| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling Zhang, Yan-Ping Ma, Gu Jia, Yu-Jin Lu, Li Zhang, Hong Lu, Ming-Xing Chan. [Inhibitory effect of histone deacetylase inhibitor LBH589 on multiple myeloma MM1R cells in vitro]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 5. 2013-12-05. PMID:23114131. |
western blot analysis showed that the histone h4 acetylation level was enhanced in concentration-dependent manner after mm1r cells were treated with different concentrations of lbh589 for 24 h. it is concluded that the lbh589 can inhibit the proliferation of mm1r cells, block the cell cycle, induce cell apoptosis, moreover lbh589 combined with bor has synergistic effect on mm1r cells. |
2013-12-05 |
2023-08-12 |
Not clear |
| Chun-Yu Liu, Chung-Wai Shiau, Hsin-Yu Kuo, Hsiang-Po Huang, Ming-Huang Chen, Cheng-Hwai Tzeng, Kuen-Feng Che. Cancerous inhibitor of protein phosphatase 2A determines bortezomib-induced apoptosis in leukemia cells. Haematologica. vol 98. issue 5. 2013-12-03. PMID:22983581. |
drug efficacy was evaluated by apoptosis assays and associated molecular events assessed by western blot. |
2013-12-03 |
2023-08-12 |
human |
| Ferda Ari, Engin Ulukaya, Mehmet Sarimahmut, Veysel T Yilma. Palladium(II) saccharinate complexes with bis(2-pyridylmethyl)amine induce cell death by apoptosis in human breast cancer cells in vitro. Bioorganic & medicinal chemistry. vol 21. issue 11. 2013-12-03. PMID:23601820. |
it was demonstrated that complex 3 caused cell death by apoptosis determined by fluorescence imaging and western blot. |
2013-12-03 |
2023-08-12 |
human |
| Hong Xin, Ying Kong, Yong Wang, Yingjun Zhou, Yizhun Zhu, Dapeng Li, Wenfu Ta. Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 20. issue 7. 2013-11-26. PMID:23562365. |
apoptosis exerted by evn-50 or vb1 was measured by tunel assay and dapi staining, and western blot analysis was utilized to assess the influence on expression and phosphorylation of proteins which are closely related to cell cycle and apoptosis. |
2013-11-26 |
2023-08-12 |
Not clear |
| Kai-Lin Yang, Yu-Shan Wang, Chao-Chun Chang, Su-Chen Huang, Yi-Chun Huang, Mau-Shin Chi, Kwan-Hwa Ch. Reciprocal complementation of the tumoricidal effects of radiation and natural killer cells. PloS one. vol 8. issue 4. 2013-11-26. PMID:23634213. |
western blot analysis and immunoprecipitation methods were used to determine xiap (x-linked inhibitor of apoptosis protein) and smac (second mitochondria-derived activator of caspase) expression and interaction in tumor cells. |
2013-11-26 |
2023-08-12 |
human |
| Tae Kwun Ha, Mi Eun Kim, Ju Hwa Yoon, Sung Jin Bae, Jihye Yeom, Jun Sik Le. Galangin induces human colon cancer cell death via the mitochondrial dysfunction and caspase-dependent pathway. Experimental biology and medicine (Maywood, N.J.). vol 238. issue 9. 2013-11-19. PMID:23925650. |
we also determined that galangin increased the activation of caspase-3 and -9, and release of apoptosis inducing factor from the mitochondria into the cytoplasm by western blot analysis. |
2013-11-19 |
2023-08-12 |
human |
| Ping Chen, Lixiang Wang, Na Li, Qiong Liu, Jiazuan N. Comparative proteomics analysis of sodium selenite-induced apoptosis in human prostate cancer cells. Metallomics : integrated biometal science. vol 5. issue 5. 2013-11-18. PMID:23589036. |
western blot analyses showed that selenite-induced apoptosis was accompanied by activation of caspase-8 and specific proteolytic cleavage of parp. |
2013-11-18 |
2023-08-12 |
human |
