| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandro Balbi, Maria Anzaldi, Chiara Macciò, Cinzia Aiello, Mauro Mazzei, Rosaria Gangemi, Patrizio Castagnola, Mariangela Miele, Camillo Rosano, Maurizio Vial. Synthesis and biological evaluation of novel pyrazole derivatives with anticancer activity. European journal of medicinal chemistry. vol 46. issue 11. 2012-02-13. PMID:21920636. |
the expression of p53 and p21(waf1), which induce apoptosis and cell cycle arrest, was evaluated by western blot analysis in cells treated with compound 12d. |
2012-02-13 |
2023-08-12 |
human |
| Vinicius F Carvalho, Luisa T Florim, Emiliano de O Barreto, Rafael C Torres, Marcelo M Batista, Fabio C Amendoeira, Renato S B Cordeiro, Marco A Martins, Patrícia M R E Silv. Inhibition of advanced glycation end products by aminoguanidine restores mast cell numbers and reactivity in alloxan-diabetic rats. European journal of pharmacology. vol 669. issue 1-3. 2012-02-08. PMID:21864526. |
mast cell apoptosis and levels of bax, a pro-apoptotic member of bcl-2 family, were evaluated by tunel and western blot, respectively. |
2012-02-08 |
2023-08-12 |
rat |
| Nils Schallner, Sven Schwemmers, Christian I Schwer, Christian Froehlich, Patrick Stoll, Matjaz Humar, Heike L Pahl, Alexander Hoetzel, Torsten Loop, Ulrich Goebe. p38β-regulated induction of the heat shock response by carbon monoxide releasing molecule CORM-2 mediates cytoprotection in lung cells in vitro. European journal of pharmacology. vol 670. issue 1. 2012-02-06. PMID:21925493. |
apoptosis was induced by staurosporine and analyzed by flow cytometry following annexin-v staining, caspase-3 activity assay, and by western blot for caspase-3 cleavage. |
2012-02-06 |
2023-08-12 |
cattle |
| Uk Koo, Kung-Woo Nam, Ahrom Ham, Dahyun Lyu, Bora Kim, Sung-Jin Lee, Kyeong Ho Kim, Ki-Bong Oh, Woongchon Mar, Jongheon Shi. Neuroprotective effects of 3α-acetoxyeudesma-1,4(15),11(13)-trien-12,6α-olide against dopamine-induced apoptosis in the human neuroblastoma SH-SY5Y cell line. Neurochemical research. vol 36. issue 11. 2012-01-27. PMID:21688047. |
flow cytometric and western blot analysis showed that aeto significantly inhibited da-induced apoptosis along with suppression of intracellular tyrosinase activity, ros generation, quinoprotein, and α-syn formation (p < 0.01). |
2012-01-27 |
2023-08-12 |
human |
| Tullia Maraldi, Massimo Riccio, Laura Zambonin, Marco Vinceti, Anto De Pol, Gabriele Haki. Low levels of selenium compounds are selectively toxic for a human neuron cell line through ROS/RNS increase and apoptotic process activation. Neurotoxicology. vol 32. issue 2. 2012-01-25. PMID:21215776. |
the results indicated that: (1) sknbe neuroblastoma cells treated with sodium selenite, sodium selenate and seleno-methionine (0.1, 0.5 and 0.5 μm, respectively) for 24h exhibited a viability decrease, unlike kidney or prostatic cells; (2) the parp (poly-adp-ribose-polymerase) degradation and caspase activation detected by western blot and flow cytometry fluorimetric examination showed induction of apoptosis; (3) during selenium treatment, a ros/rns increase occurred despite the gsh increment, as revealed by fluorimetric analysis; (4) the rns production could be blocked by a peroxynitrite scavenger; (5) after exposure to selenium compounds, the concentration of nitric oxide synthase, manganese superoxide dismutase (sod2), p-nf-kb (phospho nuclear factor kb), glutathione reductase and glutathione peroxidase increased, whereas that of p-erk (phospho extracellular signal-regulated kinase) decreased; (6) selenium presence induced copper/zinc superoxide dismutase (sod1) translocation into mitochondria, in a way similar to what is observed in amyotrophic lateral sclerosis (als). |
2012-01-25 |
2023-08-12 |
human |
| B Cheng, S Pan, X Liu, S Zhang, X Su. Cell apoptosis of taste buds in circumvallate papillae in diabetic rats. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 119. issue 8. 2012-01-25. PMID:21667436. |
