| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing Zhai, Xiao-Lan Bian, Sheng-Rong Lu, Bin Zhu, Bo Y. Carbocisteine reduces the cytotoxicity of oxaliplatin. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 67. issue 3-4. 2012-06-06. PMID:22624338. |
western blot analysis demonstrated that oxaliplatin could induce apoptosis of l02 cells by reducing the bcl-2/bim ratio, stimulating the cytochrome c release, and activating caspase-3. |
2012-06-06 |
2023-08-12 |
Not clear |
| Bingqing Deng, Shuanglun Xie, Jingfeng Wang, Zhengyuan Xia, Ruqiong Ni. Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits. Journal of vascular research. vol 49. issue 2. 2012-06-04. PMID:22261918. |
the apoptosis process was assessed by hoechst 33342 stain, flow cytometry and western blot analysis, while intracellular reactive oxygen species (ros) production was detected by 2,7'-dichlorodihydrofluorescein diacetate (dcfh-da). |
2012-06-04 |
2023-08-12 |
human |
| Xiaodong Weng, Youlin Kuang, Xiuheng Liu, Zhiyuan Chen, Hengcheng Zhu, Hui Chen, Botao Jiang, Hao She. Construction of a recombinant adenovirus co-expressing truncated human prostate-specific membrane antigen and mouse 4-1BBL genes and its effect on dendritic cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 44. issue 3. 2012-05-30. PMID:21243315. |
after dcs were exposed to the recombinant adenovirus with 250 multiplicity of infection, the expression of tpsma and m4-1bbl proteins were detected by western blot, and the apoptosis and phenotype of dcs were analyzed by flow cytometry. |
2012-05-30 |
2023-08-12 |
mouse |
| Stephanie Krifka, Karl-Anton Hiller, Carola Bolay, Christine Petzel, Gianrico Spagnuolo, Franz-Xaver Reichl, Gottfried Schmalz, Helmut Schweik. Function of MAPK and downstream transcription factors in monomer-induced apoptosis. Biomaterials. vol 33. issue 3. 2012-05-29. PMID:22033125. |
while apoptosis induced by tegdma remained unchanged, western blot analyses revealed that the activation of erk1/2 in the presence of tegdma was inhibited by pd98059. |
2012-05-29 |
2023-08-12 |
mouse |
| Lin An, Xiwen Zhao, Jian Wu, Jianguo Jia, Yunzeng Zou, Xizhi Guo, Lin He, Hongxin Zh. Involvement of autophagy in cardiac remodeling in transgenic mice with cardiac specific over-expression of human programmed cell death 5. PloS one. vol 7. issue 1. 2012-05-29. PMID:22253891. |
western blot and immunohistochemistry analysis showed autophagy was dramatically increased in transgenic mice as compared to wt littermates control mice, while apoptosis remained unchanged. |
2012-05-29 |
2023-08-12 |
mouse |
| Chao Yuan, Yu-Sheng Zhang, Yan-Na Cheng, Xia Xue, Wen-Fang Xu, Xian-Jun Q. A112, a tamibarotene dimethylaminoethyl ester, may inhibit human leukemia cell growth more potently than tamibarotene. Leukemia & lymphoma. vol 53. issue 2. 2012-05-25. PMID:21846186. |
western blot analysis revealed that a112 increased the expression of caspase-3, caspase-9 and cleaved poly(adp-ribose) polymerase (parp) in leukemia cells both in vitro and in vivo, indicating that induction of apoptosis was involved in the inhibition of leukemia growth. |
2012-05-25 |
2023-08-12 |
mouse |
| Junyu Wang, Qi Wang, Yong Cui, Zhen Yang Liu, Wei Zhao, Chun Lin Wang, Yan Dong, Lijun Hou, Guohan Hu, Chun Luo, Juxiang Chen, Yicheng L. Knockdown of cyclin D1 inhibits proliferation, induces apoptosis, and attenuates the invasive capacity of human glioblastoma cells. Journal of neuro-oncology. vol 106. issue 3. 2012-05-21. PMID:21912938. |
