| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akari Takahashi, Toshihiko Torigoe, Yasuaki Tamura, Takayuki Kanaseki, Tomohide Tsukahara, Yasushi Sasaki, Hidekazu Kameshima, Tetsuhiro Tsuruma, Koichi Hirata, Takashi Tokino, Yoshihiko Hirohashi, Noriyuki Sat. Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes. Cell stress & chaperones. vol 17. issue 6. 2013-03-05. PMID:22777894. |
to address the molecular mechanisms of this phenomenon, we investigated the apoptosis status of ctls, expression of cd3, cd8, and tcrαβ by flow cytometry, and expression of perforin, granzyme b, and fas ligand by western blot analysis. |
2013-03-05 |
2023-08-12 |
Not clear |
| Rong-Huai Zhang, Jian-Yuan Gao, Hai-Tao Guo, Glenda I Scott, Anna R Eason, Xiao-Ming Wang, Jun Re. Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction and apoptosis. Biochimica et biophysica acta. vol 1832. issue 1. 2013-03-04. PMID:22967841. |
western blot analysis was used to evaluate cyp2e1, heme oxygenase-1 (ho-1), inos, the intracellular ca(2+) regulatory proteins sarco(endo)plasmic reticulum ca(2+)-atpase, na(+)ca(2+) exchanger and phospholamban, pro-apoptotic protein cleaved caspase-3, bax, c-jun-nh(2)-terminal kinase (jnk) and apoptosis signal-regulating kinase (ask-1). |
2013-03-04 |
2023-08-12 |
mouse |
| Zhixiang Zhou, Chen Zhao, Wei Liu, Qianqian Li, Lina Zhang, Wang Sheng, Zelin Li, Yi Zeng, Rugang Zhon. Involvement of the mitochondria-caspase pathway in HeLa cell death induced by 2-ethanolamino-2-demethoxy-17-ethanolimino-hypocrellin B (EAHB)-mediated photodynamic therapy. International journal of toxicology. vol 31. issue 5. 2013-03-04. PMID:23008347. |
in order to elucidate the mechanism of cytotoxicity photoinduced by 2-ethanolamino-2-demethoxy-17-ethanolimino-hypocrellin b (eahb), a derivative of hypocrellin b (hb), cellular uptake, subcellular localization as well as photodynamic therapy (pdt) efficiency of eahb, and cell apoptosis photoinduced by eahb were investigated in hela cells by laser confocal fluorescence microscopy, 3-(4,5-dimethylthiazol-2-thiazolyl)-2,5-diphenyl-2h-tetrazolium bromide assay, flow cytometry, dna fragmentation on agarose gel, and western blot. |
2013-03-04 |
2023-08-12 |
Not clear |
| Lu Xia, Qing-Lu Luo, Hai-Dan Lin, Jin-Long Zhang, Hua Guo, Cheng-Qi H. The effect of different treatment time of millimeter wave on chondrocyte apoptosis, caspase-3, caspase-8, and MMP-13 expression in rabbit surgically induced model of knee osteoarthritis. Rheumatology international. vol 32. issue 9. 2013-03-01. PMID:21881990. |
chondrocytes apoptosis was tested by the tunel assessment, and the expressions of related proteins were tested by the immunohistochemistry observation and western blot. |
2013-03-01 |
2023-08-12 |
rabbit |
| Mingyang Zhang, Haiyan Shan, Zhenyong Gu, Donglin Wang, Tao Wang, Zhiwei Wang, Luyang Ta. Increased expression of calcium/calmodulin-dependent protein kinase type II subunit δ after rat traumatic brain injury. Journal of molecular neuroscience : MN. vol 46. issue 3. 2013-02-25. PMID:22048920. |
in addition, western blot detection showed that the third day postinjury was also the apoptosis peak indicated by the elevated expression of caspase-3.importantly, immunohistochemistry analysis revealed that injury-induced expression of camkiiδ was colabeled by caspase-3 (apoptosis cells marker). |
2013-02-25 |
2023-08-12 |
rat |
| Zun-Ling Li, Shu-Hong Shao, Shu-Yang Xie, Zhen Yue, Ying M. [Anti-sense nucleic acid of CyclinD1 induces apoptosis of lung adenocarcinoma cancer cell A549]. Sheng li xue bao : [Acta physiologica Sinica]. vol 63. issue 3. 2013-02-21. PMID:21681345. |
