| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenzhi Wang, Jianyong Shi, Lei Zhen. Identification of Circular RNA circ_0017068 as a Regulator of Proliferation and Apoptosis in Trophoblast Cells by miR-330-5p/XIAP Axis. Reproductive sciences (Thousand Oaks, Calif.). 2022-01-04. PMID:34981461. |
the levels of circ_0017068, microrna (mir)-330-5p and x-linked inhibitor of apoptosis protein (xiap) were measured by quantitative real-time polymerase chain reaction (qrt-pcr) or western blot analysis. |
2022-01-04 |
2023-08-13 |
Not clear |
| Fang Zhu, Wei Duan, Chao Zhong, Bing Ji, Xinjun Li. The protective effects of dezocine on interleukin-1β-induced inflammation, oxidative stress and apoptosis of human nucleus pulposus cells and the possible mechanisms. Bioengineered. vol 13. issue 1. 2022-01-03. PMID:34974796. |
tunel staining was employed to detect cell apoptosis and western blot was used to determine the expression of proteins related to inflammation, oxidative stress, apoptosis, endoplasmic reticulum stress (ers) and mapk signaling. |
2022-01-03 |
2023-08-13 |
human |
| Hui Qi, Xing Zhang, Huanhuan Liu, Meng Han, Xuzhen Tang, Shulan Qu, Xiaoyu Wang, Yifu Yan. Shikonin induced Apoptosis Mediated by Endoplasmic Reticulum Stress in Colorectal Cancer Cells. Journal of Cancer. vol 13. issue 1. 2022-01-03. PMID:34976186. |
the flow cytometry and western blot results indicated that shikonin induced cell apoptosis by down-regulating bcl-2 and activating caspase-3/9 and the cleavage of parp. |
2022-01-03 |
2023-08-13 |
Not clear |
| Lihua Wu, Yinfang Wang, Qinghua Liu, Jianman Wu, Hao Zheng, Biyu Lin, Shaopeng Huan. Circ_0001665 contributes to the occurrence of vestibular schwannoma via targeting miR-302a-3p/Adam9/EGFR signaling pathway. Neuroscience. 2022-01-03. PMID:34979261. |
supported by western blot analysis, circ_0001665 inhibition was validated to impede the proliferation while inducing the apoptosis of vs cells via functional assays. |
2022-01-03 |
2023-08-13 |
human |
| Zongting Shi, Jun He, Jian He, Yuan X. Micro-fragmented adipose tissue regulated the biological functions of osteoarthritis synoviocytes by upregulating MiR-92a-3p expression. Tissue & cell. vol 74. 2022-01-03. PMID:34979377. |
cell viability, apoptosis and apoptosis-related protein expression of tumor necrosis factor-α (tnf-α)-activated synoviocytes were detected by cell counting kit-8, flow cytometry and western blot, respectively. |
2022-01-03 |
2023-08-13 |
Not clear |
| Gang Li, Yongli Wang, Jingyuan Wang, Gong Chen, Haiyan Wan. Long non-coding RNA placenta‑specific protein 2 regulates micorRNA-19a/tumor necrosis factor α to participate in polycystic ovary syndrome. Bioengineered. vol 13. issue 1. 2021-12-30. PMID:34967266. |
in addition, western blot analysis and cell apoptosis assay were conducted. |
2021-12-30 |
2023-08-13 |
Not clear |
| Xueqin Zhu, Lei Luo, Yanyan Xiong, Nan Jiang, Yurun Wang, Yuan Lv, Ying Xi. VDAC1 oligomerization may enhance DDP-induced hepatocyte apoptosis by exacerbating oxidative stress and mitochondrial DNA damage. FEBS open bio. 2021-12-30. PMID:34967508. |
cell apoptosis was tested by annexin v/fluorescein isothiocyanate (fitc) assay, protein expression of caspase-3, γh2ax and ndufb6 were observed by western blot assay, reactive oxygen species (ros) and mitochondrial superoxide anion radical (o |
2021-12-30 |
2023-08-13 |
Not clear |
