| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanhong Wu, Meiling Zhao, Zhaoheng Li. Pyrroloquinoline quinone (PQQ) alleviated sepsis-induced acute liver injury, inflammation, oxidative stress and cell apoptosis by downregulating CUL3 expression. Bioengineered. vol 12. issue 1. 2021-11-11. PMID:34227919. |
moreover, tunel staining, flow cytometric analysis and western blot were applied to determine cell apoptosis. |
2021-11-11 |
2023-08-13 |
rat |
| Xiangyu Cao, Chengying Liu, Mengmeng Zhang, Ruochen Bi, Mingyang Fu, Elena Korik, Jiahe Chen, Jianyun Gao, Igor Semak, Jianli Li. Bovine lactoferrin and Lentinus edodes mycelia polysaccharide complex: The formation and the activity to protect islet β cells. International journal of biological macromolecules. vol 191. 2021-11-11. PMID:34592222. |
cell viability, reactive oxygen species (ros) level, apoptosis and the related signaling pathways were detected with thiazolyl blue tetrazolium bromide (mtt) assay, 2,7-dichlorofluorescin diacetate (dcfh-da) staining, hoechst 33258 staining and western blot methods respectively. |
2021-11-11 |
2023-08-13 |
cattle |
| Junping Guo, Wei Chen, Beibei Bao, Dayong Zhang, Jianping Pan, Mao Zhan. Protective effect of berberine against LPS-induced endothelial cell injury via the JNK signaling pathway and autophagic mechanisms. Bioengineered. vol 12. issue 1. 2021-11-10. PMID:33896366. |
cell viability, proliferation, and apoptosis were detected by the cck-8 assay, the edu kit, and flow cytometry, respectively, and autophagy-related protein expression, the number of autophagic vacuoles, and lc3 double-fluorescence were examined using western blot analysis, transmission electron microscopy, and confocal microscopy, respectively. |
2021-11-10 |
2023-08-13 |
human |
| Jianhua Han, Shigeng Li, Yawei Feng, Yufeng He, Weilong Hong, Zhiqiang Y. A novel circular RNA (hsa_circ_0059930)-mediated miRNA-mRNA axis in the lipopolysaccharide-induced acute lung injury model of MRC-5 cells. Bioengineered. vol 12. issue 1. 2021-11-10. PMID:34002668. |
after hsa_circ_0059930 knockdown, the proliferation and apoptosis of mrc-5 cells were identified by cck-8, flow cytometer, and western blot assays. |
2021-11-10 |
2023-08-13 |
Not clear |
| Deyuan Zhi, Meng Zhang, Jin Lin, Pei Liu, Meili Dua. GPR120 Ameliorates Apoptosis and Inhibits the Production of Inflammatory Cytokines in Renal Tubular Epithelial Cells. Inflammation. vol 44. issue 2. 2021-11-09. PMID:33009637. |
cell apoptosis experiments included the annexin v and pi double-staining method combined with flow cytometry, tunel method, and western blot. |
2021-11-09 |
2023-08-13 |
mouse |
| Junting Kou, Xuewei Wang, Yuan Wei, Rong Zhao, Xiuli Wang, Jiefeng He, Xiaozhong Li, Xiaoxia Wan. Aurora kinase inhibitor VX-680 enhances sensitivity of esophageal squamous cell carcinoma cells to cisplatin chemotherapy. Anti-cancer drugs. vol 32. issue 9. 2021-11-09. PMID:34016831. |
2-(4-amidinophenyl)-6-indolecarbamidine dihydrochloride staining and western blot analysis suggested that vx-680 increased cisplatin-mediated cell apoptosis. |
2021-11-09 |
2023-08-13 |
Not clear |
| Eloisa D Castro, Pedro Paulo M Mathias, Wagner L Batista, Alex Yuri S Sato, Maytê S Toledo, Victor T de Almeida, Marli F Curcio, Paulo E da Costa, Arnold Stern, Hugo P Monteir. Knockdown of the inducible nitric oxide synthase (NOS2) splicing variant S3 promotes autophagic cell death from nitrosative stress in SW480 human colon cancer cells. Cell biology international. 2021-11-09. PMID:34719858. |
western blot analysis and quantitative real-time polymerase chain reaction (qrt-pcr) were used to determine apoptosis and autophagy markers. |
