| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Koichi Shoji, Jun Teishima, Tetsutaro Hayashi, Shinya Ohara, Wallace L Mckeehan, Akio Matsubar. Restoration of fibroblast growth factor receptor 2IIIb enhances the chemosensitivity of human prostate cancer cells. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24839986. |
the effects of chemotherapeutic agents (docetaxel, cisplatin, 5-fluorouracil and zoledronic acid) on cell viability and apoptosis were examined by mtt assay and western blot analysis, respectively. |
2015-01-14 |
2023-08-13 |
human |
| Ai-Ling Liang, Ting-Ting Zhang, Ning Zhou, Di-Nan Huang, Xin-Guang Liu, Yong-Jun Liu, Zhi-Guang T. Fused polypeptide with DEF induces apoptosis of lung adenocarcinoma cells. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 12. 2015-01-06. PMID:24460299. |
western blot analyses indicated that the polypeptide inhibition of tumor cell growth was apoptosis dependent. |
2015-01-06 |
2023-08-12 |
human |
| Yong Peng, Zhan-Zhao Fu, Cong-Shan Guo, Yan-Xia Zhang, Ya Di, Bin Jiang, Qing-Wang L. Effects and Mechanism of Baicalin on Apoptosis of Cervical Cancer HeLa Cells I n -v itro. Iranian journal of pharmaceutical research : IJPR. vol 14. issue 1. 2015-01-06. PMID:25561931. |
moreover, western blot was used for investigating the expression of apoptosis related proteins; spectrophotometry was used to examine caspase-3 activation. |
2015-01-06 |
2023-08-13 |
human |
| Lisa Lange, Sarah Keppner-Witter, Juline Grigat, Birgit Spänkuc. Combinatorial inhibition of Plk1 and PKCβ in cancer cells with different p53 status. Oncotarget. vol 5. issue 8. 2015-01-05. PMID:24810255. |
we analyzed cell proliferation and apoptosis induction, and did western blot and facscan analyses to examine the combined pkcβ and plk1 inhibition. |
2015-01-05 |
2023-08-13 |
Not clear |
| G G Sun, Y D Wang, Y J Cheng, W N H. BTG1 underexpression is an independent prognostic marker in esophageal squamous cell carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 10. 2015-01-05. PMID:24969561. |
the expression of proteins involved in cell cycle regulation (cyclin d1) and apoptosis (bcl-2) and cell migration (mmp-9) in lebtg1 cells was analyzed by western blot. |
2015-01-05 |
2023-08-13 |
human |
| Zhenchang Sun, Kai Huang, Xiaorui Fu, Zhiyuan Zhou, Yingying Cui, Haopeng L. A chemically sulfated polysaccharide derived from Ganoderma lucidum induces mitochondrial-mediated apoptosis in human osteosarcoma MG63 cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 10. 2015-01-05. PMID:24997619. |
western blot analysis identified that scglp1-induced apoptosis was associated with an increased protein expression of proapoptotic bax and bad, decreased expression of antiapoptotic bcl-2 and bcl-xl, loss of mitochondrial membrane potential (Δψm), the release of mitochondrial cytochrome c to cytosol, and cleavage of caspase-9, caspase-3, and poly(adp-ribose) polymerase (parp). |
2015-01-05 |
2023-08-13 |
human |
| Somnath Kandekar, Ranjan Preet, Maneesh Kashyap, M U Renu Prasad, Purusottam Mohapatra, Dipon Das, Shakti Ranjan Satapathy, Sumit Siddharth, Vaibhav Jain, Maitrayee Choudhuri, Chanakya N Kundu, Sankar K Guchhait, Prasad V Bharata. Structural elaboration of a natural product: identification of 3,3'-diindolylmethane aminophosphonate and urea derivatives as potent anticancer agents. ChemMedChem. vol 8. issue 11. 2014-12-29. PMID:23983049. |
biophysical and immunological studies, including dapi nuclear staining, western blot analysis with apoptotic protein markers, flow cytometry, immunocytochemistry, and comet assays of the two most potent compounds revealed good efficacies in apoptosis and dna damage. |
2014-12-29 |
