| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Zhang, Xiao-Hong Fu, Yong Yu, Ruo-Hong Shui, Chun Li, Hai-Ying Zeng, Yu-Lei Qiao, Li-Yan Ni, Qiang Wan. Treatment with CA-074Me, a Cathepsin B inhibitor, reduces lung interstitial inflammation and fibrosis in a rat model of polymyositis. Laboratory investigation; a journal of technical methods and pathology. vol 95. issue 1. 2015-03-02. PMID:25384123. |
inflammation, fibrosis and apoptosis cells, and cytokines were assessed by histological examinations and immunohistochemical analyses, western blot analysis and transferase-mediated dutp nick-end labeling assay. |
2015-03-02 |
2023-08-13 |
rat |
| Miroslav Barancik, Viera Bohacova, Lenka Gibalova, Jan Sedlak, Zdena Sulova, Albert Breie. Potentiation of anticancer drugs: effects of pentoxifylline on neoplastic cells. International journal of molecular sciences. vol 13. issue 1. 2015-02-26. PMID:22312258. |
the effects of ptx on the sensitization of l1210/vcr cells to vcr correlate with the stimulation of apoptosis detected by annexin v/propidium iodide apoptosis necrosis kit and proteolytic activation of both caspase-3 and caspase-9 monitored by western blot analysis. |
2015-02-26 |
2023-08-12 |
mouse |
| Xiuwei Wang, Jianhua Wang, Tao Guan, Qian Xiang, Mingsheng Wang, Zhen Guan, Guannan Li, Zhiqiang Zhu, Qiu Xie, Ting Zhang, Bo Ni. Role of methotrexate exposure in apoptosis and proliferation during early neurulation. Journal of applied toxicology : JAT. vol 34. issue 8. 2015-02-26. PMID:23836430. |
tunel, immunohistochemical assays and western blot were further used to detect apoptosis and proliferation in the ntd animal model. |
2015-02-26 |
2023-08-12 |
mouse |
| Bo Huang, Yi-Sheng Lu, Xia Li, Zhi-Chuan Zhu, Kui Li, Ji-Wei Liu, Jing Zheng, Ze-Lan H. Androglobin knockdown inhibits growth of glioma cell lines. International journal of clinical and experimental pathology. vol 7. issue 5. 2015-02-23. PMID:24966926. |
in addition, western blot showed that adgb knockdown altered levels of several proteins related to proliferation, survival or apoptosis in u251 cells. |
2015-02-23 |
2023-08-13 |
Not clear |
| Ramadevi Subramani, Rebecca Lopez-Valdez, Alyssa Salcido, Thiyagarajan Boopalan, Arunkumar Arumugam, Sushmita Nandy, Rajkumar Lakshmanaswam. Growth hormone receptor inhibition decreases the growth and metastasis of pancreatic ductal adenocarcinoma. Experimental & molecular medicine. vol 46. 2015-02-20. PMID:25301264. |
flow cytometric and western blot analyses revealed the induction of apoptosis in ghr silenced cells. |
2015-02-20 |
2023-08-13 |
Not clear |
| Xi Yu, Boxing Su, Peng Ge, Zicheng Wang, Sen Li, Bingwei Huang, Yanqing Gong, Jian Li. Human adipose derived stem cells induced cell apoptosis and s phase arrest in bladder tumor. Stem cells international. vol 2015. 2015-02-18. PMID:25691904. |
western blot revealed adsc-cm increased the expression of cleaved caspase-3 and cleaved parp, indicating that adsc-cm induced apoptosis in a caspase-dependent way. |
2015-02-18 |
2023-08-13 |
human |
| Maryam Moosavi, Amir Hossein Zarifkar, Yaghoub Farbood, Mahin Dianat, Alireza Sarkaki, Rasoul Ghasem. Agmatine protects against intracerebroventricular streptozotocin-induced water maze memory deficit, hippocampal apoptosis and Akt/GSK3β signaling disruption. European journal of pharmacology. vol 736. 2015-02-13. PMID:24769303. |
after complement of behavioral studies the hippocampi was isolated and the amounts of hippocampal cleaved caspase-3 (the landmark of apoptosis), bax/bcl-2 ratio, total and phosphorylated forms of gsk-3β and akt were analyzed by western blot. |