to investigate the mechanism for anti-sense nucleic acid of cyclind1 inducing a549 cells apoptosis, the expression levels of retinoblastoma protein (prb), adenovirus e2 factor-1 (e2f-1), vascular endothelial growth factor (vegf), matrix metalloproteinase (mmp)-2 and mmp-9 were detected by western blot, and the results showed the expressions of these proteins were all decreased significantly in anti-sense nucleic acid of cyclind transfected group, compared with those in negative control and empty vector groups. |
2013-02-21 |
2023-08-12 |
Not clear |
| Kaiyu Liu, Duanyang Shu, Na Song, Zhongchao Gai, Yuan Yuan, Juan Li, Min Li, Shuying Guo, Jianxin Peng, Huazhu Hon. The role of cytochrome c on apoptosis induced by Anagrapha falcifera multiple nuclear polyhedrosis virus in insect Spodoptera litura cells. PloS one. vol 7. issue 8. 2013-02-19. PMID:22952575. |
our previous studies have showed that cytochrome c released from the mitochondria was an early event by western blot analysis and caspase-3 activation was closely related to cytochrome c release during apoptosis induced by baculovirus in spodoptera litura cells (sl-1 cell line). |
2013-02-19 |
2023-08-12 |
Not clear |
| Huiying Luo, He Su, Xiaopeng Wang, Lijuan Wang, Juan L. N-Succinyl-chitosan nanoparticles induced mitochondria-dependent apoptosis in K562. Molecular and cellular probes. vol 26. issue 4. 2013-02-15. PMID:22465598. |
here, by western blot we revealed that apoptosis induced by nscnp was associated with accumulation of cytochrome c in cytosol and elevating expression of apoptosis-promoted protein bax while depressing expression of apoptosis-restrained protein bcl-2 in time- and dose-dependence. |
2013-02-15 |
2023-08-12 |
Not clear |
| M Festa, M Caputo, C Cipolla, Cw D'Acunto, Ag Rossi, Mf Tecce, A Capass. The involvement of xanthohumol in the expression of annexin in human malignant glioblastoma cells. The open biochemistry journal. vol 7. 2013-02-15. PMID:23407460. |
importantly, apoptosis induced by xh was reduced in sirna-anxa1 transfected cells where western blot analysis shows a significant reduction of anxa1 protein levels. |
2013-02-15 |
2023-08-12 |
human |
| Bo Cai, Shuiliang Wang, Jingcao Huang, Choon-Kee Lee, Chunji Gao, Bolin Li. Cladribine and bendamustine exhibit inhibitory activity in dexamethasone-sensitive and -resistant multiple myeloma cells. American journal of translational research. vol 5. issue 1. 2013-02-08. PMID:23390564. |
an apoptotic-elisa and western blot assays of parp cleavage and activation of caspase-8 and caspase-3 indicated that cladribine or bendamustine induced apoptosis in both cell lines. |
2013-02-08 |
2023-08-12 |
Not clear |
| Qin-Shan Li, Yang Liu, Zan-Jie Feng, Zhi-Shun Lu, Min-Zhang Qia. The molecular mechanism of apoptosis of human umbilical vein endothelial cells induced by monocyte chemotacitic protein-1. Sheng li xue bao : [Acta physiologica Sinica]. vol 62. issue 1. 2013-01-24. PMID:20179890. |
the expressions of apoptosis related proteins fas, bcl-2, bax were detected by flow cytometry (facs) and western blot. |
2013-01-24 |
2023-08-12 |
human |
| Qin-Shan Li, Yang Liu, Zan-Jie Feng, Zhi-Shun Lu, Min-Zhang Qia. The molecular mechanism of apoptosis of human umbilical vein endothelial cells induced by monocyte chemotacitic protein-1. Sheng li xue bao : [Acta physiologica Sinica]. vol 62. issue 1. 2013-01-24. PMID:20179890. |
as shown in our preliminary study, mcp-1 induced apoptosis of huvecs in a dose-dependent manner at both 24 h and 48 h. facs and western blot analysis results in the present study indicated that mcp-1 promoted the expression of proapoptotic proteins bax and fas and inhibited the expression of antiapoptotic protein bcl-2. |
2013-01-24 |
2023-08-12 |
human |
| Sankar Ramachandran, Mahitosh Manda. Induction of apoptosis of azurin synthesized from P. aeruginosa MTCC 2453 against Dalton's lymphoma ascites model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 65. issue 7. 2013-01-17. PMID:22000294. |
further, the cause of apoptosis was revealed by western blot which showed the reduction in the ratio of bcl-2 and bax protein expression, the activation of caspases-3 through the release of cytochrome c in dl cells. |
