| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin Wang, Feng-Xia Ma, Shi-Hong Lu, Ying Chi, Fang Chen, Xue Li, Juan-Juan Li, Wen-Jing Du, Ying Feng, Jun-Jie Cui, Bao-Quan Song, Zhong-Chao Ha. [Effects of rapamycin on biological characteristics of bone marrow mesenchymal stem cells from patients with aplastic anemia]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 3. 2014-12-11. PMID:24989291. |
bm-msc were treated with different concentrations of rapamycin (0, 10, 50, 100 nmol/l) for 48 h, the expression of lc3b protein was detected by western blot to observe the effect of rapamycin on cell autophagy; cell apoptosis and cell cycles were detected by flow cytometry; the proliferation of bm-msc of aa patients was measured by cell counting kit-8; the adipogenic differentiation of bm-msc were tested by oil red o staining after adipogenic induction for 2 weeks; the adipogenic related genes (lpl, cfd, pparγ) were detected by real-time pcr. |
2014-12-11 |
2023-08-13 |
Not clear |
| Claudine Irles, Alicia T Nava-Kopp, Julio Morán, Limei Zhan. Neonatal maternal separation up-regulates protein signalling for cell survival in rat hypothalamus. Stress (Amsterdam, Netherlands). vol 17. issue 3. 2014-12-08. PMID:24730533. |
expression of factors related to apoptosis and cell survival in the hypothalamus was examined at pnd 1, 3, 6, 9, 12, 15, 20 and 43 by western blot. |
2014-12-08 |
2023-08-13 |
rat |
| S Correia, M G Alves, P F Oliveira, M R Alves, A M M van Pelt, J E Cavaco, S Socorr. Transgenic overexpression of regucalcin leads to suppression of thapsigargin- and actinomycin D-induced apoptosis in the testis by modulation of apoptotic pathways. Andrology. vol 2. issue 2. 2014-12-04. PMID:24519986. |
expression levels of key regulators of apoptosis in set of tg-rgn and wt animals were determined by quantitative real-time pcr and western blot analysis. |
2014-12-04 |
2023-08-12 |
rat |
| Jing Shen, Jing-Shi Wang, Li Fu, Da-Yong Huang, Zhao Wan. [Inhibitory effect of genistein on the proliferation of Raji cells and its related mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 4. 2014-12-04. PMID:25130812. |
cell apoptosis, protein expression and the interaction of bcl-6 and ncor were detected by pi/av dual staining, western blot and co-ip method, respectively. |
2014-12-04 |
2023-08-13 |
Not clear |
| Paulraj Raja Singh, Ramachandran Arunkumar, Velayutham Sivakamasundari, Govindaraj Sharmila, Perumal Elumalai, Elayapillai Suganthapriya, Amalanathan Brindha Mercy, Kalimuthu Senthilkumar, Jegadeesan Arunakara. Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line. Cell biochemistry and function. vol 32. issue 3. 2014-12-01. PMID:23963693. |
the mrna expression of fas ligand, fas-associated death domain receptor (faddr), bcl-2-associated x protein (bax), bcl-2-associated death promoter (bad), phosphatidylinositide 3-kinases (pi3k), akt, igf1, igf1 receptor (igf1r) and igf binding protein 3 were quantified by reverse transcription polymerase chain reaction and protein expression of bax, cytochrome c, x-linked inhibitor of apoptosis protein (xiap), b-cell lymphoma 2 (bcl-2), caspases -8, -9, -10 and -3, poly(adp-ribose) polymerase (parp), cleaved parp, igf1r, pi3k, akt, p-akt was determined by western blot analysis, in nimbolide-treated pc-3 cell line. |
2014-12-01 |
2023-08-12 |
Not clear |
| Dongfang Qiao, Jingtao Xu, Cuiyun Le, Enping Huang, Chao Liu, Pingming Qiu, Zhoumeng Lin, Wei-Bing Xie, Huijun Wan. Insulin-like growth factor binding protein 5 (IGFBP5) mediates methamphetamine-induced dopaminergic neuron apoptosis. Toxicology letters. vol 230. issue 3. 2014-11-28. PMID:25127757. |
