| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shi-Chun Zhu, Jun Cai, Cheng-Yu Wu, Chun-Song Chen. [Molecular mechanism of Spatholobi Caulis in treatment of ovarian cancer based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 3. 2022-02-18. PMID:35178962. |
western blot showed that prunetin could induce skov3 cell apoptosis by inhibiting gsk-3β phosphorylation and regulating the expression of downstream bcl-2 and bax proteins. |
2022-02-18 |
2023-08-13 |
human |
| Xiaojuan Liu, Hui Ma, Lisha Ma, Kun Li, Yanhua Kan. The potential role of methyltransferase-like 5 in deficient mismatch repair of uterine corpus endometrial carcinoma. Bioengineered. vol 13. issue 3. 2022-02-15. PMID:35166644. |
we observed ucec proliferation, development, and apoptosis using a mettl5 knockdown lentivirus and, coupled with mettl5 bioinformatics and western blot analysis, detected microsatellite instability (msi) and mmr. |
2022-02-15 |
2023-08-13 |
Not clear |
| Xiong Zhang, Chenlin Su, Shuxin Zhao, Ji Li, Feng Y. Combination therapy of Ulinastatin with Thrombomodulin alleviates endotoxin (LPS) - induced liver and kidney injury via inhibiting apoptosis, oxidative stress and HMGB1/TLR4/NF-κB pathway. Bioengineered. vol 13. issue 2. 2022-02-12. PMID:35148668. |
results of tunel staining and western blot showed that uti combined with tm inhibited the excessive apoptosis of liver and kidney cells caused by lps. |
2022-02-12 |
2023-08-13 |
rat |
| T Tuerxun, X Li, F Lou, X Wang, L M. YBX1 Protects against Apoptosis Induced by Oxygen-Glucose Deprivation/Reoxygenation in PC12 Cells via Activation of the AKT/GSK3β Pathway. Folia biologica. vol 67. issue 4. 2022-02-12. PMID:35151240. |
next, the effect of ybx1 on the apoptosis and viability of ogd/r-treated pc12 cells was evaluated by flow cytometry, mtt assay, and western blot. |
2022-02-12 |
2023-08-13 |
cat |
| Maryam Farzaneh Behelgardi, Zahra Gholami Shahvir, S Mohsen Asghar. Apoptosis induction in human lung and colon cancer cells via impeding VEGF signaling pathways. Molecular biology reports. 2022-02-10. PMID:35142981. |
in addition, the level of proteins involved in vegf signaling pathways related to apoptosis was investigated using western blot analysis. |
2022-02-10 |
2023-08-13 |
human |
| Mansoureh Hashemi, Aida Abbasiazam, Saeed Oraee-Yazdani, Janice Lenze. Response of human glioblastoma cells to hyperthermia: Cellular apoptosis and molecular events. Tissue & cell. vol 75. 2022-02-10. PMID:35144007. |
cell survival rate by mtt assay and apoptosis using quantitative real-time rt-pcr and western blot were evaluated. |
2022-02-10 |
2023-08-13 |
human |
| Wei Chen, Haotian Zheng, Xuan Zhang, Yude Xu, Zhibin Fu, Xing Ji, Changhao Wei, Guoyao An, Mingyuan Tan, Mingwang Zho. Columbianetin alleviates lipopolysaccharides (LPS)-induced inflammation and apoptosis in chondrocyte through activation of autophagy by inhibiting serum and glucocorticoid-induced protein kinase 1 (SGK1) expression. Bioengineered. vol 13. issue 2. 2022-02-07. PMID:35129051. |
the expression of apoptosis and autophagy-related proteins was tested with western blot. |
2022-02-07 |
2023-08-13 |
mouse |
| Aikaterini G Karra, Aikaterini Sioutopoulou, Vyron Gorgogietas, Martina Samiotaki, George Panayotou, Anna-Maria G Psarr. Proteomic analysis of the mitochondrial glucocorticoid receptor interacting proteins reveals pyruvate dehydrogenase and mitochondrial 60 kDa heat shock protein as potent binding partners. Journal of proteomics. 2022-02-06. PMID:35124280. |