| Lei Xia, Wei Guan, Dong Wang, Yun-Song Zhang, Lin-Li Zeng, Zeng-Peng Li, Ge Wang, Zhen-Zhou Yan. Killing effect of Ad5/F35-APE1 siRNA recombinant adenovirus in combination with hematoporphrphyrin derivative-mediated photodynamic therapy on human nonsmall cell lung cancer. BioMed research international. vol 2013. 2013-11-12. PMID:23509821. |
by using the technologies of mtt, flow cytometry, elisa, and western blot, we observed that the proliferation inhibition and apoptosis of the a549 cells were significantly higher than the control group (p < 0.05) after hpd-pdt was performed. |
2013-11-12 |
2023-08-12 |
human |
| Yu-Fang He, Min-Lun Nan, Jia-Ming Sun, Zhao-Jie Meng, Wei Li, Ming Zhan. Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives. Bioorganic & medicinal chemistry letters. vol 23. issue 9. 2013-11-08. PMID:23558236. |
the apoptosis mechanism of compound 4 in hela cells was investigated by western blot analysis. |
2013-11-08 |
2023-08-12 |
human |
| Wanli Xie, Huiqing Wang, Lei Wang, Chengye Yao, Ruixia Yuan, Qingping W. Resolvin D1 reduces deterioration of tight junction proteins by upregulating HO-1 in LPS-induced mice. Laboratory investigation; a journal of technical methods and pathology. vol 93. issue 9. 2013-11-04. PMID:23857007. |
the severity of pulmonary edema was assessed by wet-to-dry rate and evans blue infiltration; expressions of tight junction (tj) proteins occludin and zona occludin-1 (zo-1) were examined by immunofluorescence staining and western blot; mrna in lung tissue was studied by real time-pcr; the tunel kit was performed for the detection of apoptosis of pulmonary barrier. |
2013-11-04 |
2023-08-12 |
mouse |
| Giuseppe Musumeci, Paola Castrogiovanni, Carla Loreto, Sergio Castorina, Karin Pichler, Annelie Martina Weinber. Post-traumatic caspase-3 expression in the adjacent areas of growth plate injury site: a morphological study. International journal of molecular sciences. vol 14. issue 8. 2013-11-01. PMID:23899790. |
immunohistochemistry, histomorphometry and western blot analyses of the caspase-3 and cleaved parp-1 showed that the physeal apoptosis rate of the experimental bones was significantly higher than that of the control ones. |
2013-11-01 |
2023-08-12 |
Not clear |
| Lakkyong Hwang, In-Young Choi, Sung-Eun Kim, Il-Gyu Ko, Mal-Soon Shin, Chang-Ju Kim, Sang-Hoon Kim, Jun-Jang Jin, Jun-Young Chung, Jae-Woo Y. Dexmedetomidine ameliorates intracerebral hemorrhage-induced memory impairment by inhibiting apoptosis and enhancing brain-derived neurotrophic factor expression in the rat hippocampus. International journal of molecular medicine. vol 31. issue 5. 2013-10-29. PMID:23503673. |
terminal deoxynucleotidyl transferase‑mediated dutp nick end-labeling (tunel) assay, immunohistochemistry for caspase‑3, and western blot analysis for bcl‑2, bax, bid and caspase-3 expression were performed for the detection of apoptosis in the hippocampus. |
2013-10-29 |
2023-08-12 |
rat |
| Xiao-Dong Sun, Xing-E Liu, Dong-Sheng Huan. Curcumin reverses the epithelial-mesenchymal transition of pancreatic cancer cells by inhibiting the Hedgehog signaling pathway. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23563640. |
the growth inhibition rate of the cells was measured by mtt assay, apoptosis was detected by flow cytometry, the expression levels of shh, gli1, e-cadherin and vimentin were detected by western blot analysis, and cell invasion and migration ability were examined by transwell cell invasion assay and wound healing assay. |
