| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaobing Liu, Jianmin Gu, Yuqi Fan, Huihua Shi, Mier Jian. Baicalin attenuates acute myocardial infarction of rats via mediating the mitogen-activated protein kinase pathway. Biological & pharmaceutical bulletin. vol 36. issue 6. 2014-01-07. PMID:23546333. |
evidence for myocardial apoptosis was detected by caspase-3 activity measurement and western blot analysis. |
2014-01-07 |
2023-08-12 |
rat |
| Lei Tian, Xiao-qian Dang, Chun-sheng Wang, Pei Yang, Chen Zhang, Kun-zheng Wan. Effects of sodium ferulate on preventing steroid-induced femoral head osteonecrosis in rabbits. Journal of Zhejiang University. Science. B. vol 14. issue 5. 2014-01-06. PMID:23645179. |
the apoptosis expressions of caspase-3 and bcl-2 were analyzed by immunohistochemistry and western blot. |
2014-01-06 |
2023-08-12 |
rabbit |
| Jing Liu, Zhaohong Chen, Yujing Zhang, Mingchao Zhang, Xiaodong Zhu, Yun Fan, Shaolin Shi, Ke Zen, Zhihong Li. Rhein protects pancreatic β-cells from dynamin-related protein-1-mediated mitochondrial fission and cell apoptosis under hyperglycemia. Diabetes. vol 62. issue 11. 2013-12-26. PMID:23919963. |
western blot and functional analysis confirmed that rhein protected the pancreatic β-cells against hyperglycemia-induced apoptosis via suppressing mitochondrial drp1 level. |
2013-12-26 |
2023-08-12 |
mouse |
| Ju-Hee Han, Junglim Lee, Soo-Jin Jeon, Eun-Sun Choi, Sung-Dae Cho, Bo-Yeon Kim, Dong-Jae Kim, Jae-Hak Park, Jong-Hwan Par. In vitro and in vivo growth inhibition of prostate cancer by the small molecule imiquimod. International journal of oncology. vol 42. issue 6. 2013-12-23. PMID:23588478. |
flow cytometry and western blot analysis revealed that imiquimod induced direct apoptosis in tramp-c2 cells via a mitochondrial‑dependent pathway. |
2013-12-23 |
2023-08-12 |
mouse |
| Li-Lin Ye, Wei-Ke Cao, Yu-Ye Shi, Zhi-Kui Deng, Shan-Dong Tao, Ping Ji, Xian-Hua Fu, Ming-Zhu Zong, Yu-Feng L. [Effect of homoharringtonine on expression of NF-κB and BCL-2 proteins in K562 cells]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 1. 2013-12-16. PMID:23484696. |
the cells proliferation was assayed with mtt method, the cell apoptosis, cell cycle and bcl-2 expression were analyzed with flow cytometry, nf-κb protein expression was detected with western blot. |
2013-12-16 |
2023-08-12 |
Not clear |
| Bao-Lan Liu, Xin Liu, Nai-Cen Zhou, Mei-Ying Qi, Bo X. [Mechanisms of oxaliplatin-induced apoptosis of human multiple myeloma cell RPMI8226]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 1. 2013-12-16. PMID:23484700. |
the proliferation inhibitory rate of rpmi8226 cells was assayed by mtt, the morphological changes of rpmi-8226 cells were observed by inverted fluorescent microscopy and transmission electron microscopy, the apoptosis rate and the cell cycle distribution of rpmi-8226 cells were detected by flow cytometry, the effects of oxaliplatin on the expression of bcl-2, caspase-8, caspase-3 mrna were tested by rt-pcr, bcl-2 protein expression of rpmi-8226 cells was analyzed by western blot. |
2013-12-16 |
2023-08-12 |
human |
| Yi Huang, Jian-Da Hu, Yan-An Wu, Jing Zheng, Yuan-Lin Qi, Ying-Yu Chen, Xiao-Li Huan. [Effects of eEF1A1 re-expression on proliferation and apoptosis of Jurkat cells with knocked down eEF1A1 gene and its mechanisms]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 2. 2013-12-16. PMID:23628016. |
then, the expressions of eef1a1 mrna and protein were detected by real time pcr(rt-pcr) and western blot respectively.cell proliferation, apoptosis and cycle were detected by mtt method, annexin v-apc labeling and dna ploidy analysis respectively. |