in this study, applying immunoprecipitation, mass spectrometry and western blot analysis of the gr interacting proteins in total or mitochondrial extracts of hepg2 cells and of hepg2 cells overexpressing a mitochondrial targeted gr we found pyruvate dehydrogenase (pdh), chaperones such as and heat shock protein (hsp) -60, -70, -75 and -90, and 78 kda glucose-regulated protein, mitochondrial transcription factors and enzymes involved in the regulation of the mitochondrial protein biosynthesis, lipid metabolism, atp production and apoptosis as glucocorticoid receptor interacting proteins. |
2022-02-06 |
2023-08-13 |
Not clear |
| Hao Zha, Wei Miao, Wei Rong, Aimei Wang, Weiqi Jiang, Rui Liu, Lanqi Liu, Ying Wan. Remote ischaemic perconditioning reduces the infarct volume and improves the neurological function of acute ischaemic stroke partially through the miR-153-5p/TLR4/p65/IkBa signalling pathway. Folia neuropathologica. vol 59. issue 4. 2022-02-04. PMID:35114774. |
overexpressed or silenced mir-153-5p was transfected into the cells to analyse the effects of oxygen-glucose deprivation (ogd) treatment on neuro-2a cell viability, apoptosis, and related gene expressions by performing quantitative real-time polymerase chain reaction (qrt-pcr), mtt assay, flow cytometry, and western blot. |
2022-02-04 |
2023-08-13 |
mouse |
| Xiaoling Zhang, Si Wang, Yuyan Cai, Weihong He, Qing Yang, Chen L. Regulatory Mechanism of MicroRNA-9 / Long Non-Coding RNA XIST Expression on Mouse Macrophage RAW264.7 Apoptosis Induced by Oxidized Low Density Lipoprotein. Bioengineered. vol 13. issue 2. 2022-02-03. PMID:35109760. |
methylthiazolyl tetrazolium (mtt) method, flow cytometry, and western blot were used to detect and compare the differences of cell proliferation, apoptosis, and the expression levels of apoptosis signal-regulating kinase 1 (ask1), c-jun n-terminal kinase (jnk), matrix metalloproteinase-9 (mmp-9), and b-cell lymphoma-2 (bcl-2) after ox-ldl induction and transfection of mir-9 mimic, mir-9 inhibitor and xist expression vector, respectively. |
2022-02-03 |
2023-08-13 |
mouse |
| Wenjing Ma, Siyu Wang, Yihai Wang, Jia Zeng, Jingwen Xu, Xiangjiu H. Antiproliferative Amaryllidaceae alkaloids from the bulbs of Hymenocallis littoralis (Jacq.) Salisb. Phytochemistry. vol 197. 2022-02-01. PMID:35101748. |
meanwhile, cell morphological assessment, flow cytometric analysis, western blot analysis, clone formation and scratch wound assays were utilized for an undescribed belladine-type alkaloid and two known alkaloids, which had antiproliferative effects on the hepg2 cell line via induction of apoptosis in a dose-dependent manner. |
2022-02-01 |
2023-08-13 |
human |
| Li Zhang, Bingxin Jia, Periyannan Velu, Hong W. Corilagin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine. Environmental toxicology. 2022-02-01. PMID:35103375. |
in western blot analysis showed released higher apoptotic marker of caspase-3, -9, bax while bcl-2 levels were significantly reduced confirming that corilagin triggers apoptosis in gastric cancer. |
2022-02-01 |
2023-08-13 |
rat |
| Lin Zhu, Chuan H. Crocetin alleviates the caerulein-induced apoptosis and inflammation in AR42J cells by activating SIRT1 via NF-κB. Journal of natural medicines. 2022-01-30. PMID:35094239. |
apoptosis and inflammation of these treated cells were detected by terminal deoxynucleotidyl transferase dutp nick-end labeling (tunel), western blot and enzyme linked immunosorbent assay (elisa). |
2022-01-30 |
2023-08-13 |
Not clear |
| Haoran Zhang, Jiaqiang Huang, Jie Yang, Jingzeng Cai, Qi Liu, Xintong Zhang, Jun Bao, Ziwei Zhan. Cadmium induces apoptosis and autophagy in swine small intestine by downregulating the PI3K/Akt pathway. Environmental science and pollution research international. 2022-01-29. PMID:35091949. |
