| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshihiro Akihisa, Xin Pan, Yasuhiro Nakamura, Takashi Kikuchi, Nami Takahashi, Masahiro Matsumoto, Eri Ogihara, Makoto Fukatsu, Kazuo Koike, Harukuni Tokud. Limonoids from the fruits of Melia azedarach and their cytotoxic activities. Phytochemistry. vol 89. 2013-09-26. PMID:23465718. |
western blot analysis suggested that both compounds induced apoptosis via both the mitochondrial and death receptor-mediated pathways. |
2013-09-26 |
2023-08-12 |
human |
| Ying Liu, Zu-an Zhu, Shang-Nuan Zhang, Jie Mou, Lei Liu, Tao Cui, Dong-Sheng Pe. Combinational effect of PPARγ agonist and RXR agonist on the growth of SGC7901 gastric carcinoma cells in vitro. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 4. 2013-09-26. PMID:23605322. |
then, the cell growth, apoptosis, morphological changes, and the expression of pparγ, rxrγ, bcl-2, and bax were detected by mtt assay, flow cytometry, he staining, immunocytochemistry staining, and western blot assay, respectively. |
2013-09-26 |
2023-08-12 |
Not clear |
| Anna Ptak, Elzbieta Kolaczkowska, Ewa L Gregoraszczu. Leptin stimulation of cell cycle and inhibition of apoptosis gene and protein expression in OVCAR-3 ovarian cancer cells. Endocrine. vol 43. issue 2. 2013-09-25. PMID:22968658. |
the expression of selected cell cycle and apoptosis genes was evaluated by real-time pcr and confirmed by western blot. |
2013-09-25 |
2023-08-12 |
Not clear |
| Etchison Ryan, A Jacobson Blake, A Benoit, M Ferguson David, A Kratzke Rober. Efficacy of substituted 9-aminoacridine derivatives in small cell lung cancer. Investigational new drugs. vol 31. issue 2. 2013-09-24. PMID:22821172. |
western blot analysis of p62/lc3 levels, the akt/mtor pathway, and the erk1/2 pathway indicate that autophagy is occurring as the primary mechanism of cell death; furthermore, the guava nexin and caspase 3/7 activation assays indicate that apoptosis does not occur. |
2013-09-24 |
2023-08-12 |
Not clear |
| Wanxin Tang, Zejun Chen, Weihua Wu, Hongyu Qiu, Hong Bo, Ling Zhang, Ping F. Renal protective effects of early continuous venovenous hemofiltration in rhabdomyolysis: improved renal mitochondrial dysfunction and inhibited apoptosis. Artificial organs. vol 37. issue 4. 2013-09-24. PMID:23441644. |
the terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling assay method and western blot analysis were used to detect apoptosis and apoptosis-related proteins. |
2013-09-24 |
2023-08-12 |
dog |
| Yao Sun, Fansong Mu, Chunying Li, Wei Wang, Meng Luo, Yujie Fu, Yuangang Z. Aspidin BB, a phloroglucinol derivative, induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells. Chemico-biological interactions. vol 204. issue 2. 2013-09-03. PMID:23628508. |
western blot analysis showed that aspidin bb suppressed bcl-2 expression and enhanced bax expression to desintegrate the outer mitochondrial membrane, then caused cytochrome c release which led to the activation of effector caspase-3, and further cleaved the poly adp-ribose polymerase (parp) in the nucleus, finally induced cell apoptosis. |
2013-09-03 |
2023-08-12 |
human |
| Rick Sai-Chuen Wu, Kuo-Ching Liu, Nou-Ying Tang, Hsiung-Kwang Chung, Siu-Wan Ip, Jai-Sing Yang, Jing-Gung Chun. cDNA microarray analysis of the gene expression of murine leukemia RAW 264.7 cells after exposure to propofol. Environmental toxicology. vol 28. issue 8. 2013-08-29. PMID:21786383. |
western blot analysis demonstrated that propofol promoted fas, cytochrome c, caspase-9 and -3 active form and bax levels, but inhibited bcl-xl protein level which led to cell apoptosis. |
2013-08-29 |
2023-08-12 |
mouse |