2023-08-12 |
Not clear |
| Zhaohui Pei, Zhiqiang Zhuang, Hanfei Sang, Zhenbiao Wu, Rongsen Meng, Emily Y He, Glenda I Scott, Jackie R Maris, Ruiman Li, Jun Re. α,β-Unsaturated aldehyde crotonaldehyde triggers cardiomyocyte contractile dysfunction: role of TRPV1 and mitochondrial function. Pharmacological research. vol 82. 2014-12-29. PMID:24705155. |
apoptosis and trpv1 were evaluated using western blot analysis. |
2014-12-29 |
2023-08-13 |
Not clear |
| Liu Ying, Zhu Zu-An, Liu Qing-Hua, Kong Qing-Yan, Liu Lei, Cui Tao, Wu Yong-Pin. RAD001 can reverse drug resistance of SGC7901/DDP cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 9. 2014-12-29. PMID:24920069. |
to investigate the role of rad001 in the reversing of drug resistance of sgc7901/ddp, we cultured sgc7901/ddp cells with different groups of drugs (rad001, cisplatin (ddp) alone, or the combination of rad001 and ddp); after that, we detected the drug sensitivity, cell apoptosis, and levels of p-gp, mrp1, and survivin in the cells of sgc7901/ddp by mtt (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphe-nyltetrazolium bromide) assay, flow cytometry, immunohistochemical analysis, and western blot analysis. |
2014-12-29 |
2023-08-13 |
Not clear |
| Ma Ma Lay, Saiful Anuar Karsani, Sri Nurestri Abd Male. Induction of apoptosis of 2,4',6-trihydroxybenzophenone in HT-29 colon carcinoma cell line. BioMed research international. vol 2014. 2014-12-24. PMID:24579081. |
western blot revealed an upregulation of puma, bak, bcl-2, and mcl-1 proteins suggesting that the compound induced apoptosis in ht-29 cells by regulating these proteins. |
2014-12-24 |
2023-08-12 |
human |
| Fangjing Chen, Li Zhang, Yueping OuYang, Huapeng Guan, Qi Liu, Bin N. Glucocorticoid induced osteoblast apoptosis by increasing E4BP4 expression via up-regulation of Bim. Calcified tissue international. vol 94. issue 6. 2014-12-23. PMID:24658772. |
western blot, reverse-transcription-pcr, flow cytometry, and hoechst 33258 staining were employed to investigate the role of e4bp4 in dexamethasone (dex)-induced osteoblast apoptosis. |
2014-12-23 |
2023-08-12 |
Not clear |
| Virginie Dubois, Thierry Jardé, Laetitia Delort, Hermine Billard, Dominique Bernard-Gallon, Emmanuelle Berger, Alain Geloen, Marie-Paule Vasson, Florence Caldefie-Cheze. Leptin induces a proliferative response in breast cancer cells but not in normal breast cells. Nutrition and cancer. vol 66. issue 4. 2014-12-22. PMID:24738610. |
expressions of leptin and ob-r were analyzed using qrt-pcr and immunohistochemistry, proliferation using fluorimetric resazurin reduction test and xcelligence system, apoptosis and cell cycle by flow cytometry, and effect of leptin on different signalling pathways using qrt-pcr and western blot. |
2014-12-22 |
2023-08-13 |
Not clear |
| L Zong, Q H Yu, Y X Du, X M Den. Edaravone protects endotoxin-induced liver injury by inhibiting apoptosis and reducing proinflammatory cytokines. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 47. issue 3. 2014-12-19. PMID:24554039. |
hepatocyte apoptosis was measured by tunel staining; proinflammatory cytokines [tumor necrosis factor-α (tnf-α) and interleukin-6 (il-6)] in the liver were assayed by elisa; expression of caspase-8 and caspase-3 proteins was detected by western blot assay; and caspase-3 activity was also determined. |
2014-12-19 |
2023-08-12 |
mouse |
| Ling-Fei Wu, Yi-Tian Guo, Qing-Hua Zhang, Meng-Qi Xiang, Wei Deng, Yan-Qing Ye, Ze-Jin Pu, Jia-Lin Feng, Guan-You Huan. Enhanced antitumor effects of adenoviral-mediated siRNA against GRP78 gene on adenosine-induced apoptosis in human hepatoma HepG2 cells. International journal of molecular sciences. vol 15. issue 1. 2014-12-18. PMID:24394318. |