the effects of cd on the pi3k/akt pathway, as well as on apoptosis and autophagy-related protein expression in intestinal cells, were analyzed by western blot (wb) and the expression of mrna was detected by quantitative real-time polymerase chain reaction (qrt-pcr). |
2022-01-29 |
2023-08-13 |
Not clear |
| Na Hu, Ziwei Gao, Peng Cao, Haoying Song, Junjie Hu, Zhenpeng Qiu, Cong Chang, Guohua Zheng, Xuehua Shan, Yan Men. Uniform and disperse selenium nanoparticles stabilized by inulin fructans from Codonopsis pilosula and their anti-hepatoma activities. International journal of biological macromolecules. 2022-01-29. PMID:35092739. |
moreover, the effects on proliferation and apoptosis of cpw1-se to both normal cells (293t) and liver cancer cells (huh-7 and hepg2) were evaluated systematically by using the cck8 assay, plate clone formation assay, flow cytometry and western blot. |
2022-01-29 |
2023-08-13 |
Not clear |
| Xiaoxiao Tao, Yaping Jiang, Xian Zheng, Xiaoxiao Ji, Feifei Pen. Dihydromyricetin ameliorates oxygen‑glucose deprivation and re‑oxygenation‑induced injury in HT22 cells by activating the Wnt/β‑catenin signaling pathway. Molecular medicine reports. vol 25. issue 3. 2022-01-28. PMID:35088876. |
the effects of dmy on the viability, oxidative stress and apoptosis of ht22 cells following oxygen‑glucose deprivation and re‑oxygenation (ogd/r) were examined using mtt, lactate dehydrogenase (ldh), superoxide (sod), malondialdehyde (mda), western blot and tunel assays. |
2022-01-28 |
2023-08-13 |
Not clear |
| Lin Sun, Huangxing Cai, Tengchao Zhou, Hua Xiang, Lin Lon. Verbascoside enhances radiosensitivity of hepatocellular carcinoma cells through regulating miR-101-3p/Wee1 axis. Drug development research. 2022-01-26. PMID:35080031. |
then, cck-8 and flow cytometry assays were used to detect the proliferation and apoptosis of hcc cells after verbascoside and x-ray combined treatment, and the expressions of wee1 and apoptosis-related proteins bax and bcl-2 were detected by western blot. |
2022-01-26 |
2023-08-13 |
human |
| Xuhui Chen, Zuofan Li, Bo Zhang, Tongtong Liu, Wenlong Yao, Li Wan, Chuanhan Zhang, Yue Zhan. Antinociception role of 14,15-epoxyeicosatrienoic acid in a central post-stroke pain model in rats mediated by anti-inflammation and anti-apoptosis effect. Neurochemistry international. 2022-01-25. PMID:35074479. |
immunostaining, elisa, and western blot were performed to evaluate neuroinflammation and apoptosis. |
2022-01-25 |
2023-08-13 |
rat |
| Yunguang Cen, Wei Liao, Taihao Wang, Daimin Zhan. APPL1 ameliorates myocardial ischemia-reperfusion injury by regulating the AMPK signaling pathway. Experimental and therapeutic medicine. vol 23. issue 2. 2022-01-24. PMID:35069838. |
additionally, cell viability was detected using a cell counting kit-8 assay and ros production was analyzed using ros staining, whereas the expression levels of inflammatory mediators (tnf-α, monocyte chemoattractant protein 1 and il-1β), apoptosis mediators [cleaved caspase-3, cleaved poly (adp-ribose) polymerase and bcl-2] and nuclear factor erythroid 2-related factor 2 signaling pathway-related proteins were detected via western blot analysis following overexpression of appl1 alone or in combination with compound c treatment (an ampk inhibitor). |
2022-01-24 |
2023-08-13 |
Not clear |
| Danning Shi, Hongbo Li, Zeye Zhang, Yueshuang He, Meng Chen, Liping Sun, Piwen Zha. Cryptotanshinone inhibits proliferation and induces apoptosis of breast cancer MCF-7 cells via GPER mediated PI3K/AKT signaling pathway. PloS one. vol 17. issue 1. 2022-01-21. PMID:35061800. |
apoptosis and cell cycle related proteins, as well as the key proteins on pi3k/akt signaling pathway were detected by western blot. |
2022-01-21 |
2023-08-13 |
Not clear |