| Sulev Kõks, Rupert W Overall, Marilin Ivask, Ursel Soomets, Mithu Guha, Eero Vasar, Cathy Fernandes, Leo C Schalkwy. Silencing of the WFS1 gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage. Physiological genomics. vol 45. issue 5. 2013-08-20. PMID:23321269. |
quantitative rt-pcr and western blot analysis confirmed clear silencing of the expression of wfs1 after 48 h. significant (fdr value<10%) changes in the expression of 11 genes was identified with most of these genes being related to the mitochondrial dysfunction and apoptosis. |
2013-08-20 |
2023-08-12 |
human |
| Heng-Yi Yu, Xiao-Qiong Zhang, Xue- Li, Fan-Bo Zeng, Han-Li Rua. 2-methoxyjuglone induces apoptosis in HepG2 human hepatocellular carcinoma cells and exhibits in vivo antitumor activity in a H22 mouse hepatocellular carcinoma model. Journal of natural products. vol 76. issue 5. 2013-08-20. PMID:23597099. |
western blot analysis of apoptosis-related proteins revealed that 1 induces hepg2 cell apoptosis through mitochondrial cytochrome c-dependent activation of the caspase-9 and caspase-3 cascade pathway (intrinsic pathway). |
2013-08-20 |
2023-08-12 |
mouse |
| Manickam Pandiaraj, Thangamuthu Madasamy, Paradesi Naidu Gollavilli, Murugesan Balamurugan, Srigiridhar Kotamraju, Vepa Kameswara Rao, Kalpana Bhargava, Chandran Karunakara. Nanomaterial-based electrochemical biosensors for cytochrome c using cytochrome c reductase. Bioelectrochemistry (Amsterdam, Netherlands). vol 91. 2013-08-19. PMID:23220491. |
the ccr-cnt-ppy-pt biosensor was further applied to quantify the mitochondrial cyt c released in cytosol of a549 cells upon induction of apoptosis with doxorubicin, the results agreed well with standard western blot analysis. |
2013-08-19 |
2023-08-12 |
Not clear |
| Toni Ibrahim, Chiara Liverani, Laura Mercatali, Emanuele Sacanna, Michele Zanoni, Francesco Fabbri, Wainer Zoli, Dino Amador. Cisplatin in combination with zoledronic acid: a synergistic effect in triple-negative breast cancer cell lines. International journal of oncology. vol 42. issue 4. 2013-08-19. PMID:23403907. |
drug-induced growth inhibition was detected by sulforhodamine b assay, apoptosis and cell cycle regulation were detected by flow cytometry, and protein expression was evaluated by western blot analysis. |
2013-08-19 |
2023-08-12 |
human |
| Yuan Gao, Zan Liu, Xiuwei Zhang, Jiani He, Yongqi Pan, Fengxia Hao, Lingling Xie, Qingchang Li, Xueshan Qiu, Enhua Wan. Inhibition of cytoplasmic GSK-3β increases cisplatin resistance through activation of Wnt/β-catenin signaling in A549/DDP cells. Cancer letters. vol 336. issue 1. 2013-08-15. PMID:23673211. |
the regulation of cisplatin resistance, apoptosis, β-catenin and survivin protein expression by inhibition of cytoplasmic gsk-3β were determined by mtt assay, flow cytometry analysis, immunofluorescence technique and western blot analysis. |
2013-08-15 |
2023-08-12 |
human |
| Xiao-Xia Fang, Xiao-Lin Jiang, Xin-Hua Han, Yu-Ping Peng, Yi-Hua Qi. Neuroprotection of interleukin-6 against NMDA-induced neurotoxicity is mediated by JAK/STAT3, MAPK/ERK, and PI3K/AKT signaling pathways. Cellular and molecular neurobiology. vol 33. issue 2. 2013-08-08. PMID:23161148. |
dynamic intracellular ca(2+) fluorescence intensity, cytosolic ca(2+)-dependent phospholipase a2 (cpla2) expression, and apoptosis and necrosis in cultured cgns were measured by laser scanning confocal microscope, real-time pcr and western blot, and annexin v-fitc/propidium iodide staining, respectively. |
2013-08-08 |
2023-08-12 |
rat |
| Raquel T Lima, Gemma A Barron, Joanna A Grabowska, Giovanna Bermano, Simranjeet Kaur, Nilanjan Roy, M Helena Vasconcelos, Paul K T Li. Cytotoxicity and cell death mechanisms induced by a novel bisnaphthalimidopropyl derivative against the NCI-H460 non-small lung cancer cell line. Anti-cancer agents in medicinal chemistry. vol 13. issue 3. 2013-08-05. PMID:23092269. |