immunohistochemical and western blot analyses revealed the downregulation of bcl-2, upregulation of bax, and increased activation of caspase-9 and -3, in diabetic rats, indicating that the apoptosis of taste bud cells may be mediated via the intrinsic mitochondrial pathway in diabetics. |
2012-01-25 |
2023-08-12 |
rat |
| Wei Zhang, Bao-An Chen, Wen Bao, Jian Cheng, Yan Sun, Jie Cheng, Min Zhang, Xiao-Min Zhang, Yan Che. [Effects of hyperbaric oxygen combined with adriamycin in inducing apoptosis of K562/A02 cells]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 3. 2012-01-19. PMID:21729536. |
the cell apoptosis and expression of caspase-3 activity were analyzed by flow cytometry and transmission electron microscopy; the expression levels of hif-1α, bcl-2 and bax mrna were detected by quantitative real time pcr; the caspase 8 activity was determined by using caspase 8 kit; the expression level of p-gp was detected by western blot. |
2012-01-19 |
2023-08-12 |
Not clear |
| Xiao-Feng Li, Jing-He Li, Chun-Hong Wang, Xiu-Li Wang, Qiu-Ju Liu, Wen Xu, Bo Jia, Lin Qiu, Jun M. [Apoptosis of KBM5R cell line with T315I point mutation induced by arsenic trioxide]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 3. 2012-01-19. PMID:21729541. |
resistance of kbm5r cells to im and proliferation of kbm5 and kbm5r cells treated with ato were detected by mtt; apoptosis of kbm5 and kbm5r cells were quantified by flow cytometry; the expression of apoptosis-related protein caspase-3, -8, -9 was determined by western blot. |
2012-01-19 |
2023-08-12 |
Not clear |
| Lei Zhang, Yonggeng Zhao, Cheng-guo Wang, Zhou Fei, Yuan Wang, Lexiang Li, Liang Li, Hai-ning Zhe. Neuritin expression and its relation with proliferation, apoptosis, and angiogenesis in human astrocytoma. Medical oncology (Northwood, London, England). vol 28. issue 3. 2012-01-18. PMID:20405246. |
the expression of neuritin messenger rna, protein and the relationship with proliferation, apoptosis, and angiogenesis were examined in human astrocytoma samples and three glioma cell lines by immunohistochemistry, western blot, and quantitative real-time rt-pcr and so on. |
2012-01-18 |
2023-08-12 |
human |
| Hannah Rachel Vasanthi, Subhendu Mukherjee, Diptarka Ray, Karuppiah Shanmugasundara Pandian Jayachandran, Istvan Lekli, Dipak Kumar Da. Protective role of air potato (Dioscorea bulbifera) of yam family in myocardial ischemic reperfusion injury. Food & function. vol 1. issue 3. 2012-01-16. PMID:21776477. |
role of db on apoptosis was also evaluated by determining caspase 3 as well as by examining pro-apoptotic and anti-apoptotic proteins bax and bcl2 by western blot analysis followed by tunel assay. |
2012-01-16 |
2023-08-12 |
rat |
| Guang-Ping Wang, Kai Wang, Hong-Ya Xin, Zhao-Jun Duan, Zhao-Zheng Jing, San-Qing Tan, Zhen-Hua Qi, Fang-Ping Che. [Chimeric Ad5F35 adenoviral vector-mediated expression of mutant IκBα induces apoptosis of leukemia cells]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 2. 2012-01-12. PMID:21518483. |
the apoptosis, nf-κb dna binding activity, the expressions of iκbα, ciap-2 and xiap in hl-60 cells were detected by dna binding assay, flow cytometry, real-time quantitative polymerase chain reaction and western blot respectively. |
2012-01-12 |
2023-08-12 |
human |
| Ruo-Zhi Xiao, Yan Chen, Li-Lin Wang, Xing-Xing Ruan, Cheng-Ming He, Mu-Jun Xiong, Dong-Jun Li. [Sorafenib induces apoptosis of U937 cells via inhibiting WNT signal pathway]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 2. 2012-01-12. PMID:21518487. |
cell viability was determined by cell counting kit-8; cell apoptosis and cell ratio in cell cycle were detected by flow cytometry with annexin v/pi staining and pi staining respectively; expressions of gsk-3β, β-catenin and cyclin-d1 were assayed by western blot. |
2012-01-12 |
2023-08-12 |
Not clear |
