| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chan-Min Liu, Yuan-Lin Zheng, Jun Lu, Zi-Feng Zhang, Shao-Hua Fan, Dong-Mei Wu, Jie-Qiong M. Quercetin protects rat liver against lead-induced oxidative stress and apoptosis. Environmental toxicology and pharmacology. vol 29. issue 2. 2012-10-02. PMID:21787598. |
western blot analysis showed that quercetin significantly inhibited apoptosis by modulating the ratio of bax to bcl-2 expression and suppressing the expression of phosphorylated jnk1/2 and cleaved caspase-3 in the liver of lead-treated rat. |
2012-10-02 |
2023-08-12 |
rat |
| Lili Ji, Ying Chen, Zhengtao Wan. Protection of S-adenosyl methionine against the toxicity of clivorine on hepatocytes. Environmental toxicology and pharmacology. vol 26. issue 3. 2012-10-02. PMID:21791384. |
dna fragmentation assay showed that sam (5μm) improved clivorine-induced l-02 cell apoptosis, and the results of western blot showed that sam (5μm) decreased clivorine-induced caspase-3 activation. |
2012-10-02 |
2023-08-12 |
human |
| P Fathi Rezaei, Sh Fouladdel, Silvia Cristofanon, S M Ghaffari, G R Amin, E Aziz. Comparative cellular and molecular analysis of cytotoxicity and apoptosis induction by doxorubicin and Baneh in human breast cancer T47D cells. Cytotechnology. vol 63. issue 5. 2012-10-02. PMID:21818667. |
furthermore, western blot analyses have been done to study the role of key molecular players of apoptosis including caspase 3 and parp. |
2012-10-02 |
2023-08-12 |
human |
| Xue-mei Chen, Jun Liu, Tao Wang, Jing Shan. Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 5. 2012-10-02. PMID:22342440. |
the effect of colchicine on apoptosis in l-02 cells and the apoptosis-associated signaling pathways were determined using different tests including cell viability assay, annexin v and propidium idodide binding, pi staining, hoechst 33342 staining, mitochondrial membrane potential assay, caspase activity assay and western blot analysis. |
2012-10-02 |
2023-08-12 |
human |
| Y T An, Z Zhao, Y C Sheng, Y Min, Y Y Xi. Therapeutic time window of YGY-E neuroprotection of cerebral ischemic injury in rats. Drug discoveries & therapeutics. vol 5. issue 2. 2012-10-02. PMID:22466144. |
furthermore, we evaluated effects of this compound on neuronal apoptosis and synthesis of bcl-2 and bax in ischemic brain tissue with in situ dna end labeling (tunel), immunohistochemistry assay, and western blot analysis. |
2012-10-02 |
2023-08-12 |
rat |
| R Shehadeh Masha'our, R Heinrich, H J Garzozi, I Perlma. Acetylcholinesterase (AChE) is an important link in the apoptotic pathway induced by hyperglycemia in Y79 retinoblastoma cell line. Frontiers in molecular neuroscience. vol 5. 2012-10-02. PMID:22685426. |
apoptosis was detected by the cleavage of poly adp-ribose polymerase (parp) using western blot, and by terminal deoxynucleotidyl-transferase-mediated dutp nick-end-labeling (tunel) assay. |
2012-10-02 |
2023-08-12 |
Not clear |
| Fang Zhao, Qinghua Wan. The protective effect of peroxiredoxin II on oxidative stress induced apoptosis in pancreatic β-cells. Cell & bioscience. vol 2. issue 1. 2012-10-02. PMID:22709359. |
western blot showed that treatment of min6 β-cell line with proinflammatory cytokines, palmitic acid or streptozotocin dose- or time-dependently increased apoptosis, which was associated with reduced endogenous expression levels of prdx2. |
2012-10-02 |
2023-08-12 |
Not clear |
| Zhongyong Jiang, Jin Chai, Henry Hon Fung Chuang, Shifeng Li, Tianran Wang, Yi Cheng, Wensheng Chen, Deshan Zho. Artesunate induces G0/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis in A431 human epidermoid carcinoma cells. Anti-cancer drugs. vol 23. issue 6. 2012-09-28. PMID:22421370. |
furthermore, art induced mitochondrial apoptosis, as evidenced by annexin v/propidium iodide staining and western blot analysis. |
2012-09-28 |
2023-08-12 |
human |
| Jianhui Zhou, Deyang Kong, Xu Zhang, Yuanda Wang, Zhe Feng, Xueguang Zhang, Li Zhang, Yan Wang, Yuansheng Xie, Xiangmei Che. Myoglobin-induced apoptosis: two pathways related to endoplasmic reticulum stress. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. vol 16. issue 3. 2012-09-25. PMID:22607572. |
the apoptosis related protein expression is determined by western blot. |
2012-09-25 |
2023-08-12 |
human |
| Jie Cao, Dong-Ling Dai, Long Yao, Hui-Hong Yu, Bo Ning, Qin Zhang, Juan Chen, Wen-Hui Cheng, Wei Shen, Zhao-Xia Yan. Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway. Molecular and cellular biochemistry. vol 364. issue 1-2. 2012-09-20. PMID:22246806. |
mtt assay was used for cell viability, flow cytometry and hoechst 33258 staining for apoptosis, rt-pcr for mrna expression, and western blot for protein expression. |
2012-09-20 |
2023-08-12 |
human |
| Zu-An Zhu, Zheng-Qiu Zhu, Hong-Xing Cai, Ying Li. Reversion of multidrug resistance by SKI-II in SGC7901/DDP cells and exploration of underlying mechanisms. Asian Pacific journal of cancer prevention : APJCP. vol 13. issue 2. 2012-09-20. PMID:22524836. |