this effect was further supported by annexin v/pi staining and by analysing the expression of proteins related to apoptosis (cleaved parp and caspase-3) by western blot. |
2013-08-05 |
2023-08-12 |
Not clear |
| Xin Wang, Hua Bai, Xiaodi Zhang, Jiangzheng Liu, Peipei Cao, Nai Liao, Wei Zhang, Zhao Wang, Chunxu Ha. Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis. Carcinogenesis. vol 34. issue 6. 2013-08-01. PMID:23404993. |
apoptosis and cell cycle arrest-related markers and signaling cascades were determined by western blot, immunofluorescence, reverse transcriptase-polymerase chain reaction and flow cytometric analysis. |
2013-08-01 |
2023-08-12 |
mouse |
| Bo Cai, Hui Lyu, Jingcao Huang, Shuiliang Wang, Choon-Kee Lee, Chunji Gao, Bolin Li. Combination of bendamustine and entinostat synergistically inhibits proliferation of multiple myeloma cells via induction of apoptosis and DNA damage response. Cancer letters. vol 335. issue 2. 2013-07-30. PMID:23459296. |
an apoptotic-elisa and western blot assays on parp cleavage and caspase-8 and caspase-3 revealed that bendamustine in combination with entinostat exhibited a much more potent activity than either agent alone to promote the mm cells undergoing apoptosis in a dose-dependent manner. |
2013-07-30 |
2023-08-12 |
Not clear |
| S-J Liao, Q Gong, X-R Chen, L-X Ye, Q Ding, J-S Zeng, J Y. Netrin-1 rescues neuron loss by attenuating secondary apoptosis in ipsilateral thalamic nucleus following focal cerebral infarction in hypertensive rats. Neuroscience. vol 231. 2013-07-25. PMID:23232257. |
then, immunoreactivity was determined in the ipsilateral vpn for neun, glial fibrillary acidic protein, netrin-1 and its receptors (dcc and unc5h2), apoptosis was detected with terminal deoxynucleotidyl transferase-mediated digoxigenin-dutp-biotin nick-end labeling (tunel) assay, and the expressions of caspase-3, netrin-1, dcc, and unc5h2 were quantified by western blot analysis. |
2013-07-25 |
2023-08-12 |
rat |
| Ana Cárdeno, Marina Sánchez-Hidalgo, M Angeles Rosillo, Catalina Alarcón de la Lastr. Oleuropein, a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1α. Nutrition and cancer. vol 65. issue 1. 2013-07-22. PMID:23368925. |
cell cycle and apoptosis were assessed by flow cytometry and changes in mapk cascade protein expression, hif-1α, p53, pparγ, and nfkβ signaling pathways by western blot. |
2013-07-22 |
2023-08-12 |
human |
| Xiuxiu Lv, Xiaohui Yu, Yiyang Wang, Faqiang Wang, Hongmei Li, Yanping Wang, Daxiang Lu, Renbin Qi, Huadong Wan. Berberine inhibits doxorubicin-triggered cardiomyocyte apoptosis via attenuating mitochondrial dysfunction and increasing Bcl-2 expression. PloS one. vol 7. issue 10. 2013-07-19. PMID:23077597. |
tunel and western blot assays showed that ber not only decreased myocardial apoptosis, caspase-3 activation, ampkα and p53 phosphorylation, but also increased bcl-2 expression in myocardium of rats exposed to dox for 84 h. these findings indicate that ber attenuates dox-induced cardiomyocyte apoptosis via protecting mitochondria, inhibiting an increase in the amp/atp ratio and ampkα phosphorylation as well as elevating bcl-2 expression, which offer a novel mechanism responsible for protection of ber against dox-induced cardiomyopathy. |
2013-07-19 |
2023-08-12 |
rat |
| Chiachen Chen, Yuan-Ching Chang, Michael S Lan, Mary Bresli. Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways. International journal of oncology. vol 42. issue 3. 2013-07-16. PMID:23354006. |
using western blot analysis, we found that leptin enhanced the expression of cyclin d1 and mcl-1, which are important regulators of cell proliferation and the inhibition of apoptosis. |
2013-07-16 |
2023-08-12 |
Not clear |