| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryotaro Wake, Shokei Kim-Mitsuyama, Yasukatsu Izumi, Kaoru Yoshida, Yasuhiro Izumiya, Tokihito Yukimura, Masayuki Shiota, Minoru Yoshiyama, Junichi Yoshikawa, Hiroshi Iwa. Beneficial effect of candesartan on rat diastolic heart failure. Journal of pharmacological sciences. vol 98. issue 4. 2005-11-03. PMID:16079469. |
cardiac fibrosis, apoptosis, and gene expression were estimated by sirius red-staining, tunel-staining, and northern blot analysis, respectively. |
2005-11-03 |
2023-08-12 |
rat |
| Magdalena Marcińczyk, Ewa Jabłońska, Wioletta Puzewska, Teresa Hermanowska-Szpakowic. [Effect of rhIL-15 on TLR2 expression and apoptosis of PMN from patients with Lyme disease]. Medycyna doswiadczalna i mikrobiologia. vol 57. issue 1. 2005-11-01. PMID:16130298. |
expression of tlr2 was estimated in lysates of pmn by western blot, apoptosis of pmn by immunofluorescent analysis. |
2005-11-01 |
2023-08-12 |
Not clear |
| Shubha Varma, Brajesh K Lal, Ruifang Zheng, Jerome W Breslin, Satoshi Saito, Peter J Pappas, Robert W Hobson, Walter N Durá. Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction. American journal of physiology. Heart and circulatory physiology. vol 289. issue 4. 2005-10-24. PMID:15964918. |
we assessed apoptosis by annexin v and propidium iodide staining and flow cytometry, analyzed cell lysates obtained on culture day 8 for total and phosphorylated pi3k and akt by western blot analysis, and measured akt kinase activity using a gsk fusion protein. |
2005-10-24 |
2023-08-12 |
human |
| Arabinda Das, Eric A Sribnick, James M Wingrave, Angelo M Del Re, John J Woodward, Stanley H Appel, Naren L Banik, Swapan K Ra. Calpain activation in apoptosis of ventral spinal cord 4.1 (VSC4.1) motoneurons exposed to glutamate: calpain inhibition provides functional neuroprotection. Journal of neuroscience research. vol 81. issue 4. 2005-10-20. PMID:15968645. |
western blot analyses showed an increase in bax:bcl-2 ratio, release of cytochrome c from mitochondria, and calpain and caspase-3 activities during apoptosis. |
2005-10-20 |
2023-08-12 |
Not clear |
| Charles E Ducker, John J Upson, Kevin J French, Charles D Smit. Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. Molecular cancer research : MCR. vol 3. issue 8. 2005-10-18. PMID:16123142. |
western blot analyses revealed that loss of nmt2 shifted the expression of the bcl family of proteins toward apoptosis. |
2005-10-18 |
2023-08-12 |
human |
| Jiajun Liu, Renwei Huang, Dongjun Lin, Xiangyuan Wu, Jun Peng, Qu Lin, Xianglin Pan, Maohong Zhang, Ming Hou, Feng Che. Apoptotic effect of oridonin on NB4 cells and its mechanism. Leukemia & lymphoma. vol 46. issue 4. 2005-10-05. PMID:16019488. |
cell growth inhibition, apoptosis and related pathways were assessed by mtt assay as well as flow cytometry (fcm) and western blot analysis. |
2005-10-05 |
2023-08-12 |
Not clear |
| C-C Chiu, C-H M Y Lin, K Fan. Etoposide (VP-16) sensitizes p53-deficient human non-small cell lung cancer cells to caspase-7-mediated apoptosis. Apoptosis : an international journal on programmed cell death. vol 10. issue 3. 2005-09-27. PMID:15909125. |
to assess the regulation of cell cycle modulators, western blot analysis of h1299 cell lysates showed the release of apoptosis initiator, cytochrome c and apaf-1 hours following drug induction. |
2005-09-27 |
2023-08-12 |
human |
| Seung-Jae Hong, Gyu Sung Rim, Hyung In Yang, Chang Shik Yin, Hyeong Gyun Koh, Mi-Hyeon Jang, Chang-Ju Kim, Bong-Keun Choe, Joo-Ho Chun. Bee venom induces apoptosis through caspase-3 activation in synovial fibroblasts of patients with rheumatoid arthritis. Toxicon : official journal of the International Society on Toxinology. vol 46. issue 1. 2005-09-22. PMID:15922390. |
