| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shu Han, Fan Zhang, Zhiying Hu, Yayi Sun, Jing Yang, Henry Davies, David T W Yew, Marong Fan. Dose-dependent anti-inflammatory and neuroprotective effects of an ανβ3 integrin-binding peptide. Mediators of inflammation. vol 2013. 2014-10-14. PMID:24347822. |
multiple histological and immunohistochemical staining, electron microscopy observation, elisa assay, western blot, and magnetic resonance imaging (mri) were employed to assess the degree of inflammation, axonal loss, neuronal apoptosis, white matter demyelination, and extent of gliosis in the brain and spinal cord of differently treated eae models. |
2014-10-14 |
2023-08-12 |
rat |
| Abdelkader Daoud, Jing Song, Feiyang Xiao, Jing Shan. B-9-3, a novel β-carboline derivative exhibits anti-cancer activity via induction of apoptosis and inhibition of cell migration in vitro. European journal of pharmacology. vol 724. 2014-10-14. PMID:24380828. |
this pattern includes a dose-dependent induction of apoptosis, or necroptosis as confirmed by hoechst staining, flow cytometry and western blot analyses, and the inhibition of cancer cells migration that was shown to be dependent on the drug׳s concentration as well. |
2014-10-14 |
2023-08-12 |
human |
| Sang-Man Jin, Hye Won Jang, Seo Young Sohn, Na Kyung Kim, Ji Young Joung, Yoon Young Cho, Sun Wook Kim, Jae Hoon Chun. Role of autophagy in the resistance to tumour necrosis factor-related apoptosis-inducing ligand-induced apoptosis in papillary and anaplastic thyroid cancer cells. Endocrine. vol 45. issue 2. 2014-10-09. PMID:23821365. |
levels of autophagy and apoptosis were confirmed by western blot of atg7, lc3, caspase-3 and poly (adp-ribose) polymerase. |
2014-10-09 |
2023-08-12 |
human |
| Gongbo Li, Sakina M Petiwala, Dana R Pierce, Larisa Nonn, Jeremy J Johnso. Selective modulation of endoplasmic reticulum stress markers in prostate cancer cells by a standardized mangosteen fruit extract. PloS one. vol 8. issue 12. 2014-10-08. PMID:24367485. |
flow cytometry, mtt, brdu and western blot were used to evaluate cell apoptosis, viability, proliferation and er stress. |
2014-10-08 |
2023-08-12 |
mouse |
| Paranthaman Thiyagarajan, Krishnamurthy Kavitha, Avaneesh Thautam, Madhulika Dixit, Siddavaram Nagin. Dietary chlorophyllin abrogates TGFβ signaling to modulate the hallmark capabilities of cancer in an animal model of forestomach carcinogenesis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 7. 2014-10-06. PMID:24715303. |
we determined the effect of dietary chlorophyllin on tgfβ signaling and the downstream events-cell proliferation, apoptosis evasion, angiogenesis, invasion, and metastasis by semiquantitative and quantitative reverse transcription (rt)-pcr, western blot, and immunohistochemical analyses. |
2014-10-06 |
2023-08-13 |
rat |
| S-H Huang, M-H Hsu, S-C Hsu, J-S Yang, W-W Huang, A-C Huang, Y-P Hsiao, C-C Yu, J-G Chun. Phenethyl isothiocyanate triggers apoptosis in human malignant melanoma A375.S2 cells through reactive oxygen species and the mitochondria-dependent pathways. Human & experimental toxicology. vol 33. issue 3. 2014-09-30. PMID:23760257. |
western blot analysis showed that peitc promoted bax expression and inhibited bcl-2 expression associated with the disintegration of the outer mitochondrial membrane causing cytochrome c release, and activation of caspase-9 and -3 cascade leading to apoptosis. |
2014-09-30 |
2023-08-12 |
human |
| Jin Wang, Jianjun Chen, Duane D Miller, Wei L. Synergistic combination of novel tubulin inhibitor ABI-274 and vemurafenib overcome vemurafenib acquired resistance in BRAFV600E melanoma. Molecular cancer therapeutics. vol 13. issue 1. 2014-09-29. PMID:24249714. |
western blot analysis revealed that the combination treatment effectively reduced the level of phosphorylated and total akt, activated the apoptosis cascade, and increased cleaved caspase-3 and cleaved parp, but had no significant influence on the level of extracellular signal-regulated kinase (erk) phosphorylation. |
