| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| João Paulo Capela, Silvana da Costa Araújo, Vera Marisa Costa, Karsten Ruscher, Eduarda Fernandes, Maria de Lourdes Bastos, Ulrich Dirnagl, Andreas Meisel, Félix Carvalh. The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons. Neurotoxicology. vol 34. 2013-07-09. PMID:22983118. |
in the mitochondrial fraction of neurons exposed 24h to doi or mdma, we found a significant increase in the 67 kda band of apoptosis inducing factor (aif) by western blot. |
2013-07-09 |
2023-08-12 |
rat |
| Dae-Young Lee, Mi-Kyoung Lee, Geum-Soog Kim, Hyung-Jun Noh, Min-Ho Le. Brazilin inhibits growth and induces apoptosis in human glioblastoma cells. Molecules (Basel, Switzerland). vol 18. issue 2. 2013-07-09. PMID:23429418. |
cell proliferation was investigated by mtt assays and growth curve analysis, apoptosis was assessed by facs analysis and western blot studies. |
2013-07-09 |
2023-08-12 |
human |
| Shuxian An, Xiujuan Zang, Weijie Yuan, Yifeng Zhuge, Qing Y. Neutrophil gelatinase-associated lipocalin (NGAL) may play a protective role against rats ischemia/reperfusion renal injury via inhibiting tubular epithelial cell apoptosis. Renal failure. vol 35. issue 1. 2013-07-02. PMID:23151253. |
serum creatinine (scr) and blood urea nitrogen (bun) were measured on automatic biochemistry analyzer; kidney sections were stained with hematoxylin-eosin; terminal dutp nick-labeling method was used to examine the apoptosis of tubular epithelial cells; cleaved caspase-3 and bax protein expression were detected by immunohistochemistry and western blot; real-time polymerase chain reaction was used to detect the expression of bax mrna. |
2013-07-02 |
2023-08-12 |
rat |
| Xiao-Ke Guo, Hao-Peng Sun, Shen Shen, Yuan Sun, Fan-Lei Xie, Lei Tao, Qing-Long Guo, Cheng Jiang, Qi-Dong Yo. Synthesis and evaluation of gambogic acid derivatives as antitumor agents. Part III. Chemistry & biodiversity. vol 10. issue 1. 2013-07-01. PMID:23341209. |
it was established that 4 induces the apoptosis of hepg2 cells by using annexin-v/pi double staining and western blot assay, thus, compound 4 can serve as a promising lead compound for the development of novel apoptosis in anticancer treatment. |
2013-07-01 |
2023-08-12 |
Not clear |
| Xiaoqin Mu, Kaiwen He, Hui Sun, Xin Zhou, Lingling Chang, Xin Li, Wenfeng Chu, Guofen Qiao, Yanjie L. Hydrogen peroxide induces overexpression of angiotensin-converting enzyme in human umbilical vein endothelial cells. Free radical research. vol 47. issue 2. 2013-06-25. PMID:23153326. |
we used tetrazolium bromide (mtt) assay for cell viability, terminal deoxynucleotidyl transferase-mediated dutp nick end labeling (tunel) assay for cell apoptosis, enzyme-linked immunosorbent assay (elisa) for camp measurement, real-time pcr for mrna detection, and western blot for protein analysis in the study. |
2013-06-25 |
2023-08-12 |
human |
| Min Jeong Kim, Hye Hyeon Lee, Min Jeong Seo, Byoung Won Kang, Jeong Uck Park, Kyoung-Sook Kim, Gi-Young Kim, Woo Hong Joo, Yung Hyun Choi, Young-Su Cho, Yong Kee Jeon. Identification of 5-hydroxy-3,6,7,8,3´,4´-hexamethoxyflavone from Hizikia fusiforme involved in the induction of the apoptosis mediators in human AGS carcinoma cells. Journal of microbiology and biotechnology. vol 22. issue 12. 2013-06-20. PMID:23221529. |
western blot analysis suggested that the flavone substantially increased the levels of the death receptor-associated apoptosis mediators fas, fas l, fadd, tradd, and dr4 in a concentration-dependent manner. |
2013-06-20 |
2023-08-12 |
human |
| Bin Pan, Shaobo Zheng, Chunxiao Liu, Yawen X. Suppression of IGHG1 gene expression by siRNA leads to growth inhibition and apoptosis induction in human prostate cancer cell. Molecular biology reports. vol 40. issue 1. 2013-06-14. PMID:23117283. |
pc3 cells were transfected with designed sirna, the expression of igg was determined by qpcr and western blot, the proliferation and apoptosis were detected by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxy-phenyl)-2-(4-sulfophenil)-2h-tetrazolium, inner salt (mts) and flow cytometry. |