the apoptosis of synovial cells treated with 10 microg/ml bv for 24 h was identified by 4,6-diamidino-2-phenylindole (dapi) staining, terminal deoxynucleotidyl transferase-mediated dutp nick end labelling (tunel) assay, dna fragmentation assay, rt-pcr, and western blot analysis. |
2005-09-22 |
2023-08-12 |
human |
| Noopur Raje, Shaji Kumar, Teru Hideshima, Aldo Roccaro, Kenji Ishitsuka, Hiroshi Yasui, Norihiko Shiraishi, Dharminder Chauhan, Nikhil C Munshi, Simon R Green, Kenneth C Anderso. Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma. Blood. vol 106. issue 3. 2005-09-21. PMID:15827128. |
cell-cycle and western blot analysis confirmed apoptosis. |
2005-09-21 |
2023-08-12 |
Not clear |
| Suresh R Volate, Destiny M Davenport, Stephanie J Muga, Michael J Wargovic. Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin). Carcinogenesis. vol 26. issue 8. 2005-09-20. PMID:15831530. |
western blot analysis of caspase 9, bax (proapoptotic) and bcl-2 (antiapoptotic) proteins from the colon scraping suggests that quercetin and curcumin induce apoptosis via the mitochondrial pathway. |
2005-09-20 |
2023-08-12 |
rat |
| Kazuhiro Noma, Yoshio Naomoto, Mehmet Gunduz, Junji Matsuoka, Tomoki Yamatsuji, Yasuhiro Shirakawa, Tetsuji Nobuhisa, Takaomi Okawa, Munenori Takaoka, Yasuko Tomono, Ohmori Hiroyuki, Esra Gunduz, Noriaki Tanak. Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines. Oncology reports. vol 14. issue 3. 2005-09-15. PMID:16077968. |
western blot analysis revealed that apoptosis related proteins were activated or suppressed by imatinib in both cell lines in the respective manner. |
2005-09-15 |
2023-08-12 |
Not clear |
| Hiroyuki Morimoto, Hirohiko Okamura, Kaya Yoshida, Seiichiro Kitamura, Tatsuji Hanej. Okadaic acid induces apoptosis through double-stranded RNA-dependent protein kinase/eukaryotic initiation factor-2alpha pathway in human osteoblastic MG63 cells. Journal of biochemistry. vol 136. issue 4. 2005-09-12. PMID:15625311. |
to investigate the functional relationship between phosphatases and apoptosis, we examined the phosphorylation levels of pkr and eif-2alpha by western blot analysis. |
2005-09-12 |
2023-08-12 |
human |
| Maurizio Viale, Maria A Mariggiò, Massimo Ottone, Barbara Chiavarina, Angela Vinella, Claudia Prevosto, Carlo Dell'Erba, Giovanni Petrillo, Marino Nov. Preliminary evaluation in vitro of the inhibition of cell proliferation, cytotoxicity and induction of apoptosis by 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene. Investigational new drugs. vol 22. issue 4. 2005-09-07. PMID:15292706. |
the study of the induction of apoptosis was carried out by 4'-6-diamidine-2'-phenylindole (dapi) staining of segmented nuclei, western blot of p53 protein and tdt-mediated dutp-biotin nick end labeling (tunel) method, while the interaction with dna was evaluated through the analysis of interstrand cross-link (iscl) formation. |
2005-09-07 |
2023-08-12 |
human |
| Myoung-Hwa Lee, Mi-Hyeon Jang, Eun-Kyung Kim, Sang-Wan Han, Seong-Yeon Cho, Chang-Ju Ki. Nitric oxide induces apoptosis in mouse C2C12 myoblast cells. Journal of pharmacological sciences. vol 97. issue 3. 2005-08-29. PMID:15781989. |
to investigate whether nitric oxide (no) induces apoptosis in myoblast cells, the effect of the sodium nitroprusside (snp), no donor, on the apoptosis of mouse c2c12 myoblast cells was examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay, flow cytometry, 4,6-diamidino-2-phenylindole (dapi) staining, terminal deoxynucleotidyl transferase (tdt)-mediated dutp nick end labeling (tunel) assay, dna fragmentation assay, reverse transcription-polymerase chain reaction (rt-pcr), western blot analysis, and caspase-3 enzyme assay. |
