| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aseem Kumar, Anand Kumar, Paul Michael, Danielle Brabant, Amadeo M Parissenti, Chilakamarti V Ramana, Xiulong Xu, Joseph E Parrill. Human serum from patients with septic shock activates transcription factors STAT1, IRF1, and NF-kappaB and induces apoptosis in human cardiac myocytes. The Journal of biological chemistry. vol 280. issue 52. 2006-02-27. PMID:16223733. |
the addition of human septic serum to human fetal myocytes induced apoptosis in human fetal myocytes and activation of the mitogen-activated protein kinase c-jun nh -terminal kinase and caspase 1 as measured by western blot. |
2006-02-27 |
2023-08-12 |
human |
| Tin Oo Khor, Young-Sam Keum, Wen Lin, Jung-Hwan Kim, Rong Hu, Guoxiang Shen, Changjiang Xu, Avanthika Gopalakrishnan, Bandaru Reddy, Xi Zheng, Allan H Conney, Ah-Ng Tony Kon. Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice. Cancer research. vol 66. issue 2. 2006-02-14. PMID:16423986. |
immunohistochemistry staining and western blot analysis revealed that the inhibition of akt and nuclear factor-kappab signaling pathways could contribute to the inhibition of cell proliferation and induction of apoptosis. |
2006-02-14 |
2023-08-12 |
mouse |
| Kai Uwe Chow, Daniel Nowak, Soo-Zin Kim, Bernd Schneider, Martina Komor, Simone Boehrer, Paris S Mitrou, Dieter Hoelzer, Eckhart Weidmann, Wolf-Karsten Hofman. In vivo drug-response in patients with leukemic non-Hodgkin's lymphomas is associated with in vitro chemosensitivity and gene expression profiling. Pharmacological research. vol 53. issue 1. 2006-02-09. PMID:16213748. |
furthermore, changes in expression patterns of apoptosis related proteins during chemotherapeutic treatment were detected by western blot. |
2006-02-09 |
2023-08-12 |
Not clear |
| Ai-Guo Wang, Sun-Uk Kim, Sang Ho Lee, Sang-Keun Kim, Sang-Beom Seo, Dae-Yeul Yu, Dong-Seok Le. Histone deacetylase 1 contributes to cell cycle and apoptosis. Biological & pharmaceutical bulletin. vol 28. issue 10. 2006-02-07. PMID:16204956. |
to find out if the over-expression of hdac1 contributes to the expression of genes related to the cell cycle, apoptosis, and lipid metabolism that eventually contribute to the pathological changes in the livers of the transgenic mice, the expression profiles of the related genes in liver tissues were determined by reverse transcription-polymerase chain reaction (rt-pcr) and western blot analysis. |
2006-02-07 |
2023-08-12 |
mouse |
| Feng Dong, Xiaochun Zhang, Loren E Wold, Qun Ren, Zhaojie Zhang, Jun Re. Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin-1. British journal of pharmacology. vol 145. issue 3. 2006-01-13. PMID:15765100. |
western blot analysis indicated that et-1 alleviated homocysteine (hcy)-induced apoptosis, likely acting by antagonizing the hcy-induced decreases in akt, pakt, pakt-to-akt, bcl-2-to-bax ratios and increases in bax and caveolin-1 expression. |
2006-01-13 |
2023-08-12 |
human |
| Debra L Bemis, Jillian L Capodice, Aristotelis G Anastasiadis, Aaron E Katz, Ralph Buttya. Zyflamend, a unique herbal preparation with nonselective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression. Nutrition and cancer. vol 52. issue 2. 2006-01-12. PMID:16201851. |
effects of zyflamend on lncap cell growth and apoptosis in vitro were assessed by cell counting, western blot detection of poly adp-ribose polymerase (parp) cleavage, and measurement of caspase-3 activity in treated and control cell extracts. |
2006-01-12 |
2023-08-12 |
human |
| Yuan Cheng, Naoko Inoue, Fuko Matsuda-Minehata, Yasufumi Goto, Akihisa Maeda, Noboru Manab. Changes in expression and localization of connexin 43 mRNA and protein in porcine ovary granulosa cells during follicular atresia. The Journal of reproduction and development. vol 51. issue 5. 2006-01-10. PMID:16034189. |