western blot analysis and quantitative reverse-transcription polymerase chain reaction (rt-pcr) revealed that cells underexpressing ccnd1 exhibited decreased multidrug resistance protein 1 (mdr1) and b-cell lymphoma-2 (bcl-2) expression, but enhanced apoptosis effector caspase-3 expression. |
2012-05-21 |
2023-08-12 |
human |
| Yi Shu, Zhaowei Zhou, Yanjie Wan, Robert D Sanders, Min Li, Chen Knien Pac-Soo, Mervyn Maze, Daqing M. Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain. Neurobiology of disease. vol 45. issue 2. 2012-05-18. PMID:22075165. |
apoptosis (caspase-3) and neuronal activation (c-fos) in the brain and spinal cord section, and cortical tnf-α and il-1β were measured with in situ immunostaining and western blot respectively. |
2012-05-18 |
2023-08-12 |
rat |
| Ying Liu, Zhibo Xiao, Daping Yang, Lihong Ren, Guofeng Liu, Lin Yan. Effects of the cyclin-dependent kinase 10 (CDK10) on the tamoxifen sensitivity of keloid samples. Molecules (Basel, Switzerland). vol 17. issue 2. 2012-05-18. PMID:22298115. |
the effects on tamoxifen-induced apoptosis were then investigated using western blot assay and flow cytometry. |
2012-05-18 |
2023-08-12 |
human |
| Jeffrey A Knipstein, Diane K Birks, Andrew M Donson, Irina Alimova, Nicholas K Foreman, Rajeev Vibhaka. Histone deacetylase inhibition decreases proliferation and potentiates the effect of ionizing radiation in atypical teratoid/rhabdoid tumor cells. Neuro-oncology. vol 14. issue 2. 2012-05-15. PMID:22156471. |
in addition, the hdi sndx-275 was able to induce apoptosis in both cell lines and induced p21(waf1/cip1) protein expression as measured by western blot. |
2012-05-15 |
2023-08-12 |
Not clear |
| Mei Liu, Xiao Yang, Jinjin Fan, Rui Zhang, Jun Wu, Youjia Zeng, Jing Nie, Xueqing Y. Altered tight junctions and fence function in NRK-52E cells induced by aristolochic acid. Human & experimental toxicology. vol 31. issue 1. 2012-05-08. PMID:21558304. |
cell viability was detected by mtt, cell apoptosis by flow cytometric analysis, the expression of zonula occludens-1 (zo-1), e-cadherin and polarity scaffold (par3) by western blot and immunofluorescence, cell membrane permeability by transepithelial electrical resistance (teer). |
2012-05-08 |
2023-08-12 |
Not clear |
| Bo Young Nam, Jisun Paeng, Seung Hye Kim, Sun Ha Lee, Do Hee Kim, Hye-Young Kang, Jin Ji Li, Seung-Jae Kwak, Jung Tak Park, Tae-Hyun Yoo, Seung Hyeok Han, Dong Ki Kim, Shin-Wook Kan. The MCP-1/CCR2 axis in podocytes is involved in apoptosis induced by diabetic conditions. Apoptosis : an international journal on programmed cell death. vol 17. issue 1. 2012-05-07. PMID:22006533. |
western blot and hoechst 33342 or tunel staining were performed to identify apoptosis. |
2012-05-07 |
2023-08-12 |
mouse |
| Barbara Dozza, Alessio Papi, Enrico Lucarelli, Katia Scotlandi, Michela Pierini, Giuseppina Tresca, Davide Donati, Marina Orland. Cell growth inhibition and apoptotic effect of the rexinoid 6-OH-11-O-hydroxyphenantrene on human osteosarcoma and mesenchymal stem cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 1. 2012-05-03. PMID:22056261. |
analysis of cells treated with 20 and 40μm iif for 24h by western blot suggests the activation of initiator caspase 9, indicating the involvement of caspases in inducing apoptosis. |
2012-05-03 |
2023-08-12 |
human |