2013-01-17 |
2023-08-12 |
mouse |
| Subat Turdi, Xuefeng Han, Anna F Huff, Nathan D Roe, Nan Hu, Feng Gao, Jun Re. Cardiac-specific overexpression of catalase attenuates lipopolysaccharide-induced myocardial contractile dysfunction: role of autophagy. Free radical biology & medicine. vol 53. issue 6. 2013-01-16. PMID:22902401. |
levels of oxidative stress, autophagy, apoptosis, and protein damage were examined using fluorescence microscopy, western blot, tunel assay, caspase-3 activity, and carbonyl formation. |
2013-01-16 |
2023-08-12 |
mouse |
| Elahe Taghiabadi, Mohsen Imenshahidi, Khalil Abnous, Fatemeh Mosafa, Mojtaba Sankian, Bahram Memar, Gholamreza Karim. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2013-01-16. PMID:23320028. |
western blot analysis showed that sn pretreatment inhibited apoptosis provoked by acr through decreasing bax/bcl-2 ratio, cytosolic cytochrome c content, and cleaved caspase-3 level in heart. |
2013-01-16 |
2023-08-12 |
mouse |
| Yong Cui, Qi Wang, Junyu Wang, Yan Dong, Chun Luo, Guohan Hu, Yicheng L. Knockdown of AKT2 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to the anticancer drug VM-26 in U87 glioma cells. Brain research. vol 1469. 2013-01-14. PMID:22771706. |
quantitative reverse-transcription polymerase chain reaction (qrt-pcr) and western blot analysis revealed that cells stably underexpressing akt2 showed lower expression of the anti-apoptotic protein b-cell lymphoma-2 (bcl-2) and enhanced expression of the apoptosis effector caspase-3 compared to u87 cells stably transfected with a control vector. |
2013-01-14 |
2023-08-12 |
human |
| Mingxing Lei, Xiufeng Bai, Tian Yang, Xiangdong Lai, Weiming Qiu, Li Yang, Xiaohua Lia. Gsdma3 is a new factor needed for TNF-α-mediated apoptosis signal pathway in mouse skin keratinocytes. Histochemistry and cell biology. vol 138. issue 3. 2013-01-07. PMID:22585037. |
to further investigate the role and the pathway of gsdma3 involved in skin keratinocyte apoptosis, using immunofluorescence, rt-pcr, western blot and tunel analysis, we showed here that accompanying tnf-α-induced apoptosis and caspase-3 expression in mouse skin keratinocytes in vivo and in vitro, gsdma3 expression was significantly upregulated. |
2013-01-07 |
2023-08-12 |
mouse |
| Na Shao, Jie Zou, Jie Li, Feng Chen, Jianjian Dai, Xun Qu, Xiulian Sun, Daoxin Ma, Chunyan J. Hyper-activation of WNT/β-catenin signaling pathway mediates anti-tumor effects of histone deacetylase inhibitors in acute T lymphoblastic leukemia. Leukemia & lymphoma. vol 53. issue 9. 2013-01-04. PMID:22303878. |
furthermore, flow cytometry and western blot for cleaved parp showed that targeting β-catenin with shrna attenuated the apoptosis induced by vpa and sbha. |
2013-01-04 |
2023-08-12 |
Not clear |
| Yi-Lin Sophia Chen, Jun-Hong Li, Chao-Yuan Yu, Ching-Ju Lin, Pai-Hsuan Chiu, Po-Wen Chen, Chai-Ching Lin, Wei-Jung Che. Novel cationic antimicrobial peptide GW-H1 induced caspase-dependent apoptosis of hepatocellular carcinoma cell lines. Peptides. vol 36. issue 2. 2012-12-28. PMID:22659412. |
gw-h1 treatment (20μm) of j5 cells for 24-72h resulted in the induction of apoptosis, as revealed by flow cytometry (increased sub-g1 populations), and western blot analysis for the appearance of activated caspase-3, -7 and -9 cleavages. |
2012-12-28 |
2023-08-12 |
mouse |
| Dezhi Zheng, Jun Hou, Yingbin Xiao, Zhe Zhao, Lin Che. Cardioprotective effect of mangiferin on left ventricular remodeling in rats. Pharmacology. vol 90. issue 1-2. 2012-12-27. PMID:22759807. |
cardiac function, myocardial apoptosis and fibrosis, serum tumor necrosis factor-α (tnf-α) and phosphorylated p38 mitogen-activated protein kinase (mapk) were examined by echocardiography, histological staining, elisa and western blot, respectively. |
2012-12-27 |
2023-08-12 |
rat |