| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanyan Li, Feng Xu, Hanyan Xiao, Feng Ha. Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-06. PMID:28657668. |
our results suggest that bdnf-as, through inverse regulation of bdnf, might play a critical role in the process of dgi apoptosis in diabetic retinopathy. |
2018-07-06 |
2023-08-13 |
human |
| Meng Ji, Wei Wang, Shujuan Li, Wenli H. Implantation of bone mesenchymal stem cells overexpressing miRNA‑705 mitigated ischemic brain injury. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28983620. |
bmscs‑ad (bmscs infected with control lentiviral particles) and bmscs‑ad‑mir‑705 markedly mitigated neurological injury, suppressed morphological damage and inhibited neuronal apoptosis, however promoted the mrna levels of brain‑derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf) examined by reverse transcription‑quantitative polymerase chain reaction and western blotting. |
2018-06-26 |
2023-08-13 |
mouse |
| Meng Ji, Wei Wang, Shujuan Li, Wenli H. Implantation of bone mesenchymal stem cells overexpressing miRNA‑705 mitigated ischemic brain injury. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28983620. |
these data indicated that bmscs‑ad‑mir‑705 promoted the secretion of vegf and bdnf, suppressed neuronal apoptosis, and stimulated neuronal regeneration, in turn mitigating the impairment of ischemic brain damage. |
2018-06-26 |
2023-08-13 |
mouse |
| Marika Cordaro, Giovanna Casili, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposit. Fumaric Acid Esters Attenuate Secondary Degeneration after Spinal Cord Injury. Journal of neurotrauma. vol 34. issue 21. 2018-06-22. PMID:27889959. |
faes significantly reduced the severity of inflammation by a modulation of pro-inflammatory cytokines and apoptosis factors, and increased neutrophic factors such as anti-brain-derived neurotrophic factor (bdnf), anti-glial cell-derived neurotrophic factor (gdnf), and neurotrophin-3 (nt3). |
2018-06-22 |
2023-08-13 |
mouse |
| Felipe Schmitz, Paula Pierozan, André F Rodrigues, Helena Biasibetti, Matheus Grunevald, Letícia F Pettenuzzo, Giselli Scaini, Emilio L Streck, Carlos A Netto, Angela T S Wys. Methylphenidate Causes Behavioral Impairments and Neuron and Astrocyte Loss in the Hippocampus of Juvenile Rats. Molecular neurobiology. vol 54. issue 6. 2018-05-10. PMID:27324900. |
bdnf and ptrkb immunocontents and ngf levels were decreased, while tnf-α and il-6 levels, iba-1 and caspase 3 cleaved immunocontents (microglia marker and active apoptosis marker, respectively) were increased. |
2018-05-10 |
2023-08-13 |
rat |
| Jian-Bin Zhong, Xie Li, Si-Ming Zhong, Jiu-Di Liu, Chi-Bang Chen, Xiao-Yan W. Knockdown of long noncoding antisense RNA brain-derived neurotrophic factor attenuates hypoxia/reoxygenation-induced nerve cell apoptosis through the BDNF-TrkB-PI3K/Akt signaling pathway. Neuroreport. vol 28. issue 14. 2018-05-02. PMID:28777258. |
brain-derived neurotrophic factor (bdnf) plays an important role in neuronal cell apoptosis. |
2018-05-02 |
2023-08-13 |
human |
| Xinchun Ye, Lu Yu, Dandan Zuo, Liang Zhang, Jie Zu, Jinxia Hu, Jiao Tang, Lei Bao, Chengcheng Cui, Ruixue Zhang, Guoliang Jin, Kun Zan, Zuohui Zhang, Xinxin Yang, Hongjuan Shi, Zunsheng Zhang, Qihua Xiao, Yonghai Liu, Jie Xiang, Xueling Zhang, Guiyun Cu. Activated mGluR5 protects BV2 cells against OGD/R induced cytotoxicity by modulating BDNF-TrkB pathway. Neuroscience letters. vol 654. 2018-04-17. PMID:28642149. |
morever, pretreatment with exogenous bdnf protected bv2 cells against ogd/r induced apoptosis and release of inflammatory cytokines. |
2018-04-17 |
2023-08-13 |
Not clear |
| Ni Zeng, Junmei Xu, Weifeng Yao, Suobei Li, Wei Ruan, Feng Xia. Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOS/NO Pathway in Rats. Oxidative medicine and cellular longevity. vol 2017. 2018-04-17. PMID:28770018. |
in rats with sepsis, a sharp decline in survival was observed after clp, with significantly reduced cardiac bdnf expression, enhanced myocardial fibrosis, elevated oxidative stress, increased myocardial apoptosis, and decreased endothelial nitric oxide (no) synthase (enos) and no. |
2018-04-17 |
2023-08-13 |
rat |
| Ni Zeng, Junmei Xu, Weifeng Yao, Suobei Li, Wei Ruan, Feng Xia. Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOS/NO Pathway in Rats. Oxidative medicine and cellular longevity. vol 2017. 2018-04-17. PMID:28770018. |
supplementation with recombined bdnf protein (rhbdnf) enhanced myocardial bdnf and increased survival rate with improved cardiac function, reduced oxidative stress, and myocardial apoptosis, which were associated with increased enos expression, no production, and trk-b, a bdnf receptor. |
2018-04-17 |
2023-08-13 |