2014-09-29 |
2023-08-12 |
mouse |
| Ting Xia, Jian-Cheng Wang, Wei Xu, Lu-Hong Xu, Chong-Hui Lao, Qi-Xiang Ye, Jian-Pei Fan. 20S-Ginsenoside Rh2 induces apoptosis in human Leukaemia Reh cells through mitochondrial signaling pathways. Biological & pharmaceutical bulletin. vol 37. issue 2. 2014-09-29. PMID:24492721. |
activation of caspases associated with the mitochondria-mediated apoptosis pathway was determined by western blot. |
2014-09-29 |
2023-08-12 |
human |
| Yong Zhuang, Dong Li, Jinqiu Fu, Qing Shi, Yuanyuan Lu, Xiuli J. Overexpression of AIOLOS inhibits cell proliferation and suppresses apoptosis in Nalm-6 cells. Oncology reports. vol 31. issue 3. 2014-09-26. PMID:24399134. |
moreover, the expression levels of genes associated with apoptosis and the cell cycle, as well as the transcription factors ikzf1 and nf-κb, were investigated by quantitative reverse transcription-polymerase chain reaction and western blot analysis. |
2014-09-26 |
2023-08-12 |
human |
| Qichao Xie, Yupeng Yang, Zhiyi Wang, Fanglin Chen, Anmei Zhang, Chengcheng Li. Resveratrol-4-O-D-(2'-galloyl)-glucopyranoside isolated from Polygonum cuspidatum exhibits anti-hepatocellular carcinoma viability by inducing apoptosis via the JNK and ERK pathway. Molecules (Basel, Switzerland). vol 19. issue 2. 2014-09-26. PMID:24473215. |
furthermore, our results demonstrated that resg could induce smmc-7721 cell apoptosis and activate caspases 3 and caspases 9 by using annexin v-fitc staining and western blot, respectively. |
2014-09-26 |
2023-08-12 |
mouse |
| Yun-Ping Hu, Zhu-Jun Tan, Xiang-Song Wu, Tian-Yu Liu, Lin Jiang, Run-Fa Bao, Yi-Jun Shu, Mao-Lan Li, Hao Weng, Qian Ding, Feng Tao, Ying-Bin Li. Triptolide induces s phase arrest and apoptosis in gallbladder cancer cells. Molecules (Basel, Switzerland). vol 19. issue 2. 2014-09-26. PMID:24566325. |
finally, western blot analysis of triptolide-treated cells revealed the activation of caspase-3, caspase-9, parp, and bcl-2; this result demonstrated that triptolide induced apoptosis in gallbladder cancer cells by regulating apoptosis-related protein expression, and suggests that triptolide may be a promising drug to treat gallbladder carcinoma. |
2014-09-26 |
2023-08-12 |
Not clear |
| Wenhui Hao, Xuenong Zhang, Wenwen Zhao, Xiuping Che. Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells. PeerJ. vol 2. 2014-09-24. PMID:25250213. |
apoptosis was detected with hoechst 33342 staining by fluorescence microscopy, annexin v-fitc by flow cytometry and western blot analysis for apoptosis-related proteins. |
2014-09-24 |
2023-08-13 |
human |
| Tinghong Ye, Xiawei Wei, Tao Yin, Yong Xia, Deliang Li, Bin Shao, Xuejiao Song, Sisi He, Min Luo, Xiang Gao, Zhiyao He, Can Luo, Ying Xiong, Ningyu Wang, Jun Zeng, Lifeng Zhao, Guobo Shen, Yongmei Xie, Luoting Yu, Yuquan We. Inhibition of FGFR signaling by PD173074 improves antitumor immunity and impairs breast cancer metastasis. Breast cancer research and treatment. vol 143. issue 3. 2014-09-19. PMID:24398778. |
western blot demonstrated that pd173074-induced apoptosis was correlated with the inhibition of mcl-1 and survivin. |
2014-09-19 |
2023-08-12 |
mouse |
| Guiru Ren, Jingjing Kong, Ning Jia, Xiuli Shan. Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats. Neural regeneration research. vol 8. issue 12. 2014-09-10. PMID:25206401. |
further western blot analysis revealed that luteolin treatment facilitated neuronal cell survival through activation of the phosphatidylinositol 3-kinase/akt signaling pathway, an extracellular signal pathway involved in the suppression of cell apoptosis and promotion of cell survival. |
2014-09-10 |
2023-08-13 |
rat |
| Ting Zou, Xiangqi Tang, Zhiling Huang, Niangui Xu, Zhiping H. The Pael-R gene does not mediate the changes in rotenone-induced Parkinson's disease model cells. Neural regeneration research. vol 9. issue 4. 2014-09-10. PMID:25206827. |
