| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuhui Zhao, Jinghua Sun, Jie Dong, Chunyan Guo, Wenwen Cai, Juanjuan Han, Hao Shen, Shuxin Lv, Ruiping Zhan. An auto-photoacoustic melanin-based drug delivery nano-platform for self-monitoring of acute kidney injury therapy via a triple-collaborative strategy. Acta biomaterialia. 2022-06-01. PMID:35643195. |
in vivo experiments showed that the gmp nanoparticles could effectively reduce oxidative stress, apoptosis, and inflammatory response in mice with rhabdomyolysis-induced aki, and the mechanism of alleviation was verified through western blot experiments. |
2022-06-01 |
2023-08-13 |
mouse |
| Xuan Zou, Kaitao Yu, Xiaoyang Chu, Lili Yan. Betanin alleviates inflammation and ameliorates apoptosis on human oral squamous cancer cells SCC131 and SCC4 through the NF-κB/PI3K/Akt signaling pathway. Journal of biochemical and molecular toxicology. 2022-06-01. PMID:35645143. |
the cytotoxicity assay, intracellular ros, mmp, cell apoptosis, and inflammatory mediators of betanin activity on scc131 and scc4 cells were evaluated by mtt assay, dcfh-da, rh-123, ao/eb, dapi, pi, analysis of western blot and rt-pcr. |
2022-06-01 |
2023-08-13 |
human |
| Yue Wang, Ying Li, Liang Wang, Buze Chen, Miaolin Zhu, Chunyi Ma, Chunyan Mu, Aibin Tao, Shibao Li, Lan Luo, Ping Ma, Shuai Ji, Ting La. Cinnamaldehyde Suppressed EGF-Induced EMT Process and Inhibits Ovarian Cancer Progression Through PI3K/AKT Pathway. Frontiers in pharmacology. vol 13. 2022-06-01. PMID:35645793. |
western blot and flow cytometry were used to detect apoptosis levels. |
2022-06-01 |
2023-08-13 |
Not clear |
| Purab Pal, Alec Millner, Svetlana E Semina, Rosemary J Huggins, Logan Running, Diana S Aga, Debra A Tonetti, Rachel Schiff, Geoffrey L Greene, G Ekin Atilla-Gokcumen, Jonna Fraso. Endocrine Therapy-Resistant Breast Cancer Cells Are More Sensitive to Ceramide Kinase Inhibition and Elevated Ceramide Levels Than Therapy-Sensitive Breast Cancer Cells. Cancers. vol 14. issue 10. 2022-05-28. PMID:35625985. |
follow-up studies included treatments of cell lines and patient-derived xenograft organoids (pdxo) with small molecule inhibitors; cytometric analyses to measure cell death, proliferation, and apoptosis; sirna-mediated knockdown; rt-qpcr and western blot for gene and protein expression; targeted lipid analysis; and lipid addback experiments. |
2022-05-28 |
2023-08-13 |
Not clear |
| Kang Gao, Huanhuan Zong, Kailong Hou, Yanduo Zhang, Ruyi Zhang, Dan Zhao, Xin Guo, Ying Luo, Shuting Ji. p53N236S Activates Autophagy in Response to Hypoxic Stress Induced by DFO. Genes. vol 13. issue 5. 2022-05-28. PMID:35627147. |
further, western blot and flow cytometry showed reduced apoptosis in |
2022-05-28 |
2023-08-13 |
mouse |
| Nadine Kretschmer, Christin Durchschein, Antje Hufner, Beate Rinner, Birgit Lohberger, Rudolf Baue. SK119, a Novel Shikonin Derivative, Leads to Apoptosis in Melanoma Cell Lines and Exhibits Synergistic Effects with Vemurafenib and Cobimetinib. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628494. |
moreover, we studied its pharmacological effects using apoptosis and western blot experiments. |
2022-05-28 |
2023-08-13 |
human |
| Yalin Zhang, Yilan Song, Chongyang Wang, Jingzhi Jiang, Siqi Liu, Qiaoyun Bai, Liangchang Li, Hainan Jin, Yongde Jin, Guanghai Ya. Panax notoginseng saponin R1 attenuates allergic rhinitis through AMPK/Drp1 mediated mitochondrial fission. Biochemical pharmacology. 2022-05-27. PMID:35623408. |
then, he staining of nasal tissue, elisa detection of immunoglobulin e (ige) and proinflammatory cytokine levels in serum and nasal lavage fluid, flow cytometry analysis of th1/th2 ratio and apoptosis, tunel staining, western blot, detection of reactive oxygen species (ros) and mitochondrial ros, immunofluorescence analysis of tom20 and mitochondrial fission protein drp1 co-localization, and, mitochondrial membrane potential detection, were performed. |