2021-11-09 |
2023-08-13 |
human |
| Xiao-Li Wang, Jing Shao, Guan-Xin Wu, Wei Zhang, Hong-Yan Zhou, Kai-Yan Li, Wei Su. [Guanxin Zhitong Capsules attenuate human endothelial cell damage induced by palmitic acid via MAPK signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 19. 2021-11-08. PMID:34738406. |
huvecs were detected for cell viability by cell counting kit-8(cck-8) assay, apoptosis by flow cytometry, mitochondrial membrane potential(mmp) by jc-1 labeled laser scanning confocal microscopy, and total and phosphorylated proteins of p38, erk1/2, and jnk1/2 in the mitogen-activated protein kinases(mapk) signaling pathway by western blot. |
2021-11-08 |
2023-08-13 |
human |
| Cihan Gur, Ozge Kandemir, Fatih Mehmet Kandemi. Investigation of the effects of hesperidin administration on abamectin-induced testicular toxicity in rats through oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, autophagy, and JAK2/STAT3 pathways. Environmental toxicology. 2021-11-08. PMID:34748272. |
markers of oxidative stress, inflammation, ers, apoptosis, and autophagy in the testicular tissues removed after the animals are sacrificed were analyzed using biochemical, real-time polymerase chain reaction (rt-pcr), or western blot techniques. |
2021-11-08 |
2023-08-13 |
rat |
| Jingli Zhang, Lixia Li. Anagliptin alleviates lipopolysaccharide-induced inflammation, apoptosis and endothelial dysfunction of lung microvascular endothelial cells. Experimental and therapeutic medicine. vol 22. issue 6. 2021-11-06. PMID:34737812. |
western blot analysis was performed to assess expression levels of proteins involved in nf-κb signaling, cell apoptosis and migration, as well as high mobility group box 1 (hmgb1)/receptor for advanced glycation end products (rage). |
2021-11-06 |
2023-08-13 |
human |
| Koji Iwanaga, Yasushi Satoh, Ryosuke Akai, Toshiaki Ishizuka, Tomiei Kazama, Takehiko Iked. Neonatal administration of a subanaesthetic dose of JM-1232(-) in mice results in no behavioural deficits in adulthood. Scientific reports. vol 11. issue 1. 2021-11-05. PMID:34145371. |
western blot analysis of forebrain extracts using cleaved poly-(adenosine diphosphate-ribose) polymerase antibody showed that jm-1232(-) is accompanied by slight but measurable apoptosis 6 h after administration, but it was relatively small compared to those of propofol and midazolam. |
2021-11-05 |
2023-08-13 |
mouse |
| Di Wu, Hongyao Jia, Zhiru Zhang, Sijie L. Circ_0000511 accelerates the proliferation, migration and invasion, and restrains the apoptosis of breast cancer cells through the miR‑326/TAZ axis. International journal of oncology. vol 58. issue 4. 2021-11-03. PMID:33649821. |
western blot analysis was used to evaluate the expression levels of b cell leukemia/lymphoma 2 (bcl‑2), bcl‑2 associated x apoptosis regulator, cleaved caspase‑3 and taz. |
2021-11-03 |
2023-08-13 |
Not clear |
| Bo-Quan Shan, Wen Li, Hui He, He-Yan Zhao, Mei-Ling Tian, Xiang Cheng, Jian-Bing Qin, Guo-Hua Ji. miR-33-3p Regulates PC12 Cell Proliferation and Differentiation In Vitro by Targeting Slc29a1. Neurochemical research. vol 46. issue 9. 2021-11-03. PMID:34152551. |
a mir-33-3p mimic was transduced into pc12 cells, and its effects on proliferation, apoptosis, and differentiation were studied using the mts assay, edu labeling, flow cytometry, qrt-pcr, western blot, elisa, and immunofluorescence. |
2021-11-03 |
2023-08-13 |
rat |
| Xiao Zhou, Tong Sun, Yuting Meng, Juan Luo, Jun Chen, Bo Xia, Zuhao Zhang, Zhixiang Cheng, Xuerong Wan. BET inhibitors combined with chemotherapy synergistically inhibit the growth of NSCLC cells. Oncology reports. vol 45. issue 5. 2021-11-02. PMID:33760217. |