we also checked the effect on neuronal apoptosis after silencing igfbp5 expression with tunel staining and flow cytometry; western blot was used for detecting the expression of apoptotic markers active-caspase3 and parp. |
2014-11-28 |
2023-08-13 |
rat |
| Lingjie Fu, Shulan Zhan. RASSF1A promotes apoptosis and suppresses the proliferation of ovarian cancer cells. International journal of molecular medicine. vol 33. issue 5. 2014-11-26. PMID:24573512. |
the morphology, structure, apoptosis and proliferation of differently treated skov-3 cells were then analyzed using a fluorescence microscope, transmission electron microscope, flow cytometer and by western blot analysis, respectively. |
2014-11-26 |
2023-08-12 |
rat |
| Dileep A K Vezzu, Qun Lu, Yan-Hua Chen, Shouquan Hu. Cytotoxicity of cyclometalated platinum complexes based on tridentate NCN and CNN-coordinating ligands: remarkable coordination dependence. Journal of inorganic biochemistry. vol 134. 2014-11-24. PMID:24531534. |
the possible pathways for the cell apoptosis were studied by western blot analysis and the activation of parp via caspase 7 was observed. |
2014-11-24 |
2023-08-12 |
human |
| Irene Riezzo, Emanuela Turillazzi, Stefania Bello, Santina Cantatore, Daniela Cerretani, Marco Di Paolo, Anna Ida Fiaschi, Paola Frati, Margherita Neri, Monica Pedretti, Vittorio Finesch. Chronic nandrolone administration promotes oxidative stress, induction of pro-inflammatory cytokine and TNF-α mediated apoptosis in the kidneys of CD1 treated mice. Toxicology and applied pharmacology. vol 280. issue 1. 2014-11-21. PMID:25065671. |
an immunohistochemical study and western blot analysis were performed to evaluate cell apoptosis and to measure the effects of renal expression of inflammatory mediators (il-1β, tnf-α) on the induction of apoptosis (hsp90, tunel). |
2014-11-21 |
2023-08-13 |
mouse |
| Qixin Bu, Xiaoyan Liu, Yuanjun Zhu, Ye Liu, Yinye Wan. w007B protects brain against ischemia-reperfusion injury in rats through inhibiting inflammation, apoptosis and autophagy. Brain research. vol 1558. 2014-11-18. PMID:24613402. |
to explore the underlying mechanisms, the expression level of apoptosis, inflammation and autophagy-related markers in brain tissue were detected with kits or by western blot. |
2014-11-18 |
2023-08-12 |
rat |
| Vivek Choudhary, Ismail Kaddour-Djebbar, Rabei Alaisami, M Vijay Kumar, Wendy B Bolla. Mitofusin 1 degradation is induced by a disruptor of mitochondrial calcium homeostasis, CGP37157: a role in apoptosis in prostate cancer cells. International journal of oncology. vol 44. issue 5. 2014-11-13. PMID:24626641. |
we used various prostate cancer cell lines and western blot analysis, qrt-pcr, sirna, m30 apoptosis assay and immunoprecipitation techniques to determine mechanisms regulating mfn1. |
2014-11-13 |
2023-08-12 |
Not clear |
| Mio Takagi, Yosuke Tachi, Jie Zhang, Takuro Shinozaki, Kenta Ishii, Takashi Kikuchi, Motohiko Ukiya, Norihiro Banno, Harukuni Tokuda, Toshihiro Akihis. Cytotoxic and melanogenesis-inhibitory activities of limonoids from the leaves of Azadirachta indica (Neem). Chemistry & biodiversity. vol 11. issue 3. 2014-11-12. PMID:24634075. |
western blot analysis suggested that compound 1 induced apoptosis via both the mitochondrial and death receptor-mediated pathways in hl60 cells. |
2014-11-12 |
2023-08-12 |
Not clear |
| Zhongyang Kou, Xin Wang, Renshun Yuan, Huabin Chen, Qiaoming Zhi, Ling Gao, Bin Wang, Zhaoji Guo, Xiaofeng Xue, Wei Cao, Liang Gu. A promising gene delivery system developed from PEGylated MoS2 nanosheets for gene therapy. Nanoscale research letters. vol 9. issue 1. 2014-11-11. PMID:25386104. |
through knockdown of plk1 with sirna carried by novel nanovector, qpcr and western blot were used to measure the interfering efficiency; apoptosis assay was used to detect the transfection effect of plk1. |