the results of reverse-transcription polymerase chain reaction and western blot analysis showed that pael-r expression was decreased after rna interference compared with the control group (no treatment) and the model group (rotenone treatment), while the rate of apoptosis and survival of dopaminergic cells did not differ significantly between groups, as detected by flow cytometry and an mtt assay. |
2014-09-10 |
2023-08-13 |
Not clear |
| Chun-Lei Liu, Yun-Yun He, Xin Li, Rui-Jun Li, Kun-Lun He, Li-Li Wan. Inhibition of serine/threonine protein phosphatase PP1 protects cardiomyocytes from tunicamycin-induced apoptosis and I/R through the upregulation of p-eIF2α. International journal of molecular medicine. vol 33. issue 3. 2014-09-09. PMID:24366244. |
western blot analysis revealed that pp1-12 induced eif2α phosphorylation and immuncytochemistry indicated that pp1-12 downregulated the expression of c/ebp homologous protein (chop), which is related to apoptosis. |
2014-09-09 |
2023-08-12 |
rat |
| Pradip De, Yuling Sun, Jennifer H Carlson, Lori S Friedman, Brian R Leyland-Jones, Nandini De. Doubling down on the PI3K-AKT-mTOR pathway enhances the antitumor efficacy of PARP inhibitor in triple negative breast cancer model beyond BRCA-ness. Neoplasia (New York, N.Y.). vol 16. issue 1. 2014-09-09. PMID:24563619. |
mechanism-based in vitro studies demonstrated that gdc-0980 treatment alone or in combination led to dna damage (increased pγh2ax(s139); western blot, immunofluorescence), gain in poly adp-ribose (par), and a subsequent sensitization of brca-competent tnbc cells to abt888 plus carboplatin with a time-dependent 1) decrease in proliferation signals (paktt308/s473, pp70s6kt421/s424, ps6rps235/236), par/poly(adp-ribose) polymerase (parp) ratios, par/pγh2ax ratios, live/dead cell ratios, cell cycle progression, and three-dimensional clonogenic growths and 2) increase in apoptosis markers (cleaved caspases 3 and 9, a pro-apoptotic bh3-only of bcl-2 family (bim), cleaved parp, annexin v). |
2014-09-09 |
2023-08-12 |
Not clear |
| Tinghong Ye, Ying Xiong, Yupeng Yan, Yong Xia, Xuejiao Song, Li Liu, Deliang Li, Ningyu Wang, Lidan Zhang, Yongxia Zhu, Jun Zeng, Yuquan Wei, Luoting Y. The anthelmintic drug niclosamide induces apoptosis, impairs metastasis and reduces immunosuppressive cells in breast cancer model. PloS one. vol 9. issue 1. 2014-09-08. PMID:24416452. |
further, western blot analysis demonstrated the occurrence of its apoptosis was associated with activation of cleaved caspases-3, down-regulation of bcl-2, mcl-1 and survivin. |
2014-09-08 |
2023-08-12 |
Not clear |
| Fangfang Zheng, Kaiwen He, Xin Li, Dan Zhao, Fei Sun, Yu Zhang, Dan Nie, Xingda Li, Wenfeng Chu, Yan Sun, Yanjie L. Transient overexpression of TGFBR3 induces apoptosis in human nasopharyngeal carcinoma CNE-2Z cells. Bioscience reports. vol 33. issue 2. 2014-09-04. PMID:23387308. |
the expression of apoptosis-related proteins, p-bad, bad, xiap (x-linked inhibitor of apoptosis), aif (apoptosis-inducing factor), bax and bcl-2, was determined by western blot or immunofluorescence analysis. |
2014-09-04 |
2023-08-12 |
human |
| Amarylis Claudine Bonito Azeredo Wanschel, Viviane Menezes Caceres, Ana Iochabel Soares Moretti, Alexandre Bruni-Cardoso, Hernandes Faustino de Carvalho, Heraldo Possolo de Souza, Francisco Rafael Martins Laurindo, Regina Célia Spadari, Marta Helena Kriege. Cardioprotective mechanism of S-nitroso-N-acetylcysteine via S-nitrosated betadrenoceptor-2 in the LDLr-/- mice. Nitric oxide : biology and chemistry. vol 36. 2014-09-04. PMID:24333561. |
ventricular histological sections were stained using terminal dutp nick-end labeling (tunel) to identify nuclei with dna degradation (apoptosis) and this was confirmed by western blot for cleaved caspase-3 and caspase-7 protein expression. |
2014-09-04 |
2023-08-12 |
mouse |