2013-12-16 |
2023-08-12 |
human |
| Su-Rong Zhao, Hai-Feng Duan, Pei Zhang, Hao Liu, Chen-Chen Jiang, Zhi-Wen Jian. [2-DG enhances TRAIL-induced apoptosis of leukemia HL-60 cells]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 2. 2013-12-16. PMID:23628031. |
apoptosis was analyzed by flow cytometry with pi staining; the expression of rip1, grp78, and parp was analyzed by western blot; the activity of caspase-3 was detected by special detection kit. |
2013-12-16 |
2023-08-12 |
Not clear |
| Wanguang Zhang, Huilan Zhan. Hypoxia-inducible factor-1alpha suppressing apoptosis and increasing tolerance of lung cancer cells to chemotherapy. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 26. issue 5. 2013-12-13. PMID:17219956. |
after a549 cells were transfected with hif-1alpha prior to addition of 5-fu, the growth activity was measured by growth curve, apoptosis was detected by flow cytometry at 48 h, and the levels of caspase3 and mdr-1 were determined by western blot. |
2013-12-13 |
2023-08-12 |
human |
| Lei Huai, Cui-Cui Wang, Cui-Ping Zhang, Qi-Hui Li, Yi-Rui Chen, Yu-Jiao Jia, Min Wang, Jian-Xiang Wan. [Effect of metformin on acute promyelocytic leukemia cell line NB4 and its mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 6. 2013-12-13. PMID:23257425. |
nb4 cells were pretreated with u0126, a specific inhibitor for extracellular signal-regulated kinase (erk) phosphorylation, erk phosphorylation was assessed by western blot analysis, apoptosis and cell adhesion ability were evaluated by flow cytometry and cell adhesion test respectively. |
2013-12-13 |
2023-08-12 |
Not clear |
| Cong He, Xin DU, Sheng-Hong DU, Pei-Min Jia, Jian-Hua Tong, Li Zho. [Mechanism of apoptosis synergistically induced by bortezomib combined with cytarabine in U937 cell line]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 6. 2013-12-13. PMID:23257432. |
cell signaling pathway related to apoptosis was analyzed by western blot. |
2013-12-13 |
2023-08-12 |
Not clear |
| Hong-Yu Bao, Jian-Ning Wang, Yan-Qiu Hou, Ming Song, Liu-Bo Zhang, Qing-Qi Meng, Chang-Geng Rua. [Apoptosis-inducing effect of annexin A2 on multiple myeloma cells and its related mechanisms]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 6. 2013-12-13. PMID:23257438. |
the human mm cell lines u266 and rpmi8226 were transfected by using sirna targeting at anxa2; the expressions of anxa2 mrna and protein in the sirna-transfected cells were detected by real-time pcr and western blot, respectively; the cell apoptosis was assayed by flow cytometry. |
2013-12-13 |
2023-08-12 |
human |
| Jun Liao, Teng Xu, Jia-Xuan Zheng, Jiu-Mao Lin, Qiao-Yan Cai, De-Biao Yu, Jun Pen. Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway. International journal of molecular medicine. vol 32. issue 1. 2013-12-10. PMID:23613111. |
the analysis of the effects of nc on apoptosis in hcc tumor xenografts in mice was carried out by terminal deoxynucleotidyl transferase-mediated dutp nick end-labeling (tunel) assay; the expression of bcl-2, bax, cyclin-dependent kinase (cdk)4, cyclin d1, p21 and proliferating cell nuclear antigen (pcna) was analyzed by immunohistochemistry; and the protein expression of jak1 and stat3 was examined by western blot analysis. |
2013-12-10 |
2023-08-12 |
mouse |
| Peipei An, Yupeng Yin, Anran Fan, Wentao Tan, Fei Gao, Kuiying Ma, Bo Tang, Xueming Zhang, Ziyi L. The effects of the WT1 gene on apoptosis and development-related gene expression in porcine kidney fibroblasts and swine testis cells. Molecular reproduction and development. vol 80. issue 5. 2013-12-09. PMID:23559339. |