effects of knockdown of grp78 on adenosine-induced cell viabilities, cell-cycle distribution and apoptosis, as well as relative protein expressions were determined by flow cytometry and/or western blot analysis. |
2014-12-18 |
2023-08-12 |
human |
| Min Chul Kim, Hee Jung Lee, Bora Lim, Ki-Tae Ha, Sung Young Kim, Insuk So, Byung Joo Ki. Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells. International journal of molecular medicine. vol 33. issue 6. 2014-12-18. PMID:24647664. |
to investigate the signaling pathway of quercetin-induced apoptosis in the ags cells, western blot analysis and mtt assay were performed. |
2014-12-18 |
2023-08-12 |
human |
| Nelson Ferreira, Alda Pereira-Henriques, Aida Attar, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan, Luís Gales, Maria João Saraiva, Maria Rosário Almeid. Molecular tweezers targeting transthyretin amyloidosis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 11. issue 2. 2014-12-16. PMID:24459092. |
immunohistochemical and western blot analyses showed a significant decrease in ttr burden in the gastrointestinal tract and the peripheral nervous system in mice treated with clr01, with a concomitant reduction in aggregate-induced endoplasmic reticulum stress response, protein oxidation, and apoptosis. |
2014-12-16 |
2023-08-12 |
mouse |
| Rasoul Ghasemi, Asadollah Zarifkar, Karim Rastegar, Nader Maghsoudi, Maryam Moosav. Repeated intra-hippocampal injection of beta-amyloid 25–35 induces a reproducible impairment of learning and memory: considering caspase-3 and MAPKs activity. European journal of pharmacology. vol 726. 2014-12-15. PMID:24418687. |
hippocampal western blot analysis revealed that behavioral impairment is in parallel with greater apoptosis and mapks activation. |
2014-12-15 |
2023-08-12 |
rat |
| Huanlong Liu, Xueyan Chen, Yu Han, Chaoyi Li, Pingping Chen, Suwen Su, Yongjian Zhang, Zhenhua Pa. Rho kinase inhibition by fasudil suppresses lipopolysaccharide-induced apoptosis of rat pulmonary microvascular endothelial cells via JNK and p38 MAPK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 68. issue 3. 2014-12-12. PMID:24406296. |
the results suggested that fasudil effectively prevented lps-induced injury of rat pmvecs, as determined by mtt assay, ldh activity assay, apoptosis and western blot analysis of apoptosis-related proteins bcl-2 and bax. |
2014-12-12 |
2023-08-12 |
rat |
| D Feng, W Wang, Y Dong, L Wu, J Huang, Y Ma, Z Zhang, S Wu, G Gao, H Qi. Ceftriaxone alleviates early brain injury after subarachnoid hemorrhage by increasing excitatory amino acid transporter 2 expression via the PI3K/Akt/NF-κB signaling pathway. Neuroscience. vol 268. 2014-12-12. PMID:24631672. |
terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling assay (tunel) staining and western blot analysis of cleaved caspase 3 showed that cef decreased hippocampal neuronal apoptosis following sah. |
2014-12-12 |
2023-08-12 |
rat |
| Li-Li Shi, Hua-Chao Zhu, Mei Zhang, Yang-Feng Liu, Yuan Wang, Jing Zhao, Fei Lei, Peng-Cheng H. [Effect of realgar on induction of apoptosis in DLBCL cell line SU-DHL-4 and its possible mechanisms]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 3. 2014-12-11. PMID:24989285. |
western blot showed that the expression of bcl-2 protein was down-regulated while the expressions of bax and caspase-3 protein were up-regulated when treating su-dhl-4 cells with realgar for 48 h. it is concluded that realgar can inhibit cell growth and induce cell apoptosis, which may be related with up-regulation of caspase-3 and bax expression and down-regulation the of bcl-2 expression. |
2014-12-11 |
2023-08-13 |
Not clear |