| Dan Liu, Ye Cheng, Zhipeng Tang, Junliang Chen, Ying Xia, Chengbin Xu, Xiangyu Ca. Potential mechanisms of methylglyoxal-induced human embryonic kidney cells damage: Regulation of oxidative stress, DNA damage, and apoptosis. Chemistry & biodiversity. 2021-12-28. PMID:34962083. |
cell viability, apoptosis and the signaling pathways were measured with mtt, fluorescent staining and western blot experiments, the results showed that mgo could induce oxidative stress and cell inflammation, the level of reactive oxygen species (ros) increased, and p38mapk, jnk and nf-κb signaling pathways were activated. |
2021-12-28 |
2023-08-13 |
human |
| Ola Gutziet, Roee Iluz, Hila Ben Asher, Linoy Segal, Dikla Ben Zvi, Yuval Ginsberg, Nizar Khatib, Osnat Zmora, Michael G Ross, Zeev Weiner, Ron Beloosesk. Maternal N-Acetyl-Cysteine Prevents Neonatal Hypoxia-Induced Brain Injury in a Rat Model. International journal of molecular sciences. vol 22. issue 24. 2021-12-24. PMID:34948425. |
each group was evaluated for: neurological function (righting reflex), serum proinflammatory il-6 protein levels (elisa), brain protein levels: nf-κb p65, neuronal nitric oxide synthase (nnos), tnf-α, and il-6 (western blot) and neuronal apoptosis (histology evaluation with tunel stain). |
2021-12-24 |
2023-08-13 |
human |
| Jin Zou, Zi-Lin Wan, Lan Yao, Meng-Yao Xu, Shu-Rong Wan. [Rhein inhibits hydrogen peroxide-induced apoptosis of human umbilical vein endothelial cells and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 23. 2021-12-24. PMID:34951247. |
cell survival rate was detected by mtt assay, apoptosis by annexin v-fitc/pi double staining and hoechst 33258 fluorescence staining, autophagy by ad-mcherry-gfp-lc3 b adenovirus transfection, and protein expression by western blot. |
2021-12-24 |
2023-08-13 |
human |
| Xuejun Wang, Jinwen Su, Zhikang Lin, Kangyong Liu, Yu Zhuan. PINCH1 knockout aggravates myocardial infarction in mice via mediating the NF-κB signaling pathway. Experimental and therapeutic medicine. vol 23. issue 1. 2021-12-22. PMID:34934433. |
in addition, cell viability, migration and apoptosis, as well as the expression levels of nf-κb-associated proteins were determined in murine hl1 cardiomyocytes with a conditional pinch1 shrna using cell counting kit-8, transwell, flow cytometry and western blot assays, respectively. |
2021-12-22 |
2023-08-13 |
mouse |
| Dong Wang, Caiyun Ya. MicroRNA-208a-3p participates in coronary heart disease by regulating the growth of hVSMCs by targeting BTG1. Experimental and therapeutic medicine. vol 23. issue 1. 2021-12-22. PMID:34934442. |
in addition, the role of the pi3k/akt pathway in mediating hvsmc apoptosis was examined via western blot analysis. |
2021-12-22 |
2023-08-13 |
human |
| Jie Zhang, Xiaoyu Liu, Jun Chen, Shufeng Xi. HDAC3-Mediated Repression of LncRNA-LET Regulates Gastric Cancer Cell Growth Proliferation, Invasion, Migration, and Apoptosis via MiR-548k. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 40. issue 4. 2021-12-22. PMID:34936297. |
the biological functions of hdac3 and lncrna-let were measured by cck-8 assay, transwell assay, western blot analysis, and cell apoptosis assays. |
2021-12-22 |
2023-08-13 |
Not clear |
| Yu Cai, Feng Zha. Fluvastatin suppresses the proliferation, invasion, and migration and promotes the apoptosis of endometrial cancer cells by upregulating Sirtuin 6 (SIRT6). Bioengineered. vol 12. issue 2. 2021-12-20. PMID:34927546. |
the apoptosis and its related proteins of fluvastatin-treated ec cells were detected by tunel and western blot, separately. |