the role of wt1 in cell proliferation was investigated by rt-pcr, immunocytochemical staining, apoptosis analysis, and western blot. |
2013-12-09 |
2023-08-12 |
human |
| Diptiman Choudhury, Paulrajpillai Lourdu Xavier, Kamalesh Chaudhari, Robin John, Anjan Kumar Dasgupta, Thalappil Pradeep, Gopal Chakrabart. Unprecedented inhibition of tubulin polymerization directed by gold nanoparticles inducing cell cycle arrest and apoptosis. Nanoscale. vol 5. issue 10. 2013-12-09. PMID:23584723. |
further, western blot analysis indicated the upregulation of mitochondrial apoptosis proteins such as bax and p53, down regulation of bcl-2 and cleavage of poly(adp-ribose) polymerase (parp) confirming mitochondrial apoptosis. |
2013-12-09 |
2023-08-12 |
Not clear |
| Diptiman Choudhury, Paulrajpillai Lourdu Xavier, Kamalesh Chaudhari, Robin John, Anjan Kumar Dasgupta, Thalappil Pradeep, Gopal Chakrabart. Unprecedented inhibition of tubulin polymerization directed by gold nanoparticles inducing cell cycle arrest and apoptosis. Nanoscale. vol 5. issue 10. 2013-12-09. PMID:23584723. |
western blot run after cold-depolymerization revealed an increase in the aggregated insoluble intracellular tubulin while the control and actin did not aggregate, suggesting microtubule damage induced cell cycle arrest and apoptosis. |
2013-12-09 |
2023-08-12 |
Not clear |
| Zhiwei Tang, Jun-Xiang Yin, Pengcheng Han, Yan Gan, Stephen W Coons, Chongqian Wang, Marwan Maalouf, Jiong Sh. Pertussis toxin attenuates experimental autoimmune encephalomyelitis by upregulating neuronal vascular endothelial growth factor. Neuroreport. vol 24. issue 9. 2013-12-09. PMID:23660634. |
vegf, neun for neurons, and caspase-3 for apoptosis were stained for localization using immunohistochemistry techniques, followed by western blot analysis for quantification. |
2013-12-09 |
2023-08-12 |
mouse |
| Shuilong Leng, Yanli Hao, Daobing Du, Shanyan Xie, Lepeng Hong, Haigang Gu, Xiao Zhu, Jinfang Zhang, Daping Fan, Hsiang-fu Kun. Ursolic acid promotes cancer cell death by inducing Atg5-dependent autophagy. International journal of cancer. vol 133. issue 12. 2013-12-09. PMID:23737395. |
ua did not induce apoptosis of tc-1 cells in vitro as determined by annexin v/propidium iodide staining, dna fragmentation, and western blot analysis of the apoptosis-related proteins. |
2013-12-09 |
2023-08-12 |
mouse |
| Tsung-Ho Ying, Chia-Wei Chen, Yu-Ping Hsiao, Sung-Jen Hung, Jing-Gung Chung, Jen-Hung Yan. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer research. vol 33. issue 10. 2013-12-09. PMID:24123010. |
cell-cycle arrest and apoptosis were investigated by 4,6-diamidino-2-phenylindole dihydrochloride (dapi) staining, flow cytometry, western blot and confocal microscopy. |
2013-12-09 |
2023-08-12 |
human |
| Ling Zhang, Yan-Ping Ma, Gu Jia, Yu-Jin Lu, Li Zhang, Hong Lu, Ming-Xing Chan. [Inhibitory effect of histone deacetylase inhibitor LBH589 on multiple myeloma MM1R cells in vitro]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 5. 2013-12-05. PMID:23114131. |
the effect of lbh589 (10, 20, 50 nmol/l) alone or combined with bor (10, 20 nmol/l) on mm1r proliferation was detected by mtt method; the effect of lbh589 on cell cycle and apoptosis of mm1r cells were determined by flow cytometry; the histone h4 acetylation level of mm1r cells treated with lbh589 (10, 20, 50 nmol/l) for 24 h was analyzed by western blot. |
2013-12-05 |
2023-08-12 |
Not clear |