2013-06-14 |
2023-08-12 |
human |
| Xin Li Xiao, Dong Liang Ma, Jing Wu, Feng-Ru Tan. Metabotropic glutamate receptor 5 (mGluR5) regulates proliferation and differentiation of neuronal progenitors in the developmental hippocampus. Brain research. vol 1493. 2013-06-13. PMID:23165119. |
western blot study suggested that programmed neuronal death was p53-dependent apoptosis in the developmental hippocampus in mglur5(+/+) mice. |
2013-06-13 |
2023-08-12 |
mouse |
| Chin-Yu Liu, Jai-Sing Yang, Shih-Ming Huang, Jo-Hua Chiang, Ming-Hua Chen, Li-Jiau Huang, Ho-Yu Ha, Shinji Fushiya, Sheng-Chu Ku. Smh-3 induces G(2)/M arrest and apoptosis through calcium‑mediated endoplasmic reticulum stress and mitochondrial signaling in human hepatocellular carcinoma Hep3B cells. Oncology reports. vol 29. issue 2. 2013-06-13. PMID:23233035. |
western blot analysis demonstrated that smh-3 increased the protein levels of caspase-4 and gadd153 that may lead to er stress and consequently apoptosis in hep3b cells. |
2013-06-13 |
2023-08-12 |
human |
| Jiege Huo, Fengxia Qin, Xueting Cai, Jianming Ju, Chunping Hu, Zhigang Wang, Wuguang Lu, Xiaoning Wang, Peng Ca. Chinese medicine formula "Weikang Keli" induces autophagic cell death on human gastric cancer cell line SGC-7901. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 20. issue 2. 2013-06-10. PMID:23141426. |
hoechst 33258 staining and western blot analysis of apoptosis-related proteins showed that wk induced sgc-7901 cell death was not through apoptosis. |
2013-06-10 |
2023-08-12 |
human |
| Gamal Badr, Mohamed K Al-Sadoon, Mostafa A Abdel-Maksoud, Danny M Rabah, Ahmed M El-Ton. Cellular and molecular mechanisms underlie the anti-tumor activities exerted by Walterinnesia aegyptia venom combined with silica nanoparticles against multiple myeloma cancer cell types. PloS one. vol 7. issue 12. 2013-06-03. PMID:23251606. |
we found that wev and wev+np clearly decreased the cxcl12/cxcr4-mediated activation of akt, erk, nfκb and rho-a using western blot analysis; abrogated the cxcl12-mediated proliferation of mm cells using the cfse assay; and induced apoptosis in mm cell as determined by pi/annexin v double staining followed by flow cytometry analysis. |
2013-06-03 |
2023-08-12 |
Not clear |
| Li-Na Hao, Min Wang, Jun-Ling Ma, Tao Yan. Puerarin decreases apoptosis of retinal pigment epithelial cells in diabetic rats by reducing peroxynitrite level and iNOS expression. Sheng li xue bao : [Acta physiologica Sinica]. vol 64. issue 2. 2013-05-30. PMID:22513471. |
western blot analysis, dna laddering, rt-pcr and immunohistochemistry were used for determining the expression of nitrotyrosine (nt, the foot print of peroxynitrite), cell apoptosis, inos mrna and fas/fas ligand (fasl) signal transduction in rpe cells, respectively. |
2013-05-30 |
2023-08-12 |
rat |
| Virginie Granci, Fang Cai, Elena Lecumberri, Aurélie Clerc, Yves M Dupertuis, Claude Pichar. Colon cancer cell chemosensitisation by fish oil emulsion involves apoptotic mitochondria pathway. The British journal of nutrition. vol 109. issue 7. 2013-05-28. PMID:22874769. |
a cationic fluorescent probe was used to evaluate mitochondrial dysfunction, and protein expression involved in mitochondrial apoptosis was determined by western blot. |
2013-05-28 |
2023-08-12 |
human |
| Karen A Urtishak, Alena Y Z Edwards, Li-San Wang, Amanda Hudome, Blaine W Robinson, Jeffrey S Barrett, Kajia Cao, Lori Cory, Jonni S Moore, Andrew D Bantly, Qian-Chun Yu, I-Ming L Chen, Susan R Atlas, Cheryl L Willman, Mondira Kundu, Andrew J Carroll, Nyla A Heerema, Meenakshi Devidas, Joanne M Hilden, ZoAnn E Dreyer, Stephen P Hunger, Gregory H Reaman, Carolyn A Feli. Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia. Blood. vol 121. issue 14. 2013-05-28. PMID:23393050. |
