| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brian J Siroky, Hong Yin, Justin T Babcock, Lu Lu, Anna R Hellmann, Bradley P Dixon, Lawrence A Quilliam, John J Bissle. Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress. American journal of physiology. Renal physiology. vol 303. issue 6. 2012-12-26. PMID:22791333. |
after proteasome inhibition with mg-132, western blot analyses showed greater induction of c/ebp-homologous protein (chop) and more poly (adp-ribose) polymerase (parp) and caspase-3 cleavage, supporting er stress-induced apoptosis. |
2012-12-26 |
2023-08-12 |
human |
| Zhen Li, Gang Cui, Junxiang Wang, Zhihua Yu, Li Zhao, Zhengwen L. Nemo-like kinase (NLK) involves in neuronal apoptosis after traumatic brain injury. Cellular and molecular neurobiology. vol 32. issue 3. 2012-12-20. PMID:22127415. |
in the model of glutamate inducing pc12 apoptosis, we analyzed the effect of over-expression of nlk on the neuronal cell line pc12 apoptosis by cck-8, western blot and tunel assays. |
2012-12-20 |
2023-08-12 |
Not clear |
| Hui-Fang Huang, Ping Chen, Rong Lu, Zhen-Xing Lin, Yong Wu, Yuan-Zhong Che. [Regulation of all-trans retinoic acid and arsenic trioxide on CD44v6 expression in NB4 cells]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 1. 2012-12-20. PMID:22391160. |
the differentiation of nb4 was detected by morphologic observation and flow cytometry; the nb4 cell apoptosis was assayed by flow cytometry with annexin v-fitc/pi double staining; the cd44v6 mrna expression in nb4 cells was determined by real-time rt-pcr, the cd44v6 protein expression and changes of pi3k/akt signal pathway in nb4 cells were analysed by western blot. |
2012-12-20 |
2023-08-12 |
Not clear |
| Jia Xie, Mei Zhang, Yan-Ping Song, Kai Hu, Jing-Jing Ren, Yun-Jie Zhan. [Caspase-independent apoptosis induced by arsenic trioxide in human multiple myeloma cell RPMI8226]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 1. 2012-12-20. PMID:22391177. |
mtt method was used to analyze the proliferation inhibition rate; flow cytometry was used to detect the apoptosis rate; western blot was used to determine the expressions of bcl-2 and caspase-3 in rpmi8226 cells. |
2012-12-20 |
2023-08-12 |
human |
| Xiao-Hui Cai, Bao-An Chen, Jian Cheng, Jun Wang, Jia-Hua Ding, Wen Bao, Yue-Jiao Zhong, Feng Gao, Wen-Lin Xu, Hui-Ling Shen, Hu-Lai Wei, Jing Che. [Effects of 5-bromotetrandrine and daunorubicin on apoptosis and expression of survivin in K562/A02 cells]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 1. 2012-12-17. PMID:21362215. |
the apoptosis of k562/a02 cells treated by dna, brtet and brtet combined with dnr for 48 hours was detected by flow cytometry; the expressions levels of survivin mrna and protein k562/a02 cells treated by dnr, brtet and brtet combined with dnr and in untreated k562 cells for 48 hours were measured by rt-pcr and western blot respectively. |
2012-12-17 |
2023-08-12 |
Not clear |
| Hui-Ling Shen, Li-Li Fang, Chen Chen, Xin-Jian Fang, Qiao-Yun Chen, Juan Li, Wen-Lin X. [VEGF shRNA enhances the sensitivity of multidrug-resistant leukemia cells to anticancer agent]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 1. 2012-12-17. PMID:21362217. |
rt-pcr was used to detect the expression of vegf and mrp1 at the mrna level;western blot was used to analyze the expression of vegf, mrp1, akt, p-akt at the protein level; mtt was used to determine the ic(50) value of transfected cells to doxorubicin (dox); flow cytometry was used to detect cell apoptosis and intracellular rho123 retention. |
2012-12-17 |
2023-08-12 |
human |
