| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue-min Nan, Fang Han, Ling-bo Kong, Ya Li, Rong-qi Wang, Su-xian Zha. [Peroxisome proliferator activated receptor gamma activation and overexpression prevent hepatocellular apoptosis of nutritional fibrotic steatohepatitis in mice]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. vol 19. issue 7. 2012-04-09. PMID:22152244. |
the expression levels of mrna and protein of pparg and apoptosis related genes, fas, fas ligand (fasl), b cell lymphoma/leukemia-2 (bcl-2), bcl-2 associated x protein (bax) and cysteine-containing aspartate-specific proteases-3 (caspase-3) were detected by real-time rt-pcr and western blot assay, respectively. |
2012-04-09 |
2023-08-12 |
mouse |
| Simona Weisheit, Claus Liebman. Allosteric modulation by protein kinase Cε leads to modified responses of EGF receptor towards tyrosine kinase inhibitors. Cellular signalling. vol 24. issue 2. 2012-04-06. PMID:21964064. |
cell cycle and western blot analysis revealed that the gefitinib-induced apoptosis was enhanced whereas the pro-apoptotic effect of lapatinib that requires another egfr conformation was reduced by pkcε. |
2012-04-06 |
2023-08-12 |
Not clear |
| Kulasekaran Gopinath, Dharmalingam Prakash, Ganapasam Sudhandira. Neuroprotective effect of naringin, a dietary flavonoid against 3-nitropropionic acid-induced neuronal apoptosis. Neurochemistry international. vol 59. issue 7. 2012-04-03. PMID:21945202. |
naringin also reduced the 3-np-induced apoptosis via decrease in the cytochrome c release from mitochondria and caspase 3 activation as revealed by western blot. |
2012-04-03 |
2023-08-12 |
rat |
| Fang Wang, Hongli Li, Haoying Shi, Baogui Su. Pro-apoptotic role of nuclear factor-κB in adriamycin-induced acute myocardial injury in rats. Molecular medicine reports. vol 5. issue 2. 2012-03-30. PMID:22011862. |
myocardial apoptosis was detected by tunel assay; myocardium p53 gene expression was examined by rt-pcr analysis; location and distribution of p53 was observed by immunohistochemical assay; myocardial expression of p53 protein was assessed by western blot analysis and activity of nf-κb was evaluated by electrophoretic mobility shift assay. |
2012-03-30 |
2023-08-12 |
rat |
| Hua Yuan, Fei Jiang, Ruixia Wang, Ming Shen, Ning Che. Lentivirus-mediated RNA interference of E2F-1 suppresses Tca8113 cell proliferation. Molecular medicine reports. vol 5. issue 2. 2012-03-30. PMID:22076063. |
the data from real-time quantitative rt-pcr and western blot analysis showed that e2f-1-shrna led to the inhibition of endogenous e2f-1 mrna and protein expression, and e2f-1 may be associated with proliferation and apoptosis pathways. |
2012-03-30 |
2023-08-12 |
human |
| Wei Cao, Yan-Hua Xie, Xiao-Qiang Li, Xiao-Kai Zhang, Yue-Tao Chen, Rong Kang, Xi Chen, Shan Miao, Si-Wang Wan. Burn-induced apoptosis of cardiomyocytes is survivin dependent and regulated by PI3K/Akt, p38 MAPK and ERK pathways. Basic research in cardiology. vol 106. issue 6. 2012-03-27. PMID:21706383. |
based on the western blot analyses, real-time pcr, elisa, and tunel, apoptosis and caspase activation both in vivo and in vitro were significantly increased after severe burn injury, while survivin expression was increased (up to 2.90-fold) during the early stage of burn injury and was almost completely abolished 8 h after the burn. |
2012-03-27 |
2023-08-12 |
rat |