2021-12-20 |
2023-08-13 |
Not clear |
| Man Long, Zhigang Wang, Luyao Shao, Jing Bi, Zebin Chen, Nina Yi. Electroacupuncture Pretreatment Attenuates Cerebral Ischemia-Reperfusion Injury in Rats Through Transient Receptor Potential Vanilloid 1-Mediated Anti-apoptosis via Inhibiting NF-κB Signaling Pathway. Neuroscience. 2021-12-20. PMID:34929338. |
then, infarct volume, nerve cell injury, neuronal apoptosis, nf-κb signaling activation, and expression of trpv1 were evaluated by ttc staining, hematoxylin-eosin staining, transmission electron microscopy, immunochemistry, immunofluorescence, and western blot, respectively. |
2021-12-20 |
2023-08-13 |
rat |
| Shuang Liu, Wen Yan, Yanbing Hu, Huiying W. Shikonin Alleviates Endothelial Cell Injury Induced by ox-LDL via AMPK/Nrf2/HO-1 Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-12-16. PMID:34912465. |
the mtt method was used to detect cell viability, flow cytometry was used to detect cell apoptosis and reactive oxygen species (ros) levels, and western blot was used to detect protein levels. |
2021-12-16 |
2023-08-13 |
human |
| Xian Tao, Jiansheng Cheng, Xinghua Wan. Effect of miRNA-200a on radiosensitivity of osteosarcoma cells by targeting Bone morphogenetic protein receptor 2. Bioengineered. vol 12. issue 2. 2021-12-14. PMID:34903128. |
the expression of mir-200a and bmpr2 mrna was detected by qrt-pcr; the expression of bmpr2 protein was detected by western blot; cell viability was detected by mmt (3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide); apoptosis rate was detected by flow cytometry. |
2021-12-14 |
2023-08-13 |
Not clear |
| RongXin Xiao, Hong Wang, Biao Yan. MicroRNA-98-5p modulates cervical cancer progression via controlling PI3K/AKT pathway. Bioengineered. vol 12. issue 2. 2021-12-13. PMID:34895048. |
reverse transcription quantitative polymerase chain reaction was applied to detect mir-98-5p expression in cc tissues and cell lines; cell counting kit-8 and edu analysis were performed for checking cell proliferation, flow cytometry for cell apoptosis, transwell for cell invasion and migration, western blot for proliferation-related proteins ki67 and proliferating cell nuclear antigen expression, apoptosis-related proteins bcl-2 and bax expression, epithelial-mesenchymal transition (emt)-related proteins snail, matrix metalloproteinase-3, e-cadherin and n-cadherin expression, as well as pi3k/akt pathway-related proteins pten, pi3k as well as akt expression levels, and the nude mouse tumor xenograft experiment was applied to verify |
2021-12-13 |
2023-08-13 |
mouse |
| Lei Sun, Hua Wang, Dan Xu, Shanshan Yu, Lin Zhang, Xiaopeng L. Lapatinib induces mitochondrial dysfunction to enhance oxidative stress and ferroptosis in doxorubicin-induced cardiomyocytes via inhibition of PI3K/Akt signaling pathway. Bioengineered. 2021-12-13. PMID:34898356. |
cell apoptosis was evaluated by tunel assay and western blot assay. |
2021-12-13 |
2023-08-13 |
cat |
| Feng Wang, Lili Ha. Upregulation of serum and glucocorticoid-regulated kinase 1 (SGK1) ameliorates doxorubicin-induced cardiotoxic injury, apoptosis, inflammation and oxidative stress by suppressing glucose regulated protein 78 (GRP78)-mediated endoplasmic reticulum stress. Bioengineered. 2021-12-13. PMID:34898378. |
besides, apoptosis-related proteins were measured by western blot assay to analyze cell apoptosis. |
2021-12-13 |
2023-08-13 |
Not clear |