| Wei Wei, Zhongchao Gai, Hui Ai, Wenxian Wu, Yongbo Yang, Jianxin Peng, Huazhu Hong, Yi Li, Kaiyu Li. Baculovirus infection triggers a shift from amino acid starvation-induced autophagy to apoptosis. PloS one. vol 7. issue 5. 2012-12-17. PMID:22629397. |
the western blot analysis showed that no cleavage of endogenous atg6 occurred during the process of apoptosis in sl-hp cells. |
2012-12-17 |
2023-08-12 |
Not clear |
| Lei Cui, Jun Fu, Jesse Chung-Sean Pang, Zhi-Kun Qiu, Xiao-Mei Liu, Fu-Rong Chen, Hong-Liu Shi, Ho-Keung Ng, Zhong-Ping Che. Overexpression of IL-7 enhances cisplatin resistance in glioma. Cancer biology & therapy. vol 13. issue 7. 2012-12-14. PMID:22415136. |
apoptosis was detected using flow cytometry and western blot analysis. |
2012-12-14 |
2023-08-12 |
human |
| Rui Li, Wei-Chang Chen, Xue-Qin Pang, Wen-Yan Tian, Wei-Peng Wang, Xue-Guang Zhan. Combined effect of sCD40L and PI3K siRNA on transplanted tumours growth and microenvironment in nude mice with gastric cancer. Molecular biology reports. vol 39. issue 9. 2012-12-14. PMID:22736104. |
microvessel density (mvd), apoptosis index, and expression levels of pi3k, survivin and vascular endothelial growth factor (vegf) proteins in transplanted tumor cells in gastric cancer nude mice were analyzed by utilizing immunohistochemistry, western blot, terminal deoxynucleotidyl transferase dutp nick end labeling assays. |
2012-12-14 |
2023-08-12 |
mouse |
| Erika L Moen, Sicheng Wen, Talha Anwar, Sam Cross-Knorr, Kate Brilliant, Faith Birnbaum, Sherida Rahaman, John M Sedivy, Steven F Moss, Devasis Chatterje. Regulation of RKIP function by Helicobacter pylori in gastric cancer. PloS one. vol 7. issue 5. 2012-12-13. PMID:22662230. |
western blot and luciferase transcription reporter assays demonstrate that the pathogenicity island of h. pylori rapidly phosphorylates rkip, which then localizes to the nucleus where it activates its own transcription and induces apoptosis. |
2012-12-13 |
2023-08-12 |
Not clear |
| Michael S Dittmar, Walter Petermichl, Felix Schlachetzki, Bernhard M Graf, Michael Grube. Isoflurane induces endothelial apoptosis of the post-hypoxic blood-brain barrier in a transdifferentiated human umbilical vein endothelial cell model. PloS one. vol 7. issue 6. 2012-12-12. PMID:22723852. |
apoptosis of ac-huvecs was investigated using light microscopy of the native culture for morphological changes, western blot (wb) analysis of bax and bcl-2, and a tunel assay. |
2012-12-12 |
2023-08-12 |
human |
| Guang Lu, Zhen-Yu Li, Wei-Wei Mou, Xu-Peng He, Xiu-Ying Pan, Kai-Lin X. [In vitro effects of Wnt3a gene modification on mitigating damage of mouse bone marrow mesenchymal stem cells induced by Ara-C]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 4. 2012-12-11. PMID:21867639. |
the expression of bcl-2 protein related with cell apoptosis was assayed by western blot. |
2012-12-11 |
2023-08-12 |
mouse |
| G S Merki-Feld, H Seeger, A O Muec. Proliferative effects of estradiol- or ethinylestradiol-progestogen combinations on human breast cancer cells in an intermitted and a long-term regimen. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 44. issue 6. 2012-12-11. PMID:22488518. |
molecular markers for proliferation and apoptosis were investigated by western blot. |
2012-12-11 |
2023-08-12 |
human |
| Seung Hyun Oh, Young Mi Whang, Hye-Young Min, Seung Ho Han, Ju-Hee Kang, Ki-Hoon Song, Bonnie S Glisson, Yeul Hong Kim, Ho-Young Le. Histone deacetylase inhibitors enhance the apoptotic activity of insulin-like growth factor binding protein-3 by blocking PKC-induced IGFBP-3 degradation. International journal of cancer. vol 131. issue 10. 2012-12-10. PMID:22362554. |