| Cyril Vidau, Rosa A González-Polo, Mireia Niso-Santano, Rubén Gómez-Sánchez, José M Bravo-San Pedro, Elisa Pizarro-Estrella, Rafael Blasco, Jean-Luc Brunet, Luc P Belzunces, José M Fuente. Fipronil is a powerful uncoupler of oxidative phosphorylation that triggers apoptosis in human neuronal cell line SHSY5Y. Neurotoxicology. vol 32. issue 6. 2012-05-02. PMID:21621551. |
flow cytometric and western blot analyses demonstrated that fipronil induces cellular events belonging to the apoptosis process, such as mitochondrial potential collapse, cytochrome c release, caspase-3 activation, nuclear condensation and phosphatidylserine externalization. |
2012-05-02 |
2023-08-12 |
human |
| Yuesheng Xia, Yongqi Li, Jianhua Wang, Huan Wang, Jing Kang, Baoying Wang, Zengxia Ho. Bidirectional function of shenghe powder on repair of radiation-induced DNA damage in glioma and astrocyte. African journal of traditional, complementary, and alternative medicines : AJTCAM. vol 8. issue 2. 2012-05-02. PMID:22238502. |
apoptosis was observed by flow cytometry, and the expression of dna-dependent protein kinase (dna-pk) and surviving proteins were assessed by western blot analysis. |
2012-05-02 |
2023-08-12 |
human |
| Tian Li, Yuebo Yang, Xiaomao Li, Chengfang Xu, Lirong Men. EGFR- and AKT-mediated reduction in PTEN expression contributes to tyrphostin resistance and is reversed by mTOR inhibition in endometrial cancer cells. Molecular and cellular biochemistry. vol 361. issue 1-2. 2012-04-27. PMID:21952748. |
cell apoptosis and the cell cycle were studied, and activation of egfr, akt, and p70s6 were detected by western blot analysis. |
2012-04-27 |
2023-08-12 |
Not clear |
| Yulin Zhang, Ying Shi, Luxin Qiao, Yu Sun, Wei Ding, Honghai Zhang, Ning Li, Dexi Che. Sigma-1 receptor agonists provide neuroprotection against gp120 via a change in bcl-2 expression in mouse neuronal cultures. Brain research. vol 1431. 2012-04-23. PMID:22133307. |
the mrna and protein levels of apoptosis associated bax and bcl-2 were determined with real-time qpcr and western blot. |
2012-04-23 |
2023-08-12 |
mouse |
| Anna Tesei, Carlo Leonetti, Gabriella Zupi, Marco Scarsella, Giovanni Brigliadori, Paola Ulivi, Francesco Fabbri, Chiara Arienti, Dino Amadori, Alessandro Passardi, Rosella Silvestrini, Wainer Zol. Low-dose taxotere enhances the ability of sorafenib to induce apoptosis in gastric cancer models. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:20015197. |
cytotoxicity was evaluated by sulforhodamine b (srb) assay, cell cycle perturbations, apoptosis and mitotic catastrophe were assessed by flow cytometric and microscopic analyses, and protein expression was studied by western blot. |
2012-04-16 |
2023-08-12 |
mouse |
| Takashi Yoshino, Hiroko Tabunoki, Shigeo Sugiyama, Keitaro Ishii, Seung U Kim, Jun-Ichi Sato. Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2. Cellular and molecular neurobiology. vol 31. issue 7. 2012-04-16. PMID:21519925. |
western blot verified activation of srebp2 in these cells, and apoptosis was enhanced by pretreatment with simvastatin, an activator of srebp2, and by overexpression of the n-terminal fragment of srebp2. |
2012-04-16 |
2023-08-12 |
human |
| Kyle Meyer, Pavan Rajanahalli, Maqusood Ahamed, John J Rowe, Yiling Hon. ZnO nanoparticles induce apoptosis in human dermal fibroblasts via p53 and p38 pathways. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 8. 2012-04-13. PMID:21903158. |
apoptosis induction was confirmed by the annexin v assay and western blot analysis showed the up-regulation of p53 and phospho-p38 proteins. |
2012-04-13 |
2023-08-12 |
human |