2022-05-27 |
2023-08-13 |
mouse |
| Shiliang Wang, Wenlu Li, Long Yang, Jianqiao Yuan, Lin Wang, Na Li, Hongyu Zha. CircPVT1 facilitates the progression of oral squamous cell carcinoma by regulating miR-143-3p/SLC7A11 axis through MAPK signaling pathway. Functional & integrative genomics. 2022-05-27. PMID:35624316. |
the levels of apoptosis and proliferation-related proteins were examined by western blot. |
2022-05-27 |
2023-08-13 |
Not clear |
| Lizhuan Ma, Xiujing Zhang, Chao Zhang, Yanli Zhou, Hongliang Zhan. Omentin-1 attenuates inflammation and barrier damage in DSS-induced ulcerative colitis in mice by inhibiting endoplasmic reticulum stress. General physiology and biophysics. vol 41. issue 3. 2022-05-26. PMID:35616002. |
cell apoptosis in colon tissues was examined by tunel and western blot. |
2022-05-26 |
2023-08-13 |
mouse |
| Z-L Yuan, Z-X Zhang, Y-Z Mo, D-L Li, L Xie, M-H Che. Inhibition of extracellular signal-regulated kinase downregulates endoplasmic reticulum stress-induced apoptosis and decreases brain injury in a cardiac arrest rat model. Physiological research. 2022-05-26. PMID:35616042. |
twenty-four hours after resuscitation, neural injury was assessed by survival rate, neurological deficit scores (nds) and nissl staining; apoptosis of brain cells was detected using terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) staining; mrna expression and protein levels of ers-related protein bip, perk, atf4 and chop were checked with rt-pcr and western blot. |
2022-05-26 |
2023-08-13 |
rat |
| Yufeng Lou, Zhenrong Huang, Hui Wu, Yun Zho. Tranilast attenuates lipopolysaccharide‑induced lung injury via the CXCR4/JAK2/STAT3 signaling pathway. Molecular medicine reports. vol 26. issue 1. 2022-05-18. PMID:35583012. |
in addition, the cell apoptosis rate and the expression levels of apoptosis‑related proteins were analyzed using a tunel staining assay and western blot analysis, respectively. |
2022-05-18 |
2023-08-13 |
Not clear |
| Qingqing Liu, Haixia Tian, Hao Yang, Xing Kang, Haixia Liu, Xiaodan Yang, Xuguang Luo, Weiping Fa. [Metformin activates AMPK to alleviate acute fulminant hepatitis induced by concanavalin A in mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 4. 2022-05-18. PMID:35583058. |
the expression of apoptosis protein caspase-3 in liver tissue was observed with immunofluorescence histochemistry and the expression of ampk and phosphorylated ampk (p-ampk) were detected by western blot analysis. |
2022-05-18 |
2023-08-13 |
mouse |
| Gonglin Fan, Jiale Qin, Xiaofeng Fu, Xing Si, Liqiang Li, Keji Yang, Beibei Wang, Haiya Lou, Jiang Zh. Low-Intensity Focused Ultrasound Targeted Microbubble Destruction Enhanced Paclitaxel Sensitivity by Decreasing Autophagy in Paclitaxel-Resistant Ovarian Cancer. Frontiers in oncology. vol 12. 2022-05-16. PMID:35574313. |
cell viability was evaluated using cck8 (cell counting kit-8), apoptosis was detected by flow cytometry, quantitative real-time pcr and western blot were used to detect the expressions of mrna and protein, and autophagy was observed by transmission electron microscopy (tem). |
2022-05-16 |
2023-08-13 |
Not clear |
| Song Qi, Li Xu, Yongyuan Han, Hongkun Chen, Anyuan Chen. miR-29a-3p mitigates the development of osteosarcoma through modulating IGF1 mediated PI3k/Akt/FOXO3 pathway by activating autophagy. Cell cycle (Georgetown, Tex.). 2022-05-16. PMID:35575588. |