2015-02-13 |
2023-08-13 |
rat |
| Min Wu, Yuan Yuan, Yue-Yin Pan, Ying Zhan. Combined gefitinib and pemetrexed overcome the acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Molecular medicine reports. vol 10. issue 2. 2015-02-12. PMID:24840891. |
cell cycle distribution and apoptosis were analyzed by flow cytometry and alterations in signaling pathways were determined by western blot analysis. |
2015-02-12 |
2023-08-13 |
human |
| Shun-Quan Wu, Zhen-Zhen Xu, Wen-Yan Niu, Hao-Bo Huang, Rong Zha. ShRNA-mediated Bmi-1 silencing sensitizes multiple myeloma cells to bortezomib. International journal of molecular medicine. vol 34. issue 2. 2015-02-12. PMID:24913180. |
cell cycle progression and apoptosis were analyzed by flow cytometry (fcm), and the mrna and protein expression of associated genes (bmi-1, p14, p21, bcl-2 and bax) was quantified by rt-qpcr and western blot analysis, respectively. |
2015-02-12 |
2023-08-13 |
human |
| Hao Wu, Devora S Schiff, Yong Lin, Hanmanth J R Neboori, Sharad Goyal, Zhaohui Feng, Bruce G Hafft. Ionizing radiation sensitizes breast cancer cells to Bcl-2 inhibitor, ABT-737, through regulating Mcl-1. Radiation research. vol 182. issue 6. 2015-02-12. PMID:25409124. |
apoptosis was identified by fitc annexin v, pi staining and western blot analysis. |
2015-02-12 |
2023-08-13 |
mouse |
| Qingyong Li, Tianyu Liu, Yunchao Li, Shuyue Luo, Qiaochu Zhu, Li Zhang, Tengfei Zha. Transport and killing mechanism of a novel camptothecin-deoxycholic acid derivate on hepatocellular carcinoma cells. Journal of drug targeting. vol 22. issue 6. 2015-02-04. PMID:24725118. |
in addition, according to the western blot and apoptosis assays, we found that a2 killed smmc-7721 cells by inducing cell apoptosis mainly via an aif (apoptosis-inducing factor) pathway and a caspase-dependent mitochondria apoptosis pathway. |
2015-02-04 |
2023-08-13 |
Not clear |
| Jiying Jiang, Shuna Yu, Zhengchen Jiang, Cuihong Liang, Wenbo Yu, Jin Li, Xiaodong Du, Hailiang Wang, Xianghong Gao, Xin Wan. N-acetyl-serotonin protects HepG2 cells from oxidative stress injury induced by hydrogen peroxide. Oxidative medicine and cellular longevity. vol 2014. 2015-02-04. PMID:25013541. |
to determine whether pretreatment with nas could reduce hydrogen peroxide- (h2o2-) induced oxidative stress in hepg2 cells by inhibiting the mitochondrial apoptosis pathway, we investigated the h2o2-induced oxidative damage to hepg2 cells with or without nas using mtt, hoechst 33342, rhodamine 123, terminal dutp nick end labeling assay (tunel), dihydrodichlorofluorescein (h2dcf), annexin v and propidium iodide (pi) double staining, immunocytochemistry, and western blot. |
2015-02-04 |
2023-08-13 |
Not clear |
| Xiaonan Lv, Peng Wang, Ru Bai, Yingying Cong, Siqingaowa Suo, Xiaofeng Ren, Chunying Che. Inhibitory effect of silver nanomaterials on transmissible virus-induced host cell infections. Biomaterials. vol 35. issue 13. 2015-02-02. PMID:24524838. |
tgev infection induced the occurring of apoptosis in swine testicle (st) cells, down-regulated the expression of bcl-2, up-regulated the expression of bax, altered mitochondrial membrane potential, activated p38 mapk signal pathway, and increased expression of p53 as evidenced by immunofluorescence assays, real-time pcr, flow cytometry and western blot. |
2015-02-02 |
2023-08-12 |
Not clear |
| Hairong Xu, Yanhong Zhou, Kathleen A Coughlan, Ye Ding, Shaobin Wang, Yue Wu, Ping Song, Ming-Hui Zo. AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts. Biochimica et biophysica acta. vol 1853. issue 1. 2015-01-29. PMID:25307521. |