rat |
| Ni Zeng, Junmei Xu, Weifeng Yao, Suobei Li, Wei Ruan, Feng Xia. Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOS/NO Pathway in Rats. Oxidative medicine and cellular longevity. vol 2017. 2018-04-17. PMID:28770018. |
it is concluded that bdnf protects the heart against septic cardiac dysfunction by reducing oxidative stress and apoptosis via trk-b, and it does so through activation of enos/no pathway. |
2018-04-17 |
2023-08-13 |
rat |
| Jin Chen, Yuanyuan Yang, Lihua Shen, Wensen Ding, Xiang Chen, Erbing Wu, Kefu Cai, Guohua Wan. Hypoxic Preconditioning Augments the Therapeutic Efficacy of Bone Marrow Stromal Cells in a Rat Ischemic Stroke Model. Cellular and molecular neurobiology. vol 37. issue 6. 2018-04-10. PMID:27858286. |
moreover, hp decreased neuronal apoptosis and enhanced the expression of bdnf and vegf in the ischemic brain. |
2018-04-10 |
2023-08-13 |
rat |
| Bangkun Yang, Jun Qin, Ying Nie, Yong Li, Qianxue Che. Brain-derived neurotrophic factor propeptide inhibits proliferation and induces apoptosis in C6 glioma cells. Neuroreport. vol 28. issue 12. 2018-04-02. PMID:28640008. |
the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and the apoptosis assay were used to assess the effects of the bdnf propeptide on the growth and apoptosis of glioma cells. |
2018-04-02 |
2023-08-13 |
Not clear |
| Bangkun Yang, Jun Qin, Ying Nie, Yong Li, Qianxue Che. Brain-derived neurotrophic factor propeptide inhibits proliferation and induces apoptosis in C6 glioma cells. Neuroreport. vol 28. issue 12. 2018-04-02. PMID:28640008. |
we found that the bdnf propeptide promoted c6 glioma cell apoptosis and decreased in-vitro cell growth. |
2018-04-02 |
2023-08-13 |
Not clear |
| D V Bazovkina, E M Kondaurova, A S Tsybko, A I Kovetskaya, T V Ilchibaeva, V S Naumenk. [The Effects of Chronic Alcoholization on the Expression of Brain-Derived Neurotrophic Factor and Its Receptors in the Brains of Mice Genetically Predisposed to Depressive-Like Behavior]. Molekuliarnaia biologiia. vol 51. issue 4. 2018-03-23. PMID:28900083. |
precursor protein of this factor (probdnf) can initiate apoptosis in the brain, while the mature form of bdnf is involved in neurogenesis. |
2018-03-23 |
2023-08-13 |
mouse |
| Weidong Huang, Facai Meng, Jie Cao, Xiaobin Liu, Jie Zhang, Min L. Neuroprotective Role of Exogenous Brain-Derived Neurotrophic Factor in Hypoxia-Hypoglycemia-Induced Hippocampal Neuron Injury via Regulating Trkb/MiR134 Signaling. Journal of molecular neuroscience : MN. vol 62. issue 1. 2018-03-06. PMID:28343294. |
we found that bdnf, p-trkb, and mir-134 expression levels decreased, and that exogenous bdnf increased survival and reduced apoptosis in hypoxic-hypoglycemic hippocampal neurons. |
2018-03-06 |
2023-08-13 |
Not clear |
| Lindsay Joy Spielman, Deanna Lynn Gibson, Andis Klegeri. Incretin hormones regulate microglia oxidative stress, survival and expression of trophic factors. European journal of cell biology. vol 96. issue 3. 2018-03-02. PMID:28336086. |
we confirm these results by demonstrating that glp-1 and gip also inhibit apoptosis of primary murine microglia, and upregulate expression of bdnf by primary murine microglia. |
2018-03-02 |
2023-08-13 |
human |
| Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pou. Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. Neurobiology of learning and memory. vol 139. 2018-02-26. PMID:28137660. |
effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal bdnf and mrna expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. |
2018-02-26 |
2023-08-13 |
rat |
| Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pou. Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. Neurobiology of learning and memory. vol 139. 2018-02-26. PMID:28137660. |
we also examined alternations in hippocampal brain-derived neurotrophic factor (bdnf) and mrna expression of apoptosis - related proteins in a rat model of ptsd: the single prolonged stress (sps) model. |
2018-02-26 |
2023-08-13 |
rat |
| Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pou. Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. Neurobiology of learning and memory. vol 139. 2018-02-26. PMID:28137660. |
sps rats also showed reduced hippocampal bdnf and enhanced apoptosis. |
2018-02-26 |
2023-08-13 |
rat |
| Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pou. Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. Neurobiology of learning and memory. vol 139. 2018-02-26. PMID:28137660. |
moderate treadmill exercise, fluoxetine and the combined treatment alleviated the sps-induced alterations in terms of anxiety levels, hpa axis inhibition, ia conditioning and extinction, hippocampal bdnf and apoptosis markers. |
2018-02-26 |
2023-08-13 |
rat |