to determine the role of connexin 43 (cx43), which is dominantly expressed in granulosa cells, in the regulation of granulosa cell apoptosis during follicular atresia, we examined the changes in the expression and localization of cx43 mrna and protein in granulosa cells during atresia using the quantitative real-time revese transcription-polymerase chain reaction, in situ hybridization, western blot, and immunohistochemistry. |
2006-01-10 |
2023-08-12 |
Not clear |
| Alessandra Pagano, Claire Pitteloud, Coralie Reverdin, Isabelle Métrailler-Ruchonnet, Yves Donati, Constance Barazzone Argiroff. Poly(ADP-ribose)polymerase activation mediates lung epithelial cell death in vitro but is not essential in hyperoxia-induced lung injury. American journal of respiratory cell and molecular biology. vol 33. issue 6. 2006-01-10. PMID:16151053. |
conversely, in primary lung fibroblasts, which die mainly by apoptosis, the complete cleavage of parp-1 was concomitant to the induction of active caspase-3, as assessed by western blot and caspase activity. |
2006-01-10 |
2023-08-12 |
mouse |
| Yoshiko Satomi, Hoyoku Nishino, Shoji Shibat. Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2. Anticancer research. vol 25. issue 6B. 2006-01-05. PMID:16309197. |
western blot analysis indicated that the induction of apoptosis by ga and ursolic acid was accompanied with an activation of caspase-8 and a reduction in the anti-apoptotic proteins, bcl-2 and bcl-xl, although the pro-apoptotic proteins, bax and bak, remained unaffected. |
2006-01-05 |
2023-08-12 |
human |
| Laurence Maggiorella, Bixiu Wen, Valerie Frascogna, Paule Opolon, Jean Bourhis, Eric Deutsc. Combined radiation sensitizing and anti-angiogenic effects of ionizing radiation and the protease inhibitor ritonavir in a head and neck carcinoma model. Anticancer research. vol 25. issue 6B. 2006-01-05. PMID:16309240. |
western blot analysis showed that apoptosis was induced by an increased expression of bax and decreased expression of bcl-2 after treatment with ritonavir and ionizing radiation. |
2006-01-05 |
2023-08-12 |
mouse |
| Kyung-Ha Ryu, So-Youn Woo, Mi-Young Lee, Yun-Jae Jung, Eun-Sun Yoo, Ju-Young Seoh, Jeong-Hae Kie, Hee-Young Shin, Hyo-Seop Ah. Morphological and biochemical changes induced by arsenic trioxide in neuroblastoma cell lines. Pediatric hematology and oncology. vol 22. issue 7. 2005-12-29. PMID:16166054. |
apoptosis was assessed by the cell morphology, by flow cytometry with annexin-v staining, and by western blot analysis for the apoptosis-related proteins (bcl-2 and parp). |
2005-12-29 |
2023-08-12 |
Not clear |
| Hubert Kin Bong Lam, Karen Li, Ki Wai Chik, Mo Yang, Venus Chi Ting Liu, Chi Kong Li, Tai Fai Fok, Pak Cheung Ng, Matthew Ming Kong Shing, Carmen Ka Yee Chuen, Patrick Man Pan Yue. Arsenic trioxide mediates intrinsic and extrinsic pathways of apoptosis and cell cycle arrest in acute megakaryocytic leukemia. International journal of oncology. vol 27. issue 2. 2005-12-23. PMID:16010437. |
in this study, we applied flow cytometry, western blot analysis and microarray techniques to investigate the effects of ato on apoptosis and the cell division cycle of amkl cell lines chrf-288-11 and meg-01. |
2005-12-23 |
2023-08-12 |
Not clear |
| Wolfgang Glienke, Yuliya Dolgova, Iris Müller, Sabine Grösch, Jochen Binder, Gerd Geisslinger, Dietger Jona. Induction of apoptosis in human prostate stromal cells by 4-hydroxytamoxifen: an alternative therapy for benign prostate hyperplasia. World journal of urology. vol 22. issue 6. 2005-12-22. PMID:15448996. |
the induction of apoptosis after oht treatment was investigated by facs-analysis (annexin v fitc staining) and western blot (parp-1 cleavage, bcl-2 and bax-alpha expression). |
2005-12-22 |
2023-08-12 |
human |
| Wolfgang Glienke, Yuliya Dolgova, Iris Müller, Sabine Grösch, Jochen Binder, Gerd Geisslinger, Dietger Jona. Induction of apoptosis in human prostate stromal cells by 4-hydroxytamoxifen: an alternative therapy for benign prostate hyperplasia. World journal of urology. vol 22. issue 6. 2005-12-22. PMID:15448996. |