| Arun Prasath Lakshmanan, Rajarajan A Thandavarayan, Suresh S Palaniyandi, Flori R Sari, Harima Meilei, Vijayasree V Giridharan, Vivian Soetikno, Kenji Suzuki, Makoto Kodama, Kenichi Watanab. Modulation of AT-1R/CHOP-JNK-Caspase12 pathway by olmesartan treatment attenuates ER stress-induced renal apoptosis in streptozotocin-induced diabetic mice. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 44. issue 5. 2012-03-25. PMID:22033153. |
we employed western blot analysis to measure the renal protein expressions level of nadph oxidase subunits, er chaperone grp78 and the er-associated apoptosis proteins. |
2012-03-25 |
2023-08-12 |
mouse |
| Yu Qing Ji, Yu Quan Zhang, Ming Qing Li, Mei Rong Du, Wei Wei Wei, Da Jin L. EPO improves the proliferation and inhibits apoptosis of trophoblast and decidual stromal cells through activating STAT-5 and inactivating p38 signal in human early pregnancy. International journal of clinical and experimental pathology. vol 4. issue 8. 2012-03-25. PMID:22135724. |
the effects of epo on the proliferation and apoptosis of trophoblasts and dscs, and activation of signal molecules were investigated by brdu proliferation assay, flow cytometry and western blot, respectively. |
2012-03-25 |
2023-08-12 |
human |
| Rong Hu, Ke Zhu, Yingchun Li, Kun Yao, Rong Zhang, Huihan Wang, Wei Yang, Zhuogang Li. Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells. Medical oncology (Northwood, London, England). vol 28. issue 4. 2012-03-22. PMID:20625944. |
western blot analysis showed that the expression of anti-apoptotic proteins x-linked inhibitor of apoptosis (xiap) was down-regulated by embelin. |
2012-03-22 |
2023-08-12 |
human |
| Faraj Terro, Amandine Magnaudeix, Marion Crochetet, Ludovic Martin, Sylvie Bourthoumieu, Cornelia-M Wilson, Catherine Yardin, Philippe Levequ. GSM-900MHz at low dose temperature-dependently downregulates α-synuclein in cultured cerebral cells independently of chaperone-mediated-autophagy. Toxicology. vol 292. issue 2-3. 2012-03-21. PMID:22185909. |
apoptosis was analyzed by dapi stain of the nuclei and western blot of cleaved caspase-3. |
2012-03-21 |
2023-08-12 |
Not clear |
| Xiaodong Bie, Yueqing Chen, Xuesheng Zheng, Haibin Da. The role of crocetin in protection following cerebral contusion and in the enhancement of angiogenesis in rats. Fitoterapia. vol 82. issue 7. 2012-03-15. PMID:21741458. |
the tunel staining and electron microscopy revealed that crocetin treatment led to an inhibition of neuronal apoptosis 72 h following treatment; this finding was confirmed by western blot analysis of b cell lymphoma/leukemia-2 (bcl-2) protein expression. |
2012-03-15 |
2023-08-12 |
rat |
| Lin-Li Zhou, Zhi-Xiu Lin, Kwok-Pui Fung, Christopher H K Cheng, Chun-Tao Che, Ming Zhao, Shi-Hua Wu, Zhong Zu. Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-κB activity. European journal of pharmacology. vol 670. issue 2-3. 2012-02-27. PMID:21951963. |
the ability of celastrol to induce apoptosis was studied by flow cytometric and western blot analyses. |
2012-02-27 |
2023-08-12 |
human |
| Lin-Li Zhou, Zhi-Xiu Lin, Kwok-Pui Fung, Christopher H K Cheng, Chun-Tao Che, Ming Zhao, Shi-Hua Wu, Zhong Zu. Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-κB activity. European journal of pharmacology. vol 670. issue 2-3. 2012-02-27. PMID:21951963. |
in addition, western blot analysis revealed a significant augmentation in the protein expression of bax and attenuation in bcl-2, suggesting that the celastrol-induced apoptosis acts through both death receptor and mitochondrial pathways. |
2012-02-27 |
2023-08-12 |
human |
| Lin-Li Zhou, Zhi-Xiu Lin, Kwok-Pui Fung, Christopher H K Cheng, Chun-Tao Che, Ming Zhao, Shi-Hua Wu, Zhong Zu. Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-κB activity. European journal of pharmacology. vol 670. issue 2-3. 2012-02-27. PMID:21951963. |