mechanistically, this combination of suppression of bet expression and chemotherapeutic treatment blocked nsclc cell growth by inhibiting autophagy and promoting apoptosis, which were revealed by both western blot and elisa results. |
2021-11-02 |
2023-08-13 |
Not clear |
| Fengfeng Sun, Peng Sun, Xiaofeng Yang, Liangliang Hu, Jianguo Gao, Tao Tia. Inhibition of FSTL3 abates the proliferation and metastasis of renal cell carcinoma via the GSK-3β/β-catenin signaling pathway. Aging. vol 13. issue 18. 2021-11-01. PMID:34555811. |
flow cytometry analyzed cell apoptosis, and western blot evaluated the protein levels of e-cadherin, twist, and slug. |
2021-11-01 |
2023-08-13 |
mouse |
| Veronica Zingales, Noemi Torriero, Luca Zanella, Mónica Fernández-Franzón, Maria-José Ruiz, Maria Rosaria Esposito, Elisa Cimett. Development of an in vitro neuroblastoma 3D model and its application for sterigmatocystin-induced cytotoxicity testing. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 157. 2021-11-01. PMID:34634377. |
ste also induced apoptosis as confirmed by immunofluorescence staining and western blot. |
2021-11-01 |
2023-08-13 |
human |
| Cheng Fang, Lan Wu, Ming-Juan Zhao, Tong Deng, Jia-Min Gu, Xing-Pei Guo, Cheng Li, Weiguang Li, Xian-Tao Zen. Periodontitis Exacerbates Benign Prostatic Hyperplasia through Regulation of Oxidative Stress and Inflammation. Oxidative medicine and cellular longevity. vol 2021. 2021-10-30. PMID:34707774. |
four weeks later, all the rats were sacrificed and the following items were measured: alveolar bone loss and histological examination of periodontal tissues were taken to assess the establishment of periodontitis model, prostate index and histological examination of prostate tissues were taken to test the establishment of the bph model, inflammatory cytokines in plasma were assessed, and bax/bcl-2 proteins related to cell apoptosis were analyzed via western blot analysis. |
2021-10-30 |
2023-08-13 |
rat |
| Wei Yang, Yunbin Chen, Chao Huang, Wenjian Wang, Congfu Huang, Yuanguang L. MiR-18a Inhibits PI3K/AKT Signaling Pathway to Regulate PDGF BB-Induced Airway Smooth Muscle Cell Proliferation and Phenotypic Transformation. Physiological research. vol 70. issue 6. 2021-10-30. PMID:34717064. |
cell proliferation, apoptosis and migration were detected by mtt, flow cytometry and transwell, respectively; the expression of contractile phenotype marker proteins (sm-22alpha, alpha-sm-actin, calponin) and key molecules of the phosphatidylinositol 3-kinase (pi3k)/akt pathway (pi3k, p-pi3k, akt and p-akt) in asmcs were detected by western blot. |
2021-10-30 |
2023-08-13 |
human |
| Xiaopeng Hu, Tie Chen, Shuquan Zhang, Qian Zhang, Chenyang Li, Xiaodong Wan. Antitumour effect of odoroside A and its derivative on human leukaemia cells through the ROS/JNK pathway. Basic & clinical pharmacology & toxicology. 2021-10-29. PMID:34634178. |
then, the cell apoptosis and autophagy induced by the compounds were detected by flow cytometry and western blot. |
2021-10-29 |
2023-08-13 |
mouse |
| A K M Nawshad Hossian, Gerardo G Mackenzie, George Mattheolabaki. Combination of miR‑143 and miR‑506 reduces lung and pancreatic cancer cell growth through the downregulation of cyclin‑dependent kinases. Oncology reports. vol 45. issue 4. 2021-10-28. PMID:33649787. |
following transfection with mir‑143 and mir‑506, we analyzed the differential gene expression of cdk4 and cdk1, using qpcr or western blot analysis, and evaluated cell cycle inhibition, apoptosis and cytotoxicity. |
2021-10-28 |
2023-08-13 |
Not clear |