2005-08-29 |
2023-08-12 |
mouse |
| Min-Cheol Lee, Gye-Ryoung Wee, Jae-Hyoo Ki. Apoptosis of skeletal muscle on steroid-induced myopathy in rats. The Journal of nutrition. vol 135. issue 7. 2005-08-23. PMID:15987869. |
to investigate the underlying molecular changes in the apoptosis of skeletal muscle, in situ end labeling (isel), fas expression, and western blot analysis for apoptosis-related proteins in the soleus muscle of triamcinolone acetonide (ta)-induced myopathy of rats were studied. |
2005-08-23 |
2023-08-12 |
rat |
| Jun Wang, Yan-Qing Wang, Jin Yu, Xiao-Ding Cao, Gen-Cheng W. Electroacupuncture suppresses surgical trauma stress-induced lymphocyte apoptosis in rats. Neuroscience letters. vol 383. issue 1-2. 2005-08-22. PMID:15936514. |
in the present study, the effect of ea on surgical trauma stress-induced lymphocyte apoptosis was investigated by using dna gel electrophoresis, terminal deoxynucleotidyl transferase-mediated dutp nick end-labeling (tunel) assay, and western blot for fas protein expression. |
2005-08-22 |
2023-08-12 |
rat |
| Gustavo Duque, Khadija El Abdaimi, Janet E Henderson, Abderrahim Lomri, Richard Kreme. Vitamin D inhibits Fas ligand-induced apoptosis in human osteoblasts by regulating components of both the mitochondrial and Fas-related pathways. Bone. vol 35. issue 1. 2005-08-19. PMID:15207741. |
to further explore the mechanism of 1,25(oh)2d3-mediated inhibition of apoptosis, we examined the changes in activation of death domain proteins, cleavage of caspases and mitochondrial regulators of apoptosis by western blot analysis. |
2005-08-19 |
2023-08-12 |
human |
| Sebastian Stintzing, Peter Heuschmann, Letterio Barbera, Matthias Ocker, Andreas Jung, Thomas Kirchner, Daniel Neureite. Overexpression of MMP9 and tissue factor in unstable carotid plaques associated with Chlamydia pneumoniae, inflammation, and apoptosis. Annals of vascular surgery. vol 19. issue 3. 2005-08-15. PMID:15818457. |
the data on tissue remodeling were correlated with the presence of inflammatory cells (t cells, b-cells, macrophages), apoptosis, and the presence of c. pneumoniae using immunohistochemistry and western blot analyses. |
2005-08-15 |
2023-08-12 |
Not clear |
| J J Liu, R W Huang, D J Lin, J Peng, X Y Wu, Q Lin, X L Pan, Y Q Song, M H Zhang, M Hou, F Che. Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-gamma ligands induces apoptosis on human myeloid leukemia cells in vitro. Annals of oncology : official journal of the European Society for Medical Oncology. vol 16. issue 3. 2005-08-04. PMID:15642706. |
reverse transcription-pcr and western blot analyses demonstrated that both survivin and bcl-2 expression were downregulated markedly, while bax expression was upregulated concurrently when apoptosis occurred. |
2005-08-04 |
2023-08-12 |
human |
| Jian-Hua Zhang, Ming-Xi Wan, Bo-Rong Pan, Bing Y. Cytotoxicity of HSVtk and hrTNF-alpha fusion genes with IRES in treatment of gastric cancer. Cancer biology & therapy. vol 3. issue 11. 2005-07-21. PMID:15477756. |
the pl(tk-tnf-alpha)sn harboring hsvtk and tnf-alpha genes in sequence was constructed with a bicistronic unit including the internal ribosomal entry site, the recombinant retroviruses were transferred into sgc7901 cells by lipofectamine, and pegfp and western blot analysis were used to detect the expression of fusion genes in transfected sgc7901 cells, and then apoptosis of the transfected cells were detected by using the tdt-mediated dutp nick end labeling, flow cytometric analysis and transmission electron microscopy. |
2005-07-21 |
2023-08-12 |
mouse |