the effects of the combination of rigfbp-3 and a number of hdac inhibitors on cell proliferation and apoptosis were assessed in vitro and in vivo by using the mtt assay, a flow cytometry-based tunel assay, western blot analyses and the nsclc xenograft tumor model. |
2012-12-10 |
2023-08-12 |
Not clear |
| Ken-ichi Kimura, Yoshimi Sakamoto, Nozomi Fujisawa, Shota Uesugi, Nobuhiro Aburai, Manabu Kawada, Shun-ichi Ohba, Takao Yamori, Eiko Tsuchiya, Hiroyuki Koshin. Cleavage mechanism and anti-tumor activity of 3,6-epidioxy-1,10-bisaboladiene isolated from edible wild plants. Bioorganic & medicinal chemistry. vol 20. issue 12. 2012-12-10. PMID:22575162. |
edbd induced apoptosis via phosphorylation of p38 mitogen-activated protein kinase (mapk) in hl60 cells, and was detected by western blot. |
2012-12-10 |
2023-08-12 |
human |
| Yan-Ling Ren, Hong-Yan Ton. [Effect of homoharringtonine combined with AG490 on JAK2-STAT5 associated signal pathway in HEL cells]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 5. 2012-12-06. PMID:22040954. |
the cell survival rates were tested by mtt, apoptosis was tested by flow cytometry after hel cells were treated by 20 ng/ml hht, 100 µmol/l ag490 and 20 ng/ml hht in combination with 100 µmol/l ag490, while the signal proteins such as p-jak2, p-stat5 and bcl-xl activated by abnormal activated jak2 were tested by western blot. |
2012-12-06 |
2023-08-12 |
Not clear |
| Yan-Ling Ren, Hong-Yan Ton. [Effect of homoharringtonine combined with AG490 on JAK2-STAT5 associated signal pathway in HEL cells]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 5. 2012-12-06. PMID:22040954. |
the results showed that both hht and ag490 could inhabit the hel cell proliferation after being treated for 24 hours, and annexin v-pi double staining confirmed early apoptosis while hht effect was more obvious, western blot showed that the expressions of p-jak2 and p-stat5 were down-regulated, while the total protein levels of jak2 and stat5 were stable. |
2012-12-06 |
2023-08-12 |
Not clear |
| Xu-Chun He, Jian-Da H. [Effects of emodin on human erythroleukemia cell line HEL]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 5. 2012-12-06. PMID:22040955. |
the proliferation inhibition was detected by mtt method; the change of morphology was observed by ao/eb stains; the cell cycle and apoptosis was analyzed by flow cytometry; the expressions of akt, p-akt, p-gsk3β and hsp70 proteins were determined by western blot. |
2012-12-06 |
2023-08-12 |
human |
| Regina Golan-Gerstl, Shulamit B Wallach-Dayan, Philip Zisman, Wellington V Cardoso, Ronald H Goldstein, Raphael Breue. Cellular FLICE-like inhibitory protein deviates myofibroblast fas-induced apoptosis toward proliferation during lung fibrosis. American journal of respiratory cell and molecular biology. vol 47. issue 3. 2012-11-30. PMID:22582174. |
c-flip levels were determined by apoptosis gene array, flow cytometry, western blot, and immunofluorescence before and after down-regulation with a specific small interfering rna. |
2012-11-30 |
2023-08-12 |
mouse |
| Regina Golan-Gerstl, Shulamit B Wallach-Dayan, Philip Zisman, Wellington V Cardoso, Ronald H Goldstein, Raphael Breue. Cellular FLICE-like inhibitory protein deviates myofibroblast fas-induced apoptosis toward proliferation during lung fibrosis. American journal of respiratory cell and molecular biology. vol 47. issue 3. 2012-11-30. PMID:22582174. |
apoptosis was assessed by caspase cleavage in western blot and by annexin v affinity labeling after facs and tissue immunofluorescence. |
2012-11-30 |
2023-08-12 |
mouse |