combined approaches including flow cytometry, western blot, obatoclax treatment with death pathway inhibition, microarray analyses, and/or electron microscopy indicated a unique killing mechanism involving apoptosis, necroptosis, and autophagy in mll-af4 all cell lines and primary mll-r and mll-g infant all cells. |
2013-05-28 |
2023-08-12 |
Not clear |
| J Kaszuba-Zwoinska, P Chorobik, K Juszczak, W Zaraska, P J Tho. Pulsed electromagnetic field affects intrinsic and endoplasmatic reticulum apoptosis induction pathways in MonoMac6 cell line culture. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 63. issue 5. 2013-05-21. PMID:23211308. |
nupage novex western blot analysis was carried out for apoptosis inducing factor (aif) abundance in cytosolic and nuclear extracts of monomac6 cells. |
2013-05-21 |
2023-08-12 |
Not clear |
| Xin Du, Pei-Min Jia, Cong He, Sheng-Hong Du, Jian-Hua Tong, Li Zho. [Effect of bortezomib and low concentration cytarabine on apoptosis in U937 cell line]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 3. 2013-05-16. PMID:22739154. |
the proliferation and apoptosis of u937 cells treated with bortezomib (10 nmol/l) and(or) ara-c (50 nmol/l) were observed by cell count, cell morphology, flow cytometry and western blot. |
2013-05-16 |
2023-08-12 |
Not clear |
| Hai-Bo Liu, Mei Zhang, Cheng-Liang Li, Peng-Cheng H. [Effect of clofarabine on proliferation and Bcl-2 expression of NB4 cells]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 3. 2013-05-16. PMID:22739157. |
mtt method was used to detect proliferation of nb4 cells treated with clofarabine 0.01 - 0.1 µmol/l for 48 h. the treated with clofarabine 0.01 - 0.1 µmol/l for 24 h, apoptosis rate and bcl-2 expression of nb4 cells were measured by flow cytometry and western blot respectively. |
2013-05-16 |
2023-08-12 |
Not clear |
| Xiao-Xia Wang, Xiao-Qin Liu, Wei Zhang, Xuan Chen, Li Zha. [Orphanin FQ combined with adriamycin reverses multi-drug resistance of K562/ADM and its molecular mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 3. 2013-05-16. PMID:22739158. |
mtt method was used to detect the proliferation ability of k562/adm treated with ofq and adm alone and their combination; flow cytometry was performed to measure the cell apoptosis rate; real time-pcr was applied to detect the mdr1 mran expression; western blot was used to determine the p-gp expression. |
2013-05-16 |
2023-08-12 |
Not clear |
| Wei Tan, Wei Zhou, Hong-gang Yu, He-Sheng Luo, Lei She. The DNA methyltransferase inhibitor zebularine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo. Biochemical and biophysical research communications. vol 430. issue 1. 2013-05-14. PMID:23167995. |
in the study, the effects of zebularine on the growth and apoptosis of gastric cancer cells were investigated by mtt assay, hoechst assay, western blot analysis, flow cytometric analysis of annexin v-fitc/pi staining, and tunel assay. |
2013-05-14 |
2023-08-12 |
mouse |
| Cheng Chen, Ji-Shi Wang, Chang Ynag, Yan-Yan Yu, Yan Li, Dan Ma, Qin Fan. [CML cell apoptosis induced by AMN107 combined with heme oxygenase-1 inhibitor]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 4. 2013-05-09. PMID:22931644. |
proliferative rate of cells treated with amn107 (10 µmol/l) and znppix (10 µmol/l) alone or both for different time was observed by mtt and trypan blue methods; the expression of ho-1 in the control group, znppix (10 µmol/l) group, amn107 (10 µmol/l) group, amn107 (10 µmol/l) combined with znppix (10 µmol/l) group was evaluated by semi-quantitative rt-pcr and western blot at 48 h. cell apoptosis was detected by flow cytometry with annexin v/pi double staining at 48 h. the results showed that the strongest inhibition of cell proliferation was detected in combined group, and in a time-dependent manner; the expression level of ho-1 was lowest in combined group; the cell apoptosis rates were (11.38 ± 0.02)%, (17.44 ± 0.08)%, (39.81 ± 0.07)% and (56.46 ± 0.19)% in the control group, znppix group, amn107 group, amn107 combined with znppix group at 48 h respectively. |
2013-05-09 |
2023-08-12 |
Not clear |