the induction of apoptosis was further proven by western blot of parp-1 protein cleavage and the expression of the anti-apoptotic bcl-2 and the pro-apoptotic bax-alpha proteins. |
2005-12-22 |
2023-08-12 |
human |
| Zili Dan, Yury Popov, Eleonora Patsenker, Dorothee Preimel, Chun Liu, Xiang-Dong Wang, Helmut K Seitz, Detlef Schuppan, Felix Sticke. Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 7. 2005-12-22. PMID:15731294. |
staining for dapi and acridine orange, facs analysis, and western blot for cleaved caspase-9 and -3 were used to detect apoptosis. |
2005-12-22 |
2023-08-12 |
rat |
| Anna Trauzold, Christian Röder, Bence Sipos, Kristin Karsten, Alexander Arlt, Ping Jiang, Jose Ignacio Martin-Subero, Daniela Siegmund, Susanne Müerköster, Laia Pagerols-Raluy, Reiner Siebert, Harald Wajant, Holger Kalthof. CD95 and TRAF2 promote invasiveness of pancreatic cancer cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 6. 2005-12-14. PMID:15670977. |
using immunohistochemistry and western blot analysis we found traf2 overexpressed in 34 of 36 pancreatic tumor samples as well as in pancreatic tumor cell lines resistant to cd95-mediated apoptosis. |
2005-12-14 |
2023-08-12 |
Not clear |
| Anton Stangelberger, Andrew V Schally, Markus Letsch, Karoly Szepeshazi, Attila Nagy, Gabor Halmos, Celia A Kanashiro, Eva Corey, Robert Vessell. Targeted chemotherapy with cytotoxic bombesin analogue AN-215 inhibits growth of experimental human prostate cancers. International journal of cancer. vol 118. issue 1. 2005-12-13. PMID:16003723. |
the effects of an-215 on apoptosis and cell proliferation were followed by histology, and the expression of bcl-2 and bax protein was determined by western blot analysis. |
2005-12-13 |
2023-08-12 |
mouse |
| Kan Kondo, Seiji Yamasaki, Tomoharu Sugie, Naoki Teratani, Takatsugu Kan, Masayuki Imamura, Yutaka Shimad. Cisplatin-dependent upregulation of death receptors 4 and 5 augments induction of apoptosis by TNF-related apoptosis-inducing ligand against esophageal squamous cell carcinoma. International journal of cancer. vol 118. issue 1. 2005-12-13. PMID:16003725. |
furthermore, western blot was used to clarify the apoptosis pathway involved, and a nude-mouse xenograft model was used to show effects in vivo. |
2005-12-13 |
2023-08-12 |
mouse |
| Hye Joung Choi, Yung Hyun Choi, Su-Bog Yee, Eunok Im, Jee Hyung Jung, Nam Deuk Ki. Ircinin-1 induces cell cycle arrest and apoptosis in SK-MEL-2 human melanoma cells. Molecular carcinogenesis. vol 44. issue 3. 2005-12-12. PMID:16163705. |
even though the inhibitor of apoptosis protein (iap) was expressed in ircinin-1-untreated or -treated sk-mel-2 cells, only the level of ciap-1, but not xiap or ciap-2, was decreased during ircinin-1-induced apoptosis at western blot and rt-pcr studies. |
2005-12-12 |
2023-08-12 |
human |
| D Ou, X Wang, D L Metzger, M Robbins, J Huang, C Jobin, J K Chantler, R F L James, P Pozzilli, A J Tingl. Regulation of TNF-related apoptosis-inducing ligand-mediated death-signal pathway in human beta cells by Fas-associated death domain and nuclear factor kappaB. Human immunology. vol 66. issue 7. 2005-12-07. PMID:16112027. |
transfectants of human cm and nes2y beta cell lines and primary islets transfected by fadd-dn (dominant-negative form of fas-associated death domain), a mutant of fadd and/or a superrepressor of nuclear factor kappab (nf-kappab) (adikappab(sa)2), were examined for their susceptibility to the trail (tnf-related apoptosis-inducing ligand)-induced death signal pathway, compared with controls, wild-type cells, and vector transfectants in caspase fluorescence, western blot, electrophoretic mobility shift, apoptosis, and cytotoxicity assays. |
2005-12-07 |
2023-08-12 |
human |