end products (rage). |
2021-11-06 |
2023-08-13 |
human |
| Koji Iwanaga, Yasushi Satoh, Ryosuke Akai, Toshiaki Ishizuka, Tomiei Kazama, Takehiko Iked. Neonatal administration of a subanaesthetic dose of JM-1232(-) in mice results in no behavioural deficits in adulthood. Scientific reports. vol 11. issue 1. 2021-11-05. PMID:34145371. |
western blot analysis of forebrain extracts using cleaved poly-(adenosine diphosphate-ribose) polymerase antibody showed that jm-1232(-) is accompanied by slight but measurable apoptosis 6 h after administration, but it was relatively small compared to those of propofol and midazolam. |
2021-11-05 |
2023-08-13 |
mouse |
| Di Wu, Hongyao Jia, Zhiru Zhang, Sijie L. Circ_0000511 accelerates the proliferation, migration and invasion, and restrains the apoptosis of breast cancer cells through the miR‑326/TAZ axis. International journal of oncology. vol 58. issue 4. 2021-11-03. PMID:33649821. |
western blot analysis was used to evaluate the expression levels of b cell leukemia/lymphoma 2 (bcl‑2), bcl‑2 associated x apoptosis regulator, cleaved caspase‑3 and taz. |
2021-11-03 |
2023-08-13 |
Not clear |
| Bo-Quan Shan, Wen Li, Hui He, He-Yan Zhao, Mei-Ling Tian, Xiang Cheng, Jian-Bing Qin, Guo-Hua Ji. miR-33-3p Regulates PC12 Cell Proliferation and Differentiation In Vitro by Targeting Slc29a1. Neurochemical research. vol 46. issue 9. 2021-11-03. PMID:34152551. |
a mir-33-3p mimic was transduced into pc12 cells, and its effects on proliferation, apoptosis, and differentiation were studied using the mts assay, edu labeling, flow cytometry, qrt-pcr, western blot, elisa, and immunofluorescence. |
2021-11-03 |
2023-08-13 |
rat |
| Xiao Zhou, Tong Sun, Yuting Meng, Juan Luo, Jun Chen, Bo Xia, Zuhao Zhang, Zhixiang Cheng, Xuerong Wan. BET inhibitors combined with chemotherapy synergistically inhibit the growth of NSCLC cells. Oncology reports. vol 45. issue 5. 2021-11-02. PMID:33760217. |
mechanistically, this combination of suppression of bet expression and chemotherapeutic treatment blocked nsclc cell growth by inhibiting autophagy and promoting apoptosis, which were revealed by both western blot and elisa results. |
2021-11-02 |
2023-08-13 |
Not clear |
| Fengfeng Sun, Peng Sun, Xiaofeng Yang, Liangliang Hu, Jianguo Gao, Tao Tia. Inhibition of FSTL3 abates the proliferation and metastasis of renal cell carcinoma via the GSK-3β/β-catenin signaling pathway. Aging. vol 13. issue 18. 2021-11-01. PMID:34555811. |
flow cytometry analyzed cell apoptosis, and western blot evaluated the protein levels of e-cadherin, twist, and slug. |
2021-11-01 |
2023-08-13 |
mouse |
| Veronica Zingales, Noemi Torriero, Luca Zanella, Mónica Fernández-Franzón, Maria-José Ruiz, Maria Rosaria Esposito, Elisa Cimett. Development of an in vitro neuroblastoma 3D model and its application for sterigmatocystin-induced cytotoxicity testing. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 157. 2021-11-01. PMID:34634377. |
ste also induced apoptosis as confirmed by immunofluorescence staining and western blot. |
2021-11-01 |
2023-08-13 |
human |