the markers for dna damage, cell cycle proteins, and apoptosis were monitored in cultured mouse embryonic fibroblasts (mefs) isolated from wild type (wt, c57bl/6j), ampkα1, or ampkα2 homozygous deficient (ampkα1(-/-), ampkα2(-/-)) mice by western blot, flow cytometry, and cellular immunofluorescence staining. |
2015-01-29 |
2023-08-13 |
mouse |
| Wu Hui, Chen Kuisheng, Zhang Hongxin, Ding Yanzhi, Zhao Zhihua, Zhang H. Influence of smoothened siRNA on human esophageal cancer cell line EC9706 proliferation and apoptosis. Pakistan journal of pharmaceutical sciences. vol 27. issue 5 Suppl. 2015-01-22. PMID:25262515. |
utilizing smosirna transfected esophageal squamous carcinoma ec9706 cells, adopting rt-pcr and western blot technology to detect smo, gli1 mrna and protein expression in each group of cells, employing mtt and fcm to detect the influence of smosirna on cell proliferation and apoptosis. |
2015-01-22 |
2023-08-13 |
human |
| Minyong Kang, Chang Wook Jeong, Ja Hyeon Ku, Choel Kwak, Hyeon Hoe Ki. Inhibition of autophagy potentiates atorvastatin-induced apoptotic cell death in human bladder cancer cells in vitro. International journal of molecular sciences. vol 15. issue 5. 2015-01-16. PMID:24815071. |
we examined apoptosis by flow cytometry using annexin-v/propidium iodide (pi and western blot using procaspase-3 and poly (adp-ribose) polymerase (parp) antibodies. |
2015-01-16 |
2023-08-13 |
human |
| Raniere Fagundes Melo-Silveira, Gabriel Pereira Fidelis, Rony Lucas Silva Viana, Vinícius Campelo Soeiro, Rodrigo Augusto da Silva, Daisy Machado, Leandro Silva Costa, Carmen Veríssima Ferreira, Hugo Alexandre Oliveira Roch. Antioxidant and antiproliferative activities of methanolic extract from a neglected agricultural product: corn cobs. Molecules (Basel, Switzerland). vol 19. issue 4. 2015-01-16. PMID:24879583. |
furthermore, its antiproliferative property against tumor cells was assessed through mtt assays and proteins related to apoptosis in tumor cells were examined by western blot. |
2015-01-16 |
2023-08-13 |
cat |
| Ling-Li Liu, Li-Sheng He, Ying Xu, Zhuang Han, Yong-Xin Li, Jia-Liang Zhong, Xian-Rong Guo, Xi-Xiang Zhang, Kam Ming Ko, Pei-Yuan Qia. Caspase-3-dependent apoptosis of citreamicin ε-induced HeLa cells is associated with reactive oxygen species generation. Chemical research in toxicology. vol 26. issue 7. 2015-01-15. PMID:23745985. |
the terminal deoxynucleotidyl transferase dutp nick-end labeling assay confirmed that citreamicin ε a (1) induced cellular apoptosis, and western blot analysis showed that apoptosis occurred via activation of caspase-3. |
2015-01-15 |
2023-08-12 |
Not clear |
| Te-Chun Hsia, Chien-Chih Yu, Shu-Chun Hsu, Nou-Ying Tang, Hsu-Feng Lu, Yi-Ping Huang, Shin-Hwar Wu, Jaung-Geng Lin, Jing-Gung Chun. Cantharidin induces apoptosis of H460 human lung cancer cells through mitochondria-dependent pathways. International journal of oncology. vol 45. issue 1. 2015-01-15. PMID:24818581. |
western blot analysis was used to examine the changes of apoptosis associated protein expression and confocal microscopy for examining the translocation apoptosis associated protein. |
2015-01-15 |
2023-08-13 |
human |
| Jia Song, Jixiang Zhang, Jing Wang, Zhuo Cao, Jun Wang, Xufeng Guo, Weiguo Don. β1 integrin modulates tumor growth and apoptosis of human colorectal cancer. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24807392. |
proliferation and apoptosis were evaluated by colony formation assay, flow cytometry and western blot analysis. |
2015-01-14 |
2023-08-13 |
mouse |