| Ping Yang, Jing Wang, Hong-Mei Jing, Xiao-Yan K. [Effect of magnetic nanoparticle of Fe3O4 combined with daunorubicin on lymphoma cell line Raji]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 2. 2012-01-12. PMID:21518493. |
the raji cells were cultured with fe3o4-magnetic nanoparticle and daunorubicin polymerized by means of mechanical absorption, the cell viability was detected by mtt and trypan-blue exclusion; the apoptosis was detected by flow cytometry, the expressions of p53 and p65 are measured by western blot. |
2012-01-12 |
2023-08-12 |
Not clear |
| Monika Hułas-Stasiak, Antoni Gawro. Follicular atresia in the prepubertal spiny mouse (Acomys cahirinus) ovary. Apoptosis : an international journal on programmed cell death. vol 16. issue 10. 2012-01-12. PMID:21739276. |
western blot analysis indicated that at the moment of birth, females undergo an increased rate of follicular atresia mediated by autophagy, while apoptosis is the dominant form of ovarian atresia in consecutive postnatal days. |
2012-01-12 |
2023-08-12 |
mouse |
| Hua Wang, Hui Liu, Zhao-Min Zheng, Kui-Bo Zhang, Tai-Ping Wang, Shilabant-Sen Sribastav, Wen-Sheng Liu, Ting Li. Role of death receptor, mitochondrial and endoplasmic reticulum pathways in different stages of degenerative human lumbar disc. Apoptosis : an international journal on programmed cell death. vol 16. issue 10. 2012-01-12. PMID:21879322. |
biomarkers of these three apoptosis pathways were detected by rt-pcr and western blot. |
2012-01-12 |
2023-08-12 |
human |
| Yonggang Cao, Xiaoyuan Mao, Chunyan Sun, Ping Zheng, Jingquan Gao, Xiaorui Wang, Dongyu Min, Hongli Sun, Ni Xie, Jiqun Ca. Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways. Brain research bulletin. vol 85. issue 6. 2012-01-11. PMID:21600966. |
evidence for neuronal apoptosis was detected by real-time rt-pcr, western blot and caspase-3 activity measurement. |
2012-01-11 |
2023-08-12 |
Not clear |
| Tie-Jun Wang, Zhong-Shan Liu, Zhao-Chong Zeng, Shi-Suo Du, Ming Qiang, Wei Jiang, Le-Yuan Zhou, Wei-Jie Ding, Hai-Ying Zen. Caffeine does not enhance radiosensitivity of normal liver tissue in vivo. Molecular biology reports. vol 38. issue 7. 2011-12-27. PMID:21116849. |
apoptosis rates in normal rat liver tissue after ir were evaluated by tunel staining and caspase-3 western blot. |
2011-12-27 |
2023-08-12 |
mouse |
| Emelie A Djerf Severinsson, Cecilia Trinks, Henrik Gréen, Avni Abdiu, Anna-Lotta Hallbeck, Olle Stål, Thomas M Wal. The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo. Biochemical and biophysical research communications. vol 414. issue 3. 2011-12-20. PMID:21982771. |
in contrast to the cytostatic effect observed at doses ≤ 5μm canertinib, higher concentrations induced apoptosis as demonstrated by the annexin v method and western blot analysis of parp cleavage. |
2011-12-20 |
2023-08-12 |
mouse |
| Xiaoqing Guo, Guangzhi Liu, Isaiah G Schauer, Gong Yang, Imelda Mercado-Uribe, Fan Yang, Shiwu Zhang, Yuanli He, Jinsong Li. Overexpression of the β subunit of human chorionic gonadotropin promotes the transformation of human ovarian epithelial cells and ovarian tumorigenesis. The American journal of pathology. vol 179. issue 3. 2011-12-09. PMID:21763678. |
immortalized nontumorigenic ovarian epithelial t29 and t80 cells stably overexpressing β-hcg were examined for alterations in cell cycle and apoptotic status by flow cytometry, expression of proteins regulating cell cycle and apoptosis by western blot, proliferation status by mtt assay, anchorage-independent colony formation, and mouse tumor formation. |
2011-12-09 |
2023-08-12 |
mouse |
| Lev M Berstein, Wei Yue, Ji-Ping Wang, Richard J Sante. Isolated and combined action of tamoxifen and metformin in wild-type, tamoxifen-resistant, and estrogen-deprived MCF-7 cells. Breast cancer research and treatment. vol 128. issue 1. 2011-12-07. PMID:20683653. |
this was confirmed with western blot analysis of parp and caspase 7 as well as with apoptosis elisa assay. |
2011-12-07 |
2023-08-12 |
Not clear |