2013-10-29 |
2023-08-12 |
Not clear |
| Jiaqiang Liu, Yi Jiang, Jing Mao, Bin Gu, Hongchen Liu, Bing Fan. High levels of glucose induces a dose-dependent apoptosis in human periodontal ligament fibroblasts by activating caspase-3 signaling pathway. Applied biochemistry and biotechnology. vol 170. issue 6. 2013-10-29. PMID:23686473. |
human periodontal ligament fibroblasts were cultured and subjected to glucose of different concentration (5.5, 15, 25, and 35 mm) for 24 h. apoptosis was studied by flow cytometry, caspase assays, fluorescent real-time pcr and western blot. |
2013-10-29 |
2023-08-12 |
human |
| Miklos Jaszberenyi, Andrew V Schally, Norman L Block, Mehrdad Nadji, Irving Vidaurre, Luca Szalontay, Ferenc G Ric. Inhibition of U-87 MG glioblastoma by AN-152 (AEZS-108), a targeted cytotoxic analog of luteinizing hormone-releasing hormone. Oncotarget. vol 4. issue 3. 2013-10-25. PMID:23518876. |
genomic (rt-pcr) and proteomic (elisa, western blot) studies revealed that an-152 activated apoptosis, as reflected by the changes in p53 and its regulators and substrates, inhibited cell growth, and elicited changes in intermediary filament pattern. |
2013-10-25 |
2023-08-12 |
mouse |
| An-Ming Tang, Wei-Juan Wang, Bin Mei, Wang-Lai Hu, Mian Wu, Gao-Lin Lian. DEVD-based hydrogelator minimizes cellular apoptosis induction. Scientific reports. vol 3. 2013-10-24. PMID:23673405. |
3-(4,5-dimethylthiazol-2-yl) 2,5 diphenyl tetrazolium bromide (mtt) and western blot analyses indicated that dedv-based hydrogelator 2 induces cell death via apoptotic pathway while the devd-based hydrogelator 1 minimizes cellular apoptosis induction. |
2013-10-24 |
2023-08-12 |
Not clear |
| Kui Yang, Yunsheng Liu, Zhixiong Liu, Jinfang Liu, Xin Liu, Xin Chen, Chuntao Li, Yu Zen. p38γ overexpression in gliomas and its role in proliferation and apoptosis. Scientific reports. vol 3. 2013-10-17. PMID:23807566. |
cell proliferation and apoptosis were assayed by cck-8 and flow cytometric analysis, and then rna and protein expression levels were measured by real-time rt-pcr and western blot, respectively. |
2013-10-17 |
2023-08-12 |
human |
| Eun Young Kim, An Keun Ki. Apigenin Sensitizes Huh-7 Human Hepatocellular Carcinoma Cells to TRAIL-induced Apoptosis. Biomolecules & therapeutics. vol 20. issue 1. 2013-10-11. PMID:24116276. |
western blot analysis suggested that apigenin sensitizes cells to trail-induced apoptosis by activating both intrinsic and extrinsic apoptotic pathway-related caspases. |
2013-10-11 |
2023-08-12 |
human |
| Bidur Parajuli, So-Jin Shin, Sang-Hoon Kwon, Soon-Do Cha, Hyun-Gyo Lee, Insoo Bae, Chi-Heum Ch. The synergistic apoptotic interaction of Indole-3-Carbinol and Genistein with TRAIL on endometrial cancer cells. Journal of Korean medical science. vol 28. issue 4. 2013-10-01. PMID:23580227. |
the induction of apoptosis was measured by caspase-3 activity test, dna fragmentation assay, annexin v binding assay and western blot analysis. |
2013-10-01 |
2023-08-12 |
Not clear |
| Yan Song, Xin Sun, Wei-Liang Bai, Wen-Yue J. Antitumor effects of Dasatinib on laryngeal squamous cell carcinoma in vivo and in vitro. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 270. issue 4. 2013-09-30. PMID:23404469. |
measuring the modulation of regulators in the cell cycle, apoptosis and signal transductions by western blot analysis showed that the effect of dasatinib was due to suppression of the expression of bax, bcl-2, caspase-3, and caspase-8. |
2013-09-30 |
2023-08-12 |
mouse |