then cell growth, apoptosis, micro- morphological changes, and expression of sphk1, p-gp, nf-kb, bcl-2 and bax were assessed by mtt assay, flow cytometry, electron microscopy, immunocytochemistry and western blot assay respectively. |
2012-09-20 |
2023-08-12 |
Not clear |
| Huiqiu Cao, Yulin Hu, Peng Wang, Jianhua Zhou, Zhenghao Deng, Jifang We. Down-regulation of Notch receptor signaling pathway induces caspase-dependent and caspase-independent apoptosis in lung squamous cell carcinoma cells. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 120. issue 6. 2012-09-11. PMID:22583356. |
cleaved poly adp-ribose polymerase (parp) was measured by western blot; x-linked inhibitor of apoptosis protein (xiap) and survivin were assessed by qrt-pcr and western blot; the release of second mitochondria-derived activator of caspase (smac) from mitochondria to cytoplasm was evaluated by western blot; the subcellular locations of endonuclease g (endo g) and apoptosis inducing factor (aif) were observed by western blot and indirect immunofluorescence analysis. |
2012-09-11 |
2023-08-12 |
Not clear |
| Zhifu Li, Jun Shen, Yuxian Chen, Janying Pan, Hua Zeng, Hang Fang, Zhiqiang Ye, Chun Zeng, Rongkai Zhang, Daozhang Ca. Mitochondrial genome sequencing of chondrocytes in osteoarthritis by human mitochondria RT2 Profiler™ PCR array. Molecular medicine reports. vol 6. issue 1. 2012-09-10. PMID:22504941. |
western blot analysis confirmed that the p53 upregulated modulator of apoptosis (puma; encoded by the bb3 gene) was significantly upregulated in oa cartilage. |
2012-09-10 |
2023-08-12 |
human |
| N Gurbuz, G Sagdic, A Sanli, A Ciftcioglu, I Bassorgun, A Baykal, M F Ust. Therapeutic effect of combination of alagebrium (ALT-711) and sildenafil on erectile function in diabetic rats. International journal of impotence research. vol 24. issue 3. 2012-09-06. PMID:22205245. |
penile tissue ages, mda (malondialdehyde), cyclic guanosine monophosphate (cgmp) (elisa), endothelial nitric oxide (no) synthase (enos), inducible no synthase (inos) (western blot), nuclear factor (nf)-κb, mitogen-activated protein (map) kinase (immunohistochemistry) and apoptosis (terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling) analyses were performed in all groups of rats. |
2012-09-06 |
2023-08-12 |
rat |
| Jae Hun Cha, Yoon Ji Choi, Seung Heon Cha, Chang Hwa Choi, Won Ho Ch. Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway. Oncology reports. vol 28. issue 1. 2012-09-04. PMID:22552443. |
apoptosis was determined by tunel and hoechst 33258 staining as well as by western blot analysis. |
2012-09-04 |
2023-08-12 |
human |
| Na Wang, Zhihua Li, Fen Tian, Ying Feng, Jintao Huang, Chaohong Li, Fukang Xi. PKCα inhibited apoptosis by decreasing the activity of JNK in MCF-7/ADR cells. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 64. issue 5. 2012-08-31. PMID:21106355. |
mtt, dna ladder and flow cytometry were used to detect cell growth inhibition or apoptosis while western blot was used to detect the activation of proteins. |
2012-08-31 |
2023-08-12 |
Not clear |
| Hisanori Miki, Norihisa Uehara, Ayako Kimura, Tomo Sasaki, Takashi Yuri, Katsuhiko Yoshizawa, Airo Tsubur. Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells. International journal of oncology. vol 40. issue 4. 2012-08-31. PMID:22218562. |
annexin v staining and western blot analysis revealed that res induced apoptosis accompanied by an increase in caspase-8 and caspase-3 cleavage. |
2012-08-31 |
2023-08-12 |
human |
| David R Abbott, Robert T Abbott, Stephen D Jenson, G Chris Fillmore, Kojo S J Elenitoba-Johnson, Megan S Li. Apoptosis of t(14;18)-positive lymphoma cells by a Bcl-2 interacting small molecule. Journal of hematopathology. vol 2. issue 2. 2012-08-27. PMID:19669197. |
western blot analyses of bcl-2 family proteins and other cell cycle-associated proteins were performed to determine the molecular sequelae of ha14-1-induced apoptosis. |
2012-08-27 |
2023-08-12 |
Not clear |
| Xiaoyan Qu, Juan Du, Chunyang Zhang, Weijun Fu, Hao Xi, Jianfeng Zou, Jian Ho. Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6. PloS one. vol 7. issue 2. 2012-08-27. PMID:22384180. |
in this study, we investigated the effect of as(2)o(3) on proliferation and apoptosis in human myeloma cell line and primary myeloma cells, and then we studied that as(2)o(3) exerts antimyeloma effects by inhibiting activity in the α-tubulin and hsp90 through western blot analysis and immunoprecipitation. |
2012-08-27 |
2023-08-12 |
human |
| Fatma Bensassi, Cindy Gallerne, Ossama Sharaf El Dein, Christophe Lemaire, Mohamed Rabeh Hajlaoui, Hassen Bach. Involvement of mitochondria-mediated apoptosis in deoxynivalenol cytotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 5. 2012-08-24. PMID:22281158. |
the don-induced apoptosis was accompanied by an activation of caspase 9 and 3, as demonstrated by western blot and caspase activity assay. |
2012-08-24 |
2023-08-12 |
human |