moreover, western blot analysis on the expression of rel/nf-κb demonstrated that the celastrol-mediated apoptosis on hacat cells was associated with the inhibition of the nf-κb pathway. |
2012-02-27 |
2023-08-12 |
human |
| Linqiang Tian, Delong Yin, Ye Ren, Chen Gong, Anmin Chen, Feng-Jin Gu. Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. Molecular medicine reports. vol 5. issue 1. 2012-02-27. PMID:21993662. |
to determine the anticancer effect of pl on osteosarcoma cell lines mg-63 and u2os, cell viability, apoptosis, cell cycle distribution, caspase-3 and caspase-9 activity and intracellular reactive oxygen species (ros) generation were measured, and western blot analyses were performed. |
2012-02-27 |
2023-08-12 |
human |
| Hans Linde Nielsen, Henrik Nielsen, Tove Ejlertsen, Jørgen Engberg, Dorothee Günzel, Martin Zeitz, Nina A Hering, Michael Fromm, Jörg-Dieter Schulzke, Roland Bücke. Oral and fecal Campylobacter concisus strains perturb barrier function by apoptosis induction in HT-29/B6 intestinal epithelial cells. PloS one. vol 6. issue 8. 2012-02-24. PMID:21887334. |
apoptosis induction was examined by tunel-staining and western blot of caspase-3 activation. |
2012-02-24 |
2023-08-12 |
human |
| Lang Li, Qiang Su, Yan Wang, Rixin Dai, Yongguang Lu, Bo Su, Yongxiang Zha. Effect of atorvastatin (Lipitor) on myocardial apoptosis and caspase-8 activation following coronary microembolization. Cell biochemistry and biophysics. vol 61. issue 2. 2012-02-23. PMID:21556942. |
tunel assay and western blot were used for myocardial apoptosis and expression of caspases-3/-8, respectively. |
2012-02-23 |
2023-08-12 |
rat |
| Edvan de Queiroz Crusoe, Patricia Maiso, Diego Fernandez-Lazaro, Laura San-Segundo, Mercedes Garayoa, Antonio Garcia-Gomez, Norma C Gutierrez, Manuel Delgado, Enrique Colado, Jesus Martin-Sanchez, Francis Y Lee, Enrique M Oci. Transcriptomic rationale for the synergy observed with dasatinib + bortezomib + dexamethasone in multiple myeloma. Annals of hematology. vol 91. issue 2. 2012-02-23. PMID:21720745. |
some of these results were further confirmed by apoptosis and cell cycle experiments and also by western blot and pcr. |
2012-02-23 |
2023-08-12 |
Not clear |
| Matthew D Thompson, Meghan M Mensack, Weiqin Jiang, Zongjian Zhu, Matthew R Lewis, John N McGinley, Mark A Brick, Henry J Thompso. Cell signaling pathways associated with a reduction in mammary cancer burden by dietary common bean (Phaseolus vulgaris L.). Carcinogenesis. vol 33. issue 1. 2012-02-17. PMID:22072617. |
initial experiments were conducted using a high dietary concentration of bean (60% wt/wt) where carcinoma burden in bean-fed rats was reduced 62.2% (p < 0.001) and histological and western blot analyses revealed that the dominant cellular process associated with reduced burden was induction of apoptosis. |
2012-02-17 |
2023-08-12 |
human |
| Lingling Xu, Yanping Deng, Lixin Feng, Defang Li, Xiaoyan Chen, Chao Ma, Xuan Liu, Jun Yin, Min Yang, Fukang Teng, Wanying Wu, Shuhong Guan, Baohong Jiang, Dean Gu. Cardio-protection of salvianolic acid B through inhibition of apoptosis network. PloS one. vol 6. issue 9. 2012-02-14. PMID:21915278. |
hemodynamic detection and pathological stain, 2-dimensional electrophoresis, maldi-tof ms/ms, western blot, pathway identification, apoptosis assay and transmission electron microscope were used to elucidate the effects and mechanism of salb on cardioprotection. |
2012-02-14 |
2023-08-12 |
rat |