then, the 3- (4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide (mtt) assay, colony formation experiment, western blot and transwell assay were conducted to validate os cell proliferation, colony formation ability, apoptosis, migration and invasion. |
2022-05-16 |
2023-08-13 |
Not clear |
| Tong Zhang, Shu-Mei Li, Yan-Nan Li, Jing-Long Cao, Hui Xue, Chang Wang, Cheng-Hao Ji. Atractylodin Induces Apoptosis and Inhibits the Migration of A549 Lung Cancer Cells by Regulating ROS-Mediated Signaling Pathways. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566297. |
western blot analysis showed that atr regulated apoptosis induced by mitogen-activated protein kinase, signal transducer and activator of transcription 3, and nuclear factor kappa b signaling pathways. |
2022-05-14 |
2023-08-13 |
Not clear |
| Lin Liu, Tingting Zhou, Tao Li, Zhanhua Liang, Xiaoguang Lu. LncRNA DLX6-AS1 promotes microglial inflammatory response in Parkinson's disease by regulating the miR-223-3p/NRP1 axis. Behavioural brain research. 2022-05-13. PMID:35550840. |
meanwhile, the cell number of th+/caspase3+/iba1+ in substantia nigra, cell viability, and apoptosis rate of bv2 microglia, inflammatory levels, and nlr family pyrin domain containing 3 (nlrp3) inflammasome were determined using immunohistochemistry, mtt assay, flow cytometry, elisa assay, and western blot. |
2022-05-13 |
2023-08-13 |
mouse |
| Joyce C Ikedif. Effects of stimulants and HIV Proteins on Pyroptosis and Apoptosis Pathways in Human Brain Microvascular Endothelial (hBMVEC). FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555731. |
western blot and rt-qpcr techniques were used to detect pyroptosis and apoptosis proteins that could lead to endothelial cell death. |
2022-05-13 |
2023-08-13 |
human |
| Yingjie Liu, Jun Peng, Xiaochuan Xiong, Liang Cheng, Xiaobing Chen. Tofacitinib enhances IGF1 via inhibiting STAT6 transcriptionally activated-miR-425-5p to ameliorate inflammation in RA-FLS. Molecular and cellular biochemistry. 2022-05-10. PMID:35536531. |
tofacitinib suppressed proliferation and accelerated apoptosis of rheumatoid arthritis synovial fibroblasts (ra-fls) as confirmed by cck-8, edu and western blot assays. |
2022-05-10 |
2023-08-13 |
Not clear |
| Ronglong Luo, Yingjie Wang, Qiao Guo, Changyong Fan, Guangyang Jiang, Lulu Wang, Mengyun Zou, Tengfei Wang, Yingfei Sun, Xiuli Pen. Andrographolide attenuates Mycoplasma gallisepticum-induced inflammation and apoptosis by the JAK/PI3K/AKT signal pathway in the chicken lungs and primary alveolar type II epithelial cells. International immunopharmacology. vol 109. 2022-05-09. PMID:35533556. |
compared with the model group, terminal deoxynucleotidyl transferase-mediated dutp nick endlabeling (tunel), western blot (wb), quantitative real-time polymerase chain reaction (qrt-pcr) and enzyme-linked immunosorbent assays (elisa) results showed andro treatment significantly reduced apoptosis in the chicken lungs and aec ii, and down-regulated the expression levels of the protein of mg adhesin 1.2 (pmga1.2), il-1β, tnf-α, il-6, bax, caspase 9 and caspase 3, and up-regulated the expression levels of bcl-2 and bcl-xl in the chicken lungs, serum and aec ii (p ≤ 0.05). |
2022-05-09 |
2023-08-13 |
chicken |
| Dingmei Deng, Xian Ye, Xiyue Wang, Guangning H. Retracted Article: Gemcitabine aggravates miR-199a-5p-mediated breast cancer cell apoptosis by promoting VEGFA downregulation RSC advances. vol 9. issue 35. 2022-05-06. PMID:35514680. |
functional experiments were performed to explore cell viability, apoptosis rate, and expressions of apoptosis-related genes: cell viability was assessed by mtt staining, apoptosis rate was recorded by flow cytometry, and western blot was used to evaluate the expressions of bcl-2, bax and cleaved caspase 3. |
2022-05-06 |
2023-08-13 |
Not clear |