2014-11-11 |
2023-08-13 |
Not clear |
| Xiaobin Tan, Ping Jin, Liang Feng, Jie Song, E Sun, Wenbo Liu, Luan Shu, Xiaobin Ji. Protective effect of luteolin on cigarette smoke extract-induced cellular toxicity and apoptosis in normal human bronchial epithelial cells via the Nrf2 pathway. Oncology reports. vol 31. issue 4. 2014-10-28. PMID:24481824. |
cytometry assay and western blot analysis showed that luteolin attenuated cse-induced apoptosis and apoptosis‑related protein activation, including caspase‑3, -8 and -9 (p<0.05). |
2014-10-28 |
2023-08-12 |
human |
| David S Pisetsk. The expression of HMGB1 on microparticles released during cell activation and cell death in vitro and in vivo. Molecular medicine (Cambridge, Mass.). vol 20. 2014-10-28. PMID:24618884. |
evidence for the physical association of hmgb1 comes from western blot analysis of microparticles derived from raw 264.7 macrophage cells stimulated by lipopolysaccharide (lps) or induced to undergo apoptosis by treatment with etoposide or staurosporine in vitro. |
2014-10-28 |
2023-08-12 |
human |
| Ke Sai, Wen-Yu Li, Yin-Sheng Chen, Jian Wang, Su Guan, Qun-Ying Yang, Cheng-Cheng Guo, Yong-Gao Mou, Wei-Ping Li, Zhong-Ping Che. Triptolide synergistically enhances temozolomide-induced apoptosis and potentiates inhibition of NF-κB signaling in glioma initiating cells. The American journal of Chinese medicine. vol 42. issue 2. 2014-10-28. PMID:24707876. |
apoptosis was assessed with flow cytometry and western blot. |
2014-10-28 |
2023-08-13 |
Not clear |
| Ji-Hong Xu, Tie-Zheng Zhang, Yan-Yan Zhao, Jun-Ke Wang, Zhi-Guo Yua. Protective effects of recombinant human bone morphogenetic protein-7 on focal cerebral ischemia-reperfusion injury. The International journal of neuroscience. vol 123. issue 6. 2014-10-24. PMID:23327662. |
apoptosis was detected using terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling assays, and immunohistochemical staining and western blot assays were used to detect nuclear nuclear factor-kappa b (nf-κb) p65 expression. |
2014-10-24 |
2023-08-12 |
human |
| Kanjoormana A Manu, Muthu K Shanmugam, Feng Li, Luxi Chen, Kodappully Sivaraman Siveen, Kwang Seok Ahn, Alan Prem Kumar, Gautam Seth. Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products. Journal of molecular medicine (Berlin, Germany). vol 92. issue 3. 2014-10-23. PMID:24233024. |
the effect of simvastatin on the proliferation of gastric cancer cells was examined by mitochondrial dye-uptake 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method, apoptosis by esterase staining, nf-κb activation by dna binding assay, and protein expression by western blot analysis. |
2014-10-23 |
2023-08-12 |
mouse |
| S U Kang, J-H Cho, J W Chang, Y S Shin, K I Kim, J K Park, S S Yang, J-S Lee, E Moon, K Lee, C-H Ki. Nonthermal plasma induces head and neck cancer cell death: the potential involvement of mitogen-activated protein kinase-dependent mitochondrial reactive oxygen species. Cell death & disease. vol 5. 2014-10-21. PMID:24525732. |
the effects of ntp on apoptosis were investigated using mtt, terminal deoxynucleotidyl transferase-mediated dutp-biotin nick-end labeling, annexin v assays, and western blot analysis. |
2014-10-21 |
2023-08-12 |
mouse |
| Isuru Wijesekara, Chen Zhang, Quang Van Ta, Thanh-Sang Vo, Yong-Xin Li, Se-Kwon Ki. Physcion from marine-derived fungus Microsporum sp. induces apoptosis in human cervical carcinoma HeLa cells. Microbiological research. vol 169. issue 4. 2014-10-15. PMID:24071573. |
the western blot analysis has revealed that physcion could significantly induce cell apoptosis through down-regulating of bcl-2 expression, up-regulating of bax expression, and activating the caspase-3 pathway. |
2014